Autologous stem cell transplantation improves outcome autologous stem cell transplantation. Medical search. Frequent questions

4. Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma. (nih.gov)
9. Autologous stem cell transplantation in multiple myeloma: improved survival in nonsecretory multiple myeloma but lack of influence of age, status at transplant, previous treatment and conditioning regimen. (nih.gov)
16. Evolving transplant options for multiple myeloma: autologous and nonmyeloablative allogenic. (nih.gov)
This concept will be investigated in this study by closely examining the metabolic profile of immune cells to see how the transplant affects their metabolism. (msaustralia.org.au)
By understanding these underlying mechanisms, it is hoped that safer and more effective transplant options may be developed for the future, enhancing our understanding of processes contributing to a successful AHSCT outcome and the best candidate for the procedure in people living with MS. (msaustralia.org.au)
The morning agenda started with the session on donor challenges, brought by Sophie Van Lancker, stem cell transplant coordinator from the paediatric clinic at the University Hospital Gent (Belgium). (ebmt.org)
Although the raising antimicrobial resistance (AMR) remains a global health and development threat, also in stem cell transplant patients. (ebmt.org)
Followed by a session on Fecal microbiota transplantation in the treatment of GVHD Dr. Anke Vanderlinden, transplant physician at the University Hospital in Antwerp, gave us an interesting literature overview about this treatment. (ebmt.org)
A practical tool such as the tasting box could be a helpful instrument to coach post-stem cell transplant patients in their taste experience and to gain back their nutritional energy. (ebmt.org)
The regimen, known as myeloablative autologous hematopoietic stem cell transplant (HSCT), includes chemotherapy and total body radiation to destroy the bone marrow followed by transplantation of the person's own blood-forming stem cells to reconstitute the marrow and immune system. (nih.gov)
The SCOT trial assessed a myeloablative transplant regimen, which researchers thought might offer better long-term outcomes. (nih.gov)
At four and a half years of follow up, participants who received a transplant experienced significantly better outcomes overall than those who received cyclophosphamide. (nih.gov)
And it compared using that same regimen to giving it with ibrutinib added to the R-CHOP portion of the chemotherapy, followed by ibrutinib maintenance after the stem cell transplant or another experimental arm that added ibrutinib to the R-CHOP portion of the chemotherapy and gave 2 years of ibrutinib maintenance without stem cell transplantation. (cancer.net)
I think, importantly, this arm compared to each of those 2 experimental arms versus the standard of care and showed graphically that both of the arms that contained ibrutinib, the BTK inhibitor, looked to have improved failure-free survival compared to the standard stem cell transplant arm. (cancer.net)
But those 2 arms look fairly similar in terms of their outcomes, and also the toxicity associated with the transplant obviously was substantially more than performing the therapy without transplant. (cancer.net)
Overall, pulmonary complications, both infectious and non-infectious, occur in 40-60% of patients after stem cell transplantation [ 3 ], and are usually classiﬁed as early or late onset, depending on whether they occur within 100 days of the transplant [ 4 ]. (ersjournals.com)
This study aim to determine the treatment effects of ixazomib, lenalidomide and dexamethasone (IRd) combination on patient reported outcomes (PROs) in newly diagnosed transplant eligible multiple myeloma patients. (rsyd.dk)
In the first podcast episode , Dr. Joshua Richter and Dr. Karthik Ramasamy discuss how to select the best approach in newly diagnosed patients with MM. They discuss personalising therapy, both in the transplant setting as well as in patients who are not eligible for transplantation. (cor2ed.com)
Autologous peripheral blood stem cell transplantation (autoPBSCT) remains a crucial aspect of treating MM, and the NCCN Guidelines recommend all eligible patients be evaluated for transplant. (jnccn.org)
There is limited data analyzing the relationship between severe obesity and transplant outcomes in MM patients in the era of modern therapy, routine post-transplant maintenance, and genetic-based risk stratification. (jnccn.org)
Recent research indicates that the transplant of autologous hematopoietic stem cells (AHSCT) is an excellent treatment for multiple sclerosis. (worldhealth.net)
Aetna considers non-myeloablative allogeneic hematopoietic cell transplantation medically necessary ("mini-transplant", reduced intensity conditioning transplant) for the treatment of persons with relapsed NHL (including persons who have relapsed after ABMT) or primary refractory (see note below) NHL (low-grade, intermediate-grade, and high-grade) when they are eligible for conventional allografting or a reduced intensity regimen is preferred by the transplant center. (aetna.com)
A Spanish group pioneered a flow cytometry version of the MRD test and has consistently shown that negative MRD was associated with a better outcome and was superior to complete response in predicting long progression free survival and overall survival, especially in the transplant setting. (healthtree.org)
Abstract: Autologous hematopoietic stem cell transplantation (auto-HCT) is considered a standard therapy for transplant-eligible patients with multiple myeloma, while allogeneic HCT (allo-HCT) is controversial. (elsevierpure.com)
and led teams at Health Canada responsible for developing guidance for biosimilars, transplant material, and cell & gene therapies. (utoronto.ca)
Using fecal transplants, researchers restored beneficial bacteria in cancer patients who received antibiotics for stem cell transplant procedures. (nih.gov)
The first 25 patients who lacked known beneficial bacteria were enrolled in the study and randomly assigned to two different treatment groups: 14 received the autologous fecal transplant by enema and 11 received standard care. (nih.gov)
Cells harvested from patients can then be corrected with these tools in vitro followed by re-infusion into the same patient by autologous transplant. (nih.gov)
Early efforts have been limited by the ability to effectively transplant cells under the retina and to avoid rejection of cells by the immune system. (nih.gov)
The BMT CTN 0401 trial compared progression-free survival after autologous hematopoietic stem cell transplantation for chemotherapy-sensitive diffuse large B-cell lymphoma using Rituxan/BEAM versus Bexxar/BEAM for pre-transplant conditioning. (nih.gov)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)

6. Modified conditioning regimen busulfan-cyclophosphamide followed by allogeneic stem cell transplantation in patients with multiple myeloma. (nih.gov)
With the trend toward more aggressive induction treatment protocols, there is a clear need amongst patients with multiple myeloma to be able to reliably and rapidly secure the necessary amount of stem cells to continue their treatment programs. (prnewswire.com)
APHEXDA has the potential to significantly improve outcomes and treatment experiences for patients with multiple myeloma, and the acceptance of our NDA brings us closer to this important goal," said Philip Serlin , Chief Executive Officer of BioLineRx. (prnewswire.com)
In the Nordic countries about 400 upfront Autologous stem cell transplantations are performed every year in patients with multiple myeloma. (rsyd.dk)
PURPOSE: Salvage autologous stem-cell transplantation (sASCT) in patients with multiple myeloma (MM) relapsing after a prior autologous stem-cell transplantation leads to increased remission duration and overall survival. (ucl.ac.uk)

High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT) is still a consolidation treatment choice for relapsed/refractory B-cell non-Hodgkin's lymphoma (NHL) patients and some aggressive B-cell NHL as frontline therapy. (nature.com)
We retrospectively compared the outcomes of 72 aggressive B-cell NHL patients treated with IEAC or BEAC regimens followed by ASCT as upfront consolidative treatment. (nature.com)
Before autologous stem cell transplantation (ASCT), hematopoietic stem cells must be stimulated to move from the bone marrow to the peripheral blood for harvesting. (nih.gov)
Autologous stem cell transplantation (ASCT) is part of the standard treatment paradigm for a number of blood cancers, including multiple myeloma. (prnewswire.com)
Autologous stem cell transplantation (ASCT) is the standard of care for multiple myeloma patients eligible for high-dose therapy, lymphoma patients undergoing second-line treatments and for acute myelogenous leukaemia (AML) [ 1 ]. (ersjournals.com)
Many reports focus on allogenic transplantation alone [ 5 ], but the only report dealing with ASCT displayed a 25% prevalence of pulmonary complications within the first year post-ASCT and a severe associated risk of death [ 6 ]. (ersjournals.com)
However, since ASCT is not a curative treatment, post-ASCT therapy are widely investigated to improve the depth of response and to achieve sustained long-term response. (rsyd.dk)
Therefore quiescent cell cycle status and stem cell/primitive progenitor frequency together with ROS production of CD34+ cells from post-ASCT bone marrow (one year after transplantation) were studied and compared to normal bone marrow cells and PBSC. (tam-receptor.com)
The results indicate that the diminished regenerative capacity of bone marrow post-ASCT might be related to a loss of quiescence of stem cells and primitive progenitors and enhanced Vincristine sulfate ROS production by progenitor cells. (tam-receptor.com)
In addition Vincristine sulfate micro-array studies demonstrated that changes in gene expression induced by mobilization are only partly restored in CD34+ bone marrow cells post-ASCT. (tam-receptor.com)
The statistical relationship between CR achievement and a better outcome was mostly seen in patients treated with high-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) because stringent CR and CR were more commonly observed in these patients than in those treated with conventional-dose chemotherapy. (healthtree.org)
More recently, combinations of new agents with or without HDT/ASCT, consolidation, and prolonged maintenance therapy not only increased the proportion of patients achieving CR but also the depth of response. (healthtree.org)
Autologous stem cell transplantation (ASCT) achieves the highest rates of complete clonal response but is confounded by substantial treatment-related mortality in AL amyloidosis unless it is restricted to highly selected patients. (qxmd.com)
Newer chemotherapy regimens appear to have a balance of better safety and respectable efficacy with overall outcomes nearly similar to ASCT, but which may be used more widely. (qxmd.com)
PFS included all patients peripheral blood progenitor cell (PBPC) harvesting, HDS and and was calculated from HDCY date until the date of ASCT.9 progression, relapse, last follow-up or death due to any cause. (bvsalud.org)

We report clinical outcomes of HDC using a novel regimen consisting of mitoxantrone, etoposide, cytarabine, and melphalan (NEAM) with auto-SCT. (nih.gov)
The research team has access to the biobank blood samples and the clinical progress reports of past patients and can match the laboratory results to clinical outcomes to gain an even deeper understanding of the procedure. (msaustralia.org.au)
The study investigators used an analytic approach based on a hierarchy of clinical outcomes specific for severe systemic sclerosis to compare every participant in the study with every other participant. (nih.gov)
The clinical outcomes demonstrated by our GENESIS Phase 3 study showed that nearly 90 percent of patients collected an optimal number of cells for transplantation following a single administration of APHEXDA and in only one apheresis session. (prnewswire.com)
We evaluated the clinical outcomes of tandem auto-HCT (n = 676) and auto/allo-HCT (n = 89). (elsevierpure.com)
Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer. (cdc.gov)
Innate immune responses restrict HSPC genetic engineering and contribute to individual variability in clinical outcomes. (nih.gov)

Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (nih.gov)
The global, randomized, phase III BELINDA trial compared the safety of tisagenlecleucel with the current second-line standard-of-care treatment strategy in 322 patients with aggressive relapsed or refractory NHL within 12 months of first therapy who were eligible for autologous hematopoietic cell transplantation (AHCT). (ascopost.com)
This Clinical Policy Bulletin addresses hematopoietic cell transplantation for non-hodgkin's lymphoma. (aetna.com)
Aetna considers autologous hematopoietic cell transplantation for the treatment of persons with relapsed or primary refractory (see "Note" below) non-Hodgkin's lymphoma (NHL) medically necessary if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
Aetna considers allogeneic hematopoietic cell transplantation medically necessary for the treatment of persons with relapsed NHL (including persons who have relapsed after autologous hematopoietic cell transplantation) or primary refractory (see "Note" below) NHL (low-grade, intermediate-grade, and high-grade) if the person meets the transplanting institution's protocol eligibility criteria. (aetna.com)
Aetna considers tandem autologous hematopoietic cell transplantion (auto-auto) or tandem autologous hematopoietic cell transplantation followed by allogenic hematopoietic cell transplantation (auto-allo) experimental and investigational for NHL due to a lack of adequate evidence in the peer-reviewed published medical literature of their safety and effectiveness. (aetna.com)

Multiple prior treatments before transplantation, auxiliary bone marrow harvest for stem cell collection, and high serum lactate dehydrogenase level were related to unfavorable treatment outcomes. (nih.gov)
Aggressive chemotherapy followed by autologous bone marrow transplantation has been used with some improvement in survival. (nih.gov)
The procedure began with doctors collecting a participant's blood-forming stem cells, after which the participant received chemotherapy and radiation to eliminate the bone marrow. (nih.gov)
Finally, doctors infused the participant's own blood stem cells to rebuild the bone marrow and a normally functioning immune system. (nih.gov)
Multiple myeloma is an incurable blood cancer that affects some white blood cells called plasma cells, which are found in the bone marrow. (prnewswire.com)
When damaged, these plasma cells rapidly spread and replace normal cells in the bone marrow with tumors. (prnewswire.com)
In 2022, it is estimated that more than 34,000 people will be diagnosed with multiple myeloma, and more than 12,000 people will die from the disease in the U.S. While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels, kidney problems or infections. (prnewswire.com)
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
Patients who have undergone autologous stem cell transplantation are subsequently more susceptible to chemotherapy-induced bone marrow toxicity. (tam-receptor.com)
while significantly higher levels of reactive oxygen species were observed in CD34+/CD38high cells following autologous stem cell transplantation compared to normal bone marrow. (tam-receptor.com)
Moreover post-transplantation CD34+ bone marrow cells demonstrated Vincristine sulfate an increased sensitivity to buthionine sulfoximine a trigger for endogenous production of reactive oxygen species. (tam-receptor.com)
Gene expression analysis on CD34+ cells revealed a set of 195 genes including HMOX1 EGR1 FOS and SIRPA that are persistently down-regulated in mobilized peripheral blood cells and post-transplantation bone marrow compared to normal bone marrow. (tam-receptor.com)
In conclusion our data indicate that the diminished regenerative capacity of bone marrow following autologous stem cell transplantation is possibly related to a loss of quiescence and a reduced tolerability to oxidative stress. (tam-receptor.com)
Potential donors for allogeneic bone marrow transplantation and patients who underwent elective total hip replacement served as normal controls. (tam-receptor.com)
Today in multiple myeloma, complete response (CR) is defined by a negative immunofixation and less than 5% plasma cells in the bone marrow. (healthtree.org)
The very high doses of chemotherapy or radiation therapy that are used to treat certain cancers can destroy blood-forming stem cells in the bone marrow. (nih.gov)
Stem cell transplants can restore these cells and re-establish the bone marrow's production of blood cells and immune function. (nih.gov)
Bone marrow mesenchymal stem cells (BMMSCs) and bone marrow mononuclear cells (BMMNCs) are both used to treat spastic cerebral palsy. (biomedcentral.com)
Among the many kinds of stem cells, bone marrow mesenchymal stem cells (BM-MSCs) have become a popular form of seed cell transplantation because of their convenience, low immunogenicity, and amplification ability [ 8 ]. (biomedcentral.com)
Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
Previous research has established the use of high-dose chemotherapy with autologous bone marrow transplantation as the standard of care for relapsed chemotherapy-sensitive diffuse large B-cell lymphoma (DLBCL). (nih.gov)
Malignant plasma cells in bone marrow produce an immunoglobulin, usually monoclonal IgG or IgA or, less commonly, immunoglobulin light chains [1]. (who.int)
MM is characterized by monoclonal paraprotein production, lytic lesions and increased plasma cells in the bone marrow [1]. (who.int)
MM is considered an incurable disease despite various methods of treatment, including autologous bone marrow transplantation [3]. (who.int)

Between 25 and 30% of patients with advanced stage HD still relapse and in subsets of this group, the outcome is dismal. (nih.gov)
Eventually, however, nearly all patients will experience a relapse of the disease because, with time, myeloma cells become resistant to current drug therapies. (schoolandyouth.org)
In an independent cohort of patients, we found that an increased number of CD68+ macrophages was correlated with a shortened progression-free survival (P = 0.03) and with an increased likelihood of relapse after autologous hematopoietic stem-cell transplantation (P = 0.008), resulting in shortened disease-specific survival (P = 0.003). (elsevierpure.com)
TriLeukeVax, an autologous AML vaccine designed to stimulate induction of anti-leukemic cytolytic activity and improve relapse free survival (RFS). (ca.gov)
These residual cells are the cause of relapse that results in poor overall survival. (ca.gov)
To increase relapse free survival, patient's AML cells are engineered to express a novel combination of immune-stimulatory proteins that stimulate the patient's immune system to kill residual AML. (ca.gov)
However, even in patients with chemotherapy-sensitive DLBCL, relapse of lymphoma is a major cause of transplantation failure. (nih.gov)

Treatment of infectious diseases after allogenic stem cell transplantations remains a huge challenge. (ebmt.org)
She started with an update on the theoretical background of our microbiota system and the impact of an allogenic stem cell transplantation on this specific topic. (ebmt.org)

[ 33 ] The failure to demonstrate improved survival may be due to the small number of patients studied. (medscape.com)
11. Long-term survival after allogeneic stem cell transplantation for advanced stage multiple myeloma. (nih.gov)
The 4-year survival of the 65 patients randomized to autologous peripheral blood stem cell transplantation or a second consolidation course of high-dose cytarabine was 37% and 27%, respectively. (haematologica.org)
Conclusions Patients with a donor and candidates for allogeneic stem cell transplantation in first complete remission may have a better disease-free survival than those without a donor in case of myelodysplastic syndromes with intermediate/high-risk cytogenetics. (haematologica.org)
Autologous peripheral blood stem cell transplantation does not provide longer survival than intensive chemotherapy. (haematologica.org)
We prospectively evaluated the effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in improving the survival of patients with atypical teratoid/rhabdoid tumors while reducing the risks of late adverse effects from radiotherapy (RT). (e-crt.org)
New clinical trial findings show that a therapeutic regimen involving transplantation of a person's own blood-forming stem cells can improve survival and quality of life for people with severe scleroderma, a life-threatening autoimmune disease. (nih.gov)
These outcomes included death, survival without scleroderma-related organ damage, progression of lung and skin disease, and quality of life. (nih.gov)
Standard annual reports (US Patient Survival Report, Current uses and outcomes of HSCT etc. (nih.gov)
Recent advances in the treatment of myeloma have resulted in improved treatment response and overall survival rates in newly diagnosed patients and in patients with relapsed myeloma. (schoolandyouth.org)
This antigen, also called TNFRSF17 (part of the tumor necrosis factor superfamily of proteins), is an important cell surface protein that is involved in supporting the survival of myeloma cells. (schoolandyouth.org)
The autologous chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel failed to improve event-free survival vs standard-of-care treatment strategies in patients with aggressive, relapsed or refractory non-Hodgkin lymphoma (NHL), according to the results of the phase III BELINDA trial, presented as a late-breaking abstract during the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition. (ascopost.com)
this is increasingly recognized as an important approach for increasing a patient's chance of cure or prolonging survival. (hoapb.com)
Those with the most severe type of the disease require red blood cell transfusions every month for survival. (luriechildrens.org)
The historically poor prognosis of AL amyloidosis appears to be improving with currently reported median survival of c. 40 months compared to 13 months in the early 1990s when low-dose oral melphalan was the mainstay of treatment. (qxmd.com)
The absence of an elevated number of CD68+ cells in patients with limited-stage disease defined a subgroup of patients with a long-term disease-specific survival of 100% with the use of current treatment strategies. (elsevierpure.com)
Conclusions: An increased number of tumor-associated macrophages was strongly associated with shortened survival in patients with classic Hodgkin's lymphoma and provides a new biomarker for risk stratification. (elsevierpure.com)
Patients who experienced lower adverse effects after sASCT had longer time to progression and overall survival, showing the need to improve symptom management peritransplantation. (ucl.ac.uk)
The trials combining Bexxar with BEAM (chemotherapeutic agents carmustine, etoposide, cytarabine, and melphalan) and autologous hematopoietic stem cell transplantation demonstrated promising early results for event-free survival in relapsed chemosensitive DLBCL patients. (nih.gov)
Therefore, the BMT CTN 0401 trial was initiated to test the primary hypothesis that the addition of 131 I-tositumomab to a standard high-dose chemotherapy transplantation regimen with BEAM would improve the 2-year progression-free survival compared with the addition of rituximab to the same chemotherapy transplantation protocol in patients with chemotherapy-sensitive persistent or relapsed DLBCL. (nih.gov)
The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)

TEL AVIV, Israel , Nov. 10, 2022 /PRNewswire/ -- BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a pre-commercial-stage biopharmaceutical company focused on oncology, today announced that the U.S. Food and Drug Administration (FDA) has accepted for review and filed the Company's New Drug Application (NDA) for APHEXDA® (motixafortide) in stem cell mobilization for autologous transplantation in multiple myeloma patients. (prnewswire.com)
The NDA is supported by the results from the GENESIS Phase 3 trial of motixafortide on top of G-CSF (versus placebo on top of G-CSF) in stem cell mobilization for autologous transplantation in multiple myeloma patients. (prnewswire.com)
GENESIS is a randomized, placebo-controlled, multicenter study, evaluating the safety, tolerability and efficacy of motixafortide and G-CSF, compared to placebo and G-CSF, for the mobilization of hematopoietic stem-cells for autologous transplantation in multiple myeloma patients. (prnewswire.com)

Autologous mesenchymal stem cell transplantation in stroke patients. (staminafoundation.org)
Mesenchymal stem cell (MSC) transplantation improves recovery from ischemic stroke in animals. (staminafoundation.org)

Background Allogeneic stem cell transplantation is usually considered the only curative treatment option for patients with advanced or transformed myelodysplastic syndromes in complete remission, but post-remission chemotherapy and autologous stem cell transplantation are potential alternatives, especially in patients over 45 years old. (haematologica.org)
Additionally, all patients without a sibling donor in complete remission after the first consolidation course were randomized to either autologous peripheral blood stem cell transplantation or a second consolidation course consisting of high-dose cytarabine. (haematologica.org)
Clinical trials are under way to develop treatments that increase the remission rate of myeloma or cure the disease. (schoolandyouth.org)
Those with RRMS, characterized by flare-ups (inflammatory attacks) and periods of remission enjoyed the optimal outcomes. (worldhealth.net)

8. Allogeneic stem cell transplantation and targeted immunotherapy for multiple myeloma. (nih.gov)
These immunotherapy agents are increasingly being used to treat myeloma, both to target the cancer cells directly and to modulate the patient's immune system. (schoolandyouth.org)

15. [Bortezomib plus dexamethasone treatment followed by reduced-intensity allogeneic stem cell transplantation for multiple myeloma refractory to high-dose chemotherapy with autologous transplantation]. (nih.gov)
We illustrate the reported pediatric experience of transplantation for lymphoma and discuss how the results from these trials are influencing how we approach the treatment in certain subgroups of pediatric patients with relapsed/refractory lymphoma. (nih.gov)
Tisagenlecleucel is an autologous anti-CD29 CAR T-cell therapy approved for relapsed or refractory diffuse large B-cell lymphoma treated with two or more prior lines of treatment. (ascopost.com)
With an increasing number of novel treatment options, choosing a regimen that does not include a drug the patient is refractory to is becoming easier. (cor2ed.com)

1. Allogeneic stem cell transplantation for multiple myeloma. (nih.gov)
2. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. (nih.gov)
3. Allogeneic hematopoietic stem cell transplantation for multiple myeloma: curative but not the standard of care. (nih.gov)
7. Role of allogeneic stem cell transplantation in multiple myeloma. (nih.gov)
12. The current status of hematopoietic stem cell transplantation for multiple myeloma. (nih.gov)
14. Progress in allogeneic transplantation for multiple myeloma. (nih.gov)
17. Allogeneic transplantation in multiple myeloma. (nih.gov)
18. Augmenting Autologous Stem Cell Transplantation to Improve Outcomes in Myeloma. (nih.gov)
20. Prevention of graft vs. host disease with alemtuzumab 'in the bag' decreases early toxicity of stem cell transplantation and in multiple myeloma is associated with improved long-term outcome. (nih.gov)
First-line treatment with immunomodulatory drugs, proteasome inhibitors and dexamethasone for multiple myeloma, and anthracycline-based protocols for lymphomas, followed by mobilisation therapy (favouring stem cell release into peripheral blood) with a high dose of cyclophosphamide was carried out. (ersjournals.com)
It is expressed at significantly higher levels in all myeloma cells, but not on other normal tissues (except normal plasma cells). (schoolandyouth.org)
Proteins on the surface of myeloma cells may be especially well-suited targets for vaccines. (schoolandyouth.org)
The experts share their experiences with CAR-T and other T cell redirection therapies, and when to use it in the treatment sequence, concluding with a look into the future of myeloma treatment. (cor2ed.com)
We retrospectively analyzed 765 patients with myeloma who underwent tandem transplantation between 1998 and 2012 using Japanese registry data. (elsevierpure.com)
Further strategies to reduce treatment-related mortality and enhance a graft-versus-myeloma effect are necessary to improve OS. (elsevierpure.com)
ABSTRACT Multiple myeloma (MM) is a systemic malignancy of pathologic plasma cells that is treatable with chemotherapeutic agents and irradiation, but rarely curable. (who.int)
Multiple myeloma (MM) is a cancer of the plasma cells. (who.int)

10. Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. (nih.gov)

These results add to the growing evidence that stem cell transplants should be considered as a potential treatment option for people with poor-prognosis scleroderma. (nih.gov)
Cancer patients who need stem cell transplants receive antibiotics that prevent life-threatening infections but can also destroy beneficial bacteria. (nih.gov)

Patients with chemosensitive aggressive non-Hodgkin lymphoma (NHL) could benefit from high-dose chemotherapy (HDC) followed by autologous stem cell transplantation (auto-SCT). (nih.gov)
It's a kind of lymphoma that can be quite aggressive, and particularly for younger patients who are suitable for aggressive therapy, the role of autologous stem cell transplantation has been something that's been important for the first-line therapy for mantle cell lymphoma. (cancer.net)
A strong possibility is that the pace of the aggressive NHL outpaces the ability of the CAR T cells to eliminate it. (ascopost.com)
Dr. Bishop noted that the type of NHL included in this trial is "probably a more aggressive disease than in cases where CAR T cells have been beneficial. (ascopost.com)
BELINDA provides data for researchers to learn from for the further design of CAR T-cell trials in this population of patients with aggressive NHL. (ascopost.com)
Intravascular large B-cell lymphoma (ILBCL) is a rare, aggressive form of extranodal lymphoma. (biomedcentral.com)
The NanoString assay of Korean medulloblastoma patients revealed a more aggressive clinical course in the SHH subgroup which may be explained by a higher proportion of large cell/anaplastic histology being present in this subgroup. (biomedcentral.com)

The researchers used fecal preparations that came from the patients themselves (autologous) before treatment and carried out autologously derived fecal microbiota transplantation (auto-FMT). (nih.gov)

With the aim of obtaining a higher anti-lymphoma activity and/or reducing the toxic effects, a number of studies suggested the possibility of improving the outcomes of NHL patients through modifying the conditioning regimens 8 , 9 , 10 . (nature.com)

The patient then received conditioning regimen with BEAM 400, consisting of bicnu (300 mg/m 2 ) for 1 day, etoposide (400 mg/m 2 ) combined to cytarabine (400 mg/m 2 ) for 4 days and melphalan (140 mg/m 2 ) for 1 day prior to autologous HSCT. (biomedcentral.com)

Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. (haematologica.org)
Unfortunately, antibiotics also unintentionally destroy these beneficial bacteria and thus increase the risk of life-threatening infections as well as graft-versus-host disease. (nih.gov)
The researchers are continuing to monitor the participants to assess whether auto-FMT improves patient outcomes, such as infections and graft-versus-host disease. (nih.gov)

Participants in the SCOT trial, conducted at 26 clinical research sites in the United States and Canada, were randomly assigned to receive either myeloablative autologous HSCT or one year of treatment with monthly doses of intravenous cyclophosphamide. (nih.gov)
Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a life-threatening complication [ 1 ] following hematopoietic stem cell transplantation (HSCT) with median incidence lower than 10% after autologous HSCT [ 2 ]. (biomedcentral.com)

There is an unmet need for treatments with better outcomes," he continued. (ascopost.com)
CONCLUSION: Patients with sASCT with relapsed MM demonstrated a comparative reduction in QoL and greater impact of treatment adverse effects lasting for 6 months and up to 2 years for pain, after which patients who had received sASCT reported better outcomes. (ucl.ac.uk)

EI-tPA emerges as a novel agent capable of improving the efficacy of stem cell therapy in SCI. (escholarship.org)
The gross motor function measure (GMFM) and the fine motor function measure (FMFM) were used to evaluate the therapeutic efficacy before transplantation and 3, 6, and 12 months after transplantation. (biomedcentral.com)
We examined the feasibility, efficacy, and safety of cell therapy using culture-expanded autologous MSCs in patients with ischemic stroke. (staminafoundation.org)

Today knowing which combinations of therapies to use and how to time them for the best possible outcomes is extremely difficult. (healthtree.org)
Clinical studies are a key element on the pathway of translational cell and gene therapies. (utoronto.ca)
The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)

Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. (escholarship.org)
Identifying strategies to optimize iPSC-derived neural progenitor cells (hiNPC) for cell transplantation is an important objective. (escholarship.org)
Genetic engineering of human hematopoietic stem and progenitor cells (HSPCs) is a promising therapy for individuals with inherited blood disorders. (nih.gov)

6 , 9 , 10 Moreover, a retrospective study comparing intensive chemotherapy alone against chemotherapy followed by transplantation did not show a clear benefit for chemotherapy followed by SCT. (haematologica.org)
We describe the case of a mantle cell lymphoma patient who developed a fulminant hepatitis following oxaliplatin-containing intensive chemotherapy and autologous transplantation. (biomedcentral.com)

A systematic review by He et al demonstrated a reduction in vertebral compressions and time to progression with early systemic treatment for asymptomatic patients, but this study also revealed an increase in acute leukemia in the early treatment group. (medscape.com)
Despite these limitations, early diagnosis and treatment is favoured in preventing irreversible axonal loss and improving functional recovery. (wikipedia.org)
For the minority of patients younger than 60 years with advanced stages of MDS, allogeneic stem cell transplantation (SCT) is usually considered the treatment of choice. (haematologica.org)
In addition to their primary focus in research, Comprehensive Sickle Cell Centers will also support career development of young investigators in sickle cell disease research, and support patient service activities that are focused on the implementation into clinical practice of the best current models of care and treatment for sickle cell disease. (nih.gov)
NIH-funded study finds transplantation superior to treatment with immune-suppressing drug. (nih.gov)
The clinical trial, called Scleroderma: Cyclophosphamide or Transplantation (SCOT), compared the safety and potential benefits of the two treatment regimens among 75 people with diffuse systemic sclerosis who had lung or kidney involvement. (nih.gov)
Secondary objectives, which this project description particularly deals with, are to determine the effects of ixazomib, lenalidomide and dexamethasone on health-related patient reported outcomes (PROs) throughout the various treatment phases. (rsyd.dk)
Red blood cell (RBC) transfusion has long been the primary treatment of severe or life-threatening anemia. (webharvest.gov)
Systemic therapy is treatment directed at eliminating cancer cells throughout the body, and usually consists of a combination of chemotherapy drugs. (hoapb.com)
Hematopoietic stem cell transplantation from someone who makes healthy hemoglobin can be a potentially curative treatment, but it requires a well-matched donor, which can be difficult to find. (luriechildrens.org)
Treatment-related adverse events were typical of autologous hematopoietic stem cell transplantation and the required chemotherapy, such as low platelets, low hemoglobin, low white blood cell count, mouth sores, fever, and hepatic veno-occlusive disease. (luriechildrens.org)
Outcomes following venetoclax-based treatment in therapy-related myeloid neoplasms. (cdc.gov)
Despite recent advances in the treatment of MM, t(4;14) and del(17p) are still associated with poor outcome. (ashpublications.org)
Conclusions: Our study suggests HDS is an efficient treatment to improve status and to reduce tumoral burden. (bvsalud.org)
BMMSC transplantation for the treatment of cerebral palsy is safe and feasible, and can improve gross motor and fine motor function significantly. (biomedcentral.com)
These encouraging results indicate that cell transplantation for the treatment of spastic CP has broad prospects in the field. (biomedcentral.com)
Therefore, to understand whether there are any significant differences between BMMSC and BMMNC transplantation, and between BMMSC and BMMNC and traditional rehabilitation treatment for children with spastic CP, we designed this experiment. (biomedcentral.com)
Current prognostic models predict the outcome of treatment with imperfect accuracy, and clinically relevant biomarkers have not been established to improve on the International Prognostic Score. (elsevierpure.com)
Methods: Using gene-expression profiling, we analyzed 130 frozen samples obtained from patients with classic Hodgkin's lymphoma during diagnostic lymph-node biopsy to determine which cellular signatures were correlated with treatment outcome. (elsevierpure.com)
We prospectively and randomly allocated 30 patients with cerebral infarcts within the middle cerebral arterial territory and with severe neurological deficits into one of two treatment groups: the MSC group (n = 5) received intravenous infusion of 1 x 10(8) autologous MSCs, whereas the control group (n = 25) did not receive MSCs. (staminafoundation.org)
There is no treatment for geographic atrophy (GA), the advanced stage of dry AMD, in which cells of the retina and associated retinal pigment epithelium (RPE) gradually degenerate and die. (nih.gov)
This trial will test whether RPE made in this way, called autologous induced pluripotent stem cell-derived RPE (iPSCs), can be feasibly and safely transplanted under the retina as a potential treatment for advanced dry macular degeneration. (nih.gov)
Enrolled patients were randomly assigned to treatment with rituximab and the BEAM regimen (R-BEAM) or Bexxar and the BEAM regimen (B-BEAM) with autologous hematopoietic stem cell transplantation infusion 24 hours later. (nih.gov)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)

A retrospective study of 72 invasive B-cell NHL patients (18-65 years old) who received either IEAC (n = 40) or BEAC (n = 32) between 01/2015 and 06/2018 were enrolled, as shown in Fig. 1 . (nature.com)

The invasive B cell NHL patients included diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) patients in first CR with high-risk factors and patients in PR after 6 cycles of standard induction therapy. (nature.com)
These methodologies will determine any changes to the metabolic profile of immune cells in MS before and after AHSCT, and in comparison to a non-autoimmune cohort of people with non-Hodgkin's lymphoma who have also undergone AHSCT, and to people who don't have either condition. (msaustralia.org.au)
The prognosis for children with newly diagnosed chemosensitive non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) has improved significantly. (nih.gov)
Some centers have investigated allogeneic stem cell transplantation in pediatric patients with recurrent/relapsed lymphoma. (nih.gov)
So the TRIANGLE study was a randomized controlled clinical trial, meaning that the trial was performed in a randomized fashion to be able to test 3 particular strategies for patients with mantle cell lymphoma. (cancer.net)
Mantle cell lymphoma, as many of you may know, is a relatively uncommon form of non-Hodgkin lymphoma. (cancer.net)
Infused peripheral blood autograft absolute lymphocyte count correlates with day 15 absolute 2014 lymphocyte count and clinical outcome after autologous peripheral hematopoietic stem cell transplantation in non-hodgkin's lymphoma. (taus.es)
We report the first ever case of synchronous ILBCL and invasive ductal carcinoma (IDC) of the breast in a patient presenting with pyrexia of unknown origin and altered mental status who underwent modified radical mastectomy and subsequent chemotherapy, and review the literature regarding intravascular large B-cell lymphoma, PBLs and synchronous carcinomas and lymphomas of the breast. (biomedcentral.com)
Intravascular large B-cell lymphoma (ILBCL) is a rare, high-grade extranodal diffuse B-cell lymphoma that has only been described in the breast once previously in a patient who had bilateral symmetrical breast engorgement with thickened, peau d'orange skin[ 3 ]. (biomedcentral.com)
A 59-year-old and overweight man (weight = 87 kg, BMI = 29.75) who suffered from a sleep apnea syndrome, was diagnosed with a stage III mantle cell lymphoma in December 2014. (biomedcentral.com)
Hodgkin lymphoma results from the clonal transformation of cells of B-cell origin, giving rise to pathognomic binucleated Reed-Sternberg cells. (msdmanuals.com)

IEAC regimen was well tolerated without increase of adverse events. (nature.com)
So a chemotherapy regimen that includes Ara-C as their component followed by autologous stem cell transplantation. (cancer.net)

The results of CAR T-cell trials have been promising in most hematologic malignancies. (ascopost.com)
Kepivance is a mucocutaneous epithelial human growth factor indicated to decrease the incidence and duration of severe oral mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of autologous hematopoietic stem cell support. (nih.gov)
Kepivance was not effective in decreasing the incidence of severe mucositis in patients with hematologic malignancies receiving myelotoxic therapy in the setting of allogeneic hematopoietic stem cell support. (nih.gov)

AHSCT involves the harvesting of a patient's own stem cells. (worldhealth.net)
This gene therapy study uses the patient's own stem cells that were treated in the lab with a modified virus to add functional copies of the gene that is defective in thalassemia. (luriechildrens.org)

An oxaliplatin-based polychemotherapy followed by high-dose therapy and autologous stem cell transplantation was proposed. (biomedcentral.com)

6 - 8 However, the outcome of autologous peripheral blood SCT for patients lacking a suitable donor, appeared, in some studies, comparable to that of allogeneic SCT. (haematologica.org)
This study addressed the issue of whether the existence of an HLA-identical sibling donor and the intention to perform an allogeneic SCT after the first consolidation course of chemotherapy results in a favorable outcome. (haematologica.org)

Deciphering the Increased Prevalence of TP53 Mutations in Metastatic Prostate Cancer. (cdc.gov)

Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. (worldhealth.net)

We report a comprehensive study on patient-reported outcomes, including quality of life (QoL) and pain in sASCT. (ucl.ac.uk)

Erythropoietin is an endogenous hormone, produced primarily in the kidney, which participates in regulating production of red blood cells (erythropoiesis). (webharvest.gov)

A key secondary objective of the study was to demonstrate that only one dose of motixafortide on top of G-CSF is superior to G-CSF alone in the ability to mobilize ≥ 6 million CD34+ cells in only one apheresis session . (prnewswire.com)
Secondary outcomes will include measures of the durability and effects of the iRPE patch. (nih.gov)

In this investigational, first-in-human, phase I/IIa, single-arm clinical trial, participants will undergo subretinal transplantation of autologous induced pluripotent stem cell-derived retinal pigment epithelium (iRPE) in one eye and will be followed for five years after surgery. (nih.gov)
This clinical trial will evaluate the safety and feasibility of investigational subretinal transplantation of RPE made from induced pluripotent stem cells as a potential autologous cell-based therapy for advanced dry AMD. (nih.gov)

Fecal samples were obtained from patients and frozen and stored prior to their stem cell transplantation procedure. (nih.gov)

In patients with severe cerebral infarcts, the intravenous infusion of autologous MSCs appears to be a feasible and safe therapy that may improve functional recovery. (staminafoundation.org)

Induced pluripotent stem cells (iPSC) may be administered by autologous transplantation, avoiding immunologic challenges. (escholarship.org)

The primary objective of this Request for Applications (RFA) is to support ten Comprehensive Sickle Cell Centers, and a Statistics and Data Management Center, to carry out research focused on the development of cures or significantly improved treatments for sickle cell disease. (nih.gov)
Compared with cyclophosphamide, transplantation offered significantly greater long-term benefits, but also carried known short-term risks, such as infections and low blood cell counts. (nih.gov)
Immune system impairment and chemotherapies significantly increase the risk of infections, particularly pneumonia [ 2 ]. (ersjournals.com)
We demonstrate that conditioning hiNPC with enzymatically-inactive tissue-type plasminogen activator (EI-tPA), prior to grafting into a T3 lesion site in a clinically relevant severe SCI model, significantly improves motor outcomes. (escholarship.org)
Importantly, only SCI rats that received EI-tPA primed hiNPC demonstrated significantly improved motor function, without exacerbating pain. (escholarship.org)
In addition, compared with BMMNC, the motor function of children improved significantly in terms of gross motor and fine motor functions. (biomedcentral.com)

Less than 40% will have disease that is still sensitive, so less than 60% are eligible for transplantation. (ascopost.com)

A number of approaches are under study, including the use of autologous and nonmyeloablative (reduced-intensity) allogeneic stem cell transplantation. (schoolandyouth.org)

è necessaria, dunque, una ricerca mirata che affronti le questioni critiche relative agli outcomes dei pazienti. (researchgate.net)
La comprensione delle complicanze potrebbero migliorare gli outcomes dei pazienti. (researchgate.net)
outcomes dei pazienti. (researchgate.net)

At least one, and preferably more than one organization listed on each application must be associated with an established medical institution with facilities and patient populations available for clinical investigations in sickle cell disease. (nih.gov)
Comprehensive Sickle Cell Centers are identifiable units within sponsoring institutions that are organized around a group of investigators and other health professionals engaged in ongoing basic and clinical research and community service related to sickle cell disease. (nih.gov)

B-Cell Maturation Antigen (BCMA). (schoolandyouth.org)

Anatomy22

Organisms4

Diseases56

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment91

Psychiatry and Psychology1

Phenomena and Processes26

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science4

Named Groups5

Health Care25

Geographicals1

Transplant31

Patients with multiple myeloma5

ASCT15

Clinical outcomes7

Hematopoietic cell transplantation6

Bone26

Relapse7

Allogenic2

Survival22

Multiple myeloma patients3

Mesenchymal stem2

Remission4

Immunotherapy2

Refractory4

Myeloma17

Malignancy1

Transplants2

Aggressive7

Microbiota transplantation1

Conditioning regimens1

Melphalan1

Versus3

HSCT2

Better outcomes2

Efficacy3

Therapies3

Progenitor cells3

Intensive chemotherapy2

Treatment25

Retrospective study1

Lymphoma11

Regimen2

Hematologic3

Patient's own stem cells2

High-dose therapy1

Donor2

Metastatic1

Long term outcomes1

Patient reported outcomes1

Kidney1

Secondary2

Investigational2

Fecal1

Feasible1

Immunologic1

Significantly6

Eligible1

Nonmyeloablative1

Pazienti3

Sickle cell di2

Antigen1