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  • epithelial
  • Methods Three commercially available HDM extracts were analysed for endotoxin levels, protease and chitinase activities and effects on transepithelial resistance, junctional proteins and pro-inflammatory cytokine release in the bronchial epithelial cell line 16HBE and normal human bronchial cells. (bmj.com)
  • In vivo, this extract induced the most profound epithelial E-cadherin delocalisation and increase in CCL20, CCL17 and interleukin 5 levels, accompanied by the most pronounced induction of HDM-specific IgE, goblet cell hyperplasia, eosinophilic inflammation and airway hyper-reactivity. (bmj.com)
  • The proteolytic activity of house dust mite allergens was hypothesised to be crucial for epithelial barrier dysfunction and subsequent activation of the innate immune response in asthma. (bmj.com)
  • estrogen receptor
  • Interrogation of expression databases showed that RIP2 expression is significantly over-expressed in triple-negative breast cancers (TNBC: estrogen-receptor (ER) negative, progesterone-receptor (PR) negative, Her2/neu- (Her2) negative), compared to other clinical subtypes. (beds.ac.uk)
  • PI3K
  • The effects of miR-218 ectopic expression on the AKT and phospho-AKT (p-AKT) expressions of imatinib mesylate-induce GIST cells were determined by Western blot and flow cytometry with the PI3K pathway inhibitor Wortmannin. (springer.com)
  • The expression of miR-218 is down-regulated in an imatinib mesylate-resistant GIST cell line (GIST430), whereas miR-218 over-expression can improve the sensitivity of GIST cells to imatinib mesylate, with PI3K/AKT signaling pathway possibly involved in the mechanism. (springer.com)
  • selective
  • Finally, we assess the putative benefits of targeting this nuclear receptor with still-to-be-identified highly selective PPAR γ modulators. (nature.com)
  • clinical
  • Although administration of sufficient cells is necessary to achieve maximal therapeutic benefits, documented MSC clinical trials have largely relied on injections of ∼1 × 10 6 cells/kg, which appears too low to elicit a robust therapeutic response according to published preclinical studies. (physiology.org)
  • The clinical utility of MSC stems in part from the recognition that MSC possess immunomodulatory properties that can be explored for nonautologous stem cell therapy ( 64 , 74 ). (physiology.org)
  • Despite encouraging results from preclinical studies, however, clinical trials of stem cell therapy have thus far demonstrated moderate and inconsistent benefits ( 2 , 48 , 73 ), indicating an urgent need to optimize the therapeutic platform and enhance stem cell potency. (physiology.org)
  • modulating their activities has the potential to facilitate the regeneration, isolation and expansion of stem cells in clinical applications. (embopress.org)
  • Inguinal orchiectomy is curative in 70-80% of clinical stage I testicular germ cell tumours (CS I TGCT). (biomedcentral.com)
  • expression
  • Using a BTK-deficient variant of DT40 chicken B cells, we found that expression of wild-type or gain-of-function mutant BTK, but not the R28C mutant, reconstituted NF-κB activity. (rupress.org)
  • Expression of BTK is limited to B, mast, and myeloid cells. (rupress.org)
  • Evidence that signaling through the c-kit receptor can induce expression of cellular function. (rupress.org)
  • Expression of LPP-1 decreases cell activation by exogenous LPA. (biochemsoctrans.org)
  • ERRα is also a phosphoprotein whose expression in human breast tumors correlates with that of the receptor tyrosine kinase ErbB2, suggesting that its transcriptional activity could be regulated by signaling cascades. (aacrjournals.org)
  • ERRα is widely expressed in normal tissues ( 2 ) and RNA expression studies show the presence of ERRα in a range of breast cancer cell lines ( 17 ). (aacrjournals.org)
  • Furthermore, analysis of the sympathetic and parasympathetic innervations of adipose tissue revealed that the autonomic nervous system modulates the fat cell number and other processes, such as adipokine expression levels, lipogenesis/lipolysis, fatty acid uptake, and glucose uptake. (nature.com)
  • Quantitative real-time PCR (qRT-PCR) was utilized to determine the expression profiles of miR-218 in both GIST cell lines. (springer.com)
  • Forty-eight hours after the transfection of the miR-218 mimic or miR-218 inhibitor in the GIST cells, the changes in the expression of miR-218 in the GIST cells were detected with qRT-PCR. (springer.com)
  • The effects of the ectopic expression of miR-218 in GIST882 or GIST430 cells on the imatinib mesylate-induced GIST cell viability were determined by MTT. (springer.com)
  • Decreased DAB2IP gene expression, which could be induced by fractionated irradiation, is associated with resistance to γ‑rays and α‑particles in prostate cancer cells. (urotoday.com)
  • growth
  • The serum-derived lipid growth factors, lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P), activate cells selectively through different members of a family of endothelial differentiation gene (EDG) receptors. (biochemsoctrans.org)
  • Evidence will be presented that the LPPs cross-talk with EDG and other growth factor receptors, thus, regulating the responses of the cells to lipid phosphate mediators of signal transduction. (biochemsoctrans.org)
  • These results reveal a mechanism through which growth factor signaling can selectively activate ERRα target genes in breast cancer cells. (aacrjournals.org)
  • A xenograft mouse model was used to assess tumor growth and chemosensitivity to docetaxel in vivo in MDA-MB-231 cells with and without RIP2 small hairpin RNA knockdown. (beds.ac.uk)
  • The CB2 agonist CB13 also reduced the growth of DLD-1 cells in a mouse model of colon cancer. (cannabisgotasdeesperanza.com)
  • Monomeric gremlin is a novel vascular endothelial growth factor receptor-2 antagonist. (urotoday.com)
  • role
  • Dimerization of SCF is a dynamic process, and it may play a regulatory role in the control of SCFR binding affinity and receptor activation. (pnas.org)
  • Our results unravel an important role for the Vav proteins as signal transducers that couple signalling downstream of RTKs with local Rac activation during morphogenetic movements. (csic.es)
  • Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies-New Therapeutic Possibilities? (semanticscholar.org)
  • downstream
  • Here, usinga multidisciplinary approach, we identify the GTP exchange factor (GEF) Vav as a key regulator of Rac activity downstream of RTKs in a developmentally regulated cell migration event, that of the Drosophila border cells (BCs). (csic.es)
  • kinases
  • The current model suggests that the spatially controlled activation of receptor tyrosine kinases (RTKs) by guidance cues limits Rac activity at the leading edge, which is crucial fo establishing and maintaining polarized cell protrusions at the front. (csic.es)
  • tissue
  • We found that in both WT and p75KO ischemic tissue Ki67 (+) cells almost exclusively were GFP (+), indicating that only BM-derived cells proliferate in the ischemic tissue. (ahajournals.org)
  • Interestingly, Ki67/GFP (+) cells started to appear in WT tissue by day 3 through day 21, whereas in p75KO tissue first proliferative activity was detected on day 28, suggesting extremely delayed recovery and regenaration in p75KO tissue. (ahajournals.org)
  • Instead, the secretion of multiple trophic factors by MSC provides the underlying tissue healing mechanism ( 4 , 12 , 25 , 40 , 61 ). (physiology.org)
  • We show that the CB1 receptor was mainly expressed in human normal colonic epithelium whereas tumor tissue was strongly positive for the CB2 receptor. (cannabisgotasdeesperanza.com)
  • Adipose tissue is not an inert cell mass contributing only to the storage of fat, but a sophisticated ensemble of cellular components with highly specialized and complex functions. (nature.com)