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  • induction
  • We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. (jci.org)
  • R. L. Dean, "The induction of autophagy in isolated insect fat body by β -ecdysone," Journal of Insect Physiology , vol. 24, no. 5, pp. 439-447, 1978. (hindawi.com)
  • study of autophagy
  • Although there are many unanswered questions, the study of autophagy and stem cell biology can help us to progress in life sciences. (springer.com)
  • With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. (springer.com)
  • autophagosome
  • Autophagy concludes by the fusion of the autophagosome with the lysosome, where the cytoplasmic constituents are degraded by lysosomal hydrolases. (abcam.com)
  • These systems produce modified complexes of autophagy regulators: Atg8-PE and Atg5-Atg12-Atg16, and that may determine the formation and size of the autophagosome. (hindawi.com)
  • D) When autophagy is suppressed at any step after complete closure of the autophagosome, only autophagosomes accumulate. (nih.gov)
  • Inspite of more than 40 AuTophaGy (ATG) proteins and several organelles as known membrane source, autophagosome biogenesis is not entirely understood. (springer.com)
  • Physiological
  • Physiological autophagy in the Syrian hamster Harderian gland / Ignacio Vega-Naredo and Ana Coto-Montes. (openlibrary.org)
  • Autophagy is activated in response to diverse stress and physiological conditions. (hindawi.com)
  • Autophagy has been implicated in many physiological and pathological processes. (nih.gov)
  • In addition to its physiological roles, autophagy also occurs in a wide variety of pathological processes, including tumour progression, metabolic disorders, and neurodegenerative and lung diseases. (royalsocietypublishing.org)
  • In mammals, autophagy plays a vital role in maintenance of physiological steady state, biosynthesis of macromolecules, cellular development, tissue remodelling and adaptation to the environment [ 6 , 7 ]. (royalsocietypublishing.org)
  • neurodegeneration
  • A breakdown in autophagy is associated with diseases such as cancer, immune disorders and neurodegeneration, but little is known about the system-wide signals between cells that control autophagy in complex, multicellular animals. (umassmed.edu)
  • neurodegenerative diseases
  • Dysfunctions in autophagy would cause a variety of illnesses including cancer, inflammatory bowel disease and neurodegenerative diseases. (springer.com)
  • In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. (jci.org)
  • In this Review we discuss the evidence that a disruption in autophagy might be a contributing factor in aggregate formation and the progression of neurodegenerative diseases. (jci.org)
  • lysosomal
  • Chaperone 중재된 autophagy 표적으로 한 단백질은 chaperone 단백질을 가진 복합물에 있는 lysosomal 막을 통해 - 이 프로세스에서 - 장소를 옭깁니다 (Hsc-70와 같은). (news-medical.net)
  • process
  • This process of autophagy ( 2 ), however, poses a problem for the body's specialized fuel-sensing cells. (sciencemag.org)
  • 4 ) show how β cells avoid inappropriate autophagy, and describe a form of this process tailored to the needs of these cells. (sciencemag.org)
  • Although the changes are quite subtle, there are differences between the way that fibroblasts that contain mutant LRRK2 respond to being starved - suggesting that there may be changes in the way that these cells regulate a key process called autophagy (a term which comes from the greek meaning to eat yourself, and is one of the ways that cells get rid of waste and recycle proteins and organellles). (ucl.ac.uk)
  • Autophagy is a powerful process for removing such proteins. (jci.org)
  • Mizushima N (2007) Autophagy: process and function. (springer.com)
  • Autophagy is the process cells use to degrade used or damaged components inside the cell for recycling. (umassmed.edu)
  • Autophagy is, broadly speaking, the process by which your cells recycle damaged components. (fightaging.org)
  • Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. (springer.com)
  • Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. (nih.gov)
  • Accordingly, there is a growing scientific need to accurately identify, quantify, and manipulate the process of autophagy. (nih.gov)
  • Immunity
  • The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. (springer.com)
  • mutations
  • This is important because, up until now, there hasn't been a clear cellular symptom linked to all these mutations and might indicate that disrupted autophagy is a common feature of LRRK2 mutations. (ucl.ac.uk)
  • A lot more work is needed in order for us to really understand how mutations in LRRK2 alter autophagy, but this study provides an intriguing hint that autophagy might be very important in Parkinson's disease. (ucl.ac.uk)
  • diseases
  • This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome. (nih.gov)
  • Deregulation of autophagy has been implicated in a number of severe human diseases, in particular neurodegenerative disorders and neoplasias. (fz-juelich.de)
  • Scheme of organ-specific (left) and systemic (right) human diseases in which alterations in autophagy are discussed in this review. (nih.gov)
  • In recent years, a growing body of evidence has shown that autophagy also plays a key role in the development of mammalian diseases, a function that has garnered substantial attention and study. (royalsocietypublishing.org)
  • morphology
  • J. Beaulaton and R. A. Lockshin, "Ultrastructural study of the normal degeneration of the intersegmental muscles of Antheraea polyphemus and Manduca sexta (Insecta, Lepidoptera) with particular reference to cellular autophagy," Journal of Morphology , vol. 154, no. 1, pp. 39-57, 1977. (hindawi.com)