CorticosteroidsRemissionMethotrexateImmunosuppressantsPurinetholUlcerative colitisPurine2023ThiopurinesImmunosuppressiveImmunosuppressantRelapseInterleukinImmunomodulatorsUveitisMedicationsCrohn'sMolecular weightLiverAutoimmuneSevereToxicityAdverse eventsDrugsMonthsDosageLaboratoryMesalamineDurationCompoundClinicalSymptomsTypicallyTreatmentCellsCasesAdministrationAffectRequireMadeCombination
Corticosteroids4
- Azathioprine is used to prevent rejections of kidney or liver allografts, usually in conjunction with other therapies including corticosteroids, other immunosuppressants, and local radiation therapy. (wikipedia.org)
- Nonsteroidal anti-inflammatory drugs and corticosteroids may be combined or continued (if they were already in use) with azathioprine, but the combination with other DMARDs is not recommended. (wikipedia.org)
- A total of 325 IBD patients were enrolled, 118 of whom were treated with corticosteroids, 88 with azathioprine/6-mercaptopurine (AZA/6-MP), and 147 with anti-TNF agents. (frontiersin.org)
- Thiopurines such as azathioprine and 6-mercaptopurine are commonly used to maintain remission and are also suitable for reducing the dose of corticosteroids in patients with steroid-dependent UC. (hindawi.com)
Remission7
- Evidence Central , evidence.unboundmedicine.com/evidence/view/EBMG/453402/all/Azathioprine_or_6_mercaptopurine_for_maintaining_remission_in_Crohn's_disease. (unboundmedicine.com)
- Azathioprine has been used in the management of moderate to severe chronically active Crohn's disease, to maintain clinical remission (absence of disease activity) in corticosteroid-dependent patients, and to provide benefit in people with fistulizing Crohn's disease. (wikipedia.org)
- Azathioprine is also used to maintain remission in people who have granulomatosis with polyangiitis. (wikipedia.org)
- Patients with active disease also had an increased prevalence of depression and anxiety compared with those in remission ( 3 , 6 ). (frontiersin.org)
- Azathioprine and other immunosuppresant drugs can be used as adjunctive therapy for active Crohn's disease and may help to maintain remission. (aafp.org)
- Other reasons for thiopurine cessation (n=37) were stable remission (n=26), patient preferences (n=9) and high 6-TGN levels (n=2). (ecco-ibd.eu)
- The immunosuppressants azathioprine, 6-mercaptopurine, methotrexate, and tacrolimus are NOT effective at inducing remission in active UC. (crohnsandcolitis.ca)
Methotrexate2
- Subjects were taken off their immuno- suppressive and disease-modifying drugs consisting of methotrexate, 6-mercaptopurine, azathioprine, or auranofin and few 0.1 mg of solubilized type II collagen daily for 1 month and then switched to 0.5 mg for the next 2 months (15). (bronsonvitamins.com)
- Immune modifiers such as azathioprine, 6-mercaptopurine, and methotrexate help suppress the immune system so that the body stops attacking its own tissues. (medbroadcast.com)
Immunosuppressants2
- Among numerous immunosuppressants, azathioprine (AZA) is a well-established medication that plays a useful role in the treatment of various autoimmune diseases, and recent studies have confirmed its efficacy in patients with BS, particularly in individuals with ocular pathology. (researchsquare.com)
- Crawford et al (1995) Rational design of immunosuppressants: thioethers-azathioprine analogues without bone marrow toxicity. (tocris.com)
Purinethol1
- Mercaptopurine (also called 6-mercaptopurine, 6-MP or its brand name Purinethol) is an immunosuppressive drug. (hmdb.ca)
Ulcerative colitis1
- Azathioprine is an immunosuppressant used to help renal transplant rejection, and treat rheumatoid arthritis, Crohn's complaint, and ulcerative colitis. (eczemafree.org)
Purine3
- Azathioprine is in the purine analogue and antimetabolite family of medications. (wikipedia.org)
- 6-thiopurines are compounds containing a purine that carries a thiol group at the 6-position. (hmdb.ca)
- These drugs, including azathioprine and 6-mercapto-purine (6-MP), help reduce inflammation of the immune system - though they can take as long as 6 months to effectively work. (healthline.com)
20231
- Value in health regional issues 2023 6 37 71-80. (cdc.gov)
Thiopurines1
- 6-Methylmercaptopurine, also known as thiopurine S-methylether, belongs to the class of organic compounds known as 6-thiopurines. (hmdb.ca)
Immunosuppressive1
- lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. (tocris.com)
Immunosuppressant1
- Azathioprine belongs to a class of medicines known as an immunosuppressant. (eczemafree.org)
Relapse2
- Data were collected retrospectively on disease-related characteristics and events including severity, recurrence, relapse, recovery and flare-up, as well as on azathioprine dosage and the duration of use. (researchsquare.com)
- Azathioprine and 6-mercaptopurine are effective at preventing relapse in inactive UC. (crohnsandcolitis.ca)
Interleukin2
- The interleukin (IL)-6-174 gene polymorphism also has a possible association with microscopic colitis by influencing the inflammation pathway. (medscape.com)
- Another competitor drug, Actemra , works by blocking the protein interleukin 6 (IL-6) from connecting to cells. (drugwatch.com)
Immunomodulators1
- For those with more moderate to severe disease, immunomodulators (5-mercaptopurine or azathioprine) and biologic medications (Table 3) are more effective. (contemporaryobgyn.net)
Uveitis1
- Oral tolerization, a method of inducing antigen-specific tolerance, suppresses animal models of the autoimmune diseases multiple sclerosis, uveitis, and diabetes (6-11). (bronsonvitamins.com)
Medications2
- There is also evidence that the use of l-dopa medications may lead to a deficiency of B-vitamins, especially niacin and vitamin B-6. (digitalnaturopath.com)
- 6.Subjects who have not adhered to abstinence of prohibited and/or concomitant medications. (who.int)
Crohn's2
- Azathioprine treatment is associated with an increased risk of lymphoma, but if this is due to the drug or a predisposition related to Crohn's disease is unclear. (wikipedia.org)
- Lower doses of azathioprine are used as a therapy in children with refractory or corticosteroid-dependent Crohn's disease, without causing many side effects. (wikipedia.org)
Molecular weight1
- Its empirical formula is C 14 H 8 N 2 Na 2 O 6 with a molecular weight of 346.21. (nih.gov)
Liver1
- Patients should take daily folate supplements (1 mg orally) and have complete blood count and liver tests every 6 to 12 months. (msdmanuals.com)
Autoimmune3
- Mechanism whereby azathioprine affects autoimmune diseases unknown. (medscape.com)
- This dose was extrapolated from experiments in the rat adjuvant arthritis model where feeding 3 to 30 p.g of collagen attenuated disease (14) and the rat experimental autoimmune encephalomyelitis (EAE) model where feeding 500 to 1000 p.g of MBP was suppressive (6,10). (bronsonvitamins.com)
- Preemptive TPMT Genotyping and Adherence to Genotype-Based Therapeutic Recommendations Reduces the Healthcare Cost in Patients Receiving Azathioprine or 6-Mercaptopurine for Autoimmune Diseases. (cdc.gov)
Severe1
- Severe Combined Immunodeficiency (SCID) disease and a history of intussusception are both contraindications to the receipt of rotavirus vaccines ( 6 ). (cdc.gov)
Toxicity1
- These agents also form covalent cross-links in DNA, more typically at the 0-6 position of guanine as the most important DNA adduct site, and have the primary adverse effects of myelosuppression and GI toxicity. (vin.com)
Adverse events2
- This study was conducted to determine the types and prevalence of adverse events related with azathioprine in patients with ocular BS. (researchsquare.com)
- Conclusion Administration of azathioprine with due attention to the signs, symptoms, and severity of the disease, results in a reduced rate of adverse events and resolution of the ocular involvement in patients with BS. (researchsquare.com)
Drugs1
- In more serious cases, stronger drugs such as 6-mercaptopurine and azathioprine may be used. (healthhub.sg)
Months2
- 6 months on thiopurine monotherapy including azathioprine, 6-mercaptopurine or tioguanine. (ecco-ibd.eu)
- More than half of patients treated for LC experienced resolution of symptoms after 6 months of treatment, while only 15% of patients had significant persistent symptoms. (medscape.com)
Dosage1
- There is need to investigate and document genetic variation at loci of pharmacogenetic relevance among different SSA populations since this information could be used to inform drug efficacy, safety and recommended dosage [ Reference Dandara 6 - Reference Masimirembwa and Hasler 8 ]. (cambridge.org)
Laboratory1
- This single-centre prospective cohort study evaluated a reduced monitoring strategy that involved 6-monthly laboratory assessment combined with alternating outpatient and phone appointments, during 104 weeks. (ecco-ibd.eu)
Mesalamine1
- The active ingredient in DIPENTUM Capsules (olsalazine sodium) is the sodium salt of a salicylate, disodium 3,3'-azobis (6-hydroxybenzoate) a compound that is effectively bioconverted to mesalamine (5-aminosalicylic acid,5-ASA), an aminosalicylate. (nih.gov)
Duration2
- At baseline, 47 patients were treated with azathioprine (55.3%), 25 with 6-mercaptopurine (29.4%) and 13 with tioguanine (15.3%) for a median duration of 6.7 years. (ecco-ibd.eu)
- Overall study duration: 6 years Multi-center study: up to 42 centers Number of subjects: 425 Duration of treatment for each subject: up to 156 weeks (3 years) The primary endpoint is percent of patients who experienced treatment failure over time. (childrenshospital.org)
Compound1
- 6-Methylmercaptopurine is a strong basic compound (based on its pKa). (hmdb.ca)
Clinical1
- Although management of the mucosal, dermal, and arthritic manifestations is mainly evidence-based, treatment options for ophthalmic, vascular, and neurological signs and symptoms are chosen through experience-based clinical decisions or evidence from simple observational studies (6). (researchsquare.com)
Symptoms2
- Being a disease-modifying antirheumatic drug (DMARD), azathioprine has been used for the management of the signs and symptoms of adult rheumatoid arthritis. (wikipedia.org)
- Anxiety/depression symptoms were found to be significantly related to steroid resistance, but independent of AZA/6-MP and anti-TNF agents nonresponse. (frontiersin.org)
Typically1
- They typically take 4 to 6 weeks to work. (healthline.com)
Treatment2
- A 2007 Cochrane review found that azathioprine reduced the number of relapses in the first year of treatment and disease progression in the first two to three years and did not find an increase in cancer, and noted the need for direct comparison of azathioprine and interferon beta, conflicting conclusions regarding cancer, and the potential for long-term risks. (wikipedia.org)
- Cases taking azathioprine treatment may have a slightly adding number of common infections similar as coughs, snap, and cold blisters. (eczemafree.org)
Cells1
- It works via 6-thioguanine to disrupt the making of RNA and DNA by cells. (wikipedia.org)
Cases1
- Such cases are met with taking azathioprine after meals or transient intravenous administration. (wikipedia.org)
Administration1
- No azathioprine or mercaptopurine is detectable in urine 8 h after administration. (medscape.com)
Affect1
- Allopurinol interferes with the metabolism of azathioprine, adding the tube situations of 6 mercaptopurine which may affect potentially fatal blood dyscrasia. (eczemafree.org)
Require1
- may require 6-12 mo of trial prior to effect. (medscape.com)
Made1
- Azathioprine was first made in 1957. (wikipedia.org)
Combination2
- A widely used therapy for idiopathic pulmonary fibrosis was azathioprine in combination with prednisone and N-acetylcysteine. (wikipedia.org)
- Allopurinol and azathioprine shouldn't beco-prescription unless the combination can not be avoided. (eczemafree.org)