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  • protein
  • These results indicate that in some cellular context, the cell sensitivity to PRIMA-1 could depend on the abolition of a gain-of-function activity of the mutated p53, through a protein degradation pathway specifically induced by this compound. (biomedsearch.com)
  • Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. (patents.com)
  • activity
  • This dualistic feature of these compounds can be attributed to activity on both the sigma receptors and calcium channels, as the PC-12 cells distinctly express both these pharmacological entities. (nwu.ac.za)
  • These compounds also have an endopeptidase inhibition activity. (google.com)
  • effect
  • The binding of [3H]MK-801 remained fairly constant in the presence of increasing concentrations of the test compounds, indicating that they exert their calcium modulating effect by binding to a site other than the phencyclidine binding site of the NMDA receptor ion channels. (nwu.ac.za)
  • possible
  • It is possible to chemically synthesize poststatin related compound having ketone radicals in the peptide chains. (google.com)
  • These findings indicate that cold storage of this browse species is a possible option for dietary supplementation of iron-binding compounds to captive black rhinoceros to reduce iron accumulation in this population. (nagonline.net)