Multiple myelomaMarrowTransplantFollowed by hematopoietic stem cell transTransplantsDose chemotherapyLymphomaHSCTRadiation therapyPost-transplantationAllogeneic and autologousLymphoproliferative disordersCommon side effects of cEtoposideDosesPatient'sMalignanciesRemissionDonorConventionalMelphalanTumorPBSCTPediatric and adultInclude chemotherapyLymphocytesProgenitorLymphoidAllogenicCyclophosphamideCancersRegimensStandard chemotherapyInduction chemotherapyUmbilical cordUnderwentIntensiveCD34RadiotherapyPlus chemotherapyPatientHematologyTreatment20182016DifferentiationImmuneCord bloodMyelomaMalignantPlatelets
Multiple myeloma7
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
- Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
- While quadruplet induction therapies deepen responses in newly diagnosed multiple myeloma patients, their impact on peripheral blood stem cell (PBSC) collection remains incompletely understood. (biomedcentral.com)
- 3.2 mg/kg/day busulfan on days -5 to -3 and 140 mg/m 2 /day melphalan on day -2) in patients with multiple myeloma (MM) following bortezomib-based induction chemotherapy. (elsevierpure.com)
- A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Marrow59
- Bone marrow transplantation , 37 (10), 929-935. (elsevierpure.com)
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- Intensive or high-dose chemotherapy with autologous bone marrow transplantation or peripheral blood stem cell rescue has not demonstrated any effectiveness in brain stem gliomas. (wikipedia.org)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
- Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
- In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
- It is more common these days to collect bone marrow stem cells from the bloodstream. (leukaemia.org.au)
- Stem cells normally live in the bone marrow, but they can be encouraged to move out of the bone marrow and into the bloodstream. (leukaemia.org.au)
- G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
- Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
- From here the stem cells make their way to your bone marrow where they become re-established and start making new blood cells. (leukaemia.org.au)
- 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- The bone marrow, on the other hand, is preserved because the healthy stem cells are integrated again. (leading-medicine-guide.com)
- Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)
- Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
- Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
- Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
- G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
- The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
- Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
- Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
- Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
- Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
- These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- Biology of Blood and Marrow Transplantation , 25 (7), 1312-1319. (elsevierpure.com)
- Hematopoietic stem cell transplantation is a procedure that involves the infusion of stem cells to treat patient malignancies or to repair diseased or defective bone marrow. (lovesorghum.com)
- The high doses of therapy lead to destruction of patient's marrow and immune system, which is then replaced by healthy marrow from self (autologous) or donor (allogeneic) hematopoietic stem cells that have been harvested from bone marrow or peripheral blood before therapy. (lovesorghum.com)
- The division is equipped with complete facility and expertise to conduct treatment like chemotherapy, anti-microbial therapy and supportive care post-chemotherapy or post bone-marrow transplantation. (jaypeehealthcare.com)
- Bone marrow transplantation is procedures in which stem cells from the donor's bone marrow, which produce the different blood cells like red blood cells, white blood cells and platelets are injected into the recipient. (jaypeehealthcare.com)
- We offer both allogeneic and autologous transplant using bone marrow, peripheral blood stem cells and cord blood stem cells for various benign and malignant blood disorders like thalassemia, aplastic anaemia, leukaemia, lymphomas, multiple myelomas and advanced solid tumours for adults and children both. (jaypeehealthcare.com)
- Patient with severe aplastic anemia is doing well after Bone Marrow Transplantation. (jaypeehealthcare.com)
- A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
- The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
- When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
- The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
- The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
- These are the important cells that are transferred during bone marrow or stem cell transplantation. (ucsfhealth.org)
- Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
- When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
- When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
- For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
- For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
- Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
- With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- Equivalent numbers of patients in both cohorts received bone marrow or peripheral blood allogeneic or autologous stem cell transplantation (SCT). (elsevierpure.com)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Transplant27
- Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
- We present an unusual case of monomorphic T cell PTLD with features of angioimmunoblastic T cell lymphoma in an 8-year-old heart transplant patient, presenting with cranial nerve palsy. (karger.com)
- Blaes AH, Morrison VA: Post-transplant lymphoproliferative disorders following solid-organ transplantation. (karger.com)
- Morovic A, Jaffe ES, Raffeld M, Schrager JA: Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. (karger.com)
- Lundell R, Elenitoba-Johnson KS, Lim MS: T-cell posttransplant lymphoproliferative disorder occurring in a pediatric solid-organ transplant patient. (karger.com)
- Yang F, Li Y, Braylan R, Hunger SP, Yang LJ: Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation. (karger.com)
- Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ: Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. (karger.com)
- 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
- What is an autologous stem cell transplant? (leukaemia.org.au)
- Most people have a single autologous transplant. (leukaemia.org.au)
- It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
- In the week leading up to your transplant you will be given a few days of very high-dose chemotherapy, and sometimes radiotherapy , to destroy your underlying disease. (leukaemia.org.au)
- In the week following the transplant, your blood counts drop dramatically. (leukaemia.org.au)
- Treatment for Hodgkin lymphoma (HL) is tailored to each individual and may include surgery, radiation therapy, chemotherapy, precision cancer medicines and or stem cell transplant in selected situations. (hoapb.com)
- Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
- The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
- When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
- Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
- A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)
- An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
- An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
- Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
- The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
- For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- Note: For transplant-eligible patients enrolled to Part 1 or Part 2, induction plus conditioning chemotherapy/ASCT +/- maintenance therapy constitute one regimen. (who.int)
Followed by hematopoietic stem cell trans2
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- Because there is no effective chemotherapeutic regimen for intrathoracic malignant neurogenic tumor, all three patients received high-dose chemotherapy followed by hematopoietic stem cell transplantation. (springeropen.com)
Transplants10
- In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
- Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
- Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
- Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
- Learn more about stem cell transplants here. (medicalnewstoday.com)
- Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
- For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
- To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
- What are the types of stem cell transplants? (mdanderson.org)
- Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Dose chemotherapy11
- The role of high-dose chemotherapy (HDCT) in patients with refractory breast cancer is not well established. (elsevierpure.com)
- Thereafter, the patient received autologous peripheral blood stem cell transplantation with high-dose chemotherapy (combination of ifosphamide, carboplatin and etoposide) as pretreatment. (karger.com)
- Miyazaki K, Masuya M, Yamaguchi M, Isaka S, Nakase K, Kobayashi T, Nakamura S, Shiku H: Angioimmunoblastic T-cell lymphoma occurring four months after autologous peripheral blood stem cell transplantation with high-dose chemotherapy for follicular lymphoma. (karger.com)
- The patient then underwent high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (auto-PBSCT). (elsevierpure.com)
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
- For example, they often use high-dose chemotherapy with special hematopoietic stem cell transplantation. (leading-medicine-guide.com)
- The remaining seven received high-dose chemotherapy and stem-cell infusion. (northwestern.edu)
- Treatment options for refractory ALL may include high dose chemotherapy, targeted therapy, immunotherapy, clinical trials , or palliative care to manage symptoms and improve quality of life. (medicalnewstoday.com)
- Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
- We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
- Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
Lymphoma20
- de Leval L, Gisselbrecht C, Gaulard P: Advances in the understanding and management of angioimmunoblastic T-cell lymphoma. (karger.com)
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
- Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- Investigators will assess LP-284 as a treatment for those with B-cell non-Hodgkin lymphoma in a phase 1 trial. (cancernetwork.com)
- Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
- Chemotherapy alone or combined modality treatment with chemotherapy and radiation therapy is typically utilized even for early stage lymphoma. (hoapb.com)
- This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
- It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. (the-medical-dictionary.com)
- We conducted a nationwide, multicenter, prospective registry study for newly diagnosed patients with peripheral T-cell lymphoma (PTCL) to better define the clinical characteristics, treatment patterns, survival outcomes, and the role of upfront autologous stem cell transplantation (ASCT) in these patients. (e-crt.org)
- The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
- The expert Oncologists and Hematologists provide related treatment and outpatient care service for all varieties of blood disorders such as anaemia, bleeding disorders such as haemophilia, blood clots, thalassemia and cancers such as leukaemia, lymphoma, and myeloma. (jaypeehealthcare.com)
- This department provides medical care for patients with blood disorders, including anemia and thrombocytopenia, and neoplastic disorders such as leukemia and malignant lymphoma. (japanhospitalsearch.org)
- The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
- Children and teens with rare childhood non-Hodgkin lymphoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Childhood Lymphoma Program in our Childhood Hematologic Malignancy Center . (dana-farber.org)
- These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
- Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
- Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
HSCT10
- There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
- There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
- The mediannumber of chemotherapy regimens was 2 after tositumomab/iodine-131 tositumomaband prior to HSCT (range: 1-4). (cancernetwork.com)
- Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Radiation therapy7
- The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
- After her diagnosis, the specialist diagnosed ordered a treatment plan that consisted of 10 cycles of chemotherapy, surgery to remove her tumor, MIBG radiation therapy, and an autologous peripheral blood stem cell transplantation. (armhc.org)
- Radiation therapy uses high-powered energy beams, such as X-rays or protons, to kill cancer cells. (hoapb.com)
- The objective of radiation therapy is to kill cancer cells for a maximum probability of cure with a minimum of side effects. (hoapb.com)
- Radiation therapy, unlike chemotherapy, is considered a local treatment. (hoapb.com)
- Radiation therapy is a cancer treatment that uses high-energy radiation to destroy cancer cells. (medicalnewstoday.com)
- External radiation therapy involves delivering radiation to the cancer cells from outside the body using a linear accelerator. (medicalnewstoday.com)
Post-transplantation2
- Draoua HY, Tsao L, Mancini DM, Addonizio LJ, Bhagat G, Alobeid B: T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience. (karger.com)
- For post-transplantation best response, an 83% rate of VGPR or better (68% CR) was observed. (elsevierpure.com)
Allogeneic and autologous2
- Expanded natural killer cells killed both allogeneic and autologous primary myeloma cells avidly via a perforin-mediated mechanism in which the activating receptor NKG2D, natural cytotoxicity receptors, and DNAX-accessory molecule-1 played a central role. (haematologica.org)
- allogeneic and autologous . (ucsfhealth.org)
Lymphoproliferative disorders2
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
Common side effects of c1
- During this time you are likely to be experiencing some of the common side effects of chemotherapy and radiotherapy which may include nausea, vomiting, mucositis (sore mouth) and bowel problems (diarrhoea). (leukaemia.org.au)
Etoposide3
- After 4 cycles of chemotherapy with topotecan and etoposide, 131 I-MIBG treatment was performed at a dose of 18 mCi/kg. (biomedcentral.com)
- Later, they were administered high-dose etoposide, 1,500 mg/[m.sup.2], followed by granulocyte colony-stimulating factor for collection of peripheral blood stem cells. (the-medical-dictionary.com)
- Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
Doses2
- They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
- 2016). The high doses of chemotherapy used in al. (bvsalud.org)
Patient's6
- Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
- Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
- Individually tailored chemotherapy that is suitable for the patient's individual case is also part of Professor Graeven's specialist field, as is the high-dosage version. (leading-medicine-guide.com)
- The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
- The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
- If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
Malignancies2
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
- TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
Remission2
- He remains in complete remission 2 years after transplantation. (elsevierpure.com)
- These cells are collected in advance (while they are in remission ) and returned to the patient at a later stage. (leukaemia.org.au)
Donor5
- Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
- Learn more about being a stem cell donor. (medicalnewstoday.com)
- In the second part of our study, combining in-situ-hybridization and immunohistochemical methods, we were able to show that there is a migration of donor cells into the central nervous system of the recipient after peripheral blood stem cell transplantation as well as a differentiation of these cells into other cell types. (uni-goettingen.de)
- This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
- Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
Conventional3
- 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
- Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
- Conventional and intensive chemotherapy is routinely performed at the hospital. (mediescapes.com)
Melphalan1
- High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (msdmanuals.com)
Tumor5
- Although arterial infusion chemotherapy (pirarubicin hydrochloride and carboplatin) was given, no tumor shrinkage was observed, and surgery was therefore performed to remove the tumor. (karger.com)
- Suppression of inducible CD4 regulatory cells by MHC class I-restricted human tumor epitope specific TCR engineered multifunctional CD4 T cells. (uchc.edu)
- The tumor nest was composed of primitive cells with round or oval hyperchromatic nuclei and scant cytoplasm (high-power view). (springeropen.com)
- ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
- Two died while receiving high-dose systemic corticosteroids, methotrexate, and after recent exposure to anti-tumor necrosis factor-α biological DMARDs, and 2 during hematopoietic stem cell transplantation procedure. (cdc.gov)
PBSCT3
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)
- Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
Pediatric and adult1
- Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
Include chemotherapy1
- Systemic therapy is any treatment directed at destroying cancer cells throughout the body and may include chemotherapy, immunotherapy or newer precision cancer medicines. (hoapb.com)
Lymphocytes5
- Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. (uchc.edu)
- Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy. (uchc.edu)
- 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
- Peripheral blood lymphocytes were analysed by flow cytometry, ELISA, and T-cell-receptor spectratyping before and after transplantation. (northwestern.edu)
- Samples of peripheral blood lymphocytes (PBLs) were obtained from ten normal untreateddonors and 18 normal donors treated with G-CSF. (fliphtml5.com)
Progenitor3
- 2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
- Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Lymphoid1
- The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
Allogenic2
- This BMT unit is at par with the best in the world, and performs both Allogenic, and Autologous BMT's. (mediescapes.com)
- Facilities for both autologous and Allogenic transplantation are available at the hospital, using a cell separator for stem cell harvest procedures and a freezing system to cryo-preserve the cells for future use. (mediescapes.com)
Cyclophosphamide2
- Subsequently, chemotherapy consisting of cisplatin (25 mg/m 2 on days 1 to 5), cyclophosphamide (1,200 mg/m 2 on days 1 and 2), vincristine (1.5 mg/m 2 on day 1), and pirarubicin-doxorubicin (40 mg/m 2 on day 3) was administered. (springeropen.com)
- We mobilised autologous haemopoietic stem cells with 2·0 g/m 2 cyclophosphamide and 10 μg/kg granulocyte colony stimulating factor daily, enriched with CD34-positive selection, and reinfused after immunosuppression with 200 mg/kg cyclophosphamide, 1 g methylprednisolone, and 90 mg/kg equine antithymocyte globulin. (northwestern.edu)
Cancers3
- Through genomic-biomarker testing performed on cells from the biopsy or collected in blood doctors are increasingly able to define the genomic alterations in a cancers DNA that are driving the growth of the cancer. (hoapb.com)
- Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
- Dana-Farber/Boston Children's offers internationally renowned care for children with cancers of the blood and immune system. (dana-farber.org)
Regimens3
- Their disease had been refractory (defined as less than partial response) to one (18 patients) or two (24 patients) regimens of neoadjuvant chemotherapy. (elsevierpure.com)
- Patients received a median of 3(range: 2-6) prior chemotherapy regimens (exclusive of tositumomab/iodine-131tositumomab) before or after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
- These findings demonstrate that bortezomib is safe and has a potential role in conditioning regimens in combination with BuMel for patients with transplantation-eligible MM. (elsevierpure.com)
Standard chemotherapy1
- After standard chemotherapy failed, a liver biopsy was performed. (bvsalud.org)
Induction chemotherapy2
- Phase II trial of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for untreated non-squamous non-small-cell lung cancer. (shengsci.com)
- abstract: PURPOSE:We conducted a phase II trial to evaluate the efficacy and safety of induction chemotherapy of pemetrexed plus split-dose cisplatin followed by pemetrexed maintenance for advanced non-squamous non-small-cell lung cancer (NSCLC). (shengsci.com)
Umbilical cord2
- peripheral blood, or placental/umbilical cord blood). (cdc.gov)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Underwent3
- Patients underwent dose-intense immune suppression and autologous haemopoietic stem-cell (CD34) infusion. (northwestern.edu)
- Results: Nine patients underwent stem-cell mobilisation but two were excluded before transplantation because of infection. (northwestern.edu)
- We examined histopathological changes in the central nervous system of 19 patients who underwent autopsy studies following peripheral blood stem cell transplantation. (uni-goettingen.de)
Intensive2
- This complex treatment offers a huge benefit for patients: even more resistant cancer cells are killed by the more intensive treatment process. (leading-medicine-guide.com)
- This procedure starts with the patient receiving intensive chemotherapy with or without total body irradiation in an attempt to kill all cancerous cells. (lovesorghum.com)
CD346
- 4 CD34 expression is historically related to hematopoietic cells and it is considered as the marker of HSCs. (bdbiosciences.com)
- An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
- 6 Fluorochrome-conjugated monoclonal antibodies directed against CD34 molecule can be used to identify CD34+ cells by flow cytometry. (bdbiosciences.com)
- The BD ® Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/µL) as well as the percentage of the total viable leucocyte count that is CD34+ (%CD34). (bdbiosciences.com)
- Single-platform flow cytometric absolute cell counting protocols have been shown to provide increased robustness of CD34 enumeration by limiting potential sources of imprecision. (bdbiosciences.com)
- The patients were evaluated based on PBSC mobilization and collection parameters, including overall collection results, CD34 + cell levels in peripheral blood, leukapheresis (LP) delays, overall number of LP sessions, and the rate of rescue mobilization with plerixafor. (biomedcentral.com)
Radiotherapy1
- Currently, the standard of care is fractionated external beam radiotherapy, as the tumour location precludes surgery and chemotherapy has shown to be ineffective. (wikipedia.org)
Plus chemotherapy1
- The FDA has set a Prescription Drug User Fee Act date of April 5, 2024 for nivolumab plus chemotherapy in unresectable or metastatic urothelial carcinoma. (cancernetwork.com)
Patient5
- The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. (biomedcentral.com)
- The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
- One type creates a new, individualized treatment for each patient by removing some of the person's immune cells, altering them genetically to kill cancer, and then infusing them back into the bloodstream the other uses precision medications to enhance the immune systems response to the cancer. (hoapb.com)
- Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma. (shengsci.com)
- Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
Hematology1
- 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Treatment10
- The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
- After you have finished this treatment, your stem cells are thawed and reinfused through a vein into your bloodstream. (leukaemia.org.au)
- The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
- 5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
- An important focal point of Professor Graeven's range of services is haematology, i.e. the diagnosis and treatment of all conditions of the blood, the hematopoietic organs and the lymphatic system. (leading-medicine-guide.com)
- In this regard, the essential hematopoietic stem cells are removed, whilst treatment with the chemotherapeutic agent, the dose of which is elevated by three to five times, takes place. (leading-medicine-guide.com)
- Chemotherapy is any treatment involving the use of drugs to kill cancer cells. (hoapb.com)
- Peripheral blood stem cell transplantation is used as a treatment for different hemic diseases and some autoimmune disorders. (uni-goettingen.de)
- The histological features of patients having received a stem cell transplantation were compared to patients who had not received any such treatment. (uni-goettingen.de)
- The division is dedicated to diagnosis and treatment of blood related cancerous and non-cancerous disorders. (jaypeehealthcare.com)
20181
- Blood (2018) 132 (Supplement 1): 81. (ashpublications.org)
20161
- Blood (2016) 128 (22): 337. (ashpublications.org)
Differentiation1
- One was a solid or isolated growth of oval primitive cells with Schwannian stroma, representative of a neuroblastoma (Figure 1 C). The second was a diffuse growth of large polygonal cells with ganglion cell differentiation and prominent Schwannian stroma, which was regarded as a ganglioneuroma. (springeropen.com)
Immune5
- We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients. (northwestern.edu)
- The immune system is a network of cells, tissues, and biologic substances that defend the body against viruses, bacteria, and cancer. (hoapb.com)
- The immune system recognizes cancer cells as foreign and can eliminate them or keep them in check-up to a point. (hoapb.com)
- Cancer cells are very good at finding ways to avoid immune destruction, however, so the goal of immunotherapy is to help the immune system eliminate cancer cells by either activating the immune system directly or inhibiting the mechanisms of suppression of the cancer. (hoapb.com)
- PD-1 and PD-L1 are proteins that inhibit certain types of immune responses, allowing cancer cells to evade detection and attack by certain immune cells in the body. (hoapb.com)
Cord blood3
- Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
- We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)
- Cord Blood, rich in stem cells, is now in use. (mediescapes.com)
Myeloma5
- We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma. (haematologica.org)
- These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
- Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
- Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
- The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
Malignant2
- The first theory on extragonadal malignant germ cell tumors postulated that the tumors developed from primitive germ cells in the endoderm of the yolk sac or from the urogenital ridge. (medscape.com)
- Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
Platelets1
- During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)