• Providing an excellent compilation of the most important and useful methods of modern stereoselective synthesis, this book features illustrative examples of drug and natural product syntheses, resulting in a rich source of stimulating ideas for the efficient use of asymmetric reactions in the users' own synthesis. (wiley-vch.de)
  • The tri-component synthesis of novel chiral benzimidazole Mannich bases, by reaction between benzimidazole, aqueous 30% formaldehyde and an amine, the biological evaluation and DFT studies of the new compounds are reported here. (biomedcentral.com)
  • Efforts are directed also to small chiral molecules such as alkyloxiranes, aziridines and fluorochloro(bromo,iodo)methane. (uni-tuebingen.de)
  • On the other hand, enantioselective chromatography is improved by the synthesis of new chiral stationary phases. (uni-tuebingen.de)
  • Seven interesting chiral amines have been synthesized and applied into the enolate chemistry of two interesting precursors of synthesis of natural products: 1,4- cyclohexanedione monoethylene ketal and tropinone.The aldol reaction between the lithium enolate of 1,4-cyclohexanedione monoethylene ketal and benzaldehyde demonstrated the high diastereoselectivity (up to 98% de) and the moderate to high enantioselectivity (up to 75% ee) induced by those chiral lithium amides. (usask.ca)
  • In recent years, however, new developments towards the enantioselective synthesis of various heterocycles and other useful compounds have evolved which take advantage of the unique properties of chiral Pd-aqua complexes. (uni-leipzig.de)
  • We report herein an asymmetric cooperative process for the enantioselective 1,6-addition of β-ketoesters to in situ generated para-quinone methides with chiral Pd−aqua complexes as mixed Brønsted acid−base catalysts. (uni-leipzig.de)
  • Transition-Metal-Catalyzed Synthesis of α-Chiral Allylsilanes. (ipcm.fr)
  • Although the aziridine motif appears in some natural products, interest in these models comes from the easy access to amine-protected derivatives obtained via the nucleophilic ring-opening of aziridines. (umontreal.ca)
  • The precise and correct determination of enantiomeric ratios is the prerequisite for the screening of enantioselective reactions (chirality pool synthesis, catalysis, kinetic resolution, enzymatic transformations) being investigated in parallel. (uni-tuebingen.de)
  • This chapter provides an overview of the methods by which epoxides and aziridines can be prepared via nucleophilic attack at the C. O or C. N bond. (hud.ac.uk)
  • The chemistry of epoxides and Aziridines or any other three-membered ring heterocycles, has caught the attention of synthetic chemists for more than a century, owing to the essentially high reactivity of these small-ring heterocycles. (moltuslab.com)
  • The accomplishment of the γ-alkylation reaction from β-keto esters of tropinone and the enantioselective aziridine formation from nortropinone is first reported. (usask.ca)
  • That will, no doubt, benefit the further enantioselective α-hydroxylation reaction of tropinone. (usask.ca)
  • Our group has recently developed a copper-catalyzed enantioselective aziridination reaction from N-tosyloxycarbamates which leads to a variety of carbamate-protected arylaziridines. (umontreal.ca)
  • Catalytic Enantioselective Reaction of 2H-Azirines with Thiols Using Cinchona Alkaloid Sulfonamide Catalysts. (buchler-gmbh.com)
  • Aziridines are commonly used in synthesis for chemical bond expansions and functional group transformations. (moltuslab.com)
  • Second, appropriate control over the subsequent ring-opening transformations of aziridines. (moltuslab.com)
  • The existing and state-of-the-art features catalytic, highly enantioselective aziridinations, reliable ring-opening transformations, and stereoselective cycloadditions, all of which illustrate the unique reactivity of Aziridines. (moltuslab.com)
  • Enantioselective Sequential Catalytic Arylation-Fukuyama Cross-coupling of 1,1-Biszincioalkane Linchpins. (ipcm.fr)
  • In 1990, he won the Nobel Prize in Chemistry "for his development of the theory and methodology of organic synthesis ", specifically retrosynthetic analysis. (kiddle.co)
  • The recent research and development of Aziridine chemistry has followed two main paths. (moltuslab.com)
  • Nitrosoalkenes in Science of Synthesis (Knowledge Update) 2015/2 , Thieme Verlag, Stuttgart, 315 - 334. (fu-berlin.de)
  • Regarded by many as one of the greatest living chemists, he has developed numerous synthetic reagents , methodologies and total syntheses and has advanced the science of organic synthesis considerably. (kiddle.co)
  • Aziridines are saturated three-membered ring compounds, that contain two carbons and one nitrogen atom. (moltuslab.com)
  • This reactivity of the small-ring heterocycles makes them versatile species in organic synthesis. (moltuslab.com)
  • Applications to natural product synthesis and mechanistic investigations are also summarized. (mdpi.com)
  • Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. (mdpi.com)
  • This entry was posted on March, 06, 2020 at 10 : 19 am and is filed under Aziridine . (moltuslab.com)
  • Dokli, I., Pohl, R., Klepetářová, B. & Jahn, U. (2019) First total synthesis of ent-asperparaline C and assignment of the absolute configuration of asperparaline C . Chemical communications, 55 (27), 3931-3934 doi:10.1039/C9CC00945K. (irb.hr)
  • Aziridine is a monomer that finds use in the preparation of cationic polymers. (moltuslab.com)
  • Finally, these conditions were applied to the synthesis of (R)-Nifenalol, a beta-blocking agent that has shown antianginal and antiarrhythmic properties as described in the third chapter. (umontreal.ca)
  • Persulfurated Benzene-Cored Asterisks with π-Extended ThioNaphthyl Arms: Synthesis, Structural, Photophysical and Covalent Dynamic Properties. (ipcm.fr)
  • As compared to other fields of utility for a multitude of properties, Aziridines are relatively new in the cosmetic industry. (moltuslab.com)
  • A unified approach toward an enantioselective separation system was developed. (uni-tuebingen.de)
  • Aziridine is a highly reactive and volatile chemical. (moltuslab.com)
  • Synthesis of 6 was accomplished and the structure of new product was assigned by their 1H/13C NMR, IR, CH-COSY and mass spectral data as well as the elemental analysis. (ivsajournals.com)
  • The research activity can be arranged in two main lines: i) synthesis of chromatographic supports for molecular recognition studies and ii) study of stability/instability of bioactive compounds mainly enantiomers. (uniroma1.it)
  • The second line is related to the study of stereochemical stability of bioactive compounds as potential new drugs or organocatalysts in asymmetric synthesis. (uniroma1.it)
  • Among these nitrogen-containing compounds, aziridines displayed distinct biological activities. (phys.org)
  • Lindsley, C. W. 'A General, Enantioselective Synthesis of N-Alkyl Terminal Aziridines and C2-Functionalized Azetidines via Organocatalysis. (clasit.org)
  • The use of the chiral bisphosphorus ligand WingPhos enables a versatile, regio- and enantioselective palladium-catalyzed tandem allylic substitution to provide a series of chiral vinyl-substituted heterocycles, including tetrahydroquinoxalines, piperazines, dihydro-2 H -benzo[ b ][1,4]-oxazines, and morpholines, in exellent ees and yields. (organic-chemistry.org)
  • Dong, S. X. * Lanthanide-catalyzed regio- and enantioselective hydrosilylation of aryl-substituted terminal and internal alkenes. (jizake-fu.com)
  • Feng, X. M.* Catalytic Regio- and Enantioselective Protonation for the Synthesis of Chiral Allenes: Synergistic Effect of the Counterion and Water. (jizake-fu.com)
  • DFT-Based Stereochemical Rationales for the Bifunctional Brønsted Acid/Base-Catalyzed Diastereodivergent and Enantioselective aza-Henry Reactions of α-Nitro Esters was published in the Journal of Organic Chemistry in October 2021. (duddinglab.com)
  • Diversity-oriented synthesis of glycomimetics was published in Communications Chemistry in June 2021. (duddinglab.com)
  • Site- and enantioselective oxidation of aliphatic C-H bonds with a general scope, predictable selectivities and in preparatively useful yields, would represent a paradigm shift in the standard logic of organic synthesis. (thieme.de)
  • Investigation into anticancer activity and synthetic transformation of aziridines bolster the potential of this electro-oxidative reaction in the organic synthesis and medical discovery, thus offering a novel synthetic strategy for olefin aziridination and furnishing an alternative approach to discovery of new drug candidates. (phys.org)
  • 323. 'Large-Scale Synthesis of Covalent Organic Frameworks: Challenges and Opportunities' Vardhan, H. (unt.edu)
  • 99%) proceeds via Lewis acid-catalyzed S N 2-type ring opening of activated aziridines with 2-halophenols followed by Cu(I)-catalyzed intramolecular C-N cyclization in a stepwise fashion. (organic-chemistry.org)
  • Lindsley C. W. 'A general, enantioselective synthesis of β and γ-fluoroamines. (clasit.org)
  • Lindsley, C.W. 'A general, enantioselective synthesis of protected morpholines and piperazines. (clasit.org)
  • 327. 'A general large-scale synthesis approach for crystalline porous materials' Liu, X. (unt.edu)
  • As a consequence, there has been increased interest in developing innovative synthetic methodologies for the production of aziridines from bioactive natural products. (phys.org)
  • As recent interest, the synthesis of aminocatalysts and their use in heterogeneous phase was embraced. (uniroma1.it)
  • The group of Professor Lei Liu at Shandong University (Jinan, P. R. of China) envisioned that integrating the KR strategy into enantioselective C(sp 3 )-H oxidation reaction design would advance the development of both research fields. (thieme.de)
  • Blackwell, H. E. 'Design, synthesis, and biochemical characterization of non-native antagonists of the Pseudomonas aeruginosa quorum sensing receptor LasR with nanomolar IC 50 values. (clasit.org)
  • O'Reilly, M. C.* 'Synthesis and Characterization of Functionalized Amino Dihydropyrimidines Toward the Analysis of their Antibacterial Structure-Activity Relationships and Mechanism of Action. (clasit.org)