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Peripheral Blood Stem Cell TransplantationTransplantation, AutologousHematopoietic Stem Cell TransplantationHematopoietic Stem Cell MobilizationStem Cell TransplantationTransplantation, HomologousTransplantation ConditioningGranulocyte Colony-Stimulating FactorMelphalanLeukapheresisCombined Modality TherapyMultiple MyelomaAntigens, CD34Hematologic NeoplasmsBlood Component RemovalAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideStem CellsTreatment OutcomeHematopoietic Stem CellsGraft vs Host DiseaseMyeloablative AgonistsBusulfanBone Marrow TransplantationRemission InductionLymphoma, Non-HodgkinGraft SurvivalRecurrenceEtoposideThiotepaAmyloidosisAntineoplastic Agents, AlkylatingSalvage TherapyCarmustineIfosfamideVincristineHodgkin DiseaseDisease-Free SurvivalCytarabineCord Blood Stem Cell TransplantationHematopoiesisTissue DonorsRetrospective StudiesSurvival RateCytophagocytosisTransplantation ChimeraWhole-Body IrradiationSurvival AnalysisNeoplasmsTime FactorsBone Marrow PurgingDoxorubicinHistocompatibilityHistocompatibility TestingInfectionBlood Cell CountPlatelet CountImmunosuppressive AgentsRecombinant ProteinsBlood CellsDexamethasoneLeukemia, Myeloid, AcutePOEMS SyndromeCarboplatinPrednisoneFollow-Up StudiesLymphomaCytomegalovirus InfectionsLeukemiaVidarabineLymphoma, T-CellTransplantation, IsogeneicAntineoplastic AgentsThalidomideProspective StudiesFeasibility StudiesEmbryonic Stem CellsFatal OutcomeBoronic AcidsAdult Stem CellsMyelodysplastic SyndromesImmunophenotypingGraft vs Leukemia EffectPyrazinesAnemia, AplasticBlood DonorsOpportunistic InfectionsHematologic DiseasesPrognosisMesenchymal Stem Cell TransplantationBone MarrowLeukemia, Myelogenous, Chronic, BCR-ABL PositiveCell SeparationFlow CytometryT-LymphocytesLymphocyte DepletionLeukocytes, MononuclearNeutropeniaLeukocyte CountPrecursor Cell Lymphoblastic Leukemia-Lymphoma
Hematopoietic stemHigh-dose chemotherapyMarrowChemotherapyMobilizationHSCTPBSCTMalignanciesMorbidity and mortaCancerDonorsLymphoidGranulocytePatientsProgenitorImmatureComplicationsMultiple myelomaTherSupportiveMalignantDonorMobilizeTumorsDifferentiationImmuneLymphomasLymphomaSmearPlateletsAutoimmuneInfiltration with leukemic cellsDifferentiateHemoglobinSubsequentProliferationPerson'sQuantitativeLymphocytesAcuteHSCsTherapyCancersCD34Tumor cellsStimulateWhite blood cellInfections
Hematopoietic stem5
High-dose chemotherapy3
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
Marrow49
  • Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
  • Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a donor (PBSC collection). (wikipedia.org)
  • The administered hematopoietic stem cells then migrate to the recipient's bone marrow, through a process known as stem cell homing, where the transplanted cells override the previous bone marrow. (wikipedia.org)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into white blood cells. (wikipedia.org)
  • In the mid-20th century, Dr. E. Donnall Thomas achieved a landmark breakthrough by successfully performing the first bone marrow transplant between identical twins in 1956 (Thomas et al. (revistadehematologia.org.mx)
  • Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
  • It was only until 1988 when the same group could report on their first successful bone marrow transplant (León-Rodríguez et al. (revistadehematologia.org.mx)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
  • G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
  • The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • Biol Blood Marrow Transplant. (uchicago.edu)
  • Patients with acute lymphoblastic leukemia (ALL) present with either symptoms relating to direct infiltration of the marrow or other organs by leukemic cells, or symptoms relating to the decreased production of normal marrow elements. (medscape.com)
  • Infiltration of the marrow by massive numbers of leukemic cells frequently manifests as bone pain. (medscape.com)
  • Evidence suggests that P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) are one of the cell-cell adhesion ligand-receptor pairs for HSCs to keep contacting bone marrow (BM) stromal cells before being mobilized into circulation. (bvsalud.org)
  • Below, you will find answers to frequently asked questions about DKMS, bone marrow and blood stem cell donation, transplants, and fundraising efforts. (dkms.org)
  • Every day, we help save lives by adding more potential donors to the bone marrow registry and connecting patients in need of a transplant with matching donors who can make it happen. (dkms.org)
  • A B-cell lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein. (jax.org)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • Be The Match® is a global leader in bone marrow transplantation. (bethematch.org)
  • A marrow transplant may be someone's only hope for a cure. (bethematch.org)
  • Learn how marrow donation works, the steps of a patient transplant, steps of donation, and factors that can impact the likelihood of finding a match. (bethematch.org)
  • A National Marrow Donor Program (NMDP) study of more than 21,000 donors compared those who donated bone marrow to those that donated peripheral blood stem cells after receiving filgrastim. (bethematch.org)
  • The results of this very large cohort study showed that donors of hematopoietic stem cells with filgrastim had no significant difference in rates of cancer, autoimmune disorders and blood clots compared to those who donated bone marrow and didn't have the drug. (bethematch.org)
  • Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • A bone marrow transplant is a medical procedure performed to replace bone marrow that has been damaged or destroyed by disease, infection, or chemotherapy. (medicaljump.com)
  • This procedure involves transplanting blood stem cells, which travel to the bone marrow where they produce new blood cells and promote growth of new marrow. (medicaljump.com)
  • Bone marrow also contains immature blood-forming stem cells known as hematopoietic stem cells, or HSCs. (medicaljump.com)
  • The HSC found in the bone marrow will make new blood cells throughout your lifespan. (medicaljump.com)
  • A bone marrow transplant replaces your damaged stem cells with healthy cells. (medicaljump.com)
  • Bone marrow transplants are performed when a person's marrow isn't healthy enough to function properly. (medicaljump.com)
  • What Are the Complications Associated with a Bone Marrow Transplant? (medicaljump.com)
  • The above symptoms are typically short-lived, but a bone marrow transplant can cause complications. (medicaljump.com)
  • There are two major types of bone marrow transplants. (medicaljump.com)
  • Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. (medscape.com)
  • The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)
  • Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)
Chemotherapy14
  • For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
  • Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. (wikipedia.org)
  • Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
  • Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • In such cases, stem cells can be harvested, or grown, before you start chemotherapy or radiation treatment. (medicaljump.com)
  • They typically involve harvesting your cells before beginning a damaging therapy to cells like chemotherapy or radiation. (medicaljump.com)
  • Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
  • Other uses of cytostatic chemotherapy agents (including the ones mentioned below) are the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and the suppression of transplant rejections (see immunosuppression and DMARDs ). (wikidoc.org)
  • As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
Mobilization11
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
  • 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
  • Innovation in this area of medicine has been needed, and today's approval of [motixafortide] addresses the demand for new therapies that can meet today's challenges by delivering more reliability in stem cell mobilization, [vs] filgrastim alone, with fewer days of apheresis sessions and fewer doses of filgrastim for people living with this cancer. (cancernetwork.com)
  • Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials. (uchicago.edu)
  • Successful mobilization with AMD3100 and filgrastim with engraftment of autologous peripheral blood stem cells in a heavily pretreated pediatric patient with recurrent Burkitt lymphoma. (childrensmercy.org)
  • BACKGROUND: Granulocyte colony-stimulating factor (G-CSF)-mediated mobilization of hematopoietic stem cells (HSCs) is a well-established method to prepare HSCs for transplantation nowadays. (bvsalud.org)
  • This study hypothesized that blockage of PSGL-1 and P-selectin may disrupt HSC-stromal cell interaction and facilitate HSC mobilization. (bvsalud.org)
  • Male mice with P-selectin deficiency (Selp-/-) were further employed to investigate whether P-selectin is essential for G-CSF-induced HSC mobilization and determine which cell lineage is sP-sel derived from. (bvsalud.org)
  • Finally, wild-type mice were injected with either G-CSF or recombinant sP-sel to investigate whether sP-sel alone is sufficient for inducing HSC mobilization and whether it accomplishes this by binding to HSCs and disrupting their interaction with stromal cells in the BM. (bvsalud.org)
  • A key requisite for ASCT is mobilization of hematopoietic stem cells into peripheral blood, where they are collected by apheresis and stored for later transplantation. (bvsalud.org)
HSCT3
PBSCT7
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. (wikipedia.org)
  • Since allogeneic PBSCT involves transformation of blood between different individuals, this naturally carries more complications than autologous PBSCT. (wikipedia.org)
  • If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required for adequate collection. (wikipedia.org)
  • Later studies on the incident and subsequent use of PBSCT found that the transplant had also induced neoendothelialization of the aortic endothelium. (wikipedia.org)
  • Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
  • For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
Malignancies3
  • TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
  • Autologous Stem Cell Transplant (ASCT) is increasingly used to treat hematological malignancies. (bvsalud.org)
  • Most of these malignancies are of B-cell origin. (oncolink.org)
Morbidity and morta2
  • 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
  • 1980). As with many countries embarking on this procedure, there were challenges related to transplant-related morbidity and mortality. (revistadehematologia.org.mx)
Cancer16
  • Biological therapies, such as pomalidomide and dexamethasone, may stimulate the immune system in different ways and stop cancer cells from growing. (clinicaltrialsgps.com)
  • Ixazomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (clinicaltrialsgps.com)
  • If you registered before 2016, you may have registered with Delete Blood Cancer. (dkms.org)
  • Everyone who registered with Delete Blood Cancer remains on file with DKMS and on the national registry. (dkms.org)
  • While we have rebranded most of our materials to reflect our new name, you may still encounter our Delete Blood Cancer name in our email addresses and on other materials. (dkms.org)
  • I registered with Delete Blood Cancer. (dkms.org)
  • In 2016, Delete Blood Cancer DKMS changed its name to DKMS as part of a global rebranding of DKMS offices around the world. (dkms.org)
  • DKMS is an international nonprofit organization committed to the fight against blood cancer. (dkms.org)
  • What is blood cancer/leukemia? (dkms.org)
  • Blood cancer' is the umbrella term used for a variety of malignant diseases of the blood-forming (hematopoietic) system. (dkms.org)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
  • The cure for blood cancer is in the hands of ordinary people. (bethematch.org)
  • Until recently, we didn't know a lot about the long-term effects of using filgrastim in cell product donors, including whether or not it put donors at increased risk for cancer, autoimmune disorders and blot clots. (bethematch.org)
  • Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
  • It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
  • Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
Donors2
  • Samples of peripheral blood lymphocytes (PBLs) were obtained from ten normal untreateddonors and 18 normal donors treated with G-CSF. (fliphtml5.com)
  • Donors who receive filgrastim usually get it for five days prior to cell collection. (bethematch.org)
Lymphoid1
  • The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
Granulocyte7
Patients12
  • Patients with ALL can have a high, normal, or low white blood cell (WBC) count, but they usually exhibit neutropenia. (medscape.com)
  • Appropriate cultures, in particular blood cultures, should be obtained in patients with fever and in those with other signs of infection even if fever is absent. (medscape.com)
  • A single dose of motixafortide results in achievement of stem cell collection goal in patients with multiple myeloma. (cancernetwork.com)
  • In total, 67.5% of patients reached the stem cell collection goal of 6x10 6 CD 34-positive cells/kg or more in 2 apheresis sessions by a central laboratory. (cancernetwork.com)
  • BioLineRx announces FDA approval of APHEXDA™ (motixafortide) in combination with filgrastim (G-CSF) to mobilize hematopoietic stem cells for collection and subsequent autologous transplantation in patients with multiple myeloma. (cancernetwork.com)
  • Patients with ALL often have decreased neutrophil counts, regardless of whether their total white blood cell (WBC) count is low, normal, or elevated. (medscape.com)
  • Although patients may present with symptoms of leukostasis (eg, respiratory distress, altered mental status) because of the presence of large numbers of lymphoblasts in the peripheral circulation, leukostasis is much less common in people with ALL than those with acute myelogenous leukemia (AML), and it occurs only in patients with the highest WBC counts (ie, several hundred thousand per μL). (medscape.com)
  • Occasionally, patients have rashes that result from infiltration of the skin with leukemic cells. (medscape.com)
  • FDA approved polatuzumab vedotin-piiq (Polivy, Genentech, Inc.) with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for adult patients who have previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), or high-grade B-cell lymphoma (HGBL) and who have an International Prognostic Index (IPI) score of 2 or greater. (org.in)
  • FDA granted accelerated approval to mosunetuzumab-axgb (Lunsumio, Genentech, Inc.), a bispecific CD20-directed CD3 T-cell engager for adult patients with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. (org.in)
  • We conduct research to improve transplant outcomes provide support and resources for patients, and partner with a global network. (bethematch.org)
  • Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
Progenitor4
  • 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
  • Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
Immature1
  • The stem cells of the spleen allow for full maturation of immature transitional B cells into naive B cells. (fliphtml5.com)
Complications1
  • Does filgrastim exposure increase donor risk for development of long-term complications? (bethematch.org)
Multiple myeloma5
  • HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma. (bdbiosciences.com)
  • The FDA has approved motixafortide (Aphexda) combined with filgrastim (G-CSF) to aid in mobilizing hematopoietic stem cells in the peripheral blood for collection, as well as succeeding autologous stem cell transplantation in a population with multiple myeloma, according to a press release from BioLineRx. (cancernetwork.com)
  • Experts in the field of multiple myeloma gathered to discuss treatment options, including bispecific antibodies, CAR T-cell therapy, and current and future FDA approvals for treatments. (cancernetwork.com)
  • The combination of G-CSF and GPC-100, a small molecule antagonist of CXCR4, showed potential in a multiple myeloma clinical trial for sufficient and rapid collection of CD34+ stem cells, compared to the historical results from the standards of care, G-CSF alone or G-CSF with plerixafor, also a CXCR4 antagonist. (bvsalud.org)
  • FDA granted accelerated approval to elranatamab-bcmm (Elrexfio, Pfizer, Inc.), a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager, for adults with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (org.in)
Ther2
Supportive1
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
Malignant3
  • Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)
  • The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
  • Malignant blast cells (i.e. diffuse large B-cell lymphoma) are fast-growing and result in aggressive disease, whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. (oncolink.org)
Donor3
  • The apheresis procedure typically lasts for 4-6 hours, depending on the blood volume of the donor. (wikipedia.org)
  • For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. (wikipedia.org)
  • Healthy stem cells can come from a donor, or they can come from your own body. (medicaljump.com)
Mobilize2
  • G-CSF was found to mobilize both CD34+ stem cells (p=0.02)and even more dramatically mobilize Hox11+ splenic stem cells (p=0.000013) into the peripheral blood. (fliphtml5.com)
  • G-CSF induces the release of sP-sel from platelets, which is sufficient to mobilize BM HSCs into the circulation of mice by disrupting the PSGL-1 and P-selectin interaction between HSCs and stromal cells. (bvsalud.org)
Tumors2
  • Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
  • With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
Differentiation1
  • Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)
Immune3
Lymphomas2
  • The belief that T-cell lymphomas have a worse prognosis than B-cell lymphomas remains controversial. (oncolink.org)
  • REAL/WHO- [6] - classification includes leukemias and lymphomas, with 3 categories based on lineage and morphology (Hodgkin, B cell, and T/NK cell). (oncolink.org)
Lymphoma4
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • FDA granted accelerated approval to glofitamab-gxbm (Columvi, Genentech, Inc.) for relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) or large B-cell lymphoma (LBCL) arising from follicular lymphoma, after two or more lines of systemic therapy. (org.in)
  • FDA granted accelerated approval to epcoritamab-bysp (Epkinly, Genmab US, Inc.) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma after two or more lines of systemic therapy. (org.in)
  • FDA granted accelerated approval to pirtobrutinib (Jaypirca, Eli Lilly and Company) for relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a BTK inhibitor. (org.in)
Smear1
  • A review of the peripheral blood smear confirms the findings of the CBC count. (medscape.com)
Platelets1
Autoimmune1
  • However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out autoimmune responses. (wikipedia.org)
Infiltration with leukemic cells1
  • Signs relating to organ infiltration with leukemic cells and, to a lesser degree, lymphadenopathy may be present. (medscape.com)
Differentiate2
Hemoglobin2
Subsequent1
  • Inhibition of centrosome clustering represents a novel strategy for drug development and leads to the formation of multipolar spindles and subsequent cell death. (blogspot.com)
Proliferation2
Person's1
Quantitative1
  • Quantitative mRNA analysis wasused to determine whether G-CSF mobilizes Hox11+ stem cells and whether expression occurs in a cell populationdistinct from CD34+ cells. (fliphtml5.com)
Lymphocytes1
Acute1
  • Extracorporeal Membrane Oxygenation as a Bridge to Chimeric Antigen Receptor T-cell Therapy for Severe Refractory Sepsis in the Setting of Relapsed Refractory Pediatric Acute Lymphoblastic Leukemia: A Case Report. (childrensmercy.org)
HSCs2
  • 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
  • A sufficient number of HSCs is critical for successful HSC transplantation. (bvsalud.org)
Therapy1
  • In addition, liver function tests and blood urea nitrogen (BUN)/creatinine measurement to determine kidney function are necessary before the initiation of therapy. (medscape.com)
Cancers1
  • All blood cancers involve the degeneration of certain blood cells, which multiply uncontrollably and suppress the healthy blood-forming system. (dkms.org)
CD343
  • An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
  • 6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
  • Single-platform flow cytometric absolute cell counting protocols have been shown to provide increased robustness of CD34 enumeration by limiting potential sources of imprecision. (bdbiosciences.com)
Tumor cells1
  • As spindle multipolarity leads to cell death, tumor cells developed centrosomal clustering mechanism to prevent multipolar spindle formation by coalescence of multiple centrosomes into two functional spindle poles. (blogspot.com)
Stimulate1
  • When you sign up to donate stem cells to help someone else through a registry such as Be The Match, how do you know the drugs you're given to stimulate cell production are safe long term? (bethematch.org)
White blood cell1
  • During a military operation in World War II, a group of people were accidentally exposed to mustard gas and were later found to have very low white blood cell counts. (wikidoc.org)
Infections1
  • This prevents the blood from performing vital functions, such as fighting infections, transporting oxygen or stopping bleeding. (dkms.org)