Multiple myelomaTransplantsPatient'sHSCTHigh-doseUmbilicalProgenitor cell transplantationASCTCellsLymphomaPatientsInternational Bone Marrow Transplant RHaving a bone marrow traCord Blood Stem Cell TransplantSolid tumorsRecurrenceLeukemiaSyngeneicIndication for transplantationLymphoproliferativePediatric BloodImmuneHSCTsDonor'sRadiationDiseaseTransfusionNeuroblastoma1988METHODSDonorsCancerPBSCTHematologyPatient
Multiple myeloma9
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- Whither the Bone Marrow Transplantation in Multiple Myeloma? (karger.com)
- Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma. (fredhutch.org)
- A Randomized Study of Melphalan 200 mg/m2 v. 280 mg/m2 as a Preparative Regimen for Patients with Multiple Myeloma undergoing Autologous Stem Cell Transplantation. (fredhutch.org)
- A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants. (biomedcentral.com)
- Subsequently, his serum creatinine stabilized at 2.1 mg/dL (185.64 μmol/L). Seventeen months after the second hematopoietic stem cell transplant, he was initiated on carfilzomib for relapse of multiple myeloma. (biomedcentral.com)
- A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
- The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT). (biomedcentral.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Transplants13
- Transplants from HLA-matched siblings are associated with a lower risk of GVHD and faster recovery of the recipient's immune system following transplantation. (medscape.com)
- In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
- Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
- Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- At the time they performed the first transplants surprisingly little was known about hematopoietic stem cells, immune responses to transplants or the complex human leucocyte antigen system. (revistadehematologia.org.mx)
- We have performed more than 1,100 bone marrow transplants and have a growing cellular therapy program offering new, effective and less toxic therapies for a variety of diseases. (childrenscolorado.org)
- Our providers specialize in pediatric blood and marrow transplants and cellular therapy, so you can trust that your child is in good hands. (childrenscolorado.org)
- With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
- To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
- What are the types of stem cell transplants? (mdanderson.org)
- Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
- Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
Patient's9
- Autologous transplantation is feasible when the patient's bone marrow is normal and there are no relevant genetic conditions. (medscape.com)
- Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
- They are used to replace stem cells that have been damaged by high doses of chemotherapy , used to treat the patient's underlying disease. (leukaemia.org.au)
- Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
- The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
- The high doses of therapy lead to destruction of patient's marrow and immune system, which is then replaced by healthy marrow from self (autologous) or donor (allogeneic) hematopoietic stem cells that have been harvested from bone marrow or peripheral blood before therapy. (lovesorghum.com)
HSCT15
- Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
- Patients who undergo HSCT experience a sequential suppression of host defenses, resulting in varying infectious risk at different phases of the transplantation process. (medscape.com)
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- In this report, we summarize the case of a patient with MM status post autologous HSCT and chronic kidney disease who experienced worsening hypertension along with a substantial increase in proteinuria shortly after the initiation of carfilzomib for the treatment of refractory disease. (biomedcentral.com)
- This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
- The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
- In contrast, surveillance of AEs associated with hematopoietic stem cell (HSC) products in HSC transplantation (HSCT) has been less rigorous, even though HSC products include a diversity of immature and mature hematopoietic cells, substantial plasma, and dimethyl sulfoxide (DMSO) in the case of cryopreserved HSC products. (elsevierpure.com)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
High-dose16
- Intensive or high-dose chemotherapy with autologous bone marrow transplantation or peripheral blood stem cell rescue has not demonstrated any effectiveness in brain stem gliomas. (wikipedia.org)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- Miyazaki K, Masuya M, Yamaguchi M, Isaka S, Nakase K, Kobayashi T, Nakamura S, Shiku H: Angioimmunoblastic T-cell lymphoma occurring four months after autologous peripheral blood stem cell transplantation with high-dose chemotherapy for follicular lymphoma. (karger.com)
- Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
- Later, they were administered high-dose etoposide, 1,500 mg/[m.sup.2], followed by granulocyte colony-stimulating factor for collection of peripheral blood stem cells. (the-medical-dictionary.com)
- Dr. George Mathé explored the transplantation of bone marrow cells from healthy donors to treat patients accidentally irradiated at high dose, expanding the possibilities of this life-saving technique (Mathé et al. (revistadehematologia.org.mx)
- In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
- We evaluated hematopoietic stem cells according to CD34 expression and aldehyde dehydrogenase (ALDH) activity in peripheral blood and apheresis product samples from patients after mobilization with granulocyte-colony-stimulating factor (G-CSF) alone or G-CSF after high-dose cyclophosphamide (4 g/m(2) once daily, intravenously on day 1). (ogu.edu.tr)
- We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
- The presence of inflammatory cytokines after high-dose chemotherapy leads to proliferation and activation of MDSCs originating from autologous hematopoietic progenitors at the time of engraftment. (biomedcentral.com)
- The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
- For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
Umbilical6
- The stem cell source may be bone marrow, peripheral blood, or umbilical cord blood. (medscape.com)
- 1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
- Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
- The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
- peripheral blood, or placental/umbilical cord blood). (cdc.gov)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Progenitor cell transplantation1
- By demonstrating compliance with the FACT-JACIE International Standards for Cellular Therapy Product Collection, Processing and Administration , the joint program of Fox Chase Cancer Center and Temple has earned FACT reaccreditation for adult allogeneic and autologous hematopoietic progenitor cell transplantation, peripheral blood cellular therapy product collection, and cellular therapy product processing with minimal manipulation. (foxchase.org)
ASCT4
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14 pos HLA-DR low/neg ) and early-stage (E-) MDSCs (Lin neg HLA-DR neg CD33 pos CD11b pos ) before and after ASCT. (biomedcentral.com)
- Both MDSC phenotypes pre-ASCT but not post-ASCT similarly suppressed in vitro autologous T and natural killer T cell proliferation. (biomedcentral.com)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Cells96
- By nature, these tumors invade diffusely throughout the brain stem, growing between normal nerve cells. (wikipedia.org)
- The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
- In GVHD, the donated stem cells view the recipient cells as foreign and attack recipient cells. (medscape.com)
- In preparation for receipt of the stem cells, recipients undergo myeloablation to eliminate their own myeloid cells. (medscape.com)
- The harvested stem cells are processed before infusion into the recipient. (medscape.com)
- The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
- The number of viable CD45+/CD34+ cells will determine the quality of the harvested specimen for transplantation. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- The BD ® Stem Cell Enumeration (SCE) Kit provides simultaneous enumeration of viable dual-positive CD45+/CD34+ hematopoietic stem cell populations in CD34+ absolute counts (cells/µL) as well as the percentage of the total viable leucocyte count that is CD34+ (%CD34). (bdbiosciences.com)
- In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
- It is more common these days to collect bone marrow stem cells from the bloodstream. (leukaemia.org.au)
- Stem cells normally live in the bone marrow, but they can be encouraged to move out of the bone marrow and into the bloodstream. (leukaemia.org.au)
- G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
- Regular blood tests will be taken over the following week to identify the best day to start collecting your stem cells. (leukaemia.org.au)
- Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
- The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
- Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
- After you have finished this treatment, your stem cells are thawed and reinfused through a vein into your bloodstream. (leukaemia.org.au)
- From here the stem cells make their way to your bone marrow where they become re-established and start making new blood cells. (leukaemia.org.au)
- During this time you will be more at risk of infections (due to the lack of infection-fighting white blood cells ) and bleeding (due to a lack of platelets ). (leukaemia.org.au)
- Forty-two female patients (median age of 46 years) with breast cancer refractory to neoadjuvant chemotherapy received HDCT (cyclophosphamide, carmustine and thiotepa) supported by an autologous peripheral blood stem cells transplant. (elsevierpure.com)
- eg, red blood cells [RBCs], platelets, plasma based on specific gravity) to use for transfusion in different patients. (msdmanuals.com)
- Through genomic-biomarker testing performed on cells from the biopsy or collected in blood doctors are increasingly able to define the genomic alterations in a cancers DNA that are driving the growth of the cancer. (hoapb.com)
- Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
- These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
- The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
- In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
- Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
- Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
- Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
- Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
- Why should mesenchymal stem cells (MSCs) cure autoimmune diseases? (cellsurgicalnetwork.com)
- Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells. (cellsurgicalnetwork.com)
- Stem cells as therapeutics for neurodegenerative disorders? (cellsurgicalnetwork.com)
- Mesenchymal Stem Cells for Multiple Sclerosis: Does Neural Differentiation Really Matter? (cellsurgicalnetwork.com)
- Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
- These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
- 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
- Changes in the sources and handling of hematopoietic stem cells were introduced. (revistadehematologia.org.mx)
- Stem cells were susceptible to cryo-preservation (Stiff et al. (revistadehematologia.org.mx)
- 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
- 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
- Bone marrow transplantation is procedures in which stem cells from the donor's bone marrow, which produce the different blood cells like red blood cells, white blood cells and platelets are injected into the recipient. (jaypeehealthcare.com)
- We offer both allogeneic and autologous transplant using bone marrow, peripheral blood stem cells and cord blood stem cells for various benign and malignant blood disorders like thalassemia, aplastic anaemia, leukaemia, lymphomas, multiple myelomas and advanced solid tumours for adults and children both. (jaypeehealthcare.com)
- Nonrelapse-related mortality was increased after carmustine (RR = 2.3) and with use of peripheral blood stem cells (RR = 2.4). (qxmd.com)
- The CD34 antigen is present on 1-4% of human marrow cells including virtually all hematopoietic progenitors detected by in vitro assays. (nih.gov)
- Since the anti-CD34 monoclonal antibody 12-8 reacts with a similar marrow population in baboons, it was possible to test whether this antigen is expressed by stem cells responsible for hematopoietic reconstitution in vivo. (nih.gov)
- CD34+ cells were enriched from marrows of five baboons using avidin-biotin immunoadsorption. (nih.gov)
- After lethal irradiation, the five animals were given 15-27 X 10(6) autologous marrow cells (3.2-4.4 X 10(6) cells/kg) containing 65-91% CD34+ cells. (nih.gov)
- Two additional animals received 184 and 285 X 10(6) marrow cells/kg depleted of CD34+ cells. (nih.gov)
- The data suggest that stem cells responsible for hematopoietic reconstitution are CD34+. (nih.gov)
- Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
- Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
- Numbers of SSClo CD45(dim) CD34(hi) cells and SSClo ALDH(br) cells were highly correlated in both peripheral blood and apheresis products (P (ogu.edu.tr)
- According to our data, numbers of SSClo ALDH(br) cells are in very good agreement with numbers of SSClo CD45(dim) CD34(hi) cells and can be a predictor of stem cell mobilization. (ogu.edu.tr)
- T cells are a type of white blood cell that develop from stem cells in the bone marrow. (childrenscolorado.org)
- For this type of cellular therapy, we draw blood from a patient to collect circulating T cells, which are an important part of the body's immune system. (childrenscolorado.org)
- B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
- These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)
- These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
- Smith and Broxmeyer, 1986), thereby making it a potential source of cells for transplantation (Bodger, 1987). (nationalacademies.org)
- FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)
- What are stem cells? (mdanderson.org)
- Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
- Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
- A hematopoietic stem cell transplant replaces faulty cells so the body can produce normal, healthy cells again. (mdanderson.org)
- An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
- Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
- Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
- With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
- Hematopoietic stem cell transplantation is a procedure that involves the infusion of stem cells to treat patient malignancies or to repair diseased or defective bone marrow. (lovesorghum.com)
- A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
- When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
- The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
- The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
- These are the important cells that are transferred during bone marrow or stem cell transplantation. (ucsfhealth.org)
- Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
- When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
- When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
- Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
- When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
- The stem cells are not administered directly back into the bone, but travel to the bones from the blood stream. (ucsfhealth.org)
- For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
- Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
- Bone marrow donation can be done either by collecting a donor's bone marrow surgically, or by removing stem cells from a donor's blood. (medlineplus.gov)
- Their stem cells are more likely to help patients than stem cells from older people. (medlineplus.gov)
- The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
- Donor stem cells can be collected in two ways. (medlineplus.gov)
- Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
- First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
- The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. (medlineplus.gov)
- The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
- To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
Lymphoma8
- Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- This department provides medical care for patients with blood disorders, including anemia and thrombocytopenia, and neoplastic disorders such as leukemia and malignant lymphoma. (japanhospitalsearch.org)
- Children and teens with rare childhood non-Hodgkin lymphoma are treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center through the Childhood Lymphoma Program in our Childhood Hematologic Malignancy Center . (dana-farber.org)
- Treatment for Hodgkin lymphoma (HL) is tailored to each individual and may include surgery, radiation therapy, chemotherapy, precision cancer medicines and or stem cell transplant in selected situations. (hoapb.com)
- The expert Oncologists and Hematologists provide related treatment and outpatient care service for all varieties of blood disorders such as anaemia, bleeding disorders such as haemophilia, blood clots, thalassemia and cancers such as leukaemia, lymphoma, and myeloma. (jaypeehealthcare.com)
- People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
Patients16
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Wisplinghoff H , Reinert RR , Cornely O , Seifert H . Molecular relationships and antimicrobial susceptibilities of viridans group streptococci isolated from blood of neutropenic cancer patients. (cdc.gov)
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- This department provides medical care for patients with heart disorders, disorders of the aortas and peripheral vessels, and hypertension. (japanhospitalsearch.org)
- Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
- Thirty-eight patients (4.83%) had pathologic findings before transplantation. (slideshare.net)
- Equivalent numbers of patients in both cohorts received bone marrow or peripheral blood allogeneic or autologous stem cell transplantation (SCT). (elsevierpure.com)
- Eight percent (4/50) of patients had low bone mineral density. (bvsalud.org)
- As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
- Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
- Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. (cellsurgicalnetwork.com)
- Stem cell-based therapy has emerged as a therapeutic option with unsolved issues for IUA patients in the past few years. (biomedcentral.com)
- Thirty patients (20 males and 10 females), who were candidates for autologous peripheral blood stem cell transplantation, were included in the study. (ogu.edu.tr)
- For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)
- Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
- Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
International Bone Marrow Transplant R1
- The International Bone Marrow Transplant Registry , the National Marrow Donor Program (NMDP) and U.S. News & World Report recognize Children's Colorado as meeting the highest standards of 100-day and one-year post-BMT survival compared to other U.S. pediatric BMT programs. (childrenscolorado.org)
Having a bone marrow tra1
- However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
Cord Blood Stem Cell Transplant2
- Iodine-131-metaiodiobenzylguanidine ( 131 I-MIBG) therapy combined with allogeneic cord blood stem cell transplantation (SCT) was used to treat a 4-year-old girl with recurrent neuroblastoma. (biomedcentral.com)
- We decided to perform cord blood stem cell transplantation (CBSCT) for hematopoietic rescue after the myeloablative therapies. (biomedcentral.com)
Solid tumors2
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
Recurrence2
- The recurrence, which presented with multiple metastases in the bone marrow, occurred 2 years after PBSCT (Figure 1 A). At this time, VAM and HVA had increased to 273.5 and 87.7 μg/mg Cr, respectively. (biomedcentral.com)
- 3: Mörner M, Gunnarsson U, Jestin P, Egenvall M. Volume of blood loss during surgery for colon cancer is a risk determinant for future small bowel obstruction caused by recurrence--a population-based epidemiological study. (cancercentrum.se)
Leukemia3
- Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. (fredhutch.org)
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Syngeneic1
- GVHD has been reported after syngeneic and autologous transplantation but is rare. (medscape.com)
Indication for transplantation1
- Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
Lymphoproliferative3
- Blaes AH, Morrison VA: Post-transplant lymphoproliferative disorders following solid-organ transplantation. (karger.com)
- Draoua HY, Tsao L, Mancini DM, Addonizio LJ, Bhagat G, Alobeid B: T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience. (karger.com)
- Yang F, Li Y, Braylan R, Hunger SP, Yang LJ: Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation. (karger.com)
Pediatric Blood2
- That's why our Pediatric Blood and Marrow Transplant and Cellular Therapy Program team is committed to the highest standards of quality, the latest and most proven treatments, and the overall care and well-being of your child and family. (childrenscolorado.org)
- Our team is the region's most experienced pediatric blood and marrow transplant and cellular therapy (BMT) program. (childrenscolorado.org)
Immune2
- Dana-Farber/Boston Children's offers internationally renowned care for children with cancers of the blood and immune system. (dana-farber.org)
- Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
HSCTs2
- G-CSF is a commonly used mobilizing agent for practically all autologous and a majority of allogeneic HSCTs and is known to increase CD34+ concentration. (bdbiosciences.com)
- Herein we report on 1125 HSCTs, including 570 peripheral blood stem cell transplantations (PBSCTs) (290 autologous [auto-] and 280 allogeneic [allo-]), 332 allo-bone marrow transplantations (allo-BMTs) and 223 allo-cord blood transplantations (allo-CBTs). (elsevierpure.com)
Donor's1
- If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
Radiation1
- The best response after surgery, HDCT, and radiation therapy was assessed 60 days after transplantation. (elsevierpure.com)
Disease4
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- Journal Article] Different impact of BCR-ABL transcripts on allogeneic hematopoietic cell transplantation from different graft sources for Ph+ALL with minimal residual disease. (nii.ac.jp)
- These subjects developed increased bone disease or symptoms of bone disease. (medscape.com)
- Intermediate-risk subjects did not have bone disease or an M protein level greater than 3 g/dL or a Bence Jones protein level greater than 5 g/24 h. (medscape.com)
Transfusion1
- This is similar to a blood transfusion. (leukaemia.org.au)
Neuroblastoma1
- The subject was a 2-year-old female with a diagnosis of stage 4 neuroblastoma with unfavorable histology according to the international neuroblastoma pathology classification, non-amplification of MYCN, and primary localization to the left adrenal gland with metastasis to the thoracic vertebrae, pelvis, and bone marrow. (biomedcentral.com)
19882
- Blood 1988;72:520-529. (karger.com)
- It was only until 1988 when the same group could report on their first successful bone marrow transplant (León-Rodríguez et al. (revistadehematologia.org.mx)
METHODS1
- The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
Donors4
- 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
- Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
- Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
- In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
Cancer6
- Gassas A , Grant R , Richardson S , Dupuis LL , Doyle J , Allen U , Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients. (cdc.gov)
- Pediatr Blood Cancer 2008;50:415-418. (karger.com)
- Pediatr Blood Cancer 2008;50:667-670. (karger.com)
- Blood Cancer Journal 2016 May 13;6:e422. (fredhutch.org)
- In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
PBSCT1
- The patient was treated with chemotherapeutic drugs (cyclophosphamide, vincristine, therarubicin, and cisplatin), irradiation of the abdominal cavity, and surgical resection of the adrenal gland, followed by autologous peripheral blood stem cell transplantation (PBSCT). (biomedcentral.com)
Hematology2
- 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
- Our top-ranked hematology, oncology, blood and marrow transplant and cellular therapy programs are national leaders in new and advanced treatments for pediatric cancers and blood diseases. (childrenscolorado.org)
Patient3
- The patient experienced relapse 2 years after receiving first-line therapies, which included chemotherapy, surgical resection, irradiation, and autologous peripheral SCT. (biomedcentral.com)
- Patient with severe aplastic anemia is doing well after Bone Marrow Transplantation. (jaypeehealthcare.com)
- The standards indicate that our transplant team has been consistently recognized through national peer review for high-quality patient care and laboratory performance for bone marrow transplant. (childrenscolorado.org)