B cell specific activator protein. Medical search. Frequent questions

Many of the protein kinase activators and inhibitors presently under investigation are natural products or are derivatives of natural products. (eurekaselect.com)
Cells were also treated with PKC activator PEP005 or specific siRNA against protein kinase Cδ (PKCδ). (medscimonit.com)
99% aa identity with rat and 60-63% aa identity with corresponding sequences in human, canine, feline and bovine M-CSF R. Activators of protein kinase C induce TACE/ADAM17 cleavage of the M-CSF receptor, releasing the functional ligand-binding extracellular domain (5). (rndsystems.com)
PRKRA, a protein kinase, interferon-inducible double stranded RNA dependent activator protein kinase, also known as PACT, a protein activator of the interferon-induced protein kinase, is a product of PRKRA gene [ 1 , 2 ] and is a member of the dsRNA binding protein family [ 3 ]. (hindawi.com)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
Finally, Western blotting assay predicted constant expression of phosphatidylinositol 3-kinase and protein kinase B and reduced expression of phosphorylated phosphatidylinositol 3-kinase. (ijpsonline.com)
Hence, evidenced the blocking of phosphatidylinositol 3-kinase/protein kinase B signaling pathway. (ijpsonline.com)
It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
Among the key pathways are those controlling cell proliferation , which coordinate a response to the cellular environment, with the mTOR kinase as a critical node. (axonmedchem.com)
The DNA-dependent activator of interferonregulatory factors (DAI) protein recognize IAV genomic RNA and through the receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and the lineage kinase domain-like (MLKL) protein pathway triggers cell death and inflammatory responses. (foxchase.org)
We are currently investigating two protein kinases, namely AMP-activated protein kinase (AMPK) and Salt-inducible kinase 2 (SIK2). (lu.se)
The intact receptor lacks tyrosine kinase activity, but binding of GH and dimerization results in association with JAK2, a member of the Janus kinase family, which results in self-phosphorylation of the JAK2 and a cascade of phosphorylation of cellular proteins. (medscape.com)

They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. (wikipedia.org)
Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. (wikipedia.org)
A paired box transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES . (nih.gov)
The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
The intracellular domain of activated M-CSF R binds more than 150 proteins that affect cell proliferation, survival, differentiation and cytoskeletal reorganization. (rndsystems.com)
See More Use our definitive endoderm (DE) differentiation kit to obtain functional DE cells that are capable of downstream differentiation to hepatic, intestinal, pancreatic and pulmonary cells. (stemcell.com)
In the eye, D-Onecut expression is independent of glass, a transcriptional regulator of R cell differentiation. (psu.edu)
In support of this notion, overexpression of a putative dominant negative form of D-Onecut during eye development does not affect early cell fate specification, but severely affects photoreceptor differentiation. (psu.edu)
Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. (thermofisher.com)
Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. (hmdb.ca)
Together, the current study demonstrates that prenatal exposure to DES triggers significant alterations in apoptotic molecules expressed on thymocytes, which may affect T-cell differentiation and cause long-term effects on the immune functions. (aspetjournals.org)
Perpetual ROS generation can cause specific molecular changes resulting in the activation or inactivation of transcription factors that may alter gene expression leading to cell proliferation, differentiation, and carcinogenesis. (cdc.gov)
The signaling pathways controlling cell growth and differentiation are almost invariably altered in cancer. (axonmedchem.com)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

Some studies suggest that it acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of other genes, although the identity of these genes is unknown. (medlineplus.gov)
The report in the June 4 issue of Cell Stem Cell reveals that an enzyme that changes the way DNA is packaged in cells allows specific genes to be turned on and off, thereby preventing a stem cell from becoming another cell type. (scienceblog.com)
There are specific enzymes that change how condensed the DNA is to help turn genes on and off. (scienceblog.com)
To turn genes on, the DNA around those genes is loosened so that activators and other proteins can interact with the DNA. (scienceblog.com)
The Johns Hopkins researchers believed that restructuring the DNA by proteins that make up chromosomes could play a role in deciding if a stem cell was going to change into another cell or stay a stem cell, since change in the DNA packaging would allow for many genes to be turned off and other genes to be turned on. (scienceblog.com)
We still don't know what is happening in this case with how NURF regulates genes to keep stem cells from changing," says Matunis. (scienceblog.com)
Both genes are highly conserved, and their proteins are thought to have 2 functions: (1) formation of a bridge or scaffold between the DNA-binding transcription factors and the RNA polymerase II complex and (2) serving as histone acetyltransferases that open the chromatin structure, a process essential for gene expression. (medscape.com)
As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body. (biologynews.net)
The fact that these epigenetic activators, such as Ash1, turn on the expression of specific target genes has been known for some time. (biologynews.net)
Innate immune cells integrate environmental signals to rapidly activate target genes and perform specialized cellular functions 5 . (nature.com)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
They also make enzymes for a variety of cell functions, and in humans they are the only cell component other than the nucleus that houses genes. (nih.gov)
These TAL effector nucleases (TALENs) can be used to add or remove specific genes or correct gene mutations-techniques that fall under the broad category of genome editing. (nih.gov)
Until now, scientists had only used TALENs to edit genes in the cell nucleus. (nih.gov)
A number of viral-based vectors are used to deliver genes to correct a known mutation that causes a disease or modulate the immune response against cancer cells. (foxchase.org)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

Schlemm's canal cell isolates reacted with antibodies specific for CD44 (hyaluron receptor), CD54 (intercellular adhesion molecule-1, ICAM-1), tissue-type plasminogen activator, and TM-inducible glucocorticoid-responsive protein-myocilin (TIGR-MYOC). (nih.gov)
Tissue plasminogen activator (abbreviated tPA or PLAT ) is a protein involved in the breakdown of blood clots . (wikidoc.org)
tPA produced by such means are referred to as recombinant tissue plasminogen activator ( rtPA ). (wikidoc.org)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)

This protein functions as both a transcriptional activator and repressor. (wikipedia.org)
It functions both as a transcriptional activator and repressor to mediate B-cell commitment. (nih.gov)

M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta (1). (rndsystems.com)
Mouse M-CSF receptor cDNA encodes a 977 amino acid (aa) type I membrane protein with a 19 aa signal peptide, a 492 aa extracellular region containing the ligand-binding domain, a 25 aa transmembrane domain and a 441 aa cytoplasmic domain. (rndsystems.com)
M-CSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction (6). (rndsystems.com)
Comparative functional multiomics showed that blood proteins induce distinct receptor-mediated transcriptional programs in microglia and macrophages, such as redox, type I interferon and lymphocyte recruitment. (nature.com)
We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
When DES-induced transcription factors were analyzed, estrogen receptor element (ERE), nuclear factor κB (NF-κB), nuclear factor of activated T cells (NF-AT), and activator protein-1 motifs on the Fas promoter, as well as ERE, NF-κB, and NF-AT motifs on the FasL promoter, showed binding affinity with the transcription factors. (aspetjournals.org)
First, VÎ³9VÎ´2 T cells recognized AML cells by receptor-ligand interaction of CD226-Nectin-2, which then induced ERK1/2 phosphorylation in VÎ³9VÎ´2 T cells. (bvsalud.org)
Curcumin activates PPAR (peroxisome proliferator-activator receptor), which is a group of key nuclear proteins that regulate gene expression and modulate sugar uptake and utilization in the bloodstream. (supervits.com)
The GH molecule binds to its specific cell surface receptor (GHR), which dimerizes with another GHR molecule so that the single GH molecule is enveloped by 2 GHR molecules. (medscape.com)
19 normal healthy in- receptor protein (CD117) that is structurally dividuals were recruited as a control group. (who.int)

Flow cytometry was used to detect cell apoptosis. (medscimonit.com)
PKCδ-siRNA transfection increased cell viabilities and reduced cell apoptosis in HAECs exposed to H/R. Baicalin treatment preserved cell viabilities and reduced apoptosis of H/R-exposed HAECs in a concentration- dependent manner. (medscimonit.com)
Baicalin treatment reduced phosphorylation levels of PKCδ and p53, as well as the expression levels of active caspase3 and bax in HAECs exposed to H/R. The treatment of PKC activator PEP005 impaired the protective effects of baicalin in increasing cell viabilities and reducing apoptosis in HAECs exposed to H/R. (medscimonit.com)
Baicalin exerts vascular a protective effect on HAECs exposed to H/R by reducing cell apoptosis. (medscimonit.com)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Phase contrast microscopy evidenced some specific morphological modifications indicating apoptosis allied cytotoxicity of piperine like apoptotic bodies, condensed nucleus and membrane blabbing. (ijpsonline.com)
Acridine orange/ethidium bromine staining assay revealed that piperine induced apoptosis in MCF-7 cells which was further investigated by Western blotting. (ijpsonline.com)
This revealed increased expression of B-cell lymphoma 2 associated X and reduced expression of B-cell lymphoma 2, indicating apoptosis induction by piperine. (ijpsonline.com)
These include the capacities to proliferate independently of exogenous growth-promoting or growth-inhibitory signals, to invade surrounding tissues and metastasize to distant sites, to elicit an angiogenic response, and to evade mechanisms that limit cell proliferation, such as apoptosis and replicative senescence. (axonmedchem.com)
A study out of China showed that curcumin was able to induce apoptosis within triple negative breast cancer cells. (supervits.com)

DISCUSSION: Maternally transferred anti-malarial IgG antibodies rapidly decline during the first 6 months of life, with variations among specific antigens and malaria transmission intensity. (cdc.gov)
cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)

In general, immunohistochemical (IHC) staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody (link antibody), an enzyme complex and a chromogenic substrate with interposed washing steps. (thermofisher.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Non-falciparum species-specific antigens showed similar patterns in waning immunity and correlation with paired mother's IgG levels compared to P. falciparum antigens. (cdc.gov)

Transcription factor AP-2 beta also known as AP2-beta is a protein that in humans is encoded by the TFAP2B gene. (wikipedia.org)
DNA meth-ylation represses transcription by interfering with transcription factor binding and indirectly by recruiting methyl-CpG-binding proteins and reducing chromatin remodeling activities ( 12 ). (spandidos-publications.com)
Pax5A transcription factor is the major isoform of B-cell-specific activator protein. (nih.gov)
The ZEBRA (Z EBV replication activator) protein is the major transcription factor of EBV, expressed upon EBV lytic cycle activation. (mdpi.com)
Expansion of tumour cells depends on nutrient supply and vascularization, which is orchestrated by the transcription factor known as HIF . (axonmedchem.com)
PAX5 (Paired box protein 5) is a type of protein called a transcription factor that plays an important role in the development and function of B cells, a type of white blood cells (WBCs) that are part of the body's immune system. (mypathologyreport.ca)

Electrophoretic mobility shift assays were performed in order to examine nuclear factor (NF)-κB and activator protein (AP)-1 binding activities. (ersjournals.com)
D-Onecut appears to be a moderate transcriptional activator and functions as a nuclear protein in neuronal tissues of both the CNS and PNS during development and in the adult. (psu.edu)
Note the nuclear staining of tumor cells. (thermofisher.com)
There was shift in mobility of probes (ERE or NF-κB2) of both Fas and FasL in the presence of nuclear proteins from DES-treated cells, and the shift was specific to DES because these probes failed to shift their mobility in the presence of nuclear proteins from vehicle-treated cells. (aspetjournals.org)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
These include genotoxicity, DNA damage, lipid peroxidation, activation of transcription factors activator protein-1 (AP-1) or nuclear factor kappa B (NF-kappaB), and p53 or k-ras gene alterations. (cdc.gov)

The paper examined how the activator Ash1 binds to target DNA elements, known as Trithorax-reponse elements (TREs), located in the gene Ultrabithorax (Ubx). (biologynews.net)

Hillman MA, Gecz J. Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator. (medlineplus.gov)
Our TMPRSS2-drug structures are made public to guide the design of more potent and specific inhibitors. (rsc.org)
VÎ³9VÎ´2 T cells are attractive effector cells for immunotherapy with potent cytotoxic activity against a variety of malignant cells. (bvsalud.org)

The concentration of our recombinant proteins is measured using the absorbance at 280nm. (antibodies-online.com)

We present evidence that D-Onecut can bind to similar DNA sequences with high specificity and affinity as other Onecut proteins through the highly conserved cut domain and homeodomain. (psu.edu)
However, how microglia integrate extracellular signals at sites of cerebrovascular damage and the specificity of blood proteins controlling innate immune cell polarization in disease remain poorly understood. (nature.com)
Based on sequence similarity, RNA-binding specificity, and functional regulation of translation, the CPEB proteins have been classified into two subfamilies. (nih.gov)

Other studies show that the protein can attach to specific regions of messenger RNA (mRNA), which is a chemical cousin of DNA that serves as the genetic blueprint for protein production. (medlineplus.gov)
It is thought that the AFF2 protein helps control the process by which the mRNA blueprint is cut and rearranged to produce different versions of proteins (alternative splicing). (medlineplus.gov)
E1A-PLECs and E1A-NLFs positive for E1A DNA, mRNA and protein expressed cytokeratin and vimentin but not smooth muscle α-actin. (ersjournals.com)
These proteins process pre-microRNAs into mature microRNAs (miRNAs) that target specific mRNA species for regulation. (hindawi.com)
CPEB-4 is an RNA-binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation. (nih.gov)

In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. (hmdb.ca)
Protein phosphorylation is a biological process that regulates most aspects of cellular life, and the enzymes that catalyze this reaction - protein kinases - constitute the largest family of enzymes encoded by the human genome. (lu.se)
We have a specific focus on protein kinases that regulate adipose tissue function, since defects in this tissue, for example in its ability to efficiently store fat, is an underlying cause of insulin resistance and diabetes. (lu.se)

The search for specific inhibitors is mainly performed in cell-based assays. (eurekaselect.com)
Inhibitors and other small molecules are critical for studying cell signaling and other mechanisms that control cell fate, function and phenotype. (merckmillipore.com)

The protein phosphorylation and expression levels were determined by Western blotting. (medscimonit.com)
To date over 4,000 proteins have been identified as targets for PTM acetylation which is comparable to phosphorylation in cellular prevelance (3). (cytoskeleton.com)
An overall aim of our research is to study the regulation and function of protein phosphorylation cascades that are important for the maintenance of a normal energy metabolism and that might be involved in the pathophysiological changes that ultimately lead to type 2 diabetes. (lu.se)

This subfamily corresponds to the RRM1 of the CPEB family of proteins that bind to defined groups of mRNAs and act as either translational repressors or activators to regulate their translation. (nih.gov)

The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. (hmdb.ca)

In vitro assays confirm that both drugs inhibit the human protein TMPRSS2, a SARS-Cov-2 spike protein activator. (rsc.org)
This model is backed by our in vitro experiments and consistent with previous virus cell entry assays. (rsc.org)
To examine the mechanism underlying DES-mediated regulation of Fas and FasL, we performed luciferase assays using T cells transfected with luciferase reporter constructs containing full-length Fas or FasL promoters. (aspetjournals.org)

Prenylation, the covalent binding of farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) moieties to proteins, is a crucial post-translational modification for the regulation of protein localization on cell membranes and, in turn, for key cellular processes. (nature.com)
Investigation of the influenza A virus infection, accompanied by lysis of infected cells, led researchers from the Fox Chase Cancer Center to the discovery of proteins involved in regulation of a specific and immunogenic form of cell death, necroptosis. (foxchase.org)
We further showed that the increase in NK susceptibility caused by C/EBPα-p42 occurred through up-regulation of the NKG2D-Ls ULBP2/5/6 in AML cells. (bvsalud.org)

In the unlikely event that the protein cannot be expressed or purified we do not charge anything (other companies might charge you for any performed steps in the expression process for custom-made proteins, e.g. fees might apply for the expression plasmid, the first expression experiments or purification optimization). (antibodies-online.com)
In a first purification step, the protein is purified from the cleared cell lysate using three different His-tag capture materials: high yield, EDTA resistant, or DTT resistant. (antibodies-online.com)
Protein containing fractions of the best purification are subjected to second purification step through size exclusion chromatography. (antibodies-online.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)
These properties reflect alterations in the cellular signaling pathways that in normal cells control cell proliferation, motility, and survival. (axonmedchem.com)
Moreover, a therapeutic effect can also be achieved by targeting and inducing multiple pathways of programmed cell death. (foxchase.org)
This includes chronic inflammation, DNA damage and disruption of cell signaling pathways. (supervits.com)

Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Furthermore, E1A DNA and protein persisted in epithelial cells in the lungs of these animals 9 . (ersjournals.com)

Different dimer combinations act as transcriptional activators or repressors, respectively. (hmdb.ca)

Co-translational acetylation occurs at the N-terminal of approximately 85% of mammalian proteins, it is irreversible and is thought to be important in protein stability, localization and synthesis (1). (cytoskeleton.com)
Furthermore, the deleterious aftereffect of missense mutations can occur not merely from immediate disruption of CAPN3 function(s), but additionally from disruption from the protein's structural integrity, that could affect its intra or intermolecular protein lead and interactions to decreased stability or altered localization. (exposed-skin-care.net)
Previously, we investigated the localization of several nuage-resident proteins in the nuage structures of spermatogenic cells by immunoelectron microscopy (IEM) [ 22 - 26 ]. (hindawi.com)

Differentiate human pluripotent stem cells (hPSCs) to cells of the endoderm lineage with our specialized cell culture media. (stemcell.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
We hypothesized that CCAAT/enhancer-binding protein α (C/EBPα), one of the most studied lineage-specific transcription factors in hematopoiesis, might influence the expression of NKG2D-Ls. (bvsalud.org)

The AAC03, anti-acetyl lysine antibody recognizes proteins post-translationally modified by acetylation on the epsilon amine groups of lysine residues that occur on 30-50% of all proteins and in particular histones, p53, tubulin and myosin. (cytoskeleton.com)
A proprietary mixture of acetylated proteins was used to produce the 19C4B2.1, highly robust antibody that has been shown to recognize a wide range of acetylated proteins. (cytoskeleton.com)
The reconstituted cells were then washed and stained with BD Horizon™ BUV395 Mouse Anti-Human CD4 antibody (Cat. (bdbiosciences.com)
The primary antibody is intended for laboratory professional use in the detection of the corresponding protein in formalin-fixed, paraffin-embedded tissue stained in manual qualitative immunohistochemistry (IHC) testing. (thermofisher.com)
C-reactive protein is an antibody found in the blood in certain acute and chronic conditions including infections and cancers. (cdc.gov)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)

The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)

Cultured human arterial endothelial cells (HAECs) were exposed to hypoxia/deoxygenation (H/R). Cells were also treated with baicalin at serially diluted concentrations. (medscimonit.com)
The current objective was to develop a technique for selective isolation and culture of endothelial cells from human SC. (nih.gov)
It is a serine protease ( EC 3.4.21.68 ) found on endothelial cells , the cells that line the blood vessels . (wikidoc.org)

In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. (uml.edu)

Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. (wikipedia.org)
Bensaid M, Melko M, Bechara EG, Davidovic L, Berretta A, Catania MV, Gecz J, Lalli E, Bardoni B. FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure. (medlineplus.gov)
The IGFBPs are a family of 6 structurally related proteins with a high affinity for binding IGF. (medscape.com)

A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)

Johns Hopkins researchers have determined why certain stem cells are able to stay stem cells. (scienceblog.com)
By genetically engineering flies to lack several proteins involved in packaging DNA, in the stem cells of the testes in fruit flies, the research team found that if the enzyme NURF is removed from testis stem cells, the stem cells disappeared. (scienceblog.com)
A constant supply of stem cells in the testes is responsible for making cells that eventually become sperm. (scienceblog.com)
So how does NURF keep stem cells as stem cells? (scienceblog.com)
Matunis' group last year discovered proteins that were able to prevent stem cells from becoming other types of cells in the fruit fly testes. (scienceblog.com)
Now they showed that these same proteins also work with NURF to keep stem cells from changing. (scienceblog.com)
It's probably a tangled hair ball of all kinds of signals going on in these cells that prevent these stem cells from differentiating. (scienceblog.com)
NURF keeps stem cells from changing in fruit fly testes, but whether NURF keeps other stem cells from changing still needs to be tested. (scienceblog.com)
Mesenchymal stem cells (MSCs) are multipotent cells with regenerative and immunomodulatory properties. (frontiersin.org)
Human mesenchymal stem cells (HMSCs) are multipotent somatic stem cells that can be isolated from a variety of tissues such as the bone marrow, adipose tissue, and dental pulp. (frontiersin.org)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
However, the effect of VÎ³9VÎ´2 T cells on chemotherapy-resistant acute myeloid leukemia (AML) blasts, especially highly refractory leukemia stem cells (LSCs) is still unknown. (bvsalud.org)
Leukocytes are produced in stem cells in bone marrow. (lu.se)

Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Getting mitoTALENs into cells in tissues presents a formidable challenge, however. (nih.gov)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)

Guinea pig primary peripheral lung epithelial cells (PLECs) transfected with adenovirus E1A (E1A-PLECs) were compared to guinea pig normal lung fibroblasts (NLFs) transfected with E1A (E1A-NLFs). (ersjournals.com)
E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
Adenoviral DNA is retained by peripheral epithelial cells of the lung (PLECs) in humans in whom the viral E1A gene is expressed 4 without replication of a complete virus 5 . (ersjournals.com)
Untreated (dashed line histogram) or treated (solid line histogram) peripheral blood mononuclear cells (PBMC) from the BD Phosflow™ T Cell Kit Lyophilized Cells (Catalog No. 560760) were reconstituted in BD Pharmingen™ Stain Buffer (Cat. (bdbiosciences.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)

Otherwise, it may function as a translational inhibitor when dephosphorylated and bind to a protein such as maskin or neuroguidin, which blocks translation initiation through interfering with the assembly of eIF-4E and eIF-4G. (nih.gov)

Cannulation of SC with gelatin-coated suture material is an effective method for the isolation of human SC cells and provides a cellular model to study the potential role of SC cells in aqueous humor outflow function. (nih.gov)

Our results are fully supportive in favor of the crucial role of calcium signaling deregulation in the HD pathogenesis and indicate that the cornerstone of excessive calcium uptake in HD-specific neurons is a calcium sensor and store-operated calcium channels activator STIM2, which should become a molecular target for medical treatment and novel neuroprotective drug development. (frontiersin.org)
At the molecular level, HD occurs due to an increase in the number of CAG repeats in the first exon of the gene encoding the huntingtin protein. (frontiersin.org)
Gecz J. The FMR2 gene, FRAXE and non-specific X-linked mental retardation: clinical and molecular aspects. (medlineplus.gov)
Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, Bardoni B. Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability. (medlineplus.gov)
Researchers at the University of California, Riverside have discovered a molecular mechanism directing the fate and function of cells during animal development. (biologynews.net)
To discover the molecular programs controlling microglial and macrophage polarization by blood proteins, we developed an unbiased blood-innate immunity multiomic and genetic loss-of-function pipeline consisting of deep sequencing of blood-induced transcriptomes, functional single-cell and oxidative stress transcriptomics, global phosphoproteomics and integration with innate immune signatures from AD and MS models (Extended Data Fig. 1 ). (nature.com)
Molecular Biology of the Cell. (lu.se)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

Rarely, small deletions of genetic material from the AFF2 gene are associated with fragile XE syndrome, although how these deletions affect the protein and lead to intellectual disability is unknown. (medlineplus.gov)
Genetic changes have also been studied in the past few decades, with documentation of aneuploid DNA content in seminomas and intratubular germ cell neoplasia of the unclassified type (IGCNU), the precursor lesion. (medscape.com)
BC comprises of variant subtypes and those subtypes arise from basal progenitor or luminal progenitor cells undergoing different genetic mutations[ 2 ]. (ijpsonline.com)

What we were able to show is that the epigenetic activator Ash1is recruited to a target gene through cell-type specific non-coding RNA" he said. (biologynews.net)

Elevated blood sugar creates hazardous glucose cross-links with proteins, causing Advanced Glycolytic Enzymes (AGEs) to form. (supervits.com)
Curcumin also reduces the activity of specific liver enzymes that release sugar into the bloodstream while activating enzymes that store sugar as glycogen. (supervits.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)
The results indicated that VÎ³9VÎ´2 T cells can efficiently kill drug-resistant AML cell lines in vitro and in vivo, and the sensitivity of AML cells to VÎ³9VÎ´2 T cell-mediated cytotoxicity is not influenced by the sensitivity of AML cells to chemotherapy. (bvsalud.org)

In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. (thermofisher.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mitochondrial-targeted TALENS (mitoTALENs) represent the most promising hope for an effective treatment of diseases caused by mutations in mtDNA," said Carlos T. Moraes, Ph.D., a professor of neurology and cell biology at the University of Miami Miller School of Medicine and principal investigator of the study. (nih.gov)

Clinical studies in bladder tissue of KIC patients have shown increases in the infiltration of eosinophil and mast cells as well as serum immunoglobulin (Ig)E level, which displayed an association with hypersensitivity and/or allergic reactions ( 7 , 8 ). (spandidos-publications.com)
Reports from several laboratories suggest that a phenomenon termed epithelial-mesenchymal transformation, in which epithelial cells transform into fibroblasts capable of producing connective tissue matrix, is an important feature of tissue remodelling 10 , 11 . (ersjournals.com)
This tissue may contain both positive and negative staining cells or tissue components and serve as both the positive and negative control tissue. (thermofisher.com)
The physiological relevance of our studies is reinforced using human cells and tissue. (lu.se)

signal transducer and activator of. (wikigenes.org)
More importantly, we revealed that the CD226-extracellular signal-regulatory kinase1/2 (ERK1/2)-lysosome-associated membrane protein 1 (LAMP1) pathway is an important mechanism for VÎ³9VÎ´2 T cell-induced cytotoxicity against AML cells. (bvsalud.org)

We report here the characterization of the Drosophila homolog of the onecut homeobox gene, which encodes a protein product with one cut domain and one homeodomain. (psu.edu)

The EP300 gene on band 22q13 encodes a protein, p300, that is highly similar to CREBBP. (medscape.com)

B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

The cytoplasmic RNA-induced silencing complex (RISC) contains dsRNA binding proteins, including PRKRA, TRBP, and Dicer. (hindawi.com)
PRKRA is contained in the cytoplasmic RNA-induced silencing complex (RISC) together with transactivation response RNA binding protein (TRBP) and Dicer [ 4 - 6 ]. (hindawi.com)
RISC assembles into processing bodies (P-bodies) which are specific cytoplasmic foci in somatic eukaryotic cells [ 7 - 9 ]. (hindawi.com)
On the other hand, there are specific cytoplasmic foci similar to the P-bodies in spermatogenic cells, which are called nuage [ 15 - 18 ]. (hindawi.com)
CPEB-1 is an RNA-binding protein that interacts with the cytoplasmic polyadenylation element (CPE), a short U-rich motif in the 3' untranslated regions (UTRs) of certain mRNAs. (nih.gov)
NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. (hmdb.ca)

Using AMPK activators and other tools, we aim to determine the role of AMPK in adipose cells. (lu.se)

Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases. (embl.de)

Although MSC EVs show great promise for regenerative medicine applications, insights into their uptake mechanisms by different target cells and the ability to control MSC EV properties for defined function in vivo have remained elusive knowledge gaps. (frontiersin.org)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
Adaptive immune mechanisms recognize and neutralize foreign molecules or microorganisms in a specific manner. (lu.se)

More recently, his group invented tools for cleavage-free large gene insertion via mining microbial recombination protein, and developed single-cell tracking approach for studying cancer biology and cancer immunology. (stanford.edu)
Our data provide an interactive resource for investigation of the immunology of blood proteins that could support therapeutic targeting of microglia activation by immune and vascular signals. (nature.com)
Moreover, our study provides a resource for the investigation of the immunology of blood proteins in inflammatory, autoimmune and neurodegenerative diseases. (nature.com)

Such cells are described as disseminated tumor cells (DTC) (Sosa et al. (biomedcentral.com)
2014 ) or sometimes as circulating tumor cells (CTC) (Kim et al. (biomedcentral.com)

Lymphoma b cell. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)

Both exhibited cuboidal morphology and junctional complexes, but did not contain lamellar bodies or express surfactant protein A, B or C mRNAs. (ersjournals.com)
CPEB-4 is overexpressed in a large variety of tumors and is associated with many mRNAs in cancer cells. (nih.gov)

The ~200 amino acid TBC/rab GTPase-activating protein (GAP) domain is well conserved across species and has been found in a wide range of different proteins from plant adhesion molecules to mammalian oncogenes. (embl.de)

At a population level, P. falciparum apical membrane antigen-1 (AMA1) and merozoite surface protein-1 19kD (PfMSP1) IgG decreased during the first 12 months of life before reaching a nadir, whereas IgGs to other targets only declined for the first 4 months of life. (cdc.gov)

CPEB-3 is a sequence-specific translational regulatory protein that regulates translation in a polyadenylation-independent manner. (nih.gov)

These AGEs damage cell membranes, vital enzyme systems and perpetuate inflammatory conditions throughout the body. (supervits.com)

Anatomy22

Organisms7

Diseases11

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes67

Disciplines and Occupations1

Information Science3

Kinase13

Differentiation19

Genes18

Plasminogen activator4

Transcriptional activator and repressor2

Receptor10

Apoptosis10

Antibodies2

Antigens4

Transcription factor6

Nuclear6

Binds1

Potent3

Recombinant1

Specificity3

MRNA5

Kinases3

Inhibitors2

Phosphorylation3

Regulate1

Repressor1

Assays3

Regulation3

Purification3

Pathways4

Induce1

Persisted in epithelial1

Repressors1

Localization3

Lineage3

Antibody7

Intracellular1

Endothelial cells3

Cytoskeletal1

Affinity3

Structurally1

Stem cells14

Tissues5

Peripheral5

Inhibitor1

Cellular1

Molecular8

Genetic3

Epigenetic1

Enzymes2

Vitro2

Dendritic cells2

Mutations2

Tissue4

Signal2

Drosophila1

Encodes a protein1

Progenitor cells1

Cytoplasmic6

AMPK1

GTPases1

Mechanisms3

Immunology3

Tumor cells2

Lymphoma3

MRNAs2

Mammalian1

Antigen1

Regulates1

Membranes1