LymphomaMarrowHSCTASCTNewly diagnosed multipleHigh-dose melphalanSolid tumorsGranulocyte-colonyLeukemiaTumors2022Candidates for autologousHematopoietic cell transplantation2018BortezomibLymphomasDonorTreat multiple myelomaPatient's bodyChemotherapy and autologousUmbilical cordTreatment of multiple myelomaLenalidomideConditioning regimens2023CordTherapyClinicalMobilizationGraft-versus-Allogeneic stem cell transInternational Myeloma Workshop2016Myelodysplastic Syndromes2021Safety of autologousAcuteMonoclonalAmyloidosisOutpatientNeutrophilRenalHematologyProgenitor cellsOutcomesComplicationsSurvivalDonorsRequires the patient to undergoDexamethasone
Lymphoma28
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
- Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
- Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma. (bdbiosciences.com)
- 211At conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model. (fredhutch.org)
- A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
- Primary diagnoses were multiple myeloma (n = 14), Hodgkin's lymphoma (n = 7), non-Hodgkin's lymphoma (n = 2), acute myloid leukemia (n = 2), chronic lymphocytic leukemia (n = 1) and germ cell testis tumor (n = 1). (ogu.edu.tr)
- Our center provides personalized, compassionate care to patients with leukemia, lymphoma, multiple myeloma, and other blood-related conditions. (koruhastanesi.com)
- Autologous BMT is used as a salvage therapy for patients with relapsed or refractory Hodgkin's lymphoma. (koruhastanesi.com)
- Autologous BMT is used as a consolidation therapy for patients with high-risk non-Hodgkin's lymphoma. (koruhastanesi.com)
- The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
- Among the conditions HSCT can treat are: acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myeloproliferative disorders, myelodysplastic syndromes, multiple myeloma, non-Hodgkin lymphoma, Hodgkin disease, aplastic anemia and pure red-cell aplasia-but this list is not exhaustive. (drugdiscoverynews.com)
- Radiation Risks of Leukemia, Lymphoma and Multiple Myeloma Incidence in the Mayak Cohort: 1948-2004. (myeloma.org.uk)
- Our Blood and Marrow Transplant and Cellular Immunotherapy Program serves patients with a number of hematological conditions, including leukemia, lymphoma, multiple myeloma, aplastic anemia and MDS, as well as select solid tumors. (diversitywork.com)
- This procedure is typically used to treat blood cancers such as leukemia, lymphoma, and multiple myeloma, as well as other disorders such as sickle cell anemia and thalassemia. (vanyahealth.com)
- Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
- The expert Oncologists and Hematologists provide related treatment and outpatient care service for all varieties of blood disorders such as anaemia, bleeding disorders such as haemophilia, blood clots, thalassemia and cancers such as leukaemia, lymphoma, and myeloma. (jaypeehealthcare.com)
- Bone marrow cancers such as multiple myeloma , leukaemia, and lymphoma , reduce the formation of HSCs in the bone marrow. (parkwaycancercentre.com)
- The procedure has been used successfully to treat a variety of cancer types, including leukemia , lymphoma , multiple myeloma , myelodysplasia and solid tumors, such as testicular cancer or breast cancer . (ucsfhealth.org)
- Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
- Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
- it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Marrow111
- Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
- Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. (stembook.org)
- Biol Blood Marrow Transplant. (stembook.org)
- Worldwide Network for Blood and Marrow Transplantation (WBMT) recommendations for establishing a hematopoietic cell transplantation program (Part I): Minimum requirements and beyond. (stembook.org)
- Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
- Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
- Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to all of the different mature blood cell types and tissues. (wikipedia.org)
- When bone marrow develops, it eventually assumes the task of forming most of the blood cells for the entire organism. (wikipedia.org)
- A stem cell transplant is a transplant intended to replace the progenitor hematopoietic stem cells Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. (wikipedia.org)
- It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. (fredhutch.org)
- Bone Marrow Transplantation 49(4):492-495, 2014. (fredhutch.org)
- Bone Marrow Transplantation doi: 10.1038/bmt.2016.123. (fredhutch.org)
- Bone Marrow Transplantation 51(1):67-71, 2016. (fredhutch.org)
- Whither the Bone Marrow Transplantation in Multiple Myeloma? (karger.com)
- Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
- With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
- With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
- Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
- WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
- Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
- Infection with varicella-zoster virus after marrow transplantation. (nature.com)
- Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
- Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
- A monoclonal population of plasma cells can be detected in the bone marrow, and an altered serum-free light chain ratio is present. (medscape.com)
- The Koru Hospital Bone Marrow Transplant Center is a state-of-the-art medical facility that offers advanced stem cell therapy for a range of hematological disorders. (koruhastanesi.com)
- We offer a range of stem cell therapy options, including bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation. (koruhastanesi.com)
- Bone marrow transplantation (BMT) is a procedure that involves replacing a patient's damaged or destroyed bone marrow with healthy bone marrow stem cells. (koruhastanesi.com)
- BMT is used in combination with chemotherapy as a treatment for multiple myeloma, a cancer that affects the plasma cells in bone marrow. (koruhastanesi.com)
- Allogeneic BMT is used as a curative therapy for MDS, a group of disorders that affect the production of blood cells in bone marrow. (koruhastanesi.com)
- At the Koru Hospital Bone Marrow Transplant Center, we provide comprehensive care to our patients, from pre-transplant evaluation to post-transplant follow-up care. (koruhastanesi.com)
- Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
- In the mid-20th century, Dr. E. Donnall Thomas achieved a landmark breakthrough by successfully performing the first bone marrow transplant between identical twins in 1956 (Thomas et al. (revistadehematologia.org.mx)
- Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
- In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
- It was only until 1988 when the same group could report on their first successful bone marrow transplant (León-Rodríguez et al. (revistadehematologia.org.mx)
- In this therapy, the patient's own stem cells are removed from his or her bone marrow or peripheral blood before the transplant. (advancells.com)
- Two) 18 bed units provide a dynamic working environment specializing in Allogeneic and Autologous Blood and Marrow Transplant patients. (diversitywork.com)
- The Blood and Marrow Transplant and Cellular Immunotherapy Program at Moffitt Cancer Center is the largest and most active program of its kind in the Southeast. (diversitywork.com)
- Committed to providing every aspect of treatment and supportive care in a single, convenient location, Moffitt is an established leader in the field of bone marrow transplantation. (diversitywork.com)
- We are a National Marrow Donor Program (NMDP) transplant and collection center, and we are fully accredited by the Foundation for the Accreditation of Cellular Therapy (FACT), speaking to the unwavering dedication and expertise of our team. (diversitywork.com)
- Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
- MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
- There are two main types of Bone Marrow Transplantation (BMT): autologous and allogeneic. (vanyahealth.com)
- The donor's stem cells will engraft in the patient's bone marrow and start producing new blood cells. (vanyahealth.com)
- However, cord blood units often have fewer stem cells than a bone marrow or peripheral blood transplant, which can increase the time it takes for the patient's blood counts to recover. (vanyahealth.com)
- Why Bone Marrow Transplant Done? (vanyahealth.com)
- There are several reasons why a bone marrow transplant may be necessary. (vanyahealth.com)
- This occurs when the donated cells do not engraft or grow properly in the patient's bone marrow. (vanyahealth.com)
- Patients who have had a bone marrow transplant are at an increased risk of infections due to the suppression of their immune system. (vanyahealth.com)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- The Registered Nurse in the BMT Clinic provides nursing support to patients in any stage of the blood and marrow transplant or cellular immunotherapy process, most of in the form of patient assessment and education during clinic visits and via phone call, including management of patient requests, such as refills, follow up on patient care issues as needed with provider and primary nurse. (biojobs.com)
- The Registered Nurse in the BMT Treatment Center provide hands-on nursing care to patients in any stage of the blood and marrow transplant or cellular immunotherapy process, including patient assessment and education, triage, administration of chemotherapy, blood products, cellular product infusions (transplants),and various other medications. (biojobs.com)
- European Society for Blood and Marrow Transplantation (EBMT). (gitmo.it)
- The division is equipped with complete facility and expertise to conduct treatment like chemotherapy, anti-microbial therapy and supportive care post-chemotherapy or post bone-marrow transplantation. (jaypeehealthcare.com)
- Bone marrow transplantation is procedures in which stem cells from the donor's bone marrow, which produce the different blood cells like red blood cells, white blood cells and platelets are injected into the recipient. (jaypeehealthcare.com)
- We are one of the best and dedicated bone-marrow transplant centres and our team that works in the most sterile and hygienic centre, equipped with ultra-modern infrastructure, is widely experienced and internationally trained. (jaypeehealthcare.com)
- We offer both allogeneic and autologous transplant using bone marrow, peripheral blood stem cells and cord blood stem cells for various benign and malignant blood disorders like thalassemia, aplastic anaemia, leukaemia, lymphomas, multiple myelomas and advanced solid tumours for adults and children both. (jaypeehealthcare.com)
- Patient with severe aplastic anemia is doing well after Bone Marrow Transplantation. (jaypeehealthcare.com)
- Conditions like bone marrow transplants or stem cells were difficult to get treated. (gomedii.com)
- Autologous Bone Marrow Treatment in India, is one of the most recent demands of many of our patients from Congo and the Middle east. (gomedii.com)
- So, what exactly is Autologous Bone Marrow? (gomedii.com)
- How is Autologous Bone Marrow Treatment in India done and what is the cost of Autologous Bone Marrow Treatment in India? (gomedii.com)
- What is an Autologous bone marrow transplant? (gomedii.com)
- We know that Bone marrow transplants can help solve many problems. (gomedii.com)
- An autologous stem cell transplant is the process where healthy blood stem cells from your own body are used to replace your damaged bone marrow. (gomedii.com)
- An autologous stem cell transplant is also called an autologous bone marrow transplant. (gomedii.com)
- Allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace bone marrow that's not producing enough healthy blood cells. (gomedii.com)
- Autologous Bone Marrow Treatment in India is an ideal one with one of the best oncologists for your treatment. (gomedii.com)
- Wondering how an Autologous bone marrow transplant can help you solve the treatment options for multiple myeloma? (gomedii.com)
- This is done to kill the cells in the bone marrow. (gomedii.com)
- When stem cell transplants were first developed, the new stem cells came from bone marrow, and so this was known as a bone marrow transplant. (gomedii.com)
- What are the types of matches in an Autologous bone marrow transplant? (gomedii.com)
- What can be the Autologous bone marrow transplant cost? (gomedii.com)
- Get your low-cost package and estimation of Autologous bone marrow transplant in India with GoMedii. (gomedii.com)
- HSCs mostly stay in the bone marrow and mature into blood cells as they grow. (parkwaycancercentre.com)
- Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
- The damaged bone marrow will then be replenished with new stem cells to alleviate the side effects of the high-dose therapy. (parkwaycancercentre.com)
- In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
- Stem cells are collected from the bone marrow - the spongy soft tissues in the bones. (parkwaycancercentre.com)
- Additionally, patients do not need to undergo the bone marrow procedure under sedation. (parkwaycancercentre.com)
- A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
- The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
- In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
- When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
- The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
- The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
- These are the important cells that are transferred during bone marrow or stem cell transplantation. (ucsfhealth.org)
- Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
- When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
- When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
- However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
- For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
- For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
- The clinical manifestations of Waldenström macroglobulinemia result from the presence of the IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissue sites. (medscape.com)
- A study by Pasricha et al found that bone marrow features, particularly the degree of plasma cell infiltration, correlates with IgM paraprotein concentration at diagnosis. (medscape.com)
- Thus, evaluation of the plasma cell compartment in the bone marrow at baseline and after therapy may be helpful. (medscape.com)
- Jalali et al reported that levels of soluble programmed cell death protein 1 (PD-1) ligands are elevated in patients with Waldenström macroglobulinemia and, in addition to surface-bound ligands in bone marrow, could regulate T-cell function. (medscape.com)
HSCT18
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- One needs to differentiate between tandem transplants, a planned sequence of two high dose treatments with HSCT salvage, and a second transplant, an approach of consolidating the first autologous HSCT with another HSCT ONLY if the first one appears partially effective. (cancertreatmenttoday.org)
- This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
- HSCT offers a way to reset the immune system, providing a novel approach to treating conditions such as multiple sclerosis, systemic sclerosis, and rheumatoid arthritis (Swart et al. (revistadehematologia.org.mx)
- Hematopoietic stem cell transplantation (HSCT) is a broad term that covers the transplantation of blood progenitor/stem cells from any source. (drugdiscoverynews.com)
- Other groups are also working on cell therapies for the treatment of poor graft function after HSCT. (drugdiscoverynews.com)
- Their ongoing Phase 2 study is evaluating whether infusion of mesenchymal stem cells (MSCs) can treat steroid-resistant acute graft-versus-host disease (GVHD) or poor graft function after HSCT. (drugdiscoverynews.com)
- GVHD, which is common among allogenic HSCT and rare in autologous HSCT, can be acute or chronic. (drugdiscoverynews.com)
- In this report, we summarize the case of a patient with MM status post autologous HSCT and chronic kidney disease who experienced worsening hypertension along with a substantial increase in proteinuria shortly after the initiation of carfilzomib for the treatment of refractory disease. (biomedcentral.com)
- This group etic stem cell transplant (HSCT) (8 allogeneic) and in 15 of patients has also been disproportionately represented patients with malignancy treated at 6 Australian tertiary cen- among those with severe infections from infl uenza A pan- ters during winter 2009. (cdc.gov)
- Ten (31.3%) patients were admit- demic (H1N1) 2009, comprising 3.4%-19.6% of patients ted to intensive care, and 9 of them were HSCT recipients. (cdc.gov)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
- HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
- Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
- In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
ASCT13
- METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
- The occurrence of varicella zoster virus (VZV) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (HZ) after autologous SCT (ASCT). (nature.com)
- We determined the incidence and the prognostic significance of HZ and its correlation with VZV serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with ASCT. (nature.com)
- We found that VZV reactivation occurred in 57 (30%) patients, in 8.5% during induction and in 21.5% after ASCT peaking at 8 months after ASCT. (nature.com)
- By immune fluorescence and Serion Elisa VZV IgG assessment, 90.8% of all patients had specific anti-VZV antibodies at ASCT. (nature.com)
- Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
- Finally, OS was better in myeloma patients with HZ after ASCT compared with patients without HZ ( P =0.007). (nature.com)
- The phase 3 PETHEMA/GEM2012 study, in 458 patients {less than or equal to} 65 years old with NDMM, is evaluating bortezomib (subcutaneous) + lenalidomide + dexamethasone (VRD) for 6 cycles followed by autologous stem cell transplant (ASCT) conditioned with intravenous busulfan + melphalan vs melphalan and posttransplant consolidation with 2 cycles of VRD. (cun.es)
- The complete response rate of 33.4% after induction in the intent-to-treat (ITT) population, which was similar in the 92 patients with high-risk cytogenetics (34.8%), also deepened with further treatment (44.1% after ASCT and 50.2% after consolidation). (cun.es)
- This trial confirmed the results of other trials that demonstrated a substantial incidence of symptomatic hypotension in MM patients in the peri-transplant period following ASCT. (astct.org)
- Bazarbachi AH, Al Hamed R, Malard F, Bazarbachi A, Harousseau JL, Mohty M. Induction therapy prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma: an update. (gitmo.it)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
- Note: For transplant-eligible patients enrolled to Part 1 or Part 2, induction plus conditioning chemotherapy/ASCT +/- maintenance therapy constitute one regimen. (who.int)
Newly diagnosed multiple6
- A phase 2 study of Bortezomib, cyclophosphamide, pegylated liposomal doxorubicin and dexamethasone (BCDD) for newly diagnosed multiple myeloma. (fredhutch.org)
- Achieving and maintaining high-quality response is the treatment goal for patients with newly diagnosed multiple myeloma (NDMM). (cun.es)
- While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
- Experts discuss key data updates in real-world newly diagnosed multiple myeloma practices, and how these findings may change the treatment paradigm. (cancernetwork.com)
- Optimizing Treatment for Elderly Patients With Newly Diagnosed Multiple Myeloma: A Personalized Approach. (myeloma.org.uk)
- Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials. (uchicago.edu)
High-dose melphalan3
- Modified High-Dose versus High-Dose Melphalan Conditioning in Older Patients Undergoing Autologous Stem Cell Transplantation for Immunoglobulin Light Chain Amyloidosis. (bu.edu)
- Sarosiek S, Zheng L, Sloan JM, Quillen K, Brauneis D, Sanchorawala V. Comparing measures of hematologic response after high-dose melphalan and stem cell transplantation in AL amyloidosis. (bu.edu)
- Anastasia A, Giglio F, Mazza R, Sarina B, Todisco E, Bramanti S, Castagna L. Early discharge after high-dose melphalan and peripheral blood stem cell reinfusion in patients with hematological and non-hematological disease. (gitmo.it)
Solid tumors1
- Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Granulocyte-colony6
- We evaluated hematopoietic stem cells according to CD34 expression and aldehyde dehydrogenase (ALDH) activity in peripheral blood and apheresis product samples from patients after mobilization with granulocyte-colony-stimulating factor (G-CSF) alone or G-CSF after high-dose cyclophosphamide (4 g/m(2) once daily, intravenously on day 1). (ogu.edu.tr)
- STUDY DESIGN AND METHODS: From May 2020 till September 2022, we retrospectively reviewed patients receiving anti-CD38 mAb-based induction therapy followed by stem cell mobilization either in a steady-state protocol (SSM) using 10 µg/kg granulocyte colony-stimulating factor (G-CSF) for 5 days or in a chemotherapy-based protocol (CM) using 1-4 g/m2 cyclophosphamide and G-CSF. (bvsalud.org)
- The current treatment for incomplete hematopoietic recovery includes administration of factors stimulating white and red blood cell growth, such as granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and erythropoietin. (drugdiscoverynews.com)
- Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
- Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
- Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
Leukemia8
- Depending on the type of leukemia, autologous or allogeneic BMT may be recommended. (koruhastanesi.com)
- Cord blood transplantation is used as a treatment option for acute and chronic leukemia. (koruhastanesi.com)
- [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
- However, their function in the pathophysiology and impact on patient outcome in acute myeloid leukemia (AML) remains elusive. (bvsalud.org)
- His pioneering work spans discoveries in basic biology of blood stem cells and leukemia to first-in-human clinical trials for people with cancer and heart diseases, alongside shaping innovative policies in state health and healthcare financing. (ufl.edu)
- A systematic review by He et al demonstrated a reduction in vertebral compressions and time to progression with early systemic treatment for asymptomatic patients, but this study also revealed an increase in acute leukemia in the early treatment group. (medscape.com)
- Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
- Peripheral smear from a patient with chronic lymphocytic leukemia, small lymphocytic variety. (medscape.com)
Tumors2
- Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
- Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
20222
- Blood Adv. 2022. (stembook.org)
- Blood Cancer J. 2022 Mar 28;12(3):47. (gitmo.it)
Candidates for autologous1
- Thirty patients (20 males and 10 females), who were candidates for autologous peripheral blood stem cell transplantation, were included in the study. (ogu.edu.tr)
Hematopoietic cell transplantation3
- Monocyte subpopulation recovery as predictors of hematopoietic cell transplantation outcomes. (stembook.org)
- Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART before the Horse. (myeloma.org.uk)
- Impact of the SARS-CoV-2 pandemic on hematopoietic cell transplantation and cellular therapies in Europe 2020: a report from the EBMT activity survey. (gitmo.it)
20181
- Patients were treated within the randomized phase III clinical trials GMMG-HD6 (NCT02495922, 24/06/2015) and GMMG-HD7 (NCT03617731, 24/07/2018). (biomedcentral.com)
Bortezomib5
- Bortezomib is the first agent of this class and is currently being used for the treatment of multiple myeloma. (biomedcentral.com)
- A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants. (biomedcentral.com)
- In view of the previously reported association of bortezomib with thrombotic microangiopathy, the temporal association of the clinical picture with the initiation of carfilzomib, and the partial resolution of symptoms after discontinuation of the drug, we conclude that carfilzomib may have precipitated a case of clinically evident renal thrombotic microangiopathy in our patient. (biomedcentral.com)
- Bortezomib is a proteasome inhibitor that was approved by the Food and Drug Administration (FDA) in 2003 for the treatment of refractory MM and subsequently in 2008 as an initial treatment of patients with MM. Although it does not target VEGF directly, bortezomib has also been reported to be associated with TMA. (biomedcentral.com)
- [ 34 ] A study by Neben et al concludes that long-term administration of bortezomib in patients with del(17p13) may result in better overall and progression-free survival. (medscape.com)
Lymphomas3
- Pretargeted Radioimmunotherapy for B-cell Lymphomas. (fredhutch.org)
- Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
- Two courses of four weekly infusions of rituximab with or without interferon-2a: final results from a randomized phase III study in symptomatic indolent B-cell lymphomas. (cancercentrum.se)
Donor27
- It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
- Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
- This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
- For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
- If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
- Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
- Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
- Allogeneic BMT involves the use of stem cells from a compatible donor, which can be a family member or an unrelated donor. (koruhastanesi.com)
- of these, 53 percent are autologous (taken from the patient) and 47 percent are allogenic (taken from a donor other than the patient). (drugdiscoverynews.com)
- When these proteins are the same for both donor and recipient, an allogeneic stem cell transplant is much more likely to be successful. (myelomablog.com)
- Allogeneic stem transplant is another form wherein the stem cells are donated to the person from a genetically matched stem cell donor. (advancells.com)
- Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
- Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)
- In this type of transplant, stem cells are taken from a donor (usually a close relative or sibling) and given to the patient. (vanyahealth.com)
- Haploidentical transplant, also known as half-matched transplant, is a type of allogeneic transplant where the donor and the recipient are not a perfect match but share one haplotype (half of the genetic material) in common. (vanyahealth.com)
- Cord blood transplants are an alternative to using stem cells from a matched adult donor. (vanyahealth.com)
- Both haploidentical BMT and cord blood transplant are considered alternative options for patients who do not have a suitable matched donor. (vanyahealth.com)
- They come with their own set of risks and benefits, and the decision to use them will depend on the patient's specific circumstances and the availability of a suitable cord blood unit or haploidentical donor. (vanyahealth.com)
- In such cases, there are cells from your own body and hence have certain advantages over stem cells from a donor. (gomedii.com)
- Based on the report Thomas will either go through Allogenic (related Donor) or Autologous (healthy cells from their own body) donor selection. (gomedii.com)
- Allogeneic stem cell (stem cells from a donor) transplant is used to help patients recover from the effects of chemotherapy and/or radiotherapy as well as to eradicate the remaining cancer cells in the patient after chemotherapy and/or radiotherapy. (parkwaycancercentre.com)
- It gives the patient a whole new and healthy immune system of the donor. (parkwaycancercentre.com)
- The donor immune cells can kill the leftover cancer cells and will exert a "graft-versus-cancer" effect, keeping the cancer cells in check. (parkwaycancercentre.com)
- A donor, either related or unrelated to the patient, who donates the stem cells for transplant. (parkwaycancercentre.com)
- Finding a donor with suitable stem cells is critical to avoid graft rejection or graft-versus-host syndrome. (parkwaycancercentre.com)
- An unsuitable donor means the immune system of the recipient recognises the difference between "self" and "non-self" tissues, and will likely destroy the foreign "non-self' tissues after a transplant. (parkwaycancercentre.com)
- Many factors dictate whether the donor stem cells are suitable for the recipient but the most important one is the human leukocyte antigen (HLA) system. (parkwaycancercentre.com)
Treat multiple myeloma2
- Autologous BMT is commonly used in combination with chemotherapy to treat multiple myeloma. (koruhastanesi.com)
- Stem cell transplant is commonly used to treat multiple myeloma. (gomedii.com)
Patient's body4
- The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
- Autologous BMT involves collecting and storing a patient's own healthy stem cells, which are later transplanted back into the patient's body after chemotherapy or radiation therapy. (koruhastanesi.com)
- After the chemotherapy and radiation therapy, the stored stem cells are thawed and returned to the patient's body. (vanyahealth.com)
- Before the transplant, drug treatment is used to reduce the number of myeloma cells in the patient's body. (gomedii.com)
Chemotherapy and autologous1
- Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
Umbilical cord5
- Cord blood transplantation involves the use of stem cells from umbilical cord blood, which is collected and stored at birth. (koruhastanesi.com)
- 1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
- Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
- For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Treatment of multiple myeloma2
- Treatment of multiple myeloma with monoclonal antibodies and the dilemma of false positive M-spikes in peripheral blood. (myeloma.org.uk)
- Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus. (myeloma.org.uk)
Lenalidomide4
- A prospective study of lenalidomide monotherapy for relapse after Allo-SCT for multiple myeloma. (fredhutch.org)
- Phase 3 Clinical Trial Comparing Iberdomide VS Lenalidomide as Maintenance Therapy Following Autologous Stem Cell Transplant in Participants with Newly Diagn. (sparkcures.com)
- In a phase III trial that was restricted to patients with high-risk SMM, the PETHEMA group found evidence of benefit from treatment with lenalidomide versus observation. (medscape.com)
- [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Conditioning regimens1
- One hundred patients (receiving 123 conditioning regimens) were included in the analysis. (nature.com)
20231
- Experts from Mayo Clinic and The University of Texas MD Anderson Cancer Center discuss results from multiple myeloma trials presented at the 2023 American Society of Clinical Oncology Annual Meeting and how they may apply to clinical practice. (cancernetwork.com)
Cord10
- The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
- Cord blood transplantation is used to treat certain genetic disorders that affect the production of blood cells, such as sickle cell anemia and thalassemia. (koruhastanesi.com)
- The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
- Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
- One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
- Cord blood transplant is a type of allogeneic transplant that uses stem cells from the umbilical cord of a newborn baby. (vanyahealth.com)
- Cord blood is a rich source of hematopoietic stem cells, which can develop into all the different types of blood cells. (vanyahealth.com)
- The main advantage is that cord blood cells are less mature than adult stem cells, which makes it less likely for the patient's immune system to reject the transplant. (vanyahealth.com)
- The blood that is left behind in the placenta and umbilical cord after a baby is delivered contains stem cells, and these can be carefully collected and stored. (parkwaycancercentre.com)
- The baby will not be harmed in any way during the cord blood collection. (parkwaycancercentre.com)
Therapy34
- The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
- Deposition Following Eculizumab Therapy for Recurrent Atypical Hemolytic Uremic Syndrome in Kidney Transplantation. (bu.edu)
- Lay Summary: I review the current status of tandem versus second transplant and Total Therapy. (cancertreatmenttoday.org)
- Two hundred thirty-one patients with symptomatic myeloma were enrolled in Total Therapy I between 1990 and 1995 (Barlogie et al. (cancertreatmenttoday.org)
- After stem cell collection, EDAP (etoposide, dexamethasone, cytarabine, cisplatin) was given to enhance reduction of tumor cells prior to high-dose therapy (melphalan 200 mg/m²) and autologous transplant. (cancertreatmenttoday.org)
- The second course of high-dose therapy and transplant was performed 3 to 6 months later. (cancertreatmenttoday.org)
- Peripheral blood stem cell transplantation (PBSCT) involves the collection of stem cells from the patient's blood and their subsequent infusion after chemotherapy or radiation therapy. (koruhastanesi.com)
- CONCLUSIONS: Stem cell collection in patients undergoing anti-CD38-based induction therapy is feasible with either CM or SSM, although SSM more frequently requires plerixafor. (bvsalud.org)
- A new agent in this class, carfilzomib, has been recently introduced as alternative therapy for relapsing and refractory multiple myeloma. (biomedcentral.com)
- Over the last few years, multiple reports have unveiled an association between anti-angiogenic therapy and TMA. (biomedcentral.com)
- This study demonstrates that stem cell collection is feasible after prolonged induction with isatuximab-RVd without collection failures and might be further explored as induction therapy. (biomedcentral.com)
- PBSC mobilization should be performed after induction therapy to ensure collection of a sufficient number of cells. (biomedcentral.com)
- Experts in the field of multiple myeloma gathered to discuss considerations prior to treatment including frailty and the number of lines of previous therapy a patient has received. (cancernetwork.com)
- Experts in the field of multiple myeloma gathered to discuss treatment options, including bispecific antibodies, CAR T-cell therapy, and current and future FDA approvals for treatments. (cancernetwork.com)
- Therefore, these patients are likely to oseltamivir therapy. (cdc.gov)
- Stem cell treatment has been widely accepted as the future of medical technology, therapy and any kind of treatment for health hazards. (advancells.com)
- Often patients who have no conventional treatment left fell prey to such establishments and loose large amount of money without getting proper therapy, and therefore, no results. (advancells.com)
- It is important for the patient to answer the basic questions of whether I am a candidate for stem cell therapy, (2) What kind of cells do I need? (advancells.com)
- Before approaching any therapy provider, patients must do a thorough research on their credentials and whether a disease-specific specialist is going to perform / supervise therapy or not. (advancells.com)
- At present, only guidelines are doing the rounds, which have resulted in the escalation of many clinics, hospitals, and nursing homes, claiming successful treatment by stem cell therapy. (advancells.com)
- Carfilzomib therapy improves quality of life in multiple myeloma. (myeloma.org.uk)
- Optimal maintenance and consolidation therapy for multiple myeloma in actual clinical practice. (myeloma.org.uk)
- 0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)
- In a combined analysis of categorical groups, the patients in the high A- ALC group transplanted in CR1 had the best prognosis for OS and PFS and patients in the low A- ALC group transplanted in CR/PR after second-line therapy had the worse prognosis for OS and PFS. (astct.org)
- Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a recently described adverse side effect of bisphosphonate therapy, with an estimated 94% of cases reported in the oncologic patients receiving intravenous nitrogen-containing bisphosphonates (BP). (ca.gov)
- Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
- In this type of transplant, the patient's own stem cells are collected before the high-dose chemotherapy and/or radiation therapy is given. (vanyahealth.com)
- This type of transplant is used when the patient's own cells are not damaged or diseased, but are being used as a rescue therapy after high-dose chemotherapy or radiation therapy. (vanyahealth.com)
- Physicians must understand both the natural history of multiple myeloma (MM) and the limitations of current therapy in the treatment of the disease. (medscape.com)
- Radiation treatment is prescribed to the patient after an exhaustive diagnosis and can include treatment procedures like external beam radiation therapy, intensity modulated radiation therapy (IMRT), low and high dose brachytherapy (HDR), stereotactic body radiation therapy (SBRT), or stereotactic brain radio-surgery (SRS). (jaypeehealthcare.com)
- A patient with left parotid gland cancer successfully treated with surgery and radiation therapy. (jaypeehealthcare.com)
- Stem cell therapy, or stem cell transplant, is a procedure that aims to restore blood-forming stem cells in patients who have undergone chemotherapy or radiotherapy . (parkwaycancercentre.com)
- A small number of stem cells can be found in the blood, and these can be collected for stem cell therapy. (parkwaycancercentre.com)
- Hematology/ Oncology and Stem Cell Therapy. (elsevierpure.com)
Clinical12
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
- The following is a list of myeloma clinical trials at this center. (sparkcures.com)
- The following is a listing of clinical trials for patients with multiple myeloma who have been newly diagnosed or have not yet received treatment . (sparkcures.com)
- These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
- Observing the everyday advancements in stem cell technology from the research and clinical perspective, stem cells do promise a healthy future for the coming generations in India. (advancells.com)
- We examined the clinical outcome of three autologous PDLP-treated patients in an effort to provide primary knowledge on the effectiveness of this treatment approach and preliminary clinical evidence for randomized controlled trial in the future. (ca.gov)
- This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
- To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
- Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
- 14: Laurell H, Hansson LE, Gunnarsson U. Impact of clinical experience and diagnostic performance in patients with acute abdominal pain. (cancercentrum.se)
- The clinical presentation is similar to that of multiple myeloma except that (1) organomegaly is common in Waldenström macroglobulinemia and is uncommon in multiple myeloma and (2) lytic bony disease and renal disease are uncommon in Waldenström macroglobulinemia but are common in multiple myeloma. (medscape.com)
Mobilization8
- This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
- Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
- According to our data, numbers of SSClo ALDH(br) cells are in very good agreement with numbers of SSClo CD45(dim) CD34(hi) cells and can be a predictor of stem cell mobilization. (ogu.edu.tr)
- However, the optimal strategy of stem cell mobilization in this context is not yet clear. (bvsalud.org)
- 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
- The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
- However, during stem cell mobilization and -collection, no study-specific therapeutic intervention was performed. (biomedcentral.com)
- Innovation in this area of medicine has been needed, and today's approval of [motixafortide] addresses the demand for new therapies that can meet today's challenges by delivering more reliability in stem cell mobilization, [vs] filgrastim alone, with fewer days of apheresis sessions and fewer doses of filgrastim for people living with this cancer. (cancernetwork.com)
Graft-versus-1
- The donor's cells are not as well matched to the patient's cells as in a standard allogeneic transplant, which increases the risk of complications such as graft-versus-host disease (GVHD) and graft rejection. (vanyahealth.com)
Allogeneic stem cell trans1
- An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
International Myeloma Workshop1
- The 2009 International Myeloma Workshop concluded that detection of any cytogenic abnormality suggests higher-risk disease, including chromosomal 13 or 13q deletion, t(4;14), and del17p and fluorescence in situ hybridization detection of t(4;14), t(14;16), and del17p. (medscape.com)
20161
- Blood Cancer Journal 2016 May 13;6:e422. (fredhutch.org)
Myelodysplastic Syndromes1
- Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)
20211
- Blood Adv. 2021. (stembook.org)
Safety of autologous2
- Safety of autologous stem cell transplantation in patients with known Human T-cell Lymphotropic Viruses Type 1 and 2 infection: A case series of four patients. (bu.edu)
- However, safety of autologous stem cells (Cells taken from the patients' body) has been established through various trials across the globe. (advancells.com)
Acute2
- After the second hematopoietic stem cell transplant, he developed acute kidney injury secondary to septic shock and required dialysis for 4 weeks. (biomedcentral.com)
- The recommended starting dose of bivalirudin for medically managed patients with acute coronary syndrome (ACS) is an intravenous bolus of 0.1 mg/kg followed by an infusion of 0.25 mg/kg/h. (medthority.com)
Monoclonal6
- 6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
- Light-chain deposition disease (LCDD) is the deposition of monoclonal light chains in multiple organs. (medscape.com)
- [ 10 ] Approximately 50-60% of patients with LCDD have associated multiple myeloma and 17% have monoclonal gammopathy of unknown significance (MGUS) or no evidence of neoplastic plasma cell proliferation. (medscape.com)
- LCDD should be distinguished from Fanconi syndrome, myeloma cast nephropathy, cryoglobulinemia, and amyloidosis, all of which are also associated with monoclonal proteins and may present similarly. (medscape.com)
- BACKGROUND: The incorporation of anti-CD38 monoclonal antibodies (mAb) in induction regimens of newly diagnosed transplant-eligible multiple myeloma (MM) patients has been established as a new standard. (bvsalud.org)
- The tumour cells are malignant plasma cells of the same clonal origin, and secrete high amounts of monoclonal antibody, known as the M-component. (touchoncology.com)
Amyloidosis1
- Safety and Efficacy of Propylene Glycol-Free Melphalan in Patients with AL Amyloidosis Undergoing Autologous Stem Cell Transplantation: Results of a Phase II Study. (bu.edu)
Outpatient5
- Martino M, Paviglianiti A, Memoli M, Martinelli G, Cerchione C. Multiple Myeloma Outpatient Transplant Program in the Era of Novel Agents: State-of-the-Art. (gitmo.it)
- Very low rate of readmission after an early discharge outpatient model for autografting in multiple myeloma patients: an Italian multicenter retrospective study. (gitmo.it)
- Autologous stem cell transplant in 716 patients with multiple myeloma: low treatment-related mortality, feasibility of outpatient transplant, and effect of a multidisciplinary quality initiative. (gitmo.it)
- A 59-year-old man with a history of IgG kappa multiple myeloma presented to an outpatient facility for evaluation of left hip pain, which was found to be a pathologic fracture. (medscape.com)
- Despite further resuscitative efforts, the patient died 13 hours after his initial presentation at the outpatient facility. (medscape.com)
Neutrophil3
- We could not find a relationship between the transplanted SSClo CD45(dim) CD34(hi) cell dose or SSClo ALDH(br) cell dose and platelet or neutrophil recovery. (ogu.edu.tr)
- The optimal thresholds for SSClo CD45(dim) CD34(hi) cells were 5.40 x 106/kg for neutrophil recovery and 7.22 x 106/kg for platelet recovery. (ogu.edu.tr)
- The optimal thresholds for SSClo ALDH(br) cells were 6.53 x 106/kg for neutrophil recovery and 8.72 x 106/kg platelet recovery. (ogu.edu.tr)
Renal4
- Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
- [ 5 , 6 ] LCDD was first described in 1976 in two patients with end-stage renal disease as granular deposits of free light chains in multiple organs, including the kidneys, that did not stain with Congo red. (medscape.com)
- Current treatments for renal failure due to multiple myeloma. (myeloma.org.uk)
- Progression of intramedullary myeloma is associated with increasingly severe secondary features (lytic bone lesions, anaemia, immunodeficiency and renal impairment) and also, in a fraction of patients, the occurrence of tumour cells in extramedullary sites, such as the blood, pleural fluid and skin. (touchoncology.com)
Hematology1
- 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Progenitor cells2
- The other daughters of HSCs (myeloid and lymphoid progenitor cells) can follow any of the other differentiation pathways that lead to the production of one or more specific types of blood cell, but cannot renew themselves. (wikipedia.org)
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Outcomes3
- Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. (haematologica.org)
- In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)
- The team uses highest standards of patient evaluation, planning of treatment procedures, supervising the progress and arriving at desired outcomes. (jaypeehealthcare.com)
Complications8
- There are complications of serial transfusions of either of these cell types, and a patient needs intense prophylactic treatments to protect from infections if his or her white counts are low. (drugdiscoverynews.com)
- Immunocompromised patients are at risk for serious complications from seasonal infl uenza ( 1 ). (cdc.gov)
- Three of these 4 patients were critically remain at increased risk for complications from the pan- ill. (cdc.gov)
- To reduce the risk of these complications, special techniques are used to purify the donor's stem cells before transplantation. (vanyahealth.com)
- In 31 patients (25%) delayed discharge was due to complications: in 14 patients (11.4%) because of GIT problems, in 16 patients (13%) because of infectious complications and in one patient because of cardiotoxicity. (nature.com)
- Overall, the care of patients with MM is complex and should focus on treatment of the disease process and any associated complications. (medscape.com)
- [ 1 ] Some patients die rapidly, within 2-3 years of diagnosis, because of complications from CLL, but most patients live 5-10 years. (medscape.com)
- Two weeks before the current visit, he received a transfusion of 2 units of red blood cells to treat anemia , but complications were documented. (medscape.com)
Survival7
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
- The final analysis of the landmark French IFM-94 trial demonstrated that double transplantation led to improved survival compared with single transplantation in patients with previously untreated myeloma. (cancertreatmenttoday.org)
- Preliminary results of several randomized trials comparing tandem and single autologous transplants, which have not been followed as long, have also shown superior event-free survival with the tandem regimen in most studies. (cancertreatmenttoday.org)
- this should lead to better overall survival in both transplant and non-transplant patients. (medscape.com)
- [ 32 ] The failure to demonstrate improved survival may be due to the small number of patients studied. (medscape.com)
- It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
Donors2
- Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
- Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
Requires the patient to undergo2
- A tandem autologous transplant, also known as a double autologous transplant, requires the patient to undergo two planned autologous stem cell transplants within 6 months. (cancertreatmenttoday.org)
- Incomplete engraftment (poor graft function) requires the patient to undergo more transfusions of red cells or platelets. (drugdiscoverynews.com)
Dexamethasone1
- Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma. (fredhutch.org)