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  • Furthermore
  • Furthermore, peptide assemblies have been shown to exhibit remarkable physical properties including high mechanical rigidity, luminescence, piezoelectricity, and semiconductivity . (esrf.eu)
  • gene
  • In this study, the researchers used a peptide nucleic acid-based gene editing technique that they had previously used to cure beta thalassemia, a genetic blood disorder that results in the reduced production of hemoglobin, in adult mice. (healthcanal.com)
  • polymer
  • We have sought to converge the two distinct fields of DNA and peptide self-assembly by using an artificially synthesised polymer that has attributes of both chemical families. (esrf.eu)
  • Several classes of nucleic acid analogs have been reported, but no synthetic informational polymer had previously proven responsive to selection pressures under enzyme free conditions. (scripps.edu)
  • modification
  • We designed and characterized an oligomer family that efficiently self-assembles via reversible covalent anchoring of nucleobase recognition units onto simple oligo-dipeptide backbones (thioester peptide nucleic acids, tPNA) and undergoes dynamic sequence modification in response to changing templates in solution. (scripps.edu)
  • chemical
  • Our studies have ranged from defining simple condensation reagents that could have acted on the early Earth, to the development of replicating peptides that participate in chemical systems displaying behavior reminiscent of biology, such as symbiosis or parasitism. (scripps.edu)
  • reactions
  • Our approach made use of the sequence-dependant auto- and cross-catalytic functional characteristics of template-directed peptide fragment condensation reactions. (scripps.edu)
  • tightly
  • As a manifestation of its inertness, [Co(NH3)l3 can be recrystallized unchanged from concentrated hydrochloric acid: the NH3 is so tightly bound to the Co(III) centers that it does not dissociate to allow its protonation. (rexresearch.com)
  • Type
  • Starting with an array of 81 sequence similar 32-residue coiled-coil peptides, we estimated the relative stability difference between all plausible A2B-type coiled-coil ensembles and used this information to predict the auto- and cross-catalysis pathways and the resulting plausible network motif and connectivities. (scripps.edu)