Axon projection. Medical search. Frequent questions

The results show that PCA administration produces a loss of fine 5-HT axon terminals in neocortex and a concomitant reduction in the number of retrogradely labeled neurons in the DR (77% decrease), when compared to controls. (erowid.org)
In contrast, beaded 5-HT axon terminals are spared and the number of labeled neurons in the MR remains unchanged after PCA. (erowid.org)
These results demonstrate that DR and MR projections to cortex are differentially vulnerable to PCA: fine axon terminals arise from neurons in the DR and are highly sensitive to the neurotoxic effects, whereas beaded axons from the MR are resistant. (erowid.org)
Since the mood-altering substances MDA, MDMA, and PCA act specifically upon 5-HT axon terminals from the dorsal raphe nucleus, DR neurons may be preferentially involved in the control of affective state. (erowid.org)
Medium spiny neurons (MSNs) are striatal output neurons forming prominent descending axon tracts that target different brain nuclei. (jneurosci.org)
Commissural neurons play the crucial role to connect neuronal information from both sides of the nervous system in bilaterians by projecting their axons contralaterally across the midline. (biorxiv.org)
So far, no common transcriptional program has been uncovered for specifying the axon laterality across the highly heterogenous commissural neurons. (biorxiv.org)
Nhlh1 and Nhlh2 should provide the key to deciphering the principle underlying the specific and balanced production of contralateral-versus ipsilateral-projection neurons from the spinal cord to the midbrain. (biorxiv.org)
This crucial task is achieved by commissural neurons that project their axons across the midline of the neural tube to connect with their target neurons on the contralateral side. (biorxiv.org)
By contrast, the transcriptional programs that specify the laterality of commissural axons, and furthermore, whether a global regulatory mechanism operates for diverse commissural neurons, are little understood. (biorxiv.org)
Both direct and indirect corticostriatal axons branch moderately but occupy vast rostrocaudal striatal territories, where they appear to contact en passant several widely distributed striatal neurons. (ulaval.ca)
The results of in vivo and in vitro experiments showed that Mn exposure caused abnormal projection of dopaminergic neurons and decreased mRNA expression and protein levels of FTO. (bvsalud.org)
Finally, it is proved that Mn induces dopaminergic neurons projection injury and motor dysfunction through Foxo3a/FTO/m6A/ ephrin-B2 /YTHDF2 signal pathway . (bvsalud.org)
The projection pattern of the neurons of the paragriseal Hofmann nuclei was mapped in the chicken embryo using the lipophilic tracer DiI. (nih.gov)
The axon trajectories of the presynaptic neurons are similar to those of the Hofmann neurons. (nih.gov)
The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete. (wikipedia.org)
FF and FB afferents showed similar cell-type selectivity, making stronger connections with looped neurons than with other projection types in layer (L)5 and L6, but not in L2/3, resulting in selective modulation of activity in looped neurons. (elifesciences.org)
Another possibility, not mutually exclusive to the previous one, is that CC projections selectively synapse onto looped neurons directly to form interareal monosynaptic loops, which would be excitatory since most long-range cortical afferents are glutamatergic. (elifesciences.org)
Thus, long-range CC projections could selectively participate in excitatory monosynaptic loops by preferentially contacting looped IT neurons, while avoiding neighboring non-looped IT, PT, and CT neurons. (elifesciences.org)
However, it remains unknown whether CC inputs selectively contact looped neurons over closely intermingled IT neurons projecting elsewhere (non-looped IT neurons), or whether they innervate IT neurons equally regardless of their projection pattern. (elifesciences.org)
Besides the axon, neurons have other branches called dendrites that are usually shorter than axons and are unmyelinated. (britannica.com)
Pharmacological, physiological, and behavioral studies suggest that inhibitory GABAergic neurons influence the projection from the midbrain periaqueductal gray matter to the medullary nucleus raphe magnus. (nih.gov)
PavWT is detected in the nuclei and dendrites and is highly concentrated in the axons of the MB neurons (Goldstein, 2005). (sdbonline.org)
TumR417L detected in both axons and in the nuclei of MB neurons. (sdbonline.org)
The cell bodies (soma) of lower motor neurons reside in the spinal cord or the brainstem, and the axons (fibers) are connected directly to muscles at the neuromuscular junctions. (medscape.com)
The somas of these third- and higher-order motor neurons reside in the brain, and their axons form associative or commissural projections within the brain. (medscape.com)
These should be distinguished from diseases in which primarily the axons of motor neurons are affected. (medscape.com)
In neuroanatomy , a neural pathway is the connection formed by axons that project from neurons to make synapses onto neurons in another location, to enable neurotransmission (the sending of a signal from one region of the nervous system to another). (wikipedia.org)
Neurons are connected by a single axon, or by a bundle of axons known as a nerve tract , or fasciculus . (wikipedia.org)
For example, motor neurons , which travel from the spinal cord to the muscle, can have axons up to a meter in length in humans. (wikipedia.org)
2013). Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord . (up.pt)
Axons are lengthy projections of the cell body that connect neurons , essential to the function of the brain. (fightaging.org)
In neurons, there is one projection called axon , it is much longer than the others, and it carries away the information from the cell body. (wordnik.com)
Myelination is the process by which the axons (projections) of neurons are encased in myelin, which enhances the speed of axon signal transmission, and makes neural networks more efficient. (mcknight.org)

1) Each neuron extends a commissural axon through the ventral gray matter and across the midline in the ventral commissure. (nih.gov)
A neurite or neuronal process refers to any projection from the cell body of a neuron. (wikipedia.org)
By day 7, the neuron should be completely polarized, with a functional dendrites and an axon. (wikipedia.org)
It has been proposed that a minor neurite could extend outward until it touches an already developed axon of another neuron. (wikipedia.org)
After forming one axon, the neuron must prevent all other neurites from becoming axons as well. (wikipedia.org)
Information is usually transmitted by electrical or electrochemical signals from the axon of one neuron to the dendrite of another neuron across a synapse. (abnova.com)
Astrocytes guide the growth of axons, the long, slender projection of a neuron that conducts electrical impulses. (sflorg.com)

In mammals, most commissural axons from the spinal cord to the midbrain, cross the midline via the floor plate, guided predominantly by a conserved molecular mechanism, i.e. (biorxiv.org)
Experiments in which the spatial relationship between the spinal cord and the limb are altered prior to axon outgrowth in the chick embryo suggest that there is a topographic projection from cord to limb. (biologists.com)
Thus, following anteroposterior reversal of the limb bud ( Stirling & Summerbell, 1985 ) or craniocaudal reversal of the spinal cord ( Lance-Jones & Landmesser, 1980 ), the trajectories of some motor axons are changed to compensate for the reversal. (biologists.com)
It also comprises collaterals from long-range corticofugal axons, which can thus provide to the striatum a copy of the neural information that is being conveyed to the brainstem and/or spinal cord. (ulaval.ca)
The vertebrate orthologue of UNC-6, netrin-1 was determined to be a key guidance cue for axons moving toward the ventral midline in the rodent embryo spinal cord. (pearltrees.com)
Each type of nerve cell that the team studied was connected at one end to the spinal cord through a thin, wire-like projection called an axon. (hopkinsmedicine.org)
The longest axon in the human body belongs to the Sciatic Nerve and runs from the great toe to the base of the spinal cord. (wikipedia.org)

This causes the other neurites to develop into dendrites as they lack sufficient concentrations of axonal growth factors to become axons. (wikipedia.org)
Mushroom spines associate with dendrites at the base (bottom) and with axons by the head (top). (cellimagelibrary.org)
produce outgrowths called axons and dendrites, by which the cells of the nervous system establish communication with one another to form a functional network. (britannica.com)
A ) Schematic depicting ORN axons and PN dendrites in the antennal lobe (left) and summary table of the cell types, cell numbers, genotypes, and stages that were profiled using snRNA-seq and scRNA-seq. (elifesciences.org)
Early studies revealed that in response to deafferentation, axons of remaining fiber systems and dendrites of mature granule cells undergo lamina-specific changes, providing one of the first examples of structural plasticity in the adult brain. (frontiersin.org)
These specialized cells have thin projections called dendrites and axons. (abnova.com)
The axon is a long, tubular fiber that transmits the action potentials from a soma to the dendrites or to an effector organ. (wordnik.com)

Robo3 and DCC expressing commissural axons are guided by Netrin-1 secreted from the floor plate and ventral neural tube. (biorxiv.org)
This is the first report of a global transcriptional mechanism that controls the laterality of all floor plate-crossing commissural axons via activating Robo3 expression. (biorxiv.org)

Wnt5a acts as an attractant for MSN axons in vitro , is expressed in a posterior high, anterior low gradient in the striatum, and Wnt5a knock-out mice phenocopy striatal anterior-posterior defects observed in Frizzled3 mutants. (jneurosci.org)
SIGNIFICANCE STATEMENT Striatal axon pathways mediate complex physiological functions and are an important therapeutic target, underscoring the need to define how these connections are established. (jneurosci.org)
Here, we determine the embryonic ontogeny of the two main striatal pathways (striatonigral and striatopallidal) and identify novel (non)cell-autonomous roles for the axon guidance receptor Frizzled3 in uncharacterized aspects of striatal pathway formation (i.e., anterior-posterior axon guidance in the striatum and axon entry into the globus pallidus). (jneurosci.org)
Further, our results link Frizzled3 to corridor guidepost cell development and suggest that an abnormal distribution of these cells has unexpected, widespread effects on the development of different axon tracts (i.e., striatal and thalamocortical axons). (jneurosci.org)
Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism. (bvsalud.org)
Mice homozygous for a reporter allele die within several weeks of birth and exhibit decreased body size and defective striatal axon growth and thalamocortical projections in the ventral telencephalon. (jax.org)

When the territory is unfamiliar, e.g. dorsal nerves invading ventral limb, the axons innervate muscles by passive deployment ( Summerbell & Stirling, 1981 ). (biologists.com)
After reaching the contralateral ventral columns the individual axons bifurcate and extend rostrally and caudally up to 5 spinal segments in each direction. (nih.gov)

Moreover, a recent anterograde transport study suggests that fine and beaded 5-HT axons arise from the dorsal raphe (DR) and median raphe (MR) nuclei, respectively. (erowid.org)
We therefore propose that there are two anatomically and functionally separate 5-HT projections to cortex having different (1) nuclei of origin, (2) axon morphology, (3) regional distributions, and (4) pharmacological properties. (erowid.org)
This report focuses on the pattern of projection from the Hofmann nuclei major observed 1-4 days prior to hatching, at which time the projection appears to be substantially developed. (nih.gov)
There is a small overlap of the axon populations originating from adjacent Hofmann nuclei. (nih.gov)

In those cases where the axons are well filled,their trajectories from the injection site are observed to change position within the radial nerve to specifically innervate the duplicated muscle. (biologists.com)
The axons modify their trajectories proximal to the level of limb duplication in a region where there is no change in the pattern of overt differentiation of the limb cells. (biologists.com)
Genetic ablation of visceral sensory trajectories results in the erratic extension of both sympathetic and parasympathetic axons, implicating that afferent axons provide an axonal scaffold to route efferent axons. (jneurosci.org)

Whatever extracellular signals may be involved in inducing axon formation are transduced through at least 4 different pathways: the Rac-1 pathway, the Ras-mediated pathway, the cAMP-liver kinase B1 pathway, and the calcium/calmodulin-dependent protein kinase pathway. (wikipedia.org)
Because perforant path axons are lesioned at a site remote from the dentate, this model is particularly useful to evaluate axonal sprouting from other pathways terminating in the dentate gyrus. (frontiersin.org)
One of the challenges in visualizing axons arises because their overlapping, maze-like pathways make it very difficult to tell one from another. (hopkinsmedicine.org)
[1] Shorter neural pathways are found within grey matter in the brain , whereas longer projections, made up of myelinated axons, constitute white matter . (wikipedia.org)
Therefore, most neural pathways are made up of axons . (wikipedia.org)
Specific modalities can be associated with unique peripheral receptors, peripheral axons of stereotyped diameter and specific central projection pathways. (cdc.gov)

Axon Guidance Molecules and Receptors (controls axon growth directions by attracting or repelling growth cones on the tips of axons) - netrins, ephrins, semaphorins, etc. (abnova.com)

This electron micrograph shows a cross section through an axon, its myelin wrap, and the associated myelin-producing Schwann cell from the the cochlear nerve of the cat. (cellimagelibrary.org)
[ citation needed ] If the axons have myelin sheaths, then the pathway appears bright white because myelin is primarily lipid . (wikipedia.org)
[ citation needed ] If most or all of the axons lack myelin sheaths (i.e., are unmyelinated ), then the pathway will appear a darker beige color, which is generally called grey . (wikipedia.org)

2) Throughout their longitudinal course the axons give rise to terminal collaterals that are concentrated in lamina 8. (nih.gov)

Research suggests that these cells control the growth of axons, or the neuronal projections that carry electrical impulses. (medicalnewstoday.com)
Axons, specialized neuronal structures, sustain damage during the early stages of AD, exerting a pivotal influence on disease progression. (fightaging.org)
The neuronal serotonin transporter (SERT) is present in the serotonin (5-HT) synapse as well as along the 5-HT axons. (cambridge.org)
A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%-25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry. (cdc.gov)

However, how MSN axon tracts in the forebrain develop remains poorly understood. (jneurosci.org)
The formation of longitudinal axon tracts in the CNS is complex and requires a myriad of molecular signals and specialized cell types, such as intermediate target and guidepost cells. (jneurosci.org)
Tracts, axons and. (cellimagelibrary.org)
A neural pathway connects one part of the nervous system to another using bundles of axons called tracts. (wikipedia.org)

We found that Robo3 promoter contains multiple copies of Nhlh1/2 binding sites and forced expression of Nhlh1/2 can induce ectopic Robo3 expression and contralateral axon projection in the hindbrain and the midbrain. (biorxiv.org)

Surprisingly, entry of MSN axons into the GP non-cell-autonomously requires Frizzled3, and our data suggest that GP entry may be contingent on the correct positioning of "corridor" guidepost cells for thalamocortical axons by Frizzled3. (jneurosci.org)

Taken together, our study provides key information regarding the development of extrinsic gut-innervating axons occurring through heterotypic axonal interactions and provides an anatomic basis to uncover neural circuit assembly in the gut-brain axis (GBA). (jneurosci.org)
However, little is known about how an astrocyte functions in synapse formation, axon specification, neuroplasticity, neural homeostasis, neural network activity following dynamic surveillance, and CNS structure in neurological diseases. (cdc.gov)

Each ORN type expresses a unique olfactory receptor or a unique combination of receptors and sends its axons to a stereotyped glomerulus. (elifesciences.org)
5 were stained with an anti-synaptophysin antibody (D and G) to label axon terminals and with BTX (E and H) to label acetylcholine receptors (AChRs). (wordnik.com)

Actin filaments retain their dynamic properties in the neurite that will become the axon in order to push the microtubules bundles outward to extend the axon. (wikipedia.org)

Visualization with characterized intrinsic markers revealed that visceral sensory, sympathetic, and parasympathetic axons arise from different anatomic locations, project in close association via the gut mesentery, and form distinctive innervation patterns within the gut from embryonic day (E)10.5 to E16.5. (jneurosci.org)
Coculture assay further confirmed the attractive effect of sensory axons on sympathetic axons. (jneurosci.org)
Here, with characterized intrinsic markers targeting vagal sensory, spinal sensory, sympathetic, and parasympathetic axons, respectively, we comprehensively traced the spatiotemporal development of extrinsic axons to the gut during embryonic development in mice. (jneurosci.org)
Two-photon calcium imaging of CA3 axonal projections to CA1 combined with simultaneous local field potential recordings revealed that CA3 projections that encode behaviourally informative sensory stimuli were selectively recruited during the memory replay events that underlie hippocampal memory consolidation 5 . (nature.com)
These axonal projections formed sequential assemblies that conjunctively link sensory features to spatial location and thus reward proximity. (nature.com)
By contrast, axons encoding uninformative, peripatetic sensory cues were notably suppressed during memory replay. (nature.com)
By contrast, each sensory axon on the fingertip occupies a much smaller territory and this permits our fingertips to accurately distinguish small objects. (hopkinsmedicine.org)

The projection of individual axons from the parabrachial region of the brain stem to the dorsal lateral geniculate nucleus in the cat. (uchicago.edu)

This projection can be either an axon or a dendrite. (wikipedia.org)
urgency flashes from one person to the next without speech, like the impulse down a neuron's axon to the dendrite s of another. (wordnik.com)

but all share the core defining feature of projecting their axons across the midline. (biorxiv.org)

Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. (nature.com)

Here, we implicate the Wnt binding receptor Frizzled3 in several uncharacterized aspects of MSN pathway formation [i.e., anterior-posterior guidance of MSN axons in the striatum and their subsequent growth into the globus pallidus (GP), an important (intermediate) target]. (jneurosci.org)
In Frizzled3 knock-out mice, MSN axons fail to extend along the anterior-posterior axis of the striatum, and many do not reach the GP. (jneurosci.org)
Our investigation shows that the primate striatum receives both direct and indirect projections from M1. (ulaval.ca)
The direct corticostriatal projection is formed by axons that remain uniformly thin and unbranched throughout their sinuous trajectory to the ipsilateral striatum. (ulaval.ca)
These findings reveal that, in contrast to current beliefs, the primate motor corticostriatal system is not exclusively formed by axons dedicated solely to the striatum. (ulaval.ca)

Previous studies have shown that there are morphologically dissimilar serotonergic (5-HT) axon types in rat cerebral cortex which are differentially sensitive to the neurotoxic effects of certain psychotropic drugs: methylenedioxyamphetamines (MDA and MDMA) and p-chloroamphetamine (PCA) cause degeneration of fine 5-HT axon terminals in cortex, while sparing beaded axons. (erowid.org)

noun cytology A nerve fibre which is a long slender projection of a nerve cell , and which conducts nerve impulses away from the body of the cell to a synapse . (wordnik.com)

The indirect corticostriatal projection derives from a thin collateral emitted within the corona radiata by thick, long-range fibers that descend toward the brainstem. (ulaval.ca)
With minor exceptions, nociceptive fibers have finely myelinated or unmyelinated axons. (nationalacademies.org)
The lobes are connected to the hypothalamus by a stalk that contains blood vessels and nerve cell projections (nerve fibers, or axons). (msdmanuals.com)

Alternatively, it has been suggested that the buildup of axonal growth factors in the neurite destined to become the axon means there is a depletion of axonal growth factors by default, as they must compete for the same proteins. (wikipedia.org)

These putative GABAergic terminals comprise almost 40% of all axon terminals in the periaqueductal gray. (nih.gov)

This suggests that axons may use a cell's positional value to navigate and provides significant support for the theory of positional information. (biologists.com)
On the other side of the cell's "body" was another axon that led to the skin. (hopkinsmedicine.org)

The majority of FasII-positive axons form a ball-like structure at their initial trajectory, and only a small subset of axons is able to extend beyond this ball-like structure into the medial lobe. (sdbonline.org)

Further, they are the first to identify a gene that provides anterior-posterior axon guidance in a large brain nucleus and link Frizzled3 to corridor cell development. (jneurosci.org)
The axons originating from a single Hofmann nucleus cross within a stretch of the cord equivalent to about one spinal segment. (nih.gov)
Axons of these cells project beyond the boundaries of the caudate nucleus and putamen. (britannica.com)
The occurrence and severity of this axon misrouting is increased when the Pav transgene has a decreased drive to enter the nucleus, indicating that Pav may act as a transporter of Tum and that local concentrations of Tum in the axon directly influences its capacity to affect axonal development (Goldstein, 2005). (sdbonline.org)

PavWT, axons bypass their normal path via the peduncle and instead project medially toward the front of the brain just below the normal medial lobe and then project dorsally to innervate the medial lobe. (sdbonline.org)

Confocal micrograph of "lost" axons - chick interneurons labeled with green fluorescent protein that were transplanted from older into younger embryos. (cellimagelibrary.org)

Taken under a microscope by Alexandre Dumoulin at the University of Zurich, Switzerland, the footage shows the elongation of axons - projections from nerve cells - between the two hemispheres of the central nervous system. (newscientist.com)

In other cases, axons fail to enter their correct path at the branch point for the dorsal and medial lobe. (sdbonline.org)

Axons that reach the GP in Frizzled3 knock-out mice fail to enter this structure. (jneurosci.org)

The axons branched in specific patterns, depending on the cell type, to reach their targets within the skin. (hopkinsmedicine.org)
One of the most remarkable axon patterns looked like an extensive vine on a trellis, with its tendrils wrapping around approximately 200 hair follicles (see image). (hopkinsmedicine.org)

However, the excessive emphasis placed on the amyloid cascade hypothesis has overshadowed the physiological nature of Aβ and tau proteins within axons. (fightaging.org)

The cues guiding the motor axons, therefore, must reside in the processes that determine the pattern of the limb itself. (biologists.com)

This suggests that Wnt5a controls anterior-posterior guidance of MSN axons through Frizzled3. (jneurosci.org)
The gain-of-function phenotype seen with coexpression of Tum and Pav suggests that they form a complex that disrupts the normal development of axons. (sdbonline.org)

The total length of one of these axons, with all its branches, was several times longer than the body of a mouse. (hopkinsmedicine.org)
That is why we can't read Braille using the skin on our backs: the multiple bumps that make up a Braille symbol are within such a small area that the axon branches can't distinguish them. (hopkinsmedicine.org)

The optic chiasm is a key structure in the visual system, where the fate of axons from the retina is decided, such that axons carrying information from the right visual hemifield are guided to the left hemisphere and vice versa. (frontiersin.org)

The complex network of cortical areas can be hierarchically ordered based on the anatomy of interareal cortico-cortical (CC) projections. (elifesciences.org)

Using this method, only axons that survive PCA treatment can take up and transport the injected label back to the cell bodies of origin, thus allowing us to determine which raphe-cortical projections remain intact after PCA. (erowid.org)
Together, these data dissect MSN pathway development and reveal (non)cell-autonomous roles for Frizzled3 in MSN axon guidance. (jneurosci.org)
Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point. (nature.com)
Using the cell model of overexpression of FTO, we found that FTO could antagonize Mn-induced the down-regulation of axon guidance molecule ephrin-B2 through RNA-seq , MeRIP-qPCR, and RT-qPCR experiments. (bvsalud.org)
Weak endogenous electric fields may be used to both facilitate and direct the growth of projections from cell soma neurites, EFs of moderate strength have been used to direct and enhance neurite outgrowth in both murine, or mouse, and xenopus models. (wikipedia.org)
It is known that 60% of the time the first neurite that protrudes from the cell body will become the axon. (wikipedia.org)
30% of the time, a neurite not destined to become the axon protrudes from the cell body first. (wikipedia.org)
10% of the time, the neurite that will become the axon protrudes from the cell body simultaneously with one or more other neurites. (wikipedia.org)
in higher nervous systems, only one fibre, the axon, carries the impulse away from the cell body. (britannica.com)
The axons of one type of nerve cell, for example, surrounded only a single hair follicle, its ends looking like a bear trap because of the vertical peaks flanking each hair column. (hopkinsmedicine.org)
The axons of other nerve cell types were simpler and shorter, branching less but still encircling, like the tendrils of a vine, multiple hair follicles. (hopkinsmedicine.org)
The axon of a nerve cell is, in general, responsible for transmitting information over a relatively long distance. (wikipedia.org)
A single large element extending outward from the other end of the cell body is called the axon d. (wordnik.com)

NEUROBIOTIN 488 Tracer is transported along axons and fine projections and is compatible with patch clamp applications and pressure injection methods. (vectorlabs.com)

We are interested in how motor axons reach their appropriate target muscles during development. (biologists.com)
This prevents the development of multiple axons. (wikipedia.org)
Owing to the limitation of intrinsic markers to distinctively visualize the three classes of extrinsic axons, which intimately associate within the gut mesentery, detailed information on the development of extrinsic gut-innervating axons remains relatively sparse. (jneurosci.org)
Here, we mapped extrinsic innervation of the gut and explored the relationships among various types of extrinsic axons during embryonic development in mice. (jneurosci.org)
One possible explanation is that cytoplasmic accumulation of Tum, by means of Pav binding, disrupts axon development (Goldstein, 2005). (sdbonline.org)

The most extensively studied nociceptors are the ones that have myelinated axons and respond only to intense mechanical or mechanical and thermal stimuli and the so-called polymodal nociceptors, which have unmyelinated axons and respond to mechanical, thermal, and chemical stimuli. (nationalacademies.org)

Electron micrograph of a nerve from the mesentery of a rat shows groups of unmyelinated axons wrapped by deeply invaginating Schwann cells in cross section. (cellimagelibrary.org)

The central thread in the axon is the axis cylinder. (wordnik.com)

Anatomy117

Organisms24

Diseases5

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology4

Phenomena and Processes23

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science7

Health Care1

Neurons34

Neuron7

Spinal cord7

Dendrites7

Commissural2

Striatal6

Ventral2

Nuclei4

Trajectories3

Pathways6

Guidance molecules1

Myelin3

Collaterals1

Neuronal4

Tracts4

Contralateral1

Thalamocortical1

Neural2

Receptors2

Bundles1

Sensory7

Individual axons1

Dendrite2

Midline1

Action potentials1

Striatum5

Cerebral cortex1

Slender projection1

Fibers3

Axonal growth1

Terminals1

Cell's2

Extend1

Nucleus4

Innervate1

Interneurons1

Nerve cells1

Dorsal1

Fail to enter1

Patterns2

Physiological1

Cues1

Suggests2

Branches2

Optic1

Anatomy1

Cell13

Tracer1

Development5

Stimuli1

Mesentery1

Axis1