AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Transplantation, AutologousBone Marrow TransplantationHematopoietic Stem Cell TransplantationStem Cell TransplantationTransplantation, HomologousTransplantation ConditioningMultiple MyelomaPeripheral Blood Stem Cell TransplantationMelphalanBone MarrowGraft vs Host DiseaseCombined Modality TherapyTreatment OutcomeRemission InductionBone Marrow CellsAntineoplastic Combined Chemotherapy ProtocolsWhole-Body IrradiationLiver TransplantationBone Marrow PurgingCyclophosphamideRecurrenceSalvage TherapyLymphoma, Non-HodgkinGraft SurvivalStem CellsDisease-Free SurvivalBusulfanHematopoietic Stem Cell MobilizationEtoposideHodgkin DiseaseCarmustineHematopoietic Stem CellsCytarabineHematologic NeoplasmsMyeloablative AgonistsKidney TransplantationSurvival RateTransplantation ChimeraSurvival AnalysisRetrospective StudiesTissue DonorsVincristineAntigens, CD34LeukemiaThiotepaTime FactorsFollow-Up StudiesGranulocyte Colony-Stimulating FactorHistocompatibility TestingCell TransplantationPrognosisLeukemia, Myeloid, AcuteAnemia, AplasticImmunosuppressive AgentsHeart TransplantationHistocompatibilityDexamethasoneLeukapheresisHematopoiesisLymphomaTransplantation, IsogeneicLung TransplantationLymphoma, Mantle-CellAmyloidosisBone and BonesMyelodysplastic SyndromesGraft RejectionAntineoplastic Agents, AlkylatingMesenchymal Stem Cell TransplantationPrednisoneDoxorubicinTransplantation ImmunologyCord Blood Stem Cell TransplantationThalidomideAntibodies, Monoclonal, Murine-DerivedBoronic AcidsNeoplasm, ResidualPyrazinesLymphoma, FollicularOrgan TransplantationLeukemia, MyeloidPodophyllotoxinAutograftsCell DifferentiationAcute DiseaseLymphoma, T-Cell, PeripheralGraft vs Tumor EffectHepatic Veno-Occlusive DiseasePrecursor Cell Lymphoblastic Leukemia-LymphomaImmunosuppressionT-LymphocytesAntineoplastic AgentsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveProspective StudiesMice, Inbred C57BLHLA AntigensAntibodies, MonoclonalIfosfamideIdarubicinGraft vs Leukemia Effect
Multiple myelomaPeripheral blood stemGraft-versus-LeukemiaLymphomaGVHDTransplantsProgenitor cellsLeukaemiaRemissionOutcomesAllogeneic stem cellMyelomaMesenchymal stemPatient's own cellsHematologyFlow cytometryPediatricFollowed by hematopoieticAdultsRefractoryMalignanciesClinicalBlood stem cellsDonor cellsChemotherapy or radiation therapyCancerThrombocytopeniaKidney transplantationLymphoidComplicationsRituximabPlatelet countHigh-doseTreatmentHSCTTherapy for Parkinson's DiseaseTransplant programHematopoietic stemCordProcedure
Multiple myeloma12
Peripheral blood stem4
Graft-versus-7
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
  • Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
  • If you received bone marrow from someone else, you may develop signs of graft-versus-host disease ( GVHD ). (medlineplus.gov)
  • The procedure was complicated by grade 2 acute graft-versus-host disease (GvHD) which resolved after implementation of immunosuppressive treatment. (bvsalud.org)
  • Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (uchicago.edu)
Leukemia75
  • Busulfan is used in pediatrics and adults in combination with cyclophosphamide or fludarabine/clofarabine as a conditioning agent prior to bone marrow transplantation, especially in chronic myelogenous leukemia (CML) and other leukemias, lymphomas, and myeloproliferative disorders. (wikipedia.org)
  • PURPOSE: This phase II trial is studying how well giving idarubicin and cytarabine together with pravastatin works in treating patients with relapsed acute myeloid leukemia (AML). (stanford.edu)
  • ADDITIONAL BACKGROUND: S0919 was initially designed for patients with relapsed acute myeloid leukemia (AML), where the patient's preceding remission had lasted ≥ 3 months. (stanford.edu)
  • Patients must have a previous morphologically confirmed diagnosis of acute myeloid leukemia (AML). (stanford.edu)
  • Note: This protocol uses the World Health Organization (WHO) diagnostic criteria for acute myeloid leukemia (AML) (see Section 4.1). (stanford.edu)
  • Patients with acute promyelocytic leukemia (APL, FAB, M3) or blastic transformation of chronic myelogenous leukemia (CMML) are not eligible. (stanford.edu)
  • Patients must have received at least one prior chemotherapy regimen for their acute myeloid leukemia (AML) and they may have received any type of chemotherapy. (stanford.edu)
  • Patients with acute lymphoblastic leukemia (ALL) present with either symptoms relating to direct infiltration of the marrow or other organs by leukemic cells, or symptoms relating to the decreased production of normal marrow elements. (medscape.com)
  • Although patients may present with symptoms of leukostasis (eg, respiratory distress, altered mental status) because of the presence of large numbers of lymphoblasts in the peripheral circulation, leukostasis is much less common in people with ALL than those with acute myelogenous leukemia (AML), and it occurs only in patients with the highest WBC counts (ie, several hundred thousand per μL). (medscape.com)
  • Patients with acute lymphoblastic leukemia (ALL) commonly have physical signs of anemia, including pallor and a cardiac flow murmur. (medscape.com)
  • Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
  • Myeloid markers in adult acute lymphocytic leukemia. (medscape.com)
  • Infectious complications in patients with acute myeloid leukemia treated accoding to the protocol with daunorubicin and cytarabine with or without addition of cladribine : a multicenter study by the Polish Adult Leukemia Group (PALG). (krakow.pl)
  • Infectious complications during the early period after autologous hematopoietic cell transplantation in patients with acute leukemia and lymphoproliferative disorders- comparative analysis. (krakow.pl)
  • 2021 , '3101 - MIR-10A AS A THERAPEUTIC TARGET AND PREDICTIVE BIOMARKER FOR MDM2 INHIBITION IN ACUTE MYELOID LEUKEMIA' , Experimental Hematology , 100 , pp. (edu.au)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)
  • Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)
  • Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all- trans retinoic acid (ATRA). (nature.com)
  • The disease is now considered to be the most curable subtype of acute myeloid leukemia (AML) in adults. (nature.com)
  • Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), with the first description as a distinct entity in 1957. (nature.com)
  • Bone marrow transplant is becoming a safer choice for elderly patients with lymphoma, myeloma, acute leukemia, and myeloid dysplastic syndrome, says Devine. (managedhealthcareexecutive.com)
  • In terms of allogeneic transplants, the most common indication is acute myeloid leukemia and myelodysplastic syndrome, which is a blood disorder that affects blood formation in older patients. (managedhealthcareexecutive.com)
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
  • Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
  • Learn about remission from acute myeloid leukemia (AML). (medicalnewstoday.com)
  • Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
  • Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies. (uchicago.edu)
  • After earning his medical degree in Scotland, he worked on the team that pioneered autologous bone marrow transplantation for acute myeloid leukemia, and was subsequently recruited to setup the bone marrow/stem cell transplant program at the University of Miami. (stemcellcryobank.com)
  • De novo acute myeloid leukemia (AML), type M2 with monocytosis or M4 in the case tested for RUNX1. (atlasgeneticsoncology.org)
  • RUNX1 and RUNX3 Genes Expression Level in Adult Acute Lymphoblastic Leukemia-A Case Control Study. (atlasgeneticsoncology.org)
  • Phenotypically-defined stages of leukemia arrest predict main driver mutations subgroups, and outcome in acute myeloid leukemia. (atlasgeneticsoncology.org)
  • Correlation Analysis and Prognostic Impacts of Biological Characteristics in Elderly Patients with Acute Myeloid Leukemia. (atlasgeneticsoncology.org)
  • Sequential approach to improve the molecular classification of childhood acute lymphoblastic leukemia. (atlasgeneticsoncology.org)
  • Monitoring minimal residual disease in RUNX1-mutated acute myeloid leukemia. (atlasgeneticsoncology.org)
  • Clinical and molecular characteristics of acute myeloid leukemia with MPL mutation. (atlasgeneticsoncology.org)
  • Acute myeloid leukemia in a child with familial platelet disorder and a cryptic runx1 intragenic deletion. (atlasgeneticsoncology.org)
  • Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm. (atlasgeneticsoncology.org)
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia. (smw.ch)
  • Campana D. Should minimal residual disease monitoring in acute lymphoblastic leukemia be standard of care? (smw.ch)
  • Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy. (smw.ch)
  • The origin and evolution of mutations in acute myeloid leukemia. (smw.ch)
  • Clonal architecture of secondary acute myeloid leukemia. (smw.ch)
  • Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. (smw.ch)
  • A study to examine acute myeloid leukemia (AML) among patients seen through the Bone Marrow Transplant Center/Team at SSM Health Saint Louis University Hospital. (slu.edu)
  • The primary objective of this study is to compare the efficacy of magrolimab + azacitidine versus venetoclax + azacitidine in adults with previously untreated TP53 mutant acute myeloid leukemia (AML) who are appropriate for non-intensive therapy as measured by overall survival (OS). (slu.edu)
  • The primary objectives of this study are to compare the efficacy of magrolimab + venetoclax + azacitidine versus placebo + venetoclax + azacitidine in participants with previously untreated acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy. (slu.edu)
  • The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
  • In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
  • The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
  • A15 - Torlontano G, Geraci L, Lombardo M, Iacone A, FIORITONI G, Di Marzio A, D'Arcangelo L: Treatment of acute non - lymphoid leukemia with vincristine adryamicine and cytosine arabinoside (AVA).Proc.of 2nd Internat. (giuseppefioritoni.it)
  • on Theraoy of acute leukemia - Rome 7 - 10th December, 1977, p. 423. (giuseppefioritoni.it)
  • A20 - Baccarani M, Guolo ML, Tura S and Italaian Cooperative study Group on chronic myeloid leukemia: Effect of early splenectomy and cyclic acute leukemia - like chemoterapy on the course of chronic myeloid leukemia. (giuseppefioritoni.it)
  • Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
  • AML is the most common acute leukemia in adults and current treatments are largely ineffective. (ca.gov)
  • Research Objective LGR5-antibody drug conjugate to target LIC in B cell tumors that undergo self-renewal Impact LIC were only defined in myeloid leukemia, while LIC populations in B cell tumors remain elusive. (ca.gov)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
  • Immunotherapies, such as CAR-T cellular therapy, have been rapidly developed, especially for refractory acute lymphoblastic leukemia. (blood-genomics.com)
  • This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
  • Elgarten CW, Aplenc R. Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy[J]. Curr Opin Pediatr , 2020, 32(1): 57−66. (blood-genomics.com)
  • Acute myeloid leukemia, version 3.2017, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw , 2017, 15(7): 926−957. (blood-genomics.com)
  • Pediatric acute lymphoblastic leukemia, version 2.2020, NCCN clinical practice guidelines in oncology[J]. J Natl Compr Canc Netw , 2020, 18(1): 81−112. (blood-genomics.com)
  • BMT is a common treatment for acute and chronic leukemia. (koruhastanesi.com)
  • Depending on the type of leukemia, autologous or allogeneic BMT may be recommended. (koruhastanesi.com)
  • Allogeneic BMT is used as a curative therapy for acute and chronic leukemia. (koruhastanesi.com)
  • PBSCT is used as a treatment option for acute and chronic leukemia. (koruhastanesi.com)
  • Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
  • Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
  • Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
  • Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Lymphoma12
  • d) treatment for a range of serious blood disorders in acute leukaemia, chronic leukaemia, myelodysplasia, myeloma and lymphoma. (epworth.org.au)
  • 90 Y-ibritumomab tiuxetan ( 90 Y-Zevalin) radioimmunotherapy as a consolidation strategy in mantle cell lymphoma (MCL) patients. (krakow.pl)
  • The tumor was successfully treated with chemotherapy, but 3 years later she was diagnosed with T-cell lymphoblastic lymphoma. (bvsalud.org)
  • Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. (smw.ch)
  • A randomized phase III trial of consolidation with autologous hematopoietic cell transplantation followed by maintenance rituximab vs. maintenance rituximab alone for patients with mantle cell lymphoma in minimal residual disease-negative first complete remission. (slu.edu)
  • Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
  • His major clinical interests are all aspects of malignant haematology, particularly in leukaemia, lymphoma, and myeloma, as well as autologous and allogeneic stem cell transplantation. (qld.gov.au)
  • Autologous BMT is used as a salvage therapy for patients with relapsed or refractory Hodgkin's lymphoma. (koruhastanesi.com)
  • Autologous BMT is used as a consolidation therapy for patients with high-risk non-Hodgkin's lymphoma. (koruhastanesi.com)
  • T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. (uchicago.edu)
  • Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
  • Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
GVHD8
  • We hypothesized that clinical risk factors could be identified within 2 weeks of onset of severe (stage 3 or 4) acute gut GVHD for identifying a patient population with a very poor outcome. (nature.com)
  • Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
  • His main research interests are in leukaemic stem cells, CLL, GVHD and autoimmune blood disorders such as immune thrombocytopenia. (epworth.org.au)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • Acute GVHD developed in 22 patients (44%) with 5 individuals presenting grade III-IV. (bvsalud.org)
  • The cumulative incidence of acute GVHD, non-relapse mortality (NRM), and graft-versus-host relapse-free survival (GRFS) were similar in both groups. (blood-genomics.com)
  • Fludarabine-melphalan conditioning for AML and MDS: alemtuzumab reduces acute and chronic GVHD without affecting long-term outcomes. (uchicago.edu)
  • Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence. (uchicago.edu)
Transplants13
  • Outcomes among patients with blood and marrow transplants have improved, thanks to better donor-recipient matching (such as through human leukocyte antigen typing), improved patient support systems, and less toxic treatment regimens, says Devine, who is also senior vice president and senior medical director of research operation at the Center for International Blood and Marrow Transplant Research. (managedhealthcareexecutive.com)
  • One big improvement has occurred in the realm of allogeneic transplants (in which donor cells are used). (managedhealthcareexecutive.com)
  • There are many clinical trials in the cellular therapies space outside of bone marrow transplants, such as CAR-T cell therapy and the use of NK cells, says Ronneberg, noting that a few CAR-T therapies have already received FDA approval. (managedhealthcareexecutive.com)
  • Learn more about stem cell transplants here. (medicalnewstoday.com)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • Blood-forming stem cell transplants. (mayoclinic.org)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of blood and marrow transplants (BMT). (ucsfhealth.org)
  • BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
  • The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
Progenitor cells7
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Melinda is highly proficient in the use of in vitro and in vivo assays for normal and malignant hematopoietic stem and progenitor cells, determination of self-renewal, expansion and lineage specific differentiation capabilities, and the use of induced pluripotent stem cells for the investigation of hematopoietic disorders and leukemic progression and the testing of targeted therapeutics. (edu.au)
  • 1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
  • Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
  • Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)
Leukaemia5
  • Evaluating the frequency, prognosis and survival of RUNX1 and ASXL1 mutations in patients with acute myeloid leukaemia in northeastern Iran. (atlasgeneticsoncology.org)
  • Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia. (atlasgeneticsoncology.org)
  • Minimal residual disease assessment in childhood acute lymphoblastic leukaemia: a Swedish multi-centre study comparing real-time polymerase chain reaction and multicolour flow cytometry. (smw.ch)
  • He has experience in managing all aspects of haematological malignancy with specific interests in the areas of acute leukaemia and allogeneic stem cell transplantation. (qld.gov.au)
  • MM is matological malignancies, which can be up characterized by monoclonal paraprotein to 75% in acute leukaemia. (who.int)
Remission3
  • People in remission from AML may be candidates for allogeneic stem cell transplantation. (clevelandclinic.org)
  • the ATO dosage is 0.15 mg/kg/day IV until bone marrow remission occurs (maximum induction, 60 doses). (medscape.com)
  • Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
Outcomes6
Allogeneic stem cell21
Myeloma2
  • Ascites in the course of plasma cell myeloma complicated by AL-amyloidosis. (myeloma.org.uk)
  • Myeloma bone disease: Progress in pathogenesis. (myeloma.org.uk)
Mesenchymal stem2
Patient's own cells2
Hematology1
  • 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Flow cytometry3
Pediatric2
  • Jamous MA1, Abdel Aziz H, "Conservative management of acute epidural hematoma in a pediatric age group. (just.edu.jo)
  • Jamous MA, "The outcome of observation of acute traumatic extradural hemorrhage in pediatric age group. (just.edu.jo)
Followed by hematopoietic2
Adults5
  • As an adjunct therapy with cyclophosphamide for conditioning prior to bone marrow transplantation in adults and children >12 kg, intravenous (IV) busulfan (Bulsulfex) is dosed at 0.8 mg/kg every six hours for 16 doses (four days). (wikipedia.org)
  • A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
  • Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
  • Figure 1 shows the trend in the annual number of allogeneic and autologous HCTs in adults with AML reported in the Japanese transplantation registry. (apbmt.org)
  • See "HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets)" and "Evaluation and treatment of hypertensive emergencies in adults" and "Catastrophic antiphospholipid syndrome (CAPS)" and "Early complications of hematopoietic cell transplantation", section on 'Thrombotic microangiopathy' . (medilib.ir)
Refractory3
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
  • Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
Malignancies2
  • Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
Clinical7
  • Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
  • Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
  • A9 - Torlontano G, FIORITONI G, Pontano O, Iacone A, Bonanni G: Normal granulocyte transfusion therapy in the management of acute leukemias.Current Studies on Standardization Problems in Clinical Patholology, Haematology and Radiotherapy in Hodgkin's Disease.Eds: G. Astaldi, C. Biagini. (giuseppefioritoni.it)
  • LICs give rise to drug-resistance and relapse and remain unsolved clinical problems in B cell tumors. (ca.gov)
  • Cameron is a Clinical Haematologist and Staff Specialist in the Department of Haematology and Bone Marrow Transplantation at the Royal Brisbane and Women's Hospital. (qld.gov.au)
  • Kirk is Acting Director of Clinical Haematology and Bone Marrow Transplantation at Royal Brisbane and Women's Hospital. (qld.gov.au)
  • 14: Laurell H, Hansson LE, Gunnarsson U. Impact of clinical experience and diagnostic performance in patients with acute abdominal pain. (cancercentrum.se)
Blood stem cells5
Donor cells1
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
Chemotherapy or radiation therapy3
Cancer28
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • RATIONALE: Drugs used in chemotherapy, such as idarubicin and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (stanford.edu)
  • Pravastatin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (stanford.edu)
  • Pravastatin may also help idarubicin and cytarabine work better by making cancer cells more sensitive to the drugs. (stanford.edu)
  • Giving idarubicin and cytarabine together with pravastatin may kill more cancer cells. (stanford.edu)
  • 3. Cancer is not the only disease benefited by transplantation. (managedhealthcareexecutive.com)
  • There are increasing indications not only for patients with cancer, but also for nonmalignant conditions like sickle cell disease and even potentially down the road, autoimmune diseases like multiple sclerosis," says Devine. (managedhealthcareexecutive.com)
  • They aim to eliminate cancer cells from the blood. (medicalnewstoday.com)
  • Chemotherapy uses drugs to kill cancer cells and slow or stop their growth. (medicalnewstoday.com)
  • Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
  • Doctors can deliver radiation externally or internally, depending on the location of the cancer cells. (medicalnewstoday.com)
  • External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
  • However, it does not mean a complete cure, as some cancer cells may remain in the body and can cause the disease to return. (medicalnewstoday.com)
  • Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer. (atlasgeneticsoncology.org)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • Immune checkpoint inhibitors are safe and effective for people living with HIV who have metastatic non-small cell lung cancer (NSCLC), according to data presented at the 2022 Society for Immunotherapy of Cancer (SITC) Annual Meeting. (ascopost.com)
  • A team at Stanford University is using a molecule known as an antibody to target cancer stem cells. (ca.gov)
  • This antibody can recognize and bind to CD47, a protein the cancer stem cells carry on their cell surface. (ca.gov)
  • The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
  • Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)
  • Research Objective Our goal is to develop and optimize novel drugs that can attack blood cancer stem cells. (ca.gov)
  • Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
  • Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)
  • http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
  • This radiation therapy is intended to destroy remaining cancer cells and further suppress the immune system. (ucsfhealth.org)
  • National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
Thrombocytopenia3
  • Busulfan also induces impotence in males (kills germ cells), thrombocytopenia, a condition of lowered blood platelet count and activity, and sometimes medullary aplasia. (wikipedia.org)
  • Bleeding can be the result of thrombocytopenia due to marrow replacement. (medscape.com)
  • INITIAL EVALUATION (ALL PATIENTS) - Individuals with a TMA may come to medical attention with any of a variety of presentations including unexplained anemia or thrombocytopenia, unexplained neurologic findings (suspected stroke or transient ischemic attack), or other acute illness. (medilib.ir)
Kidney transplantation2
Lymphoid1
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
Complications6
  • Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
  • The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
  • Moreover, she underwent effective double transplantations and was eventually found to be cured despite accompanying complications. (bvsalud.org)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • The cer is about 2%-5% and as high as 26% in most common complications include renal small-cell lung carcinoma [ 5 ]. (who.int)
Rituximab1
  • Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)
Platelet count1
  • Patients with APL may be stratified into the following 3 risk categories on the basis of white blood cell (WBC) count and platelet count. (medscape.com)
High-dose1
  • Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. (uchicago.edu)
Treatment6
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
  • Topiramate lacks efficacy in the treatment of acute mania. (pgdue.com)
  • Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
HSCT4
Therapy for Parkinson's Disease2
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • Cell Therapy for Parkinson's Disease: What Next? (lu.se)
Transplant program1
Hematopoietic stem19
Cord7
  • These stem cells may come from a family member, from someone you don't know or from umbilical cord blood. (clevelandclinic.org)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
  • The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
  • Cord blood transplantation involves the use of stem cells from umbilical cord blood, which is collected and stored at birth. (koruhastanesi.com)
  • Cord blood transplantation is used to treat certain genetic disorders that affect the production of blood cells, such as sickle cell anemia and thalassemia. (koruhastanesi.com)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Procedure4