AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationTransplantation, AutologousBone Marrow PurgingBone MarrowTransplantation, HomologousHematopoietic Stem Cell TransplantationCombined Modality TherapyWhole-Body IrradiationBone Marrow CellsCyclophosphamideCarmustineLymphoma, Non-HodgkinTransplantation ConditioningHodgkin DiseaseMelphalanGraft vs Host DiseaseRecurrenceAntineoplastic Combined Chemotherapy ProtocolsRemission InductionEtoposideBusulfanTreatment OutcomeLeukemiaCytarabineLeukemia, Myeloid, AcuteSurvival AnalysisGraft SurvivalHematopoietic Stem CellsColony-Forming Units AssayMultiple MyelomaBone and BonesActuarial AnalysisLeukemia, MyeloidPrecursor Cell Lymphoblastic Leukemia-LymphomaBone Marrow DiseasesHematopoiesisVincristinePodophyllotoxinAnemia, AplasticHematopoietic Stem Cell MobilizationRetrospective StudiesKidney TransplantationTissue DonorsDrug EvaluationTime FactorsSalvage TherapyLymphomaTransplantation ChimeraThiotepaLiver TransplantationDisease-Free SurvivalStem Cell TransplantationFollow-Up StudiesSurvival RateAcute DiseaseHistocompatibility TestingTransplantation, IsogeneicLeukocyte CountHistocompatibilityImmunosuppressive AgentsImmunosuppressionGranulocyte Colony-Stimulating FactorGraft RejectionPrednisoneLymphatic IrradiationMitoxantroneCyclosporinePrognosisMyelodysplastic SyndromesGranulocyte-Macrophage Colony-Stimulating FactorT-LymphocytesPlatelet CountLeukemia, Myelogenous, Chronic, BCR-ABL PositiveDoxorubicinHepatic Veno-Occlusive DiseaseNeuroblastomaAntibodies, MonoclonalBlood Cell CountProspective StudiesMesnaGonadal DisordersGranulocytesOvarian Function TestsHeart TransplantationHematologic DiseasesHematologic NeoplasmsMice, Inbred C57BLNeutropeniaBlood Transfusion, AutologousLymphoma, FollicularPrednimustineRicinRadiation ChimeraTransplantation ImmunologyCell SeparationBone Marrow ExaminationVindesineAgranulocytosisLomustineLung Transplantation
Cell transplantationMultiple myelomaDonorASCTLymphomaGraft-versus-Undergo bone marrow transplaHealthy bone marrowGVHDOffers autologousTherapy and autologousOffer autologousProgenitor cellsPediatricLeukemiaAplastic anemiaProcedurePeripheral blood stem cell transHaploidentical transplantsBiopsyRecipientsBloodSurvivorsNeuroblastomaDiseasesMortalityPatients undergoingPerson'sSurvivalAdultHSCTChemotherapy or radiation therapyDiseaseClinicalHospitalComplicationsAllogenic2020OutcomesEngraftmentCellsHigh dosesRadiation therapyChronic
Cell transplantation53
Multiple myeloma8
Donor10
  • Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
  • National Marrow Donor Program. (mayoclinic.org)
  • The pediatric BMT service offers pre-transplant care, such as transplant-type decision-making and multidisciplinary testing to prepare the donor and the patient for the procedure. (tasmc.org.il)
  • Physicians who specialize in managing all transplant types, including allogeneic (bone marrow from a donor), autologous (bone marrow from the patient) and haploidentical transplants (bone marrow from a half-matched donor). (templehealth.org)
  • A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
  • For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
  • An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
  • The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
ASCT2
  • The occurrence of varicella zoster virus (VZV) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (HZ) after autologous SCT (ASCT). (nature.com)
  • Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
Lymphoma7
  • The program, which is accredited by the Foundation for the Accreditation of Cellular Therapy , has pioneered a tandem stem cell transplant for Hodgkin lymphoma, reduced intensity conditioning treatments utilizing the drug mitoxantrone, ara-C and pentostatin and refrigerated marrow storage techniques that have led to wide acclaim. (nymc.edu)
  • Self-donation transplants are performed for malignant conditions, such as recurrent lymphoma, metastasized bone cancers, high-risk neuroblastoma, and specific types of brain tumors. (tasmc.org.il)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Autologous BMT is used as a salvage therapy for patients with relapsed or refractory Hodgkin's lymphoma. (koruhastanesi.com)
  • Autologous BMT is used as a consolidation therapy for patients with high-risk non-Hodgkin's lymphoma. (koruhastanesi.com)
Graft-versus-1
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
Undergo bone marrow transpla2
Healthy bone marrow3
GVHD1
  • In addition to further crystallizing transplantation's impact on survivors' sexual health, study data specifically associated diminished sexual function and satisfaction with transplant-related total body radiation in men and chronic GVHD with diminished sexual function in men and both sexual function and satisfaction in women. (science20.com)
Offers autologous1
  • The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
Therapy and autologous1
Offer autologous1
  • Saja was rescheduled an appointment at Augusta Victoria Hospital in East Jerusalem, but again the hospital could only offer autologous transplantation. (who.int)
Progenitor cells5
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Pediatric5
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • The Dana-Dwek Children's Hospital Pediatric Hemato-oncology and Bone Marrow Transplantation Department treats infants, children, and adolescents suffering from acute and chronic blood diseases and from malignant hematological and non-hematological disorders. (tasmc.org.il)
  • Hematological investigations and diagnostics including bone marrow testing and spinal taps: These tests are performed pain-free with the help of the Tel Aviv Sourasky Medical Center's Dream Service (pediatric service that helps children undergo treatment and testing under sedation). (tasmc.org.il)
  • The Pediatric Hemato-oncology Department performs a full array of bone marrow transplants (BMT) for children, sourced by self-donated (autologous) marrow, peripheral blood donations and donations from related or unrelated donors (allogeneic). (tasmc.org.il)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
Leukemia9
Aplastic anemia1
  • It has also been used as a therapy for disorders like aplastic anemia, which are associated with bone marrow failure. (ucsfhealth.org)
Procedure7
  • In 2018, at Greater Accra Regional Hospital (Ridge Hospital) 1st Bone Marrow Transplant procedure was performed in Ghana. (bonemarrowtransplantations.com)
  • When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
  • However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
  • Allogeneic transplants are significantly more dangerous and require more intensive follow-up after the transplant procedure. (ucsfhealth.org)
  • In 1996, the hospital performed the first transplantation procedure in an autoimmune disease patient (refractory autoimmune hemolytic anemia) in Brazil and, since 1999, encouraged by Julio Voltarelli, has been performing transplants for autoimmune diseases with special focus on multiple sclerosis. (factglobal.org)
  • Thanks to improved transplant survival rates, we have now been able to focus our efforts on examining how the procedure affects key aspects of recipients' overall quality of life, including sexual health," said lead study author F. Lennie Wong, PhD, of City of Hope in Duarte, California. (science20.com)
  • Blood is preferred to bone marrow as a source because the procedure is less invasive and the number (count) of blood cells returns to normal more quickly. (msdmanuals.com)
Peripheral blood stem cell trans1
  • When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
Haploidentical transplants1
Biopsy1
Recipients8
  • The purpose of our work was to evaluate pulmonary complications in autologous bone marrow transplant recipients. (nih.gov)
  • A total of 141 consecutive autologous bone marrow transplant recipients were evaluated. (nih.gov)
  • DAH is a frequent cause of respiratory compromise and a major cause of mortality in autologous bone marrow transplant recipients. (nih.gov)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Blood28
Survivors6
  • Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being. (qxmd.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
  • The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
  • Data have been limited to this point, prompting us to take a closer look at this issue in a larger, more diverse group of autologous and allogeneic transplant survivors over an extended period. (science20.com)
  • Investigators' analysis of questionnaire results (led by Dr. Wong) confirmed previous studies in demonstrating a definitive impact of SCT on survivors' post-transplant sexual activity. (science20.com)
Neuroblastoma1
  • Advanced stages of neuroblastoma are treated with intensive chemotherapy in combination with an autologous bone marrow transplant, which is usually followed by a vitamin A derivative administered orally for 6 months. (khcc.jo)
Diseases5
  • The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
  • The growing amount of bone marrow diseases will help in escalating the growth of the bone marrow market. (powershow.com)
  • Diseases treatable by transplants. (mayoclinic.org)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
Mortality1
Patients undergoing1
  • Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
Person's1
Survival3
  • In a large French study, patients with greater than 5% blasts in their bone marrow on day 15 had a lower response rate (34% vs 91%), worse disease-free survival, and worse overall survival than patients with low blast counts on day 15. (medscape.com)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Adult4
HSCT5
  • this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
  • With her expertise in T-cell depleted transplant and haploidentical HSCT, along with her several certifications and training, Dr. Smitha is a highly sought-after specialist. (hcgoncology.com)
  • Dr. Smitha's special interest lies in T cell-depleted transplant and haploidentical HSCT. (hcgoncology.com)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
Chemotherapy or radiation therapy2
  • Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
  • Autologous BMT involves collecting and storing a patient's own healthy stem cells, which are later transplanted back into the patient's body after chemotherapy or radiation therapy. (koruhastanesi.com)
Disease3
  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
  • Immune reconstitution in severe combined immunodeficiency disease following lectin-treated T-cell depleted haplocompatible bone marrow transplantation. (cellsilab.com)
  • 1 , 2 , 4 - 6 Specifically, patients with lactate dehydrogenase ≥2 times the upper limit of normal (ULN) at diagnosis, R/R disease within 6 months of diagnosis, multisite relapse, and/or R/R disease with bone marrow involvement experience a significantly decreased OS ( Table 1 ). (jnccn.org)
Clinical5
  • Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
Hospital6
  • The Fox Chase-Temple University Hospital Bone Marrow Transplant Program offers patients in the Philadelphia region access to some of the most experienced stem cell transplant specialists. (templehealth.org)
  • Throughout efforts to refer Saja for bone marrow transplant, she has been receiving chemotherapy at Rantisi Hospital in Gaza City. (who.int)
  • Hospital Israelita Albert Einstein (HIAE) in Brazil is the first Bone Marrow Transplantation Center in Latin America to receive FACT accreditation. (factglobal.org)
  • In recent decades, an expansion plan doubled the hospital's service area, expanded social programs of assistance to needy communities, and turned the hospital into a benchmark in organ transplants, in the public sector. (factglobal.org)
  • The Koru Hospital Bone Marrow Transplant Center is a state-of-the-art medical facility that offers advanced stem cell therapy for a range of hematological disorders. (koruhastanesi.com)
  • At the Koru Hospital Bone Marrow Transplant Center, we provide comprehensive care to our patients, from pre-transplant evaluation to post-transplant follow-up care. (koruhastanesi.com)
Complications3
  • Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
  • They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)
  • During this recovery period, the patient is monitored for successful acceptance of the transplant, tracked for immune system recovery, and treated for potential complications. (tasmc.org.il)
Allogenic1
20201
  • She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
Outcomes2
  • Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • HCT, whether it be autologous, allogeneic, or tandem, has been and continues to be an integral part of therapy, with varying outcomes as delineated in Table 2 . (jnccn.org)
Engraftment2
Cells16
High doses2
Radiation therapy2
  • Radiation therapy may be used to relieve bone pain or to shrink a tumor that is pushing on the spinal cord. (medlineplus.gov)
  • He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
Chronic3
  • Autologous olfactory [corrected] mucosal transplant in chronic spinal cord injury: an Indian Pilot Study. (elearnsci.org)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)