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  • receptors
  • Castriconi R, Dondero A, Negri F, Bellora F, Nozza P, Carnemolla B, Raso A, Moretta L, Moretta A, Bottino C (2007) Both CD133(+) and CD133(−) medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity. (springer.com)
  • The genetic transfer of antigen receptors provides a means to rapidly generate autologous tumor-reactive T lymphocytes. (nih.gov)
  • This function is the outcome of the capacity of inhibitory NK receptors to block cytotoxicity upon interaction with their MHC-I ligands expressed on target cells. (jimmunol.org)
  • To investigate the role of human NK cells and their various receptors in the control of MHC-I-deficient tumors, we have isolated several NK cell clones from lymphocytes infiltrating an adenocarcinoma lacking β 2 -microglobulin expression. (jimmunol.org)
  • The cytolytic and cytokine functions of NK cells are regulated by a complex balance between inhibitory and activating signals that are triggered via the engagement of different NK cell surface receptors with their specific ligands ( 1 , 2 , 3 ). (jimmunol.org)
  • Target cells expressing MHC class I (MHC-I) 3 molecules are protected from NK cell lysis by interactions between these molecules and inhibitory NK receptors. (jimmunol.org)
  • In contrast, in the absence of these interactions, target cells become sensitive to NK lysis by triggering of NK cell-activating receptors. (jimmunol.org)
  • Human triggering receptors responsible for NK cell activation have been recently identified ( 9 , 10 ). (jimmunol.org)
  • These receptors include a heterogeneous family of molecules composed of natural cytotoxicity receptors (NCRs), which are exclusively expressed by NK cells and NKG2D, which is expressed by both NK cells and CTLs. (jimmunol.org)
  • In contrast to conventional T cell receptors (TCRs), which recognize antigens in a major histocompatibility complex (MHC)-dependent manner, CARs can potentially redirect the effector functions of a T cell toward any protein or non-protein target expressed on the cell surface. (frontiersin.org)
  • patients
  • In clinical trials, patients were treated with a series of s.c. injections of irradiated autologous tumor cells (TCV), or autologous dendritic cells (DCV), loaded with antigens from their tumor cell line. (springer.com)
  • For patients with melanoma and renal cell, who were treated with TCV, observed 5-year survival rates were nearly three times longer than national figures. (springer.com)
  • Such treatment is associated with encouraging long-term survival rates, and results are superior in patients treated with DCV loaded with antigen from such cells. (springer.com)
  • High-risk patients will first receive one cycle of chemotherapy with a regimen called DT PACE, after which the white blood cells will be collected. (knowcancer.com)
  • Patients will receive pre-conditioning chemotherapy followed by MFEz T cells and then intravenous IL2. (isrctn.com)
  • T cells from patients with GBM were stimulated with autologous DCs pulsed with CMV pp65 RNA, and the function of the effector CMV pp65-specific T cells was measured. (aacrjournals.org)
  • Then, we performed a prospective single-center, double-blinded, randomized, three-arm study in which HNSCC patients undergoing definitive surgical resection of oral and oropharyngeal tumors were treated with Tadalafil 10mg/day, 20mg/day or placebo for at least 20 days preoperatively. (aacrjournals.org)
  • An alternative strategy to overcome these limitations is adoptive T cell transfer therapy, in which tumor-specific T cells are expanded ex vivo rapidly and then transferred to patients. (hindawi.com)
  • Teh investigators previous phase I study (IRB #03-04-053) already confirmed that this vaccine procedure is safe in patients with malignant brain tumors, and with an indication of extended survival in several patients. (clinicaltrials.gov)
  • Patients with a history of any other neoplastic disease less than 5 years ago (excepting treated carcinomas in situ of the cervix and basal/squamous cell carcinomas of the skin). (knowcancer.com)
  • HER2-specific T cells from 10 consecutive GBM patients were generated by transduction with a retroviral vector encoding a HER2-specific chimeric antigen receptor. (aacrjournals.org)
  • Patients' HER2-specific T cells killed CD133-positive and CD133-negative cells derived from primary HER2-positive GBMs, whereas HER2-negative tumor cells were not killed. (aacrjournals.org)
  • NEW YORK, May 21, 2015 (GLOBE NEWSWIRE) -- NeoStem, Inc. (Nasdaq:NBS) announced Thursday that it will receive one of the largest research grants of its kind to support its pioneering treatment for patients with stage III recurrent or stage IV metastatic melanoma, a potentially breakthrough approach that teaches the immune system which cells to attack and kill. (cnbc.com)
  • CIRM, whose mission it is to accelerate the availability of stem cell treatments for patients with unmet medical needs, funds promising research programs involving all types of stem cells and across a wide range of diseases. (cnbc.com)
  • In order to examine this issue, patients with resectable primary neoplasms involving the lungs, esophagus, or pleura will be vaccinated with autologous tumor cells exposed exvivo to decitabine and radiation following completion of appropriate combined modality therapy. (clinicaltrials.gov)
  • A tumor vaccine consisting of irradiated autologous tumor cells plus Bacillus Calmette-Guerin (BCG) has been used in phase III trials to treat patients after resection of primary colon cancer ( 6 , 7 ). (aacrjournals.org)
  • patient's
  • NeoStem's therapeutic candidate, NBS20, uses a patient's own cancer cells - in essence, turning the cancer against itself - in a way that is unique. (cnbc.com)
  • Instead of attacking the bulk of cancer cells, NeoStem's therapy targets a patient's cancer-initiating cells, often called "cancer stem cells," which are those that proliferate cancer cells, spreading the disease and forming new tumors throughout the body. (cnbc.com)
  • One treatment that has come from this research involves collecting and modifying a cancer patient's tumor cells in the laboratory, then returning the cells to the patient as a vaccine to encourage the immune system to respond to them. (clinicaltrials.gov)
  • therapies
  • This trial proposes to use engineered T cells (MFEz T cells) comprising polyclonal CD4 and CD8 populations in place of the selected, specific TILs and combines these with 'supportive therapies' of pre-conditioning chemotherapy and high dose intravenous IL2. (isrctn.com)
  • From 1989-2011 he was the Medical and Scientific Director for the Hoag Cancer Center where he directed a translational research laboratory focused on bench-to-bedside patient-specific cell therapies, and from 2008-2011 was the Executive Medical Director of the Hoag Family Cancer Institute. (selectbiosciences.com)
  • While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment. (biomedcentral.com)
  • Immunotherapies have the potential to target GBM stem cells, which are resistant to conventional therapies. (aacrjournals.org)
  • The recent identification of chemotherapy- and radiotherapy-resistant CD133-positive tumor stem cells in GBMs ( 4 , 5 ) may help explain why conventional therapies are ineffective. (aacrjournals.org)
  • Other therapies may treat existing cancer, but they may not be as likely as NeoStem's approach might be to prevent a recurrence of tumors. (cnbc.com)
  • This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. (indigo.ca)
  • Chemotherapy
  • The pre-conditioning chemotherapy regime and the dose of MFEz T cells will be determined by the dose escalation scheme. (isrctn.com)
  • Chemotherapy will only be commenced if adequate transduction and expansion of MFEz T cells has occurred. (isrctn.com)
  • One cycle only of chemotherapy and MFEz T cells will be given. (isrctn.com)
  • Advances in therapy for childhood leukemia have relied increasingly on the use of high-dose chemotherapy often combined with stem-cell transplantation. (uio.no)
  • Biological
  • Other crucial biological prerequisites must be fulfilled to expand tumor-reactive T cells that retain a functional phenotype, including in vivo cytolytic activity and the ability to travel to tumor sites without prematurely succumbing to apoptosis. (nih.gov)
  • specificity
  • A ) The tumor specificity of the T cell line was determined by specific IFN-γ production in response to TRAMP-C2, MC38, B16BL6, or EL4 target cells. (nih.gov)
  • B ) The tumor specificity of the T cell line was determined by cytotoxicity using a standard JAM assay. (nih.gov)
  • When expressed by a T cell, CARs confer antigen specificity determined by the targeting domain ( 1 , 2 ). (frontiersin.org)
  • survival
  • The depletion of HER2 from the surface of resistant tumors cells by novel agents may therefore provide a means for reducing tumor aggressiveness and improving patient survival. (biomedcentral.com)
  • Neurotrophic tyrosine kinase receptor type 2 (TRKB), which regulates neuronal cell survival, differentiation and plasticity, was identified as highly overexpressed in the NGN3 positive cell transcriptome compared to NGN3 negative exocrine cells. (morphogenesis-inc.com)
  • measurable
  • At least tone measurable tumor lesions according to the RECIST criteria. (knowcancer.com)
  • Proteins that play a duty as chaperone (TCP-1-alpha and HSP70), cell signaling (MAPKK), transcriptional signaling (NAD-dependent deacetylase sirtui-2), or which are M. Disruption can permit albumin, a molecule that at wide 60 kDa is clumsily four times larger than classic cytokines such as IL-1 or tumor necrosis element (TNF-), to enter the wisdom in measurable amounts. (autoportal.ru)
  • proliferation
  • Stimulation of HER2-specific T cells with HER2-positive autologous GBM cells resulted in T-cell proliferation and secretion of IFN-γ and interleukin-2 in a HER2-dependent manner. (aacrjournals.org)
  • Here, we based the route of immunization on our observations in murine models of enhanced antigen-specific T-cell proliferation and IFNγ production using intranodal injections when compared with subcutaneous or intravenous routes of immunization ( 10 ). (aacrjournals.org)
  • receptor
  • Adams EJ, Chien YH, Garcia KC (2005) Structure of a gamma delta T cell receptor in complex with the nonclassical MHC T22. (springer.com)
  • This defect was associated with alterations in the expression of natural cytotoxicity receptor (NCR) by NK cells and the NKG2D ligands, MHC-I-related chain A, MHC-I-related chain B, and UL16 binding protein 1, and the ICAM-1 by tumor cells. (jimmunol.org)
  • ligand
  • These include modulation of MHC antigens and costimulatory molecules, expression of Fas ligand and other apoptotic molecules on the cell surface, production of inhibitory molecules such as transforming growth factor- (TGF-) β and IL-10, constitutive expression of the tryptophan-depleting enzyme, indoleamine 2,3-dioxygenase (IDO), and recruitment of regulatory T cells (Tregs) [ 9 ]. (hindawi.com)
  • Bui JD, Carayannopoulos LN, Lanier LL, Yokoyama WM, Schreiber RD (2006) IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. (springer.com)
  • activation
  • Reactive DTH site biopsies manifested infiltrates of effector cells consisting of CD45RO+ T-cells, and degranulating eosinophils consistent with activation of both Th1 and Th2 T-cell responses. (aacrjournals.org)
  • As a first line of defense against tumors, the activation of immune system is important to provide necessary preventive measures against tumor. (springer.com)
  • GCs also broaden making of IL-10, which inhibits antigen presentation and T-cell activation (de Waal Malefyt et al. (autoportal.ru)
  • immunodominant
  • We show that the immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in TRAMP tumor cells, and that immunization with dendritic cells pulsed with SNC9-H(8) peptide resulted in protection against TRAMP-C2 tumor challenge. (nih.gov)
  • Experimental Design
  • Experimental Design: First, we functionally and phenotypically characterized MDSCs in HNSCCs and determined, retrospectively, whether their presence at the tumor site correlates with recurrence. (aacrjournals.org)
  • protein
  • Sera from three of eight vaccinated men contained new antibodies recognizing polypeptides of 26, 31, and 150 kDa in protein extracts from prostate cells. (aacrjournals.org)
  • Briefl y, we provide here a method of transfecting whole tumor cells with plasmid DNA encoding an immunogenic bacterial protein such as Emm55, which was derived from Streptococcus pyogenes ( S. pyogenes). (morphogenesis-inc.com)