AutophagyApoptosisApoptosis Regulatory ProteinsCaspasesPhagosomesCaspase 3Microtubule-Associated ProteinsProto-Oncogene Proteins c-bcl-2Cell Line, TumorInhibitor of Apoptosis ProteinsSignal TransductionCell SurvivalDNA Fragmentationbcl-2-Associated X ProteinMitochondriaIn Situ Nick-End LabelingX-Linked Inhibitor of Apoptosis ProteinLysosomesApoptosis Inducing FactorTOR Serine-Threonine KinasesCells, CulturedCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase InhibitorsUbiquitin-Activating EnzymesTumor Suppressor Protein p53Caspase 8Caspase 9Enzyme ActivationCell LineRNA, Small InterferingCell ProliferationCell DeathReactive Oxygen SpeciesCytochromes cBlotting, WesternModels, Biologicalbcl-X ProteinFas Ligand ProteinTumor Cells, CulturedMembrane ProteinsAntineoplastic AgentsAmino Acid Chloromethyl KetonesCysteine Proteinase InhibitorsClass III Phosphatidylinositol 3-KinasesAnnexin A5RNA InterferenceAdenineVacuolesFlow CytometryCell CycleProto-Oncogene ProteinsMembrane Potential, MitochondrialPoly(ADP-ribose) PolymerasesEnzyme InhibitorsNecrosisTransfectionDown-RegulationProto-Oncogene Proteins c-aktPhosphorylationHeLa CellsEndoplasmic Reticulum StressMice, Inbred C57BLProtein-Serine-Threonine KinasesMice, KnockoutCytoprotectionOxidative StressJurkat CellsCaspase 7Up-RegulationTNF-Related Apoptosis-Inducing LigandDose-Response Relationship, DrugLysosomal-Associated Membrane Protein 2HL-60 CellsSirolimusGene Knockdown TechniquesCell DivisionCarrier Proteinsbcl-2 Homologous Antagonist-Killer ProteinTime FactorsMicroscopy, Electron, TransmissionProteinsDNA DamageAdaptor Proteins, Signal TransducingFibroblastsMutationTumor Necrosis Factor-alphaProteolysisMitochondrial DegradationMyeloid Cell Leukemia Sequence 1 ProteinGenes, bcl-2Gene Expression RegulationNF-kappa BProtein TransportRNA, MessengerPhosphatidylinositol 3-KinasesReverse Transcriptase Polymerase Chain ReactionMembrane GlycoproteinsIntracellular Signaling Peptides and ProteinsAntineoplastic Agents, PhytogenicGene Expression Regulation, Neoplastic