Automated microfluidic platform. Medical search. Frequent questions

Microfluidics enables single-cell manipulation and analysis, reaction volumes of nano- or picoliters (thereby reducing costs), high-throughput execution of parallel experiments, automated routine liquid handling, integration of multiple biological processes in a single system, and programmability for complex protocols. (nature.com)
Cellix' VenaFlux™ platform, reported to be the first semiautomated, high-throughput microfluidic cell-based assay system, measures cells' adhesion to antibody-coated or endothelial cell cultured microchannels, mimicking physiological flow. (genengnews.com)
Microfluidic organ-on-chip (OoC) systems recapitulate the human physiology by advanced 3-dimensional (3D) cell culture, but lack in parallelization and automation and are consequently barely used for pharmakinetic analysis or high-throughput screening. (utwente.nl)
A new microfluidic system allows the high throughput phenotyping of C. elegans embryos! (cherrybiotech.com)
An equally important innovative step of »SABYDOMA« is the establishment of high-throughput platforms to manufacture nanomaterials and to test their toxicity directly at the point of production. (fraunhofer.de)
Cellomics Platform at MultiParkThe Cellomics ArrayScan VTI HCS Reader enables automated acquisition, visualization and quantification of a large number of images, with an automated fluorescence and brightfield microscopy allowing extraction of quantitative data from intensity and area measurement in high-throughput format. (lu.se)
Combined with portable systems, the magnetic barcode assay holds promise to become a sensitive, high-throughput, and low-cost platform for point-of-care diagnostics. (cdc.gov)

This newly developed microfluidic chip provided a promising platform for the rapid replacement of the cell medium and this was also the first time that an ODEP device was integrated with other active flow control components in a microfluidic device. (rsc.org)

Abstract: Microfluidic technologies developed over the past decades have underpinned the success of the Lab on Chip. (bilkent.edu.tr)

In analogy to digital microelectronics, digital microfluidic operations can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. (wikipedia.org)
By using this platform, time and efforts will be reduced and both cardiac and alveolar models will be studied for tissue repairing assays. (dim-elicit.fr)
We offer single-platform, continuous-flow, cell-based assays on a microchip that act like a human capillary, providing real-life physiological conditions and enabling researchers to look at the side effects of drugs before getting to clinical trials," explained Julia Umlauf, sales representative. (genengnews.com)
The Rheonix CARD cartridge is an inexpensive, injection molded microfluidic device that contains all the pumps, valves, and reagent and reaction reservoirs needed to perform complex molecular assays. (clpmag.com)
The device performs all the classical microfluidic operations such as dosing, dispensing and mixing, and provides a platform that supports a range of analytical assays in an automated hands-off system such as immune assays or multiplexed rapid genotypic tests. (bilkent.edu.tr)

Electrowetting, dielectrophoresis, and immiscible-fluid flows are the three most commonly used principles, which have been used to generate and manipulate microdroplets in a digital microfluidic device. (wikipedia.org)
A digital microfluidic (DMF) device set-up depends on the substrates used, the electrodes, the configuration of those electrodes, the use of a dielectric material, the thickness of that dielectric material, the hydrophobic layers, and the applied voltage. (wikipedia.org)
The first is a new programmable digital microfluidic (DMF) platform that allows precise manipulation of hundreds of nano-litre sized aqueous droplets. (bilkent.edu.tr)

Digital microfluidics (DMF) is a platform for lab-on-a-chip systems that is based upon the manipulation of microdroplets. (wikipedia.org)
Microfluidics is a relatively new discipline that allows for fast, specific, and automated manipulation of small volumes of reagents. (hindawi.com)
Companies that provide basic services to the synthetic biology community use microfluidics in their technology platforms (e.g. (nature.com)
Dolomite Microfluidics is leading the way in nanoparticle production with the release of its innovative Automated Nanoparticle (ANP) System for microfluidic formulation library generation This next generation automated platform is the result of a four-year focus on the challenges commonly associated with batch production of lipid nanoparticles and liposomes for drug and vaccine development, including inconsistent particle size and poor encapsulation efficiency. (dolomite-microfluidics.com)
Richard Gray, Commercial Director at Dolomite Microfluidics, commented: "The launch of our Automated Nanoparticle System for formulation library generation will help to meet the huge demand for consistent lipid nanoparticle and liposome preparation. (dolomite-microfluidics.com)

Gyros AB, a leader in utilization of microfluidic technologies to miniaturize and automate immunoassays, announced today that Bio Laboratories Pte. (pharmaceutical-business-review.com)
Gyros AB, a leader in utilization of microfluidic technologies to miniaturize and automate immunoassays, announced Dr. Claus Braestrup has joined. (pharmaceutical-business-review.com)
Gyros AB is the world leader in utilization of microfluidic technologies to miniaturize and automate immunoassays. (pharmaceutical-business-review.com)
Spanning the entire spectrum of immunoassays, the platform cuts the time to result significantly. (pharmaceutical-business-review.com)
Gyrolab™ xP workstation automates finely controlled immunoassays in identical microfluidic channels. (pharmaceutical-business-review.com)
More recently, bead-based methods and microfluidic platforms have started to impact immunoassays and by coupling with single molecule detection look set to take the sensitivity of traditional ELISA to new levels. (ddw-online.com)

Gyrolab™ xP workstation miniaturizes, integrates and automates analysis of large numbers of samples in parallel - minimizing user error, massively increasing productivity, cutting time to validated assay and final result, and freeing up analysts' time. (pharmaceutical-business-review.com)
Other automated instrumentation is designed to support the creation/coating of ELISA assay plates or contains cartridge-based delivery of assay reagents to reduce set-up time. (ddw-online.com)
P erhaps most significantly are the big increases in assay sensitivity and the widening of the dynamic range accomplished by using alternatives to the traditional colorimetric detection, or by the use of new platform technologies. (ddw-online.com)
The immunoassay landscape has, however, dramatically changed in recent years with the development of reduced assay steps protocols, no wash ELISAs and new automated systems designed to run ELISA. (ddw-online.com)
In this work, we developed an automated microfluidic screening assay, which uses convection-dominated Taylor-Aris dispersion to generate highresolution dose-response curves, enabling the measurements of compound EC50 values at very short incubation times. (leibniz-ipht.de)
Most recently, GeneXpert MTB/RIF (Cepheid) advanced nucleic acid-based detection by integrating PCR and a highly sensitive molecular-beacon assay into a single, automated system. (cdc.gov)

Zeiss AxioImager.Z2 and AxioObserver.Z1 instruments, Hamamatsu sCMOS and EM CCD cameras, and CellASIC ONIX microfluidic cell perfusion system. (lu.se)

A three-part system using ELISA was developed consisting of a microfluidic chip, hand crank centrifuge, and a smartphone. (hindawi.com)
A circular microfluidic chip was fabricated using clear acrylic and a CO 2 laser. (hindawi.com)
Over 15 different microfluidic patterns were tested, and a final prototype of the chip was created. (hindawi.com)
We were able to design an easy-to-use platform consisting of a circular chip to deliver proper reagents into a reaction chamber through channels and burst valves using a hand crank for energy and a companion smartphone camera and application to provide a simple read-out. (hindawi.com)
We designed a circular microfluidic chip to deliver the antibodies and reagents in the correct order to a small reaction chamber. (hindawi.com)
We will be a unique organization internationally, housing the world's first Organ-on-Chip MSc course, Organ-on-Chip infrastructure facility and Organ-on-Chip Open Technology Platform. (utwente.nl)
We aim to develop a cell culture platform to automatically differentiate human induced pluripotent stem cells (hiPSCs) for lab-on-a chip applications. (dim-elicit.fr)
Therefore, this study presents a parallelized microfluidic chip with a modular build-up consisting of a standardized fluid routing system and a customizable cell culture layer. (utwente.nl)
The larger and more complex 3D cell culture compartments can be rapidly prototyped by micro-milling, which enables fast and easy redesign of the microfluidic chip. (utwente.nl)
In the end, a 16-chamber microfluidic chip was successfully fabricated and operating. (utwente.nl)
All layers were aligned and leak-free bonded, and both a vessel-on-chip and engineered heart tissue model were integrated into the platform. (utwente.nl)
The Aria allows users to automate delivery of up to 10 different solutions into a chamber or microfluidic chip following user-defined protocols. (fluigent.com)
A "lab on a chip" refers to an entire automated laboratory on an area the size of a computer chip, able to perform chemical analysis on minute amounts of material. (sandia.gov)

The aim of this research is to investigate breast cancer extravasation in vitro, using a microfluidic system with adjustable biophysical and biochemical factors, to mimic the 3D in vivo vascular microenvironment. (selectbiosciences.com)
The screening platform comprises physiochemical sensor elements and in vitro targets of varying complexity (from 2D-biomembranes to complex cell lines). (fraunhofer.de)
The microfluidic device was validated for in vitro diagnosis of food allergies on an allergen microarray after serum interaction. (hal.science)

A low-cost microfluidic system could detect and follow therapeutic outcomes in rural areas and identify resistant strains. (hindawi.com)
The BioContinuum™ Buffer Delivery Platform integrates buffer concentrates, buffer dilution system, Mobius® Select assemblies and services providing the ideal path to intensify buffer preparation and management with simplicity and certainty. (interphex.com)
In vivo -like culture substrate made of monolayer nanofibers and microfluidic circulatory system will be used for organ tissue generation. (dim-elicit.fr)
Using this microfluidic system, breast cancer cell extravasation from the blood vessel to the artificially simulated extracellular matrix was observed. (selectbiosciences.com)
Qiagen's QIAsymphony® SP is the first system of the modular platform QIAsymphony. (genengnews.com)
Lab2Lab, an automated sample transport system, sends individual microtubes between analytical workstations or laboratories. (genengnews.com)
Plug'n'Prep technology like plug-and-play automates the whole nucleic acid purification process on one system with 30 kits of protocols," explained Vincent Prezioso, Ph.D., marketing director. (genengnews.com)
The open, automated pipetting system lets researchers choose any purification technology-Invitrogen, Promega, Macherey-Nagel, Invitek, and 5Prime-by selecting their preferred brand and type of extraction kit, downloading the pretested method, and transferring the method data file to the epMotion in less than an hour, explained Dr. Prezioso. (genengnews.com)
With an eye toward addressing the diverse concerns of clinical laboratory professionals, Rheonix Inc, Ithaca, NY, has developed a fully automated molecular diagnostic system designed to live within existing space constraints, streamline laboratory workflow, and achieve a favorable and sustainable cost structure. (clpmag.com)
Fluigent introduces the Aria, our automated sequential injection system for cellular perfusion or timed injection protocols . (fluigent.com)
Dutch firm CleanNA's quality management system has received the EN-ISO 13485 certificate for providing medical devices, research use-only products and related services. (laboratorytalk.com)
Web based water turbidity monitoring and automated filtration system: IoT application in water management. (iium.edu.my)
Using our microfluidic system, we characterized two of our in-house screening compounds. (leibniz-ipht.de)
With this proof-of-concept study, we believe that this microfluidic system is a robust primary screening tool for HBV CAM drug discovery, especially for the hit finding and hit-to-lead optimization phases. (leibniz-ipht.de)
The ANP System is available for process optimization and fully automated for walk-away library generation. (dolomite-microfluidics.com)

Akonni Biosystems is the latest company in the USA to acquire a Freedom EVO®/REMP Small- Size Store™ Factory, relying on the platform for fully automated liquid handling and sample management during manufacturing of its revolutionary TruArray™ microfluidic card-based diagnostic arrays. (tecan.com)
We have on-going efforts to use the diagnostic platform to detect biotoxins and other markers in bodily fluids to be able to diagnose exposure to a biological agent. (sandia.gov)
He moved to Southampton in 2004 after 10 years at the University of Glasgow In 2012 he was awarded a Royal Society Industry Fellowship with Sharp Labs to develop microfluidic diagnostic technologies using consumer electronics. (bilkent.edu.tr)
A sensitive and robust platform that does not require bacterial isolation or culture is critical in making informed diagnostic and therapeutic decisions. (cdc.gov)

The BioReliance® Blazar™ Platform meets the need to accelerate detection of adventitious viral contamination. (interphex.com)
Particle Works , the Royston-based provider of innovative microfluidic nanoparticle synthesis platforms, is supporting Earli Inc. via its Automated Library Synthesis (ALiS) and Automated Nanoparticle (ANP) systems - to accelerate and optimise DNA-LNP formulation screening for potential cancer treatments. (laboratorytalk.com)
AlphaFlow applies reinforcement learning to accelerate materials discovery in combination with automated microfluidic devices, said NC State's Milad Abolhasani, explaining that "AlphaFlow can conduct more experiments than 100 human chemists in the same period of time, while using less than 0.01% of the relevant chemicals. (acm.org)

The fluid routing layer consists of a dense network of channels and microfluidic large-scale integration of push-down valves. (utwente.nl)
To provide a robust platform for fluid handling, most microfluidic devices usually involve irreversible bonding methods to achieve a leak free interface between the microchannels and the holding substrate. (hal.science)

The modular instruments can be integrated to automate entire workflows from sample to result for applied testing, pharmaceutical research, life science research, and eventually molecular diagnostics, reported Michael Collasius, Ph.D., vp, automated systems. (genengnews.com)

However, reliable technological methods and platforms to characterize islets as well as relevant and reproducible islet model systems are scarce. (frontiersin.org)
Its microfluidic approach allows rapid and reproducible generation of highly monodisperse particles from 40 to 800 nm, with enhanced encapsulation efficiency. (dolomite-microfluidics.com)
We achieved faster and more reproducible results because we combined steps that ordinarily require time-consuming manual handling by many people, into a single automated device. (sandia.gov)

Major biopharmaceutical companies and their service providers utilize the Gyros platform to boost time-critical workflows and meet increasing regulatory demands. (pharmaceutical-business-review.com)

Microfluidic technologies have several advantages over traditional methods. (nature.com)
This initially reflected the fact that plate washing was perceived to be difficult to automate, and subsequently the industry's preference for homogenous screening methods, that could be miniaturised. (ddw-online.com)
Advances in microfluidic technology towards flexibility, transparency, functionality, wearability, scale reduction or complexity enhancement are currently limited by choices in materials and assembly methods. (nature.com)
The location of the sieve in the microfluidic chips is determined using photolithographical methods adapted from the semiconductor industry. (sandia.gov)

Several authors have described effective ELISAs using microfluidic techniques [ 3 - 7 ]. (hindawi.com)
New developments in automated plate washing and the minimisation of wash steps are also impacting conventional ELISAs. (ddw-online.com)

Furthermore, microtechnology can produce small-volume microfluidic devices, which allow for studying GSIS dynamics of individual islets. (frontiersin.org)
Microfluidic devices have the potential to automate and miniaturize biological experiments, but open-source sharing of device designs has lagged behind sharing of other resources such as software. (nature.com)
Despite their utility, microfluidic devices are not widely used by synthetic biologists. (nature.com)
Although thousands of proof-of-concept microfluidic devices have been reported in technical journals 14 , such systems are infrequently adopted. (nature.com)
Discuss approaches to automating the cellular immunolabeling process using microfluidic devices, thereby increasing efficiency and reproducibility. (fluigent.com)
Like the 2019 conference, this event will be produced on our robust platform, allowing you to watch, learn and connect seamlessly across all desktop or mobile devices. (labroots.com)
Here we demonstrate this method to create self-enclosed microfluidic devices with a few simple steps, in a number of flexible and transparent formats. (nature.com)
Structural colour, a property of organized microfibrillation, becomes an intrinsic feature of these microfluidic devices, enabling in-situ sensing capability. (nature.com)
Inevitably, the process of creating a complex channel, and then sealing its open surface against another material to create an enclosed channel, is a significant practical obstacle to advances in microfluidic devices. (nature.com)
a Conventional lithographic techniques for microfluidic devices require a sealing step, as shown by the schematic. (nature.com)

Microfluidic channels and burst valves directed flow without relying on mechanical valves or electricity, and the reagents were released based upon centrifugal force. (hindawi.com)
Controlled release of microfluidic reservoirs using passive valves. (hindawi.com)

We further demonstrated spatially multiplexed μFISH, enabling the use of spectrally equivalent probes for detailed and real-time analysis of a cell monolayer, which paves the way towards rapid and automated multiplexed FISH on standard cytological supports. (springer.com)

Then we could statistically validate both the perio-dontal disease biomarker and the new microfluidic instrument. (sandia.gov)

Color readings of standard ELISA and microfluidic microchip showed similar results. (hindawi.com)

Here we introduce a platform for the detection of nucleic acids based on a magnetic barcoding strategy. (cdc.gov)
Developing a platform for fast, earlier and improved TB detection is thus considered crucial for efficient TB control. (cdc.gov)
We herein report on the development of a nucleic acid platform designed to provide fast and portable detection, and demonstrated the utility by detecting MTB DNA from mechanically processed TB patient sputum samples. (cdc.gov)

Such a platform will be flexible, versatile and compatible but different from conventional tools, which are mostly for 2D and static culture. (dim-elicit.fr)
In comparison to conventional manual processes, our automated medium replacement process only took 25 minutes. (rsc.org)

Plate Runner Platform at MultiParkHigh content screening (HCS) / Analysis (HCA) enables automated acquisition, visualization and quantification of a large number of images such as rapid snapshot acquisition of fluorescence images of cells and small organisms. (lu.se)

22/10708-0 - DotAr a microfluidic platform for the automation of molecular reactions (e.g. (fapesp.br)

HJ Science & Technology (HJS & T) and the Joint BioEnergy Institute (JBEI) propose to develop an automated, software-controlled, programmable, low-cost, and compact platform capable of running rapid and complex bioengineering processes and optimization of new biomanufacturing systems. (sbir.gov)

Despite these technological advances, reports on applications of microfluidic perifusion systems for studying islets secretion are still few. (frontiersin.org)

Live Cell Imaging Platform at MultiParkNikon Ti-E is a fully motorised research microscope with Spectra X light engine and EMCCD, suitable for imaging of fluorescence labelling, such as DAPI, CFP, GFP, YFP, mCherry and Cy5. (lu.se)

The availability of consumer microfluidic products has also been limited 15 , because most systems developed in research laboratories fail to translate to the marketplace. (nature.com)
In clinical laboratory settings, automated PCR systems prove their value by being able to achieve true "sample-to-actionable-results," with little or no intervention by laboratory personnel. (clpmag.com)
But to improve their chances of adoption in clinical settings, such systems should go beyond mere automated ease of use to address other issues common in most clinical labs, including space limitations, the capital cost of instrument acquisition, and the cost per test for any necessary disposables. (clpmag.com)
The IBMT researchers contribute their long-term experience in the field of biohybrid systems to »SABYDOMA« and further develop a microfluidic cell-based module from TRL4 to TRL6. (fraunhofer.de)

This platform will consist of a culture unit, placed in an incubator for the circulation of the culture medium, a cold unit for storing and supplying the medium and cell factors to the circulating loop, and a control unit for accurate and long term regulation. (dim-elicit.fr)
Combining this microfluidic platform with an automated image analysis algorithm, cancer cell morphological changes during the migration process were quantified and they were found to be microenvironment-dependent. (selectbiosciences.com)
At the same time, existing parallelized microfluidic cell culture platforms enable automated control over the cell culture conditions, but are limited to straightforward 2D cell culture due to the use photolithography based wafer molds. (utwente.nl)

Metafluidics is intended to enable a broad community of engineers, DIY enthusiasts, and other nontraditional participants with limited fabrication skills to contribute to microfluidic research. (nature.com)
Several decades of microfluidic research and development are now behind us and I would like to share some strategies of commercialization that are used at Hahn-Schickard. (selectbiosciences.com)
Microfluidic design, research labs equipped with biosafety, and rapid prototyping facilities are required for the first proof of concepts. (selectbiosciences.com)
Human organ-on-chips are expected to transform biomedical research providing platforms that accurately replicate human tissues, enable a better understanding of human-to-human physiologic variations, and even permit patient-specific organ mimics. (selectbiosciences.com)

Confocal Microscope Platform at MultiParkLeica SP8 confocal microscope for imaging of fixed tissue and cells. (lu.se)

In totality, the simplicity and certainty of the Platform enables the evolution of bioprocessing. (interphex.com)

We use this platform to detect MTB and identify drug-resistance strains from mechanically processed sputum samples within 2.5 hours. (cdc.gov)

A microfluidic platform is presented which fully automates all incubation steps of a three-stage, multiplexed magnetic bead immunoassay, such as the Luminex® xMAP technology. (psu.edu)

We demonstrated the integration of a microfluidic device with an optically induced dielectrophoresis (ODEP) device such that the critical medium replacement process was performed automatically and the cells could be subsequently manipulated by using digitally projected optical images. (rsc.org)
Novel Modelling Of A Bio-Analysis Platform (Biochip) With The Integrated Dielectrophoresis (Dep) And Magnetophoresis (Map) Forces For Particles Manipulations. (iium.edu.my)

Multi-laboratory evaluation of the Illumina iSeq platform for whole genome sequencing of Salmonella, Escherichia coli and Listeria. (cdc.gov)

It also examines interest in adopting new or emerging ELISA or immunoassay platforms with potential to significantly improve performance. (ddw-online.com)

In the future many other types of applications could be integrated into the platform. (utwente.nl)
The proliferation of such PCR-based testing has led to the development of a variety of commercial platforms designed to simplify and automate the use of PCR in both clinical and nonclinical applications. (clpmag.com)

Here, we present a new generation of the microfluidic hanging-drop-based islet perifusion platform that was developed to study the alterations in insulin secretion dynamics from single pancreatic islet microtissues at high temporal resolution. (frontiersin.org)

More importantly, the survival rate of the cells was greatly enhanced due to this faster automated process. (rsc.org)

This μFISH implementation makes use of a non-contact scanning probe technology, namely, a microfluidic probe (MFP) that hydrodynamically shapes nanoliter volumes of liquid on a surface with micrometer resolution. (springer.com)
The test platforms will be further developed during the course of the project from Technology Readiness Level (TRL) 4 (test setup in the laboratory) to 6 (prototype in a deployment environment). (fraunhofer.de)

The Platform delivers a competitive edge by supplying process buffers from point of manufacturing to point of use utilizing a fraction of the resources and facility space while increasing speed and flexibility. (interphex.com)

This project aims to develop a microfluidic platform able to perform genetic tests of patients for medical doctors. (fapesp.br)

The platform was completely redesigned to increase experimental throughput and to reduce operational complexity. (frontiersin.org)
Abolhasani added that AlphaFlow "effectively miniaturizes the experiments and performs the same laboratory operations that would require an entire wet chemistry lab in a suitcase-sized end-to-end experimental platform. (acm.org)

It is intended to flexibly integrate the module into the manufacturing process during product development and manufacturing to provide automated toxicity data. (fraunhofer.de)

Analysis of $α$B-crystallin polydispersity in solution through native microfluidic electrophoresis. (kolabtree.com)

Her priorities will include strengthening ABL's R&D work in its GMP production platforms for Adeno Associated Viruses and LentiViruses and she will launch a commercial production facility equipped with bioreactors of up to 2,000 litres at the Strasbourg. (laboratorytalk.com)

The Gyroslab ™xP immunoassay platform increases productivity and efficiency during development of biotherapeutics and vaccines, saving time and labor. (pharmaceutical-business-review.com)

This rapid molecular platform/degenerate PCR approach detects panel specific targeted viruses and related, but unknown viral contaminants and benefits the industry in several ways. (interphex.com)

We present Metafluidics, an open-source, community-driven repository that hosts digital design files, assembly specifications, and open-source software to enable users to build, configure, and operate a microfluidic device. (nature.com)
Microfluidic circuits are currently designed by hand, using a combination of the designer's domain knowledge and educated intuition to determine unknown design parameters. (uwaterloo.ca)

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