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  • viral
  • Hanafusa H. Synthesis and integration of viral DNA in chicken cells at different times after infection with various multiplicities of avian oncornavirus. (medkursor.ru)
  • Khoury G., May E. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen. (medkursor.ru)
  • We have previously demonstrated recombinational rescue of primer binding site (PBS)-impaired Akv murine leukemia virus-based vectors involving initial priming on endogenous viral sequences and template switching during cDNA synthesis to obtain PBS complementarity in second-strand transfer of reverse transcription (Mikkelsen et al. (asm.org)
  • Endogenous viral RNAs found to be encapsidated in virus particles ( 13 , 32 , 43 , 49 ) may thus serve to provide the functional sequences required for repair of deleterious viral mutations. (asm.org)
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • Antibodies against synthetic peptides of herpes simplex virus type 1 glycoprotein D and their capability to neutralize viral infectivity in vitro. (asm.org)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Analysis by microinjection of the biological effects of site-directed mutagenesis in cloned avian leukosis viral DNAs. (asm.org)
  • Becker S., Fenyo E. M., Klein E. The «natural killer» cell in the mouse does not require H - 2 homology and is not directed against type or group - specific antigens of murine С viral proteins. (medkursor.ru)
  • Photochemical addition of the cross-linking reagent 4,5', 8-trimethylpsoralen (trioxaslen) to intracellular and viral simian virus 40 DNA-histone complexes. (asm.org)
  • Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: identification of genome-length and subgenome-leghth viral RNAs. (asm.org)
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Visna virus encodes a post-transcriptional regulator of viral structural gene expression by Tiley LS1, Brown PH, Le SY, Maizel JV, Clements JE, Cullen BR. (rapeutation.com)
  • Thus, the main hypothesis currently being tested in clinical trials is that CTL responses can be induced safely in humans and will impact upon viral load and disease progression as they have done in primate models of simian-human immunodeficiency virus (SHIV) infection. (centrallakesclinic.biz)
  • simian
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Bergholz С M., Wolfe L. G., Delnhardt F. Oncogenicity in marmosets of HL - 23/V, a type С oncornavirus isolated from human leukemic cells, and comparison with simian sarcoma virus type I (SSV - I/SSAV - I). - «J. nat. (medkursor.ru)
  • Beth E., Cikes M., Schloen L. Interspecies species- and type - specific determinants of human papovaviruses (JC and BK) and of simian virus 40. (medkursor.ru)
  • Measurements of the molecular size of the simian virus 40 large T antigen. (asm.org)
  • recombinant
  • By use of the same forced recombination system, we have now found recombinant proviruses of different structures, suggesting that PBS knockout vectors may be rescued through initial priming on endogenous virus RNA, read-through of the mutated PBS during minus-strand synthesis, and subsequent second-strand transfer mediated by the R-U5 complementarity of the plus strand and the extended minus-strand DNA acceptor template. (asm.org)
  • In macaque models, vaccination with DNA plasmids or recombinant viruses bearing SIV SHIV antigenic inserts leads to significant attenuation of viremia after subsequent infection with the highly pathogenic X4-tropic hybrid isolate SHIV89.6P. Although they do not afford sterilizing immunity under any regimen tested thus far, such vaccines enable long-term suppression of viremia and prevent disease progression. (centrallakesclinic.biz)
  • replication
  • Reverse transcription-mediated recombination may involve endogenous virus-like elements, as seen in studies of various replication-defective retroviral mutants ( 6 , 7 , 9 , 31 , 32 , 34 , 51 ). (asm.org)
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • Structures of herpes simplex virus type 1 genes required for replication of virus DNA. (asm.org)
  • polyoma virus
  • Charge microheterogeneity of the major capsid protein of polyoma virus. (asm.org)
  • Characterization of a DNA-protein complex and capsomere subunits derived from polyoma virus by treatment with ethyleneglycol-bis-N,N'-tetraacetic acid and dithiothreitol. (asm.org)
  • thymus
  • Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss. (springer.com)
  • genes
  • Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. (asm.org)
  • tumour
  • Kaschka-Dierich C, Adams A., Klein G. Intracellular forms of Epstein - Barr virus DNA in human tumour ceils in vivo. (medkursor.ru)
  • He postulated that RNA tumour viruses made DNA copies which then integrated into host chromosomal DNA, analogous to integration of prophage in bacteria. (royalsocietypublishing.org)
  • Indeed, germ-line integration has not yet been described for DNA tumour viruses, although we now know that it occasionally occurs with human herpesvirus 6 [ 9 , 10 ]. (royalsocietypublishing.org)
  • protein
  • Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1. (asm.org)
  • Isolation
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Isolation and preliminary characterization of temperature-sensitive mutants of encephalomyocarditis virus. (asm.org)
  • Synthesis
  • Effect of tunicamycin on the synthesis of herpes simplex virus type 1 glycoproteins and their expression on the cell surface. (asm.org)
  • infection
  • Normal DBA/2 mouse cells synthesize a glycoprotein which interferes with MCF virus infection. (springer.com)
  • Biegeleisen K., Rush M. G. Association of herpes simples virus type I DNA with host chromosomal DNA during productive infection. (medkursor.ru)
  • Genetic
  • Kumar V., Eckner R. J., Bennett M. Mechanism of genetic resistance to immune suppression by friend leukemia virus: the role of marrow - dependent cells. (medkursor.ru)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • purification
  • Quntaka R. V., Bishop J. M., Varmus H. E. Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. (medkursor.ru)
  • Molecular
  • Molecular cloning of cDNA for murine interleukin-3. (springer.com)
  • Biologic, serologic, and molecular characterization of several HIV-1 and HIV-2 strains has revealed their extensive heterogeneity and how viruses can evolve differently in the same individual in the immune system, bowel, and the brain. (ucsf.edu)
  • immune
  • Research in the Levy laboratory is directed at understanding the interaction of viruses and the immune system in microbial pathogenesis. (ucsf.edu)
  • Immune responses to virus-induced tumours. (jax.org)
  • reverse transcription
  • In agreement with the essential role of the PBS in initiation and completion of reverse transcription ( 35 , 47 , 62 ), we previously observed a strong restriction in transduction of Akv murine leukemia virus (MLV) vectors with PBSs having only partial (PBS-XXX) or no [PBS-UMU and PBS-Met(i)int] homology with the 3′ end of any known murine tRNA molecule ( 32 ). (asm.org)
  • cell
  • Kerr I M., Olshevsky U., Baltimore D. Translation of murine leukemia virus RNA in cell - free systems from animal cells. (medkursor.ru)
  • A high frequency of interleukin-3 dependent cell lines are derived from myeloid and erythroid leukemias. (springer.com)
  • However, it has also illustrated the potential dangers involved, with 2 out of 10 patients developing T cell leukemia as a consequence of the treatment. (biomedcentral.com)
  • The first retro viruses were identified as cell free oncogenic factors in chickens. (biomedcentral.com)
  • The DMF10 62.3 mAb stained a number of immortalized murine and human cell lines and, where tested, blocked their proliferation and caused death to varying extents by apoptosis. (jimmunol.org)
  • type
  • Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. (ucsf.edu)
  • Visna virus is an ungulate lentivirus that is distantly related to the primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1). (rapeutation.com)