Autologous satellite cells satellite cells. Medical search. Frequent questions

Muscle tissue engineering is a subset of the general field of tissue engineering, which studies the combined use of cells and scaffolds to design therapeutic tissue implants. (wikipedia.org)
The field of muscle tissue engineering attempts to address this problem through the design of a functional muscle construct that can be used to treat the damaged muscle instead of harvesting an autologous muscle flap from elsewhere on the patient's body. (wikipedia.org)
Directional cell migration is a critical process underlying morphogenesis and post-natal tissue regeneration. (crick.ac.uk)
S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction. (researchmap.jp)
This series of articles discusses the difficulties we have encountered in adopting stem cell research to clinical therapeutics in regeneration of cardiac tissue damaged post myocardial infarct. (pharmaceuticalintelligence.com)
Enormous problems have been encountered in the selection of progenitor cells, the growth into compatible and functional myocardial tissue, and the survival of the myocardium. (pharmaceuticalintelligence.com)
Due to the avascular nature of the chondral surface and the specialised rigid extracellular matrix with a low cell density this tissue rarely regenerates by itself (Mankin 1982 ). (springeropen.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
Tissue-engineering and cell-based therapies, two prominent branches of Regenerative Medicine, are considered as the most suitable techniques to repair the tissue damage. (sciepub.com)
The response of target cells is further regulated by their microenvironment, involving the extracellular matrix, which may be modified by MSC-produced matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs. (biomedcentral.com)
MSCs can be defined by their ability to adhere to tissue culture plastic, their expression of several cell surface molecular epitopes-cluster of differentiation CD73, CD90, and CD105, and others-as well as their lack of several surface markers, including CD45 [ 6 ]. (biomedcentral.com)
Focus: Factors influencing outcomes of microsurgical procedures, including the treatment and prevention of lymphedema and autologous tissue reconstruction. (wustl.edu)
Combination of the 3D printing technology that allows for uniform and equal-density distribution of the cells and the use of patient's autologous tissue/cells can lead to rapid migration of keratinocytes and neovascularization at the wound site, resulting in effective regeneration of the skin at treated lesion. (australiafitnesstoday.com)
In regenerative biology, the overarching goal is to rebuild degenerating or absent tissue with a patient's own cells. (uconn.edu)
More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organized muscle tissue that restores normal muscle weight and function in a rodent model of muscle defect injury. (nature.com)
Human Myoblast Genome Therapy (HMGT) is a platform technology of cell transplantation, nuclear transfer, and tissue engineering. (jgc301.com)
GNB show well-defined microscopic foci of differentiating neuroblastic cells distributed in a ganglio-neuromatous tissue background. (hospitalpharmacyeurope.com)
So far, these printers have produced early versions of blood vessels , bones , and different types of living tissue by churning out repeated layers of bioink-a substance comprised of living human cells and other tissue that's meant to mimic the natural environment that surrounds growing organs. (skill-magazine.com)

Additionally, safe and efficient migration of transplanted cells is critical in cell therapies, both allogeneic and autologous. (crick.ac.uk)
Biological substitutes of skin - autologous transplants, allografts, cultures of autologous and allogeneic keratinocytes, living substitues of skin, complex substitutes of skin. (edu.pl)
We perform approximately 45-50 transplants annually, including autologous, related and unrelated allogeneic donor transplants. (phoenixchildrens.com)
Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined. (biomedcentral.com)

Intramuscular transplantation of myogenic cells in primates: importance of needle size, cell number, and injection volume. (medecinesciences.org)
Autologous transplantation of muscle-derived CD133 + stem cells in Duchenne muscle patients. (medecinesciences.org)
Furthermore, strategies utilised to improve migratory capacity of myogenic cells are examined in order to identify potential treatments that may be applied to future transplantation protocols. (crick.ac.uk)
Objective.Brachial plexus injuries (BPIs) result in serious dysfunction, especially brachial plexus defects which are currently treated using autologous nerve graft (autograft) transplantation. (bvsalud.org)
Peripheral glial cell transplantation with Schwann cells (SCs) is a promising approach for treating spinal cord injury (SCI). (bvsalud.org)
PEG-MGF has been shown to enhance the proliferation and migration of bone marrow-derived mesenchymal stem cells, which are a source of autologous stem cells for transplantation to the heart. (peptide-powder.com)
The Center for Cancer and Blood Disorders (CCBD) at Phoenix Children's Hospital (PCH) is seeking a pediatric hematologist/oncologist to serve as Section Chief of Pediatric Stem Cell Transplantation and Cell Therapy in Phoenix, Arizona. (phoenixchildrens.com)
Responsibilities include oversight for the Clinical and Quality programs in BMT and Cell Therapy at CCBD, participation in collaborative efforts with the adult BMT program at Mayo Clinic, shared inpatient and night call responsibilities on the BMT service, and development of a translational and/or laboratory research program in a field relevant to stem cell transplantation and cellular therapy. (phoenixchildrens.com)
Qualified candidates should have a strong interest in mentoring and program development, be academically productive, and must be board certified by the American Board of Pediatrics, subspecialty Pediatric Hematology/Oncology, with additional significant experience and national recognition as a leader in stem cell transplantation and cellular therapies. (phoenixchildrens.com)
Myoblasts cultured from satellite cells of adult muscle biopsies survive, develop, and function to revitalize degenerative muscles upon transplantation. (jgc301.com)

There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
d) Experimental therapies of dysfunctional muscles involving the application of stem cells. (edu.pl)
These cells, theoretically, would not require transfection of dystrophin, and could potentially provide an autologous source of cells for transplant therapies. (umn.edu)
In addition, the program administers more than minimally manipulated cell therapies, including haploidentical stem cell transplants and CAR-T cell treatments. (phoenixchildrens.com)
From a research, medical, and business standpoint, mesenchymal stem cell (MSC)-based therapies are fascinating. (biomedcentral.com)

ROKIT's treatment strategy uses INVIVO ® , ROKIT's proprietary 3D bioprinter, and patient's autologous tissues and cells to "print" a dermal patch graft to treat scarred lesions. (australiafitnesstoday.com)

Current clinical procedures include bone marrow stimulation techniques, cartilage plug transplant, and expanded autologous chondrocyte implantation (Camp et al. (springeropen.com)
Ultimately, we hope to transplant our EOM-derived progenitor cells into injured limb muscle of mdx mice in order to determine the regenerative capabilities in vivo . (umn.edu)
We are looking for an experienced, transformational physician-scientist to lead and further grow one of the largest pediatric bone marrow/stem cell transplant (BMT) and cell therapy programs in the Southwest. (phoenixchildrens.com)
The pediatric BMT/cell therapy program is a COG-approved transplant site, and actively participates in cooperative group trials through the PTCTC, the PIDTC and the Sickle Cell consortium, and offers several institutional investigator-initiated clinical trials. (phoenixchildrens.com)
Position Summary: The successful candidate must have several years of experience in the clinical care of pediatric stem cell transplant patients, prior experience with academic leadership, and preferably an active bench-to-bedside research program with a track record of obtaining external funding. (phoenixchildrens.com)
Since being diagnosed with a second primary cancer earlier this year, I have a special interest in poster presentation #4358, 'The Risk Factors of Second Primary Cancers after Autologous Stem Cell Transplant for Multiple Myeloma before and after the Introduction of Proteasome Inhibitors/Immunomodulatory Agent. (myeloma.org)

Although muscle contains a stem cell population called satellite cells that are capable of regenerating small muscle injuries, muscle damage in VML is so extensive that it overwhelms muscle's natural regenerative capabilities. (wikipedia.org)
Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche. (medecinesciences.org)
Regenerative Effects of Mesenchymal Stem Cells: Contribution of Muse Cells, a Novel Pluripotent Stem Cell Type that Resides in Mesenchymal Cells. (researchmap.jp)
The satellite cells isolated from transplanted muscles comprised a fraction of MAB-derived cells, indicating that the transfected MABs may colonize the satellite stem cell niche. (pacb.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
Epidermal stem cells - localization of stem cells, epidermal stem cell markers, epidermal stem cells in vitro and in vivo, application of epidermal stem cells in medicine. (edu.pl)
I am fortunate and thankful to have had the opportunity over the years to work on amazing science with some of the best partners at Scripps Research, the Summit for Stem Cell Foundation and Aspen Neuroscience. (wgntv.com)
At Aspen Neuroscience, Dr. Bratt-Leal is helping lead the development of the world's first autologous (personalized) induced pluripotent stem cell (iPSC) technology to benefit people with Parkinson's Disease (PD). (wgntv.com)
The work by Andrés and his team is helping to progress the entire stem cell field by advancing the development of a new treatment modality. (wgntv.com)
Serra M, Brito C and Alves PM. "Bioengineering strategies for stem cell expansion and differentiation. (sciepub.com)
It is a novel way of overcoming some of the most pronounced limitations associated with traditional stem cell therapy. (australiafitnesstoday.com)

Resident memory CD8 + T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. (lifeboat.com)
The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
Adipose tissues contain two distinct types of fat cells, white and brown. (bioseek.eu)
While this ultimate aim is rather ambitious, the motivation to achieve these ideal clinical tissues has driven the field of stem and progenitor cell biology to unprecedented levels of scientific and public involvement. (uconn.edu)
Also, a vascularization strategy using co-culture with endothelial cells (ECs) and fibroblasts improved the survival of the bioengineered skeletal muscle tissues 20 , 21 . (nature.com)
Under normal conditions, neural crest cells delaminate and migrate from the dorsal neural tube, and those neuroblastic precursor cells differentiate upon reaching their final embryonic location into tissues and organs that will constitute the sympathetic nervous system. (hospitalpharmacyeurope.com)

Currently VML is treated through an autologous muscle flap or graft but there are various problems associated with this procedure. (wikipedia.org)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)

This study thus provides a proof-of-principle that PiggyBac transposon vectors may mediate full-length dystrophin expression as well as functional amelioration of the dystrophic muscles within a potential autologous cell-based therapeutic approach of DMD. (pacb.com)
More precisely we are working on RNA metabolism , muscle regeneration , muscle stem cells , and fibrosis , with the final aim of developing innovative therapeutic approaches. (institut-myologie.org)
These cell lines are shared in collaboration with many international teams, either to study physiological or pathophysiological mechanisms, or to test innovative therapeutic approaches. (institut-myologie.org)
Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)

Here, we review mechanisms of myogenic stem/progenitor cell migration during skeletal muscle development and post-natal regeneration. (crick.ac.uk)
Additionally, many pathological ailments, such as cancer and heterotopic ossification, are believed to be the consequence of abnormal progenitor cell behavior. (uconn.edu)

Direct isolation of satellite cells for skeletal muscle regeneration. (medecinesciences.org)
Alameddine HS, Dehaupas M, Fardeau M. Regeneration of skeletal muscle fibers from autologous satellite cells multiplied in vitro. (medecinesciences.org)
Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. (medecinesciences.org)
During embryonic myogenesis, migration of skeletal myogenic progenitors is essential to generate the anlagen of limbs, diaphragm and tongue, whereas in post-natal skeletal muscles, migration of muscle satellite (stem) cells towards regions of injury is necessary for repair and regeneration of muscle fibres. (crick.ac.uk)
This is Part 3 of a series of contributions on cardiac regeneration after myocardial infarct with stem cells. (pharmaceuticalintelligence.com)
Part I went into some detail on a method of obtaining suitable cells, growing them in sheets, and transferring the sheets to the surface for regeneration and repair, which is now going into clinical trials. (pharmaceuticalintelligence.com)
b) Participation of satellite cell in muscle regeneration. (edu.pl)
Satellite cells (SCs), which are precursors of skeletal muscles, such as the TA muscle, play a key role in muscle homeostasis and regeneration. (biomedcentral.com)
In this study, we investigate the effects of neural cell integration into the bioprinted skeletal muscle construct to accelerate functional muscle regeneration in vivo. (nature.com)
20% of the original mass invariably results in functional impairment with limited regeneration capacity, which requires reconstructive surgical procedures such as autologous muscle flap transfers 1 . (nature.com)

Instead, we identify a novel mesenchymal cell type located in the interstitial space of skeletal muscle that harnesses robust in vivo chondrogenic, osteogenic and adipogenic capabilities. (uconn.edu)

Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. (medecinesciences.org)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
In vitro cultures of isolated skin cells - 2D and 3D cultures. (edu.pl)
Our experiments will use in vitro cell culture including activated caspase and stress-induced death assays. (umn.edu)
To assess the differentiation capabilities of these cells, we will use flow cytometry to sort the CD34+ population, followed by in vitro differentiation assays using various growth factors and serum deprivation. (umn.edu)
Since only small numbers of cells are obtainable from the patient, it requires expansion of cells in vitro . (sciepub.com)
Nevertheless, these primary cells grow slowly in vitro and lose their general characteristics during prolonged culturing period. (sciepub.com)
Furthermore, we decisively prove through in vitro clonal assays that the majority of these mesenchymal progenitors are capable of multilineage differentiation, contributing to spontaneously forming adipogenic and fibrocyte-like cells, and to BMP-induced osteogenic cells. (uconn.edu)
In vitro and in vivo studies have shown that NBTs originate from a block in the process of normal differentiation of these precursor cells. (hospitalpharmacyeurope.com)

I will perform the following experiments: 1) examine the phenotype and differentiation potential of these cells, 2) determine the mechanism for their resiliency to injury, and 3) examine their ability to repair or regenerate muscle in vivo . (umn.edu)
Khadra M, Lyngstadaas SP, Haanaes HR, Mustafa K. "Effect of laser therapy on attachment, proliferation and differentiation of human osteoblast-like cells cultured on titanium implant material. (sciepub.com)
While acknowledging progress in the other areas mentioned, this work will focus on the current debates concerning sourcing, MSC alterations of angiogenesis, cell differentiation/stimulation, and strategies to improve MSC differentiation. (biomedcentral.com)
Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)

One of the key reasons for this negative outcome is the limited migration of donor cells, which hinders the overall cell engraftment potential. (crick.ac.uk)

Transfusion of autologous tumor-specific CTLs 1-4 and blockade of T cell inhibitory receptors 5-7 have demonstrated to elicit durable clinical benefit in a significant proportion of patients with melanoma, leukemia, lymphoma and other cancers, who failed to respond to conventional treatments. (lifeboat.com)
Walker thinks that if we can somehow get the HIV-specific T-help back, CTLs capable of attacking and destroying HIV-infected cells will be effectively remobilized and HIV infection will be officially turned into a chronic, manageable viral infection - like herpes or, say, genital warts. (treatmentactiongroup.org)

Part I will be confined to the importance of source of progenitor cells, whether adult stem cells or umbilical cord blood. (pharmaceuticalintelligence.com)
Skeletal muscle, a known and plentiful source of progenitor cells is commonly associated with extraskeletal pathologies such as muscular dystrophy and heterotopic ossification. (uconn.edu)

Given that autologous blood products are safe treatments, we have used a technique which stimulates the release of certain growth factors in the autologous conditioned serum (ACS). (cellsurgicalnetwork.com)

Oxygen carriers (perfluorotributylamine, PFTBA) have been shown to provide oxygen to Schwann cells (SCs) for a short period. (bvsalud.org)
Herein, we developed a TENG modified with extracellular matrix generated by skin-derived precursor Schwann cells (SKP-SCs) and expand its application in upper brachial plexus defects in rats.Approach.SKP-SCs were co-cultured with chitosan neural conduits or silk fibres and subjected to decellularization treatment. (bvsalud.org)
Mature Schwann cells represent the dominant component of the tumour, characteristically forming multiple fascicles covered with perineurial cells. (hospitalpharmacyeurope.com)

Dystrophin expression in muscles of Duchenne muscular dystrophy patients after high-density injections of normal myogenic cells. (medecinesciences.org)
Systemic delivery of allogenic muscle stem cells induces long-term muscle repair and clinical efficacy in Duchenne muscular dystrophy dogs. (medecinesciences.org)
Autologous cell therapy approach for Duchenne muscular dystrophy using PiggyBac transposons and mesoangioblasts. (pacb.com)
Our hypothesis is that the EOM are spared from the degenerative effects of Duchenne muscular dystrophy (DMD) due to the presence of higher numbers of a unique precursor cell capable of maintaining a normal phenotype under conditions that normally result in atrophy. (umn.edu)
This activity, developed with the full support of the AFM as well as the Dutch Duchenne Parent Project NL (DPP-NL) and the Jain Foundation, has resulted in the creation of a platform for the immortalisation of human cells. (institut-myologie.org)

A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
Memory CD8 + T cell responses have the potential to mediate long-lasting protection against cancers. (lifeboat.com)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)

2012. The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices. (wikipedia.org)

6. Application of non-embryonic stem cells in treatment of nerve system diseases such as brain stroke, Parkinson's disease, Huntington's disease. (edu.pl)

Treatment with G-CSF further increased the number of vessels in the myocardium, possibly due to mobilization of bone marrow cells. (pharmaceuticalintelligence.com)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. (sciepub.com)

A single, early local administration of high-dose bFGF prevented atrophic changes in the thyroarytenoid muscles by activating satellite cell proliferation and reforming neuromuscular junctions. (biomedcentral.com)
Osathanon T, Bespinyowong K, Arksornnukit M, Takahashi H, Pavasant P. "Human osteoblast-like cell spreading and proliferation on Ti-6Al-7Nb surfaces of varying roughness. (sciepub.com)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
Utilizing 3D bioprinting techniques allows for effective delivery of autologous cells unto the wound site, minimizing cell loss and greatly enhancing cell viability and proliferation. (australiafitnesstoday.com)

These primitive-like cells hold promise as an autologous cell source for regenerative treatments and importantly, afford us the opportunity to begin to understand seemingly normal cellular processes in pathological contexts. (uconn.edu)

Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. (medecinesciences.org)
Therefore, in collaboration with W. Wright, we have developed an approach for the immortalisation of human muscle precursors that allows them to retain their ability to differentiate: this has enabled the generation of immortal cell lines derived from patient cells. (institut-myologie.org)
Intradermal, but not intraperitoneal vaccination, generated memory precursors expressing skin-homing molecules in circulation and Trm cells in skin. (lifeboat.com)
Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)

Aspen recently announced that the U.S. Food and Drug Administration (FDA) cleared its Investigational New Drug (IND) application for ANPD001, enabling the company to proceed with an upcoming clinical trial for its personalized cell therapy to treat PD by replacing lost dopamine neurons. (wgntv.com)
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. (mdc-berlin.de)

c) Miogenic potential of stem cells - hematopoietic stem cells, mesenchymal stem cells, stem cells derived from blood vessels, embryonic stem cells. (edu.pl)

Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacities. (medecinesciences.org)
Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle. (medecinesciences.org)
Defining the heterogeneity of skeletal muscle-derived side and main population cells isolated immediately ex vivo. (umn.edu)
Two groups of resident progenitors, the skeletal muscle satellite cells (SCs) and vascular endothelium (VE)/vascular endothelial progenitors (VEPs), have been considered to be putative cell sources for ectopic lesions of heterotopic ossification due to their reported multipotent characteristics. (uconn.edu)
In conclusion, these data decisively establish degrees of potency for skeletal muscle resident progenitors and identify the putative cell-of-origin for the ectopic skeletal anlagen of heterotopic ossification. (uconn.edu)

We hope to identify a new source of cells for use in myoblast transfer therapy. (umn.edu)
By describing a means for EOM sparing in DMD, we may advance our understanding of the disease and identify a new source of cells for myoblast transfer therapy. (umn.edu)
Evaluation of low-level laser therapy of osteoblastic cells. (sciepub.com)
Opportunity: The pediatric BMT/cell therapy program at PCH is one of the largest pediatric programs in the Southwestern US. (phoenixchildrens.com)
This position is an opportunity to lead one of the largest BMT and Cell Therapy programs in the Southwestern US. (phoenixchildrens.com)
I was intrigued with the presentations on #BiTE therapy (Bi-specific T-cell engager) that was all the buzz. (myeloma.org)
Cell therapy, however, holds the promise of repleting the damage heart with new contractile cells that can be engi-neered to secrete concoctions that promote healing by recruiting new blood vessel development or angiogenesis. (jgc301.com)

Attachment of human marrow stromal cells to titanium surfaces. (sciepub.com)

Those growth factors are known to improve the proliferative activity of myogenic precursor cells. (cellsurgicalnetwork.com)
Sparing of extraocular muscle in aging and muscular dystrophies: a myogenic precursor cell hypothesis.Exp Cell Res. (umn.edu)
Myogenic precursor cells in craniofacial muscles. (umn.edu)

PEG-MGF has been shown to stimulate proangiogenic activities in human vascular endothelial cells. (peptide-powder.com)

This is unlike the satellite cells of limb muscles, which remain quiescent unless injury is sustained. (umn.edu)
These cells from EOM are more resistant to apoptosis than similar cells from limb muscles. (umn.edu)
Unlike stem cells, myoblasts are differentiated, immature cells destined to become muscles. (jgc301.com)

Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)

Although administration of various myogenic cell types has been done intramuscularly or intravascularly, functional restoration has not been achieved yet in patients with degenerative diseases affecting multiple large muscle. (crick.ac.uk)
We use in parallel many technologies that have been considerably refined to identify, isolate, and characterize, specific and practically pure cell populations, critically allowing us to attribute functional outcomes of potency tests to unique cell types. (uconn.edu)

ROKIT Healthcare, Inc. is a South Korea based regenerative medicine company headquartered in Seoul, South Korea , with satellite offices in Sulzbach, Germany and Boston, MA. (australiafitnesstoday.com)

Vaccination-induced Trm cells were largely resistant to in vivo intravascular staining and antibody-dependent depletion. (lifeboat.com)

We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)

We investigated the use of the PiggyBac transposon for full-length dystrophin expression in murine mesoangioblast (MABs) progenitor cells. (pacb.com)

Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)

Cultures of autologous chondrocytes, contemporary practical applications. (edu.pl)

More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
Neuroblastic tumours (NBTs) derive from primordial neural crest cells and are the most common extracranial solid childhood tumours in Europe. (hospitalpharmacyeurope.com)

An experimental model for testing cultured cell myogenicity. (medecinesciences.org)
Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. (biomedcentral.com)

Despite successes in pre-clinical animal models with stem cells, a problem arises with respect to the biology of the transplanted progenitor cells. (pharmaceuticalintelligence.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
Because of this alternative use of MSCs, Caplan and Sorell [ 14 ] suggested a renaming of MSCs to medicinal signaling cells to suggest a new era of MSC clinical relevance due to their immunomodulatory properties. (biomedcentral.com)

8-10 Long-lasting protective immunity relies on the efficient establishment of long-lived memory CD8 + T cells, which have the potential to eradicate primary and disseminated tumors. (lifeboat.com)

Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
By supplying products and services for small satellites (SmallSats) we intend to establish an infrastructural ecosystem that enables small satellites to become the most sustainable solution for achieving interplanetary missions. (emiliaromagnastartup.it)

Immortalized Canine Dystrophic Myoblast Cell Lines for Development of Peptide-Conjugated Splice-Switching Oligonucleotides. (institut-myologie.org)

Anatomy26

Organisms16

Diseases8

Chemicals and Drugs36

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Phenomena and Processes20

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Therapies6

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Regeneration10

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