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Hematopoietic Stem Cell TransplantationTransplantation, AutologousHematopoietic Stem CellsTransplantation ConditioningStem CellsMelphalanPeripheral Blood Stem Cell TransplantationMultiple MyelomaCombined Modality TherapyAntigens, CD34Hematologic NeoplasmsMyeloablative AgonistsTreatment OutcomeWhole-Body IrradiationCyclophosphamideDisease-Free SurvivalHematopoietic Stem Cell MobilizationSalvage TherapyLymphoma, Non-HodgkinGraft SurvivalHematopoiesisRetrospective StudiesStem Cell TransplantationRemission InductionSurvival RateTransplantation, HomologousAntineoplastic Combined Chemotherapy ProtocolsCell DifferentiationRecurrenceImmunosuppressive AgentsStem Cell NicheCell LineageAdult Stem CellsBone Marrow CellsEmbryonic Stem CellsSurvival AnalysisColony-Forming Units AssayAntineoplastic AgentsBone Marrow TransplantationPrognosisStem Cell FactorPluripotent Stem CellsMice, Inbred C57BLMultipotent Stem CellsGraft vs Host DiseaseFlow CytometryBone MarrowCells, CulturedCell SeparationFetal BloodCell ProliferationHematopoietic SystemInduced Pluripotent Stem CellsMesenchymal Stem Cell TransplantationMesenchymal Stromal CellsMesonephrosNeural Stem CellsMice, SCIDFetal Stem CellsTransplantation ChimeraBlood Transfusion, AutologousCord Blood Stem Cell TransplantationMice, Inbred NODProto-Oncogene Proteins c-kitCell Culture TechniquesLentivirusGranulocyte Colony-Stimulating FactorTransduction, GeneticLeukemiaChimerismAntigens, CDGenetic VectorsRetroviridaeMyeloid Progenitor CellsTime FactorsTissue DonorsNeoplastic Stem CellsLymphopoiesisMice, KnockoutMice, TransgenicBusulfanHematopoiesis, ExtramedullaryRadiation ChimeraCell DivisionCoculture TechniquesGenetic TherapyRegenerationStromal CellsT-LymphocytesHistocompatibility TestingSignal TransductionThrombopoietinAntigens, CD38Antigens, LyEmbryo, MammalianLeukemia, Myeloid, AcuteHematologic DiseasesHistocompatibilityReverse Transcriptase Polymerase Chain ReactionImmunophenotyping
HSCTTransplantsMorbidity and MortaChemotherapyAHSCTEmbryonic stemCancersMobilizationIntravenous infusionInfusionTransplantation versusDonorFollicular lymphomaRemissionHigh-doseTherapyPatientsMarrowComplicationsDoseHematologicalRecipientsClinicalUmbilicalTumor cellsProgenitorTreatmentRegimenEfficacyMultipleDiffuse large B-SignificantlyRefractoryBindsTherapiesMesenchymalLymphomaToxicityPatient'sTypes of stemSurvivalBlood
HSCT14
  • Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. (ox.ac.uk)
  • The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. (ox.ac.uk)
  • Hematopoietic stem cell transplantation (HSCT) has been shown to be effective. (medscape.com)
  • In the prospective Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, a phase 3 comparison of autologous HSCT with 12 successive monthly intravenous pulses of cyclophosphamide in 156 patients with early diffuse cutaneous systemic sclerosis, HCST was associated with higher treatment-related mortality than in the first year after treatment. (medscape.com)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • 1 line of systemic therapy in case of participants ineligible for high-dose chemotherapy and autologous Hematopoietic stem cell transplantation (HSCT). (who.int)
Transplants5
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • To understand the different types of stem cell transplants and how they work, we spoke with Borje S. Andersson, M.D., Ph.D. Here's what he had to say. (mdanderson.org)
  • What are the types of stem cell transplants? (mdanderson.org)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
Morbidity and Morta2
Chemotherapy11
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Patients undergo myeloablative chemotherapy conditioning to kill stem cells in the bone marrow before infusion with elivaldogene autotemcel, which allows their modified stem cells to replace stem cells lacking a functional copy of the ABCD1 gene. (wikipedia.org)
  • Ablative (myeloablative) treatment -- High-dose chemotherapy, radiation, or both are given to kill any cancer cells. (medlineplus.gov)
  • Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. (medlineplus.gov)
  • After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make normal blood cells. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • We extract blood cells, treat the cancer with high-dose chemotherapy , then place the cells back into the patient. (mdanderson.org)
  • Once the cancer is less active and the patient has been pre-treated with chemotherapy (known as conditioning), he or she receives the donor's healthy stem cells. (mdanderson.org)
  • They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
AHSCT1
  • Background: Effectiveness of autologous haematopoietic stem-cell transplantation (AHSCT) in relapsing-remitting multiple sclerosis (MS) is well known, but in secondary-progressive (SP-) MS it is still controversial. (unifi.it)
Embryonic stem4
Cancers6
  • For many cancers, the donor's white blood cells may attack any remaining cancer cells, which are seen as foreign, similar to when white cells attack bacteria or viruses when fighting an infection. (medlineplus.gov)
  • A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
  • Blood cancers multiply uncontrollably, hindering the growth of these cells. (mdanderson.org)
  • Lymphomas are cancers that involve white blood cells, and can be divided depending on the type of cell involved, either B-lymphocytes or T-lymphocytes. (rarediseases.org)
  • Mantle cell lymphoma belongs to a group of diseases known as non-Hodgkin's lymphomas, which are related malignancies (cancers) that affect the lymphatic system. (rarediseases.org)
  • My core clinical focus is autologous, allogeneic and cord blood hematopoietic stem cell transplant patients with blood cancers. (dukehealth.org)
Mobilization2
Intravenous infusion1
  • Elivaldogene autotemcel is a one-time treatment given as an autologous intravenous infusion. (wikipedia.org)
Infusion2
  • Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
  • Modified bone marrow replaces dysfunctional bone marrow with elivaldogene autotemcel infusion, which allows differentiated hematopoietic cells to breakdown VLCFAs in the blood and brain, slowing or stabilizing the progression of CALD. (wikipedia.org)
Transplantation versus1
Donor9
  • Elivaldogene autotemcel is indicated for the treatment of people with early, active CALD in boys aged 4 to 17 for whom a matched hematopoietic stem cell donor is not available. (wikipedia.org)
  • Stem cells are removed from another person, called a donor. (medlineplus.gov)
  • Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
  • The red blood cells are returned to the donor. (medlineplus.gov)
  • Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
  • With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
  • This allows us to collect more cells in a short period, decrease patient/donor downtime and freeze the cells for future use. (mdanderson.org)
  • If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
  • Or, the cells from the donor may recognize the new body as foreign and attack. (mdanderson.org)
Follicular lymphoma2
Remission3
  • Multivariable analysis revealed that creatinine ≥2 mg/dl, extramedullary disease, ≤very good partial remission and non-autologous hematopoietic stem cell transplantation are independent risk factors for shorter survival. (scielo.br)
  • Following that, patients may be eligible for a stem cell transplant, and/or an extended course of immunotherapy that is meant to prolong cancer remission. (rarediseases.org)
  • Remission is when there are less than 5% blast cells in the bone marrow. (oncolink.org)
High-dose1
Therapy15
  • Elivaldogene autotemcel is a form of autologous hematopoietic stem cell therapy where stem cells are mobilized and collected from the patient and genetically modified to carry a functional copy of the ABCD1 gene using a lentiviral vector. (wikipedia.org)
  • Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). (ox.ac.uk)
  • Explore REVLIMID for multiple myeloma maintenance therapy after receiving a stem cell transplant. (revlimid.com)
  • Although safety remains a concern, investigators are breaking ground in cell and gene therapy, and many believe that ultimately, a string of cancer cures will follow. (ajmc.com)
  • Although only a handful of cell and gene therapies are on the market, FDA officials predicted in 2019 that the agency will receive more than 200 investigational new drug applications per year for cell and gene therapies, and that by 2025, it expects to have accelerated to 10 to 20 cell and gene therapy approvals per year. (ajmc.com)
  • Cell therapy involves cultivating or modifying immune cells outside the body before injecting them into the patient. (ajmc.com)
  • Gene therapy modifies or manipulates cell expression. (ajmc.com)
  • Juliette Hordeaux, PhD, senior director of translational research for the University of Pennsylvania's gene therapy program, is cautious about the FDA's predictions, saying she'd be "thrilled" with 5 cell and/or gene therapy approvals annually. (ajmc.com)
  • Safety has been the main brake around adeno-associated virus vector (AAV) gene therapy," added Hordeaux, whose hospital's program has the institutional memory of both Jesse Gelsinger's tragic death during a 1999 gene therapy trial as well as breakthroughs by Carl June, MD, and others in CAR T-cell therapy. (ajmc.com)
  • Yescarta), a CAR T-cell therapy for adults with large B-cell non-Hodgkin lymphoma. (ajmc.com)
  • Is Stem Cell Therapy Safe for Relapsing-Remitting Multiple Sclerosis Treatment? (medindia.net)
  • Relapsing-remitting multiple sclerosis has been successfully treated using autologous hematopoietic stem cell therapy. (medindia.net)
  • some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
Patients11
  • In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
  • The applicant was Bluebird Bio (Netherlands) B.V. In July 2021, the European Commission approved elivaldogene autotemcel under the tradename Skysona for CALD patients who have certain genetic mutations and don't have a sibling who is a match for a stem cell transplant. (wikipedia.org)
  • 3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
  • Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials. (ox.ac.uk)
  • Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)
  • In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. (scienceblog.com)
  • Although multiple myeloma patients younger than 66 years of age have an aggressive presentation, this did not translate into an inferior overall survival, particularly in those undergoing autologous hematopoietic stem cell transplantation. (scielo.br)
  • Patients with monoclonal gammopathy of unknown significance, smoldering MM, plasma cell leukemia and amyloidosis were excluded. (scielo.br)
  • The hematopoietic stem cells (CD34+ cells) are collected from the peripheral blood and used for autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma . (drugs.com)
  • I am also part of the autologous stem cell transplant team for patients with systemic scleroderma. (dukehealth.org)
  • To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
Marrow13
Complications1
  • The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
Dose1
  • Up to 12 adult participants with r/r aggressive B-cell NHL may be enrolled into a Run In dose level. (who.int)
Hematological1
Recipients1
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
Clinical3
  • Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
  • Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis. (unm.edu)
  • Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Umbilical3
  • Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
  • Umbilical cord blood cells are very immature so there is less of a need for perfect matching. (medlineplus.gov)
  • The cells for a cord blood transplant come from an umbilical cord collected at birth by the MD Anderson Cord Blood Bank . (mdanderson.org)
Tumor cells3
  • Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
  • At last, scientists had devised a way to reprogram a person's own T cells to attack tumor cells. (ajmc.com)
  • elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
Progenitor1
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Treatment8
  • Treatment with elivaldogene autotemcel adds functional copies of the ABCD1 gene using a lentiviral vector, which integrates the functional gene into the stem cell genome. (wikipedia.org)
  • An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
  • REVLIMID ® (lenalidomide) is a prescription medicine, used to treat adults with multiple myeloma (MM) in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation (a type of stem cell transplant that uses your own stem cells). (revlimid.com)
  • Novartis) for the treatment of B-cell precursor acute lymphoblastic leukemia. (ajmc.com)
  • The treatment is designed to wipe out the abnormally functioning leukemia cells. (oncolink.org)
  • But this treatment also destroys many healthy cells. (oncolink.org)
  • These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis as well as the development of new teeth. (bvsalud.org)
  • 8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)
Regimen1
  • Relapse rates dropped to zero after an intensive regimen of autologous hematopoietic stem cell transplant, but improvement is greater with lower baseline disability. (medscape.com)
Efficacy1
  • Stem Cells in MS Show Promise The results of this trial suggest that RCTs to assess safety and efficacy of autologous hematopoietic SCT in multiple sclerosis are warranted, says Dr Barclay. (medscape.com)
Multiple3
  • Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • Monoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells. (medscape.com)
  • Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Diffuse large B-1
  • Several factors hinder the identification of risk factors for central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL), including the retrospective nature of most studies, the relatively low frequency of CNS relapse in DLBCL, and the heterogeneity of CNS prophylaxis methods used in these studies. (haematologica.org)
Significantly1
  • Significantly, we observed that following autoHSCT, NK cells acquired a decidual-like gene expression profile , including the expression of CD9. (bvsalud.org)
Refractory1
  • Kite Pharma, a subsidiary of Gilead, received an accelerated approval in July 2020 for brexucabtagene autoleucel (Tecartus) for adults with relapsed or refractory mantle cell lymphoma. (ajmc.com)
Binds2
  • Hematopoietic stem cell mobilizer binds to the CXCR4 chemokine receptor and inhibits the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1-alpha). (drugs.com)
  • When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
Therapies2
  • In total, 3 CAR T-cell therapies are now on the market, all targeting the CD19 antigen. (ajmc.com)
  • Conclusion: stem cells from dental origin are an interesting alternative for research and application in regenerative therapies in Dentistry. (bvsalud.org)
Mesenchymal1
  • Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)
Lymphoma3
  • Serum Levels of the Chemokine CXCL13, Genetic Variation in CXCL13 and Its Receptor CXCR5, and HIV-Associated Non-Hodgkin B-Cell Lymphoma Risk. (medscape.com)
  • Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, which is a form of cancer that affects the lymphatic system. (rarediseases.org)
  • MCL is a B-cell lymphoma that develops from malignant B-lymphocytes within a region of the lymph node known as the mantle zone. (rarediseases.org)
Toxicity1
  • Receptors recognizing and then attacking normal cells is what can cause toxicity. (ajmc.com)
Patient's3
  • The patient has low blood counts until the replaced cells replenish the patient's body with healthy cells. (mdanderson.org)
  • The transplanted cells kill any remaining cancer cells and restore the patient's immune system. (mdanderson.org)
  • After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system. (scienceblog.com)
Types of stem1
  • Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. (bvsalud.org)
Survival1
  • Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Blood7