AutophagyCell ProliferationApoptosisApoptosis Regulatory ProteinsCell Line, TumorSignal TransductionCaspasesCells, CulturedCaspase 3Cell SurvivalMicrotubule-Associated ProteinsPhagosomesProto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsCell LineCell CycleCell DivisionIn Situ Nick-End LabelingBlotting, WesternDNA FragmentationRNA, Small Interferingbcl-2-Associated X ProteinMitochondriaTumor Cells, CulturedEnzyme ActivationTumor Suppressor Protein p53TOR Serine-Threonine KinasesCell DifferentiationFlow CytometryMice, Inbred C57BLModels, BiologicalX-Linked Inhibitor of Apoptosis ProteinPhosphorylationLysosomesAntineoplastic AgentsRNA, MessengerCell DeathRNA InterferenceDown-RegulationMice, KnockoutCaspase InhibitorsApoptosis Inducing FactorMembrane ProteinsTransfectionCASP8 and FADD-Like Apoptosis Regulating ProteinProto-Oncogene ProteinsImmunohistochemistryReactive Oxygen SpeciesUbiquitin-Activating EnzymesDose-Response Relationship, DrugCaspase 9Proto-Oncogene Proteins c-aktCaspase 8Enzyme InhibitorsReverse Transcriptase Polymerase Chain ReactionUp-RegulationTime FactorsFibroblastsGene Expression Regulationbcl-X ProteinGene Expression Regulation, NeoplasticCytochromes cFas Ligand ProteinMice, TransgenicProtein-Serine-Threonine KinasesEpithelial CellsGene Knockdown TechniquesLymphocyte ActivationMutationT-LymphocytesCysteine Proteinase InhibitorsAnnexin A5Gene ExpressionMice, NudeAmino Acid Chloromethyl KetonesCell MovementPhosphatidylinositol 3-KinasesHeLa CellsClass III Phosphatidylinositol 3-KinasesTranscription FactorsPoly(ADP-ribose) PolymerasesAdenineBromodeoxyuridineCarrier ProteinsNecrosisVacuolesMembrane Potential, MitochondrialProteinsDisease Models, AnimalSirolimusMolecular Sequence DataNeoplasmsDNA-Binding ProteinsRats, Sprague-DawleyIntracellular Signaling Peptides and ProteinsMice, Inbred BALB CJurkat CellsHL-60 CellsNF-kappa BTumor Necrosis Factor-alpha