Autologous hematopoietic stem cell transplantation for patients with multiple myeloma survival allogeneic stem cell transplantation. Medical search. Frequent questions

Indication HIV in AIDS-lymphoma patients. (ca.gov)
Therapeutic Mechanism Bone marrow transplants are standard of care for AIDS-lymphoma patients providing a cure for the patient's lymphoma. (ca.gov)
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
Other than comorbidities, significant impact was observed for heavily pretreated patients, age ≥ 55 years, non-Hodgkin lymphoma, and bendamustine-etoposide-citarabine-melphalan conditioning. (austral.edu.ar)
Bone marrow cancers such as multiple myeloma , leukaemia, and lymphoma , reduce the formation of HSCs in the bone marrow. (parkwaycancercentre.com)
SummaryDiffuse large B‑cell lymphoma (DLBCL) comprises 30-40% of non-Hodgkin's lymphoma. (deepdyve.com)
Autologous HCT (auto-HCT) in older patients may confer a slightly increased risk of specific toxicities (such as cardiac toxicities and mucositis) and have modestly lower effectiveness (in the case of lymphoma). (nccn.org)
However, auto-HCT remains a feasible, safe, and effective therapy for selected older adults with multiple myeloma and lymphoma. (nccn.org)
In this review, we aim to summarize the composition of CAR-T cell and its application in the treatment of acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), multiple myeloma (MM), and acute myeloid leukemia (AML). (hindawi.com)
The tumor was successfully treated with chemotherapy, but 3 years later she was diagnosed with T-cell lymphoblastic lymphoma. (bvsalud.org)
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Pre-emptive treatment with rituximab of molecular relapse after autologous stem cell transplantation in mantle cell lymphoma. (smw.ch)
T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. (uchicago.edu)
Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
The European Medicines Agency's Committee for Medicinal Products for Human Use has recommended the approval of lisocabtagene maraleucel for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and follicular lymphoma grade 3B following 2 or more lines of systemic therapy. (onclive.com)
liso-cel) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), and follicular lymphoma grade 3B (FL3B) following 2 or more lines of systemic therapy. (onclive.com)
Patients who previously underwent hematopoietic stem cell transplantation were permitted, as well as those with secondary central nervous system (CNS) lymphoma. (onclive.com)
Moreover, 99% of patients had an ECOG performance status of 0, 3% had secondary CNS lymphoma, 67% were refractory to chemotherapy, and 44% had never achieved a CR. (onclive.com)
Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
Diffuse large B cell lymphoma (DLBCL) represents the most frequent form of non-Hodgkin's lymphoma (NHL). (frontiersin.org)
Her clinical and research interests lie in improving the outcomes of patients with lymphoma. (mdanderson.org)
Dr. Pinnix's ultimate aspiration is to advance the clinical outcomes of patients afflicted with Hodgkin's and Non-Hodgkin's lymphoma via the minimization of normal tissue toxicity related to radiotherapy. (mdanderson.org)
Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
In addition to systemic treatments and/or targeted therapies, both autologous and allogeneic haematological progenitor transplantation (commonly called bone marrow transplantation) continues today to be part of the treatment plan for many patients with various haematological diagnoses such as leukaemia, lymphoma and multiple myeloma . (mdanderson.es)

Abstract Introduction: Graft-versus-host disease (GVHD) is a serious complication in allogeneic transplantation. (scielo.org)
Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)
Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide. (stembook.org)
Chronic Graft-Versus-Host Disease, Non-Relapse Mortality and Disease Relapse in Older versus Younger Adults Undergoing Matched Allogeneic Peripheral Blood Hematopoietic Cell Transplantation: A CIBMTR Analysis. (stembook.org)
Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (uchicago.edu)
Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)

Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. (wikipedia.org)
Results showed that adding quizartinib to standard chemotherapy with or without allogeneic hematopoietic stem cell transplantation, followed by continuation monotherapy for up to 3 years, resulted in improved overall survival. (medscape.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Seventy-six percent of patients were treated with intensive chemotherapy. (scielo.org)
The median survival of patients treated with intensive chemotherapy aged less than 60 years and 60 years and above was 3.4 and 1 year, respectively. (scielo.org)
Stem cell therapy, or stem cell transplant, is a procedure that aims to restore blood-forming stem cells in patients who have undergone chemotherapy or radiotherapy . (parkwaycancercentre.com)
Autologous stem cell (patient's own stem cells) transplant is used to help patients recover from the effects of chemotherapy. (parkwaycancercentre.com)
Allogeneic stem cell (stem cells from a donor) transplant is used to help patients recover from the effects of chemotherapy and/or radiotherapy as well as to eradicate the remaining cancer cells in the patient after chemotherapy and/or radiotherapy. (parkwaycancercentre.com)
Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
The patient first receives a high dose of chemotherapy and/ or radiotherapy to eliminate the remaining cancer cells in the body. (parkwaycancercentre.com)
In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
We determined the incidence and the prognostic significance of HZ and its correlation with VZV serology in 191 consecutive myeloma patients undergoing high-dose melphalan chemotherapy with ASCT. (nature.com)
Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
The occurrence of secondary neoplasms in adult patients treated with chemotherapy in childhood is not uncommon. (bvsalud.org)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
Patients with early-stage CLL, including low Binet or Rai stages, are not treated with chemotherapy until they become symptomatic or display evidence of rapid progression of disease. (medscape.com)
Early initiation of chemotherapy has failed to show survival benefit in CLL. (medscape.com)
Clinical scientists continue to observe superior survival of patients treated with combined chemotherapy and radiation approaches, yet the mechanisms behind this synergistic therapeutic approach are not fully understood. (mdanderson.org)
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
Previously in July 2023, the FDA granted approval to the combination of quizartinib and standard cytarabine and anthracycline induction and standard cytarabine consolidation chemotherapy, and as continuation monotherapy following consolidation, for the treatment of adult patients with newly-diagnosed, FLT3 -ITD-positive AML based on published findings from QuANTUM-First. (oncnursingnews.com)
Chemotherapy is not needed in CLL until patients become symptomatic or display evidence of rapid progression of disease. (medscape.com)
Once prepared, the haematopoietic progenitors are infused back into the patient after an intensification process with high doses of chemotherapy . (mdanderson.es)
After applying high doses of chemotherapy, we rescue the person with his or her own cells to repopulate his or her bone marrow and start the normal production of red blood cells, white blood cells and platelets again ," states the doctor. (mdanderson.es)
For its part, an allogeneic transplant does not focus its curative intention on chemotherapy but on the contrary: here, chemotherapy serves to prepare the patient who will receive the cells from a donor and to help him/her nest these cells properly . (mdanderson.es)
In autologous transplantation the tool is chemotherapy, in allogeneic transplantation it is the new immune system and in CAR-T cell therapy it is the patient's own re-educated T-lymphocytes ," concludes this expert. (mdanderson.es)
The patients underwent chemotherapy prior to receiving their gene-edited stem cells, similar to a patient undergoing an autologous blood and marrow transplant. (healthcare.pro)

In our program, transplants with age- adjusted conditioning are performed in patients until 70 years old. (scielo.org)
Frequently, stem cells are taken from the pelvic bone, filtered, and stored under special conditions for future transplants. (parkwaycancercentre.com)
Additionally, stem cell transplants can also be categorised based on who donates the stem cells. (parkwaycancercentre.com)
There are several types of stem cell transplants, with allogeneic stem cell transplantation being one of the most common. (medical-definitions.net)
Contrary to popular belief, stem cell transplants have a relatively low death rate. (medical-definitions.net)
Blood-forming stem cell transplants. (mayoclinic.org)
Survival Outcomes of Allogeneic Hematopoietic Cell Transplants with EBV positive or EBV negative Post Transplant Lymphoproliferative Disorder (PTLD), A CIBMTR Study. (stembook.org)
BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
Firstly, precisely these haematopoietic progenitors are key in autologous and allogeneic transplants, but not in CAR-T therapies. (mdanderson.es)

In a study published in the journal "Blood" in 2015, the non-relapse mortality rate at 1 year post-transplant was 15.4% for myelofibrosis patients undergoing reduced-intensity allogeneic stem cell transplantation. (medical-definitions.net)
Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)

The plasma cells can also form a mass in the bone marrow or soft tissue. (wikipedia.org)
Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibody proteins - (often using electrophoretic techniques revealing the presence of a monoclonal spike in the results - termed an m-spike), bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)
Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (merckmanuals.com)
Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)
Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. (scielo.org)
HSCs mostly stay in the bone marrow and mature into blood cells as they grow. (parkwaycancercentre.com)
The damaged bone marrow will then be replenished with new stem cells to alleviate the side effects of the high-dose therapy. (parkwaycancercentre.com)
Stem cells are collected from the bone marrow - the spongy soft tissues in the bones. (parkwaycancercentre.com)
Additionally, patients do not need to undergo the bone marrow procedure under sedation. (parkwaycancercentre.com)
Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
Design and Methods OPM2 and high-risk primary myeloma tumors were grown in human fetal bone implanted into non-obese diabetic severe combined immunodeficiency mice with a deficient interleukin-2 receptor gamma chain. (haematologica.org)
These mice are devoid of endogenous natural killer and T-cell activity and were used to determine whether adoptively transferred expanded natural killer cells could inhibit myeloma growth and myeloma-associated bone destruction. (haematologica.org)
The transferred, expanded natural killer cells proliferated in vivo in an interleukin-2 dose-dependent fashion, persisted up to 4 weeks, were readily detectable in the human bone, inhibited myeloma growth and protected bone from myeloma-induced osteolysis. (haematologica.org)
Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
Patients with low monthly family income (OR=3.14, p=0.010) and complications of MM bone disease (OR=2.95, p=0.029) were more likely to belong to class 2. (bmj.com)
We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
A 78-year-old woman with lung adenocarcinoma and multiple bone metastases received maintenance therapy with pemetrexed + pembrolizumab for a year. (journaltocs.ac.uk)
WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
The morphological examination of peripheral blood or bone marrow smears, although still an indispensable part of routine laboratory testing, is clearly insufficient for patient management, and clinicians should not ask themselves whether to look for MRD or not, but how and when. (smw.ch)
Choice of conditioning regimens for bone marrow transplantation in severe aplastic anemia. (stembook.org)
Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
Abstract Objective To evaluate the clinical and radiographic results and survival of the acetabular revision surgery of total hip arthroplasty with cemented implant without the use of reinforcement ring, associated with structural homologous bone grafting. (bvsalud.org)
Also, there was an association between absence of radiographic signs of osseointegration of the structural graft and failure in this series of patients with large bone defects. (bvsalud.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
For example, neutropenia or autologous bone marrow transplantation (BMT) have less adverse prognostic implications than two decades ago. (springeropen.com)
Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
It is these donor cells that, once infused into the patient, will populate the bone marrow and rebuild the immune system, which is called the graft-versus-disease effect ," highlights this specialist. (mdanderson.es)
Multiple myeloma is a bone marrow disease characterized by the presence of malignant plasma cells, & abnormal serum &/or urine immunoglobulin secondary to clonal plasma cell expansion. (mims.com)
Patient usually presents with bone pain & nonspecific symptoms, or due to abnormalities in laboratory exams. (mims.com)

Findings were presented at the 11th Annual Meeting of the Society of Hematologic Oncology (SOHO 2023) and focused on the subset of patients from the trial who went to transplant in first remission. (oncnursingnews.com)

Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Simply put, this procedure entails introducing healthy stem cells into a patient's body to replace damaged or unhealthy cells. (medical-definitions.net)
Cancer immunotherapies aim to support or boost the patient's immune system to enable the effective clearance of cancer cells. (nature.com)
First, T or NK cells are isolated from patient's or donor's blood. (nature.com)

Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. (haematologica.org)
Despite chemo-induction therapy and autologous stem cell transplantation (ASCT), the vast majority of patients with Multiple Myeloma (MM) relapse within 7 years and the disease remains incurable. (biomedcentral.com)
We first demonstrated that myeloma bearing-Balb/c mice initially respond clinically to irradiation and auto-BMT but eventually relapse, similar to MM patients undergoing induction therapy and ASCT. (biomedcentral.com)
By then infusing the animals with B10.D2 T cells from only the TCR Vβ 2, 3 and 8.3 families appropriately pre-activated in vitro, we saw a vigorous GvM response without any clinical or histological signs of GvHD or disease relapse, which translated into long-term, disease-free survival. (biomedcentral.com)
Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial. (smw.ch)
Predictors for survival after transplant relapse. (uchicago.edu)
National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
I. Estimate overall survival (OS), cumulative incidences of relapse/disease progression, and non-relapse mortality (NRM) in each arm at 100 days, and 1 year post-transplant. (survivornet.com)
This phase III trial comparing idarubicin with high-dose daunorubicin as part of induction therapy in AML did not find significant differences in complete remission rates, relapse, or survival. (ascopost.com)
however, patients who experience early relapse, or who are refractory to initial immunochemotherapy have a poor prognosis ( 3 ). (frontiersin.org)
Additional exploratory end points of the study were relapse-free survival and duration of CR. (oncnursingnews.com)
Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)

Elranatamab is indicated for adults with relapsed or refractory multiple myeloma who have received at least 4 prior therapies, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (medscape.com)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)
Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)

SummaryChimeric antigen receptor T cells (CAR-T cells) are a novel form of cellular immunotherapy for patients with hematologic and oncologic malignancies. (deepdyve.com)
Hematopoietic cell transplantation (HCT) provides a life-prolonging or potentially curative treatment option for patients with hematologic malignancies. (nccn.org)
T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
Current treatment protocols for haematological malignancies allow most patients to obtain some form of MRD state, but cure seldom follows and in most cases fatal relapses occur sooner or later, leaving a bitter impression of having won a battle yet lost the war. (smw.ch)
Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
Regimen-related toxicity after fludarabine-melphalan conditioning: a prospective study of 31 patients with hematologic malignancies. (uchicago.edu)
Natural killer (NK) cells can kill cancer cells in the absence of prior stimulation and hold considerable potential for cell-based therapies targeting human malignancies ( 1 - 4 ). (aacrjournals.org)
Although the initial reports showed dismal prognosis, recent data suggest that an increased number of patients with solid and hematological malignancies benefit from intensive care support, with dramatically decreased mortality rates. (springeropen.com)
Advances in the management of the underlying malignancies and support of organ dysfunctions have led to survival gains in patients with life-threatening complications from the malignancy itself, as well as infectious and toxic adverse effects related to the oncological treatments. (springeropen.com)
The research in this laboratory is primarily focused on developing new approaches to improve the outcome of patients with hematologic malignancies undergoing allogeneic hematopoietic stem cell transplantation. (columbia.edu)
The authors used a voluntary data collection registry for which providers or sites caring for patients with hematologic malignancies and COVID-19 infection submitted deidentified data via an online data collection platform. (healthcare.pro)

Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. (wikipedia.org)
Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma. (stembook.org)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
The patient received allogeneic hematopoietic stem cell transplantation (allo-HSCT) from human leukocyte antigen (HLA) matched related donor. (bvsalud.org)
The implementation of reduced intensity conditioning and progress in supportive care enabled to perform allo-HSCT in elderly patients. (bvsalud.org)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)

Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)
It gives the patient a whole new and healthy immune system of the donor. (parkwaycancercentre.com)
The donor immune cells can kill the leftover cancer cells and will exert a "graft-versus-cancer" effect, keeping the cancer cells in check. (parkwaycancercentre.com)
A donor, either related or unrelated to the patient, who donates the stem cells for transplant. (parkwaycancercentre.com)
Finding a donor with suitable stem cells is critical to avoid graft rejection or graft-versus-host syndrome. (parkwaycancercentre.com)
Many factors dictate whether the donor stem cells are suitable for the recipient but the most important one is the human leukocyte antigen (HLA) system. (parkwaycancercentre.com)
Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
Since GvT responses involve T-cell recognition of tumor-specific peptides presented by MHC molecules [ 14 ], it may be possible to identify and select donor T cells that provide beneficial GvT responses but minimal GvHD risk. (biomedcentral.com)
The implication of these results would be that myeloma-specific T cell subfamilies might be positively selected from the donor inoculum and infused to myeloma patients post ASCT, to afford separation of allo- from tumor-reactive T cells without the prior need to define specific target antigens. (biomedcentral.com)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor type. (medical-definitions.net)
Most patients (65%) were transplanted from 10/10-HLA or 9/10-HLA matched unrelated donor, seven patients (14%) received stem cells from matched related donor and ten patients (20%) from haploidentical donor. (bvsalud.org)
Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
While in an autologous transplant there is no donor and the patient is the focus of the whole process, in an allogeneic transplant there is a donor and therefore compatibility studies must be carried out before starting the process ," explains the doctor. (mdanderson.es)

Tumor stem cell-targeted immunotherapy for metastatic melanoma -a randomized phase 3 clinical trial. (ca.gov)
Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Material and Methods: Review of electronic clinical records of 114 patients with AML with a median age of 57 years (59% men). (scielo.org)
Immuno-oncology has entered the field, and besides the checkpoint death receptor and ligand molecules PD-1/PD-L1 more molecules have been detected and are also tested in clinical studies.To provide equal opportunities to our patients the tests have to be implemented in all pathological institutes involved in lung cancer management. (deepdyve.com)
Clinical factors such as a high International Prognostic Index (IPI) or molecular factors as cell of origin (COO) have an influence on the clinical outcome after conventional immunochemotherapy. (deepdyve.com)
The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. (hindawi.com)
Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
Objectives To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status. (bmj.com)
The identification of patients with high symptom burden management should focus on the assessment of demographic and clinical characteristics, in addition to functional status. (bmj.com)
This study assessed between-group differences in the demographic and clinical characteristics and functional status of patients with MM. (bmj.com)
Patient clinical characteristics did not include the evaluation of treatment response. (bmj.com)
Most CAR-T cell-based gene therapy products that are under clinical evaluation consist of autologous enriched T cells, whereas CAR-NK cell-based approaches can be generated from allogeneic donors. (nature.com)
In this review, we are going to take a closer look at the commercial CAR-T cell therapies, as well as on CAR-T and CAR-NK cell products, which are currently under evaluation in clinical trials, that are being conducted in Germany. (nature.com)
The case described here presents a unique clinical scenario of a female patient who was successfully treated for her double malignancy. (bvsalud.org)
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms. (smw.ch)
The impact of pre-apheresis Health Related Quality of Life on peripheral blood progenitor cell yield and donor's health and outcome: Secondary analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials. (stembook.org)
We therefore adapted the K562-mb15-41BBL stimulation method to large-scale clinical-grade conditions, generating large numbers of highly cytotoxic NK cells. (aacrjournals.org)
The results that we report here provide rationale and practical platform for clinical testing of expanded and activated NK cells for cell therapy of cancer. (aacrjournals.org)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Blood cell and serum markers, along with clinical data of DLBCL patients who were scheduled for CART cell therapy were evaluated to search for biomarkers predicting CART cell responsiveness. (frontiersin.org)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
The study aimed to evaluate the impact of allo-HCT in CR1 and the interrelationship with quizartinib on clinical trial results in this patient population. (oncnursingnews.com)
In one study, Haydar Frangoul, M.D., of Children's Hospital at TriStar Centennial in Nashville, Tennessee, and colleagues found that gene editing using CRISPR-Cas9 is safe and feasible and can provide clinical benefit to patients with sickle cell disease and transfusion-dependent Ã -thalassemia. (healthcare.pro)

In 2020, there were an estimated 170,405 people living with myeloma in the U.S. It is difficult to judge mortality statistics because treatments for the disease are advancing rapidly. (wikipedia.org)
Hematopoietic Cell Transplantation-Specific Comorbidity Index Predicts Morbidity and Mortality in Autologous Stem Cell Transplantation. (austral.edu.ar)
The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) score is a useful tool to assess the risk for nonrelapse mortality (NRM) after allogeneic hematopoietic stem cell transplantation. (austral.edu.ar)
Added to this, there are patients who do not improve on any immunosuppressive treatment, with subsequent deteriorated quality of life and high mortality. (scielo.org)
Causes of mortality in those patients were severe viral pneumonia, post-transplantation hemophagocytic syndrome and meningeal GVHD refractory to ruxolitinib. (scielo.org)
However, the GVHD mortality remains high in refractory patients, showing that better therapeutic strategies are needed. (scielo.org)
In a study published in the journal "Biology of Blood and Marrow Transplantation" in 2010, the transplant-related mortality rate was less than 5% for patients undergoing autologous stem cell transplantation. (medical-definitions.net)
Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
However, their in-hospital mortality rates are not higher compared with critically ill patients with other comorbidities, such as heart failure, liver cirrhosis, or other serious chronic diseases [ 15 ]. (springeropen.com)
Reduction in late mortality among patients with Multiple Myeloma treated with Autologous Peripheral Blood Stem Cell Transplantation - a BMTSS Report. (stembook.org)

Prior to infusion of the CAR-modified immune cells, lymphodepletion is performed in most therapeutic settings to allow efficient cell engraftment [ 10 ]. (nature.com)
Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
The researchers found that gene editing using CRISPR-Cas9 to target the BCL11A in the erythroid cells resulted in stable and sustained engraftment. (healthcare.pro)

Indication The target indication is for the transplantation of patients with severe X-linked Chronic Granulomatous Disease (XCGD) lacking matched donors. (ca.gov)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
However, long-term disease-free survival rates may be lower than those with HLA-identical sibling donors. (msdmanuals.com)
Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)

Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)

Although the HCT-CI has been investigated in autologous stem cell transplantation (ASCT), its use is limited. (austral.edu.ar)
We retrospectively reviewed a cohort of 1730 records of adult patients who received an ASCT in Argentinean center's between October 2002 and August 2016. (austral.edu.ar)
The occurrence of varicella zoster virus (VZV) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (HZ) after autologous SCT (ASCT). (nature.com)
We found that VZV reactivation occurred in 57 (30%) patients, in 8.5% during induction and in 21.5% after ASCT peaking at 8 months after ASCT. (nature.com)
By immune fluorescence and Serion Elisa VZV IgG assessment, 90.8% of all patients had specific anti-VZV antibodies at ASCT. (nature.com)
Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
Finally, OS was better in myeloma patients with HZ after ASCT compared with patients without HZ ( P =0.007). (nature.com)
Our data indicate that VZV reactivation after ASCT is a frequent event carrying a significant disease burden and it is associated with improved survival. (nature.com)
Survival of patients with multiple myeloma (MM) beyond 7 years remains rare even after autologous stem cell transplantation (ASCT) and treatment with novel agents [ 1 ]. (biomedcentral.com)
Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)

Results: Since 2014, seventeen patients with GVHD were treated with ruxolitinib due to refractoriness to corticosteroids and immunosuppressants and a few to extracorporeal photopheresis, 8 with acute GVHD (1 pulmonary, 4 cutaneous grade IV and 3 digestive grade IV) and 9 with chronic GHVD (5 cutaneous sclerodermiform, 2 pulmonary and 1 multisystemic). (scielo.org)
Aim: To report our experience with ALOHT in acute myelogenous leukemia (AML), analyzing patient age at transplantation in different periods and transplant results in different age groups. (scielo.org)
It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
Acute GVHD developed in 22 patients (44%) with 5 individuals presenting grade III-IV. (bvsalud.org)
Post-Transplant cyclophosphamide is associated with increase in Non-CMV Herpesvirus infections in Acute leukemia and MDS patients. (stembook.org)
Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Similar expansions could also be obtained from the peripheral blood of patients with acute leukemia undergoing therapy ( n = 11). (aacrjournals.org)
The expanded NK cells were significantly more potent than unstimulated or IL-2-stimulated NK cells against acute myeloid leukemia cells in vitro . (aacrjournals.org)
This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
Quizartinib plus standard intensive induction and consolidation therapy was associated with longer survival rates in patients with FLT3-ITD-positive acute myeloid leukemia. (oncnursingnews.com)
Regardless of prior allogeneic hematopoietic cell transplantation (allo-HCT) or pre-allo minimal residual disease (MRD) status, patients with newly diagnosed, FLT3 -ITD-positive acute myeloid leukemia (AML) in their first complete remission (CR1) were found to achieve superior overall survival (OS) when quizartinib (Vanflyta) was added to their standard intensive induction and consolidation therapy, according to data from post-hoc analyses of the phase 3 QuANTUM-First study (NCT02668653). (oncnursingnews.com)

In the SIMPLIFY-1 multicenter, randomized, double-blind, phase III study, safety and efficacy of momelotinib was compared with ruxolitinib in 432 patients with myelofibrosis who had not received prior treatment with a JAK inhibitor. (medscape.com)
Allogeneic stem cell transplantation for myelofibrosis with leukemic transformation. (medical-definitions.net)
A Simple Prognostic System in Myelofibrosis Patients Undergoing Allogeneic Stem Cell Transplant: A CIBMTR/EBMT analysis. (stembook.org)
Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis. (stembook.org)
Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)

The biomarker criteria were added so that smouldering people with multiple myeloma at high risk of developing multiple myeloma could be diagnosed before organ damage occurred, so they would therefore have a better prognosis. (wikipedia.org)
Ruxolitinib treatment in patients with a very poor prognosis showed encouraging results. (scielo.org)
Patients with resistant or relapsed (r/r) DLBCL have a poor prognosis with a median overall survival of 6,3 months and low complete response rates (CR 7%) to salvage chemoimmunotherapy. (deepdyve.com)
The risk of dying was highest in patients who were older, had more severe infection, opted to forgo more intensive treatment, and/or had poorer prognosis before their COVID-19 infection, as determined by their treating clinicians," Wood said. (healthcare.pro)

Median overall survival was 31.9 months for quizartinib versus 15.1 months for placebo. (medscape.com)
Long-term (1 and 3 years) NRM was 4% and 5.2% and overall survival 89% and 77%, respectively. (austral.edu.ar)
No significant impact was observed in overall survival. (austral.edu.ar)
Therefore, this prospective study aimed to investigate the influence of transplanted cells with cluster of differentiation (CD)184+ expression, CD26+ lymphocytes and monocytes, and reconstitution of CD3+ lymphocytes on overall survival (OS) and progression-free survival (PFS) after auto-SCT in MM. Forty-eight patients with MM underwent auto-SCT at our center from 2011 to 2013. (bvsalud.org)
Overall survival was not significantly affected either, although it was 46 months with fludarabine compared with 64 months for chlorambucil. (medscape.com)
it showed superior progression-free and overall survival with ibrutinib-rituximab compared with FCR, in particular in patients without the IGHV mutation, and lower rates of serious infectious complications with ibrutinib-rituximab. (medscape.com)
For patients with chronic myelomonocytic leukemia, the overall response rate was higher for azacitidine plus lenalidomide vs azacitidine alone (68% vs 28%, P = .02) but similar for all arms across cytogenetic subgroups, as was remission duration and overall survival. (ascopost.com)
Lenalidomide dose reduction was associated with worse overall survival (hazard ratio [HR] = 1.30, P = .05). (ascopost.com)
Key secondary end points include complete response (CR) rate by IRC, duration of response (DOR), progression-free survival (PFS), overall survival (OS), and pharmacokinetics. (onclive.com)
70%) and poor long-term outcome with an overall survival of only 6 months ( 3 ). (frontiersin.org)

Peripheral smear from a patient with chronic lymphocytic leukemia, small lymphocytic variety. (medscape.com)
Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
We determined the capacity of the leukemia cell line K562 modified to express a membrane-bound form of interleukin (IL)-15 and 41BB ligand (K562-mb15-41BBL) to generate human NK cells with enhanced cytotoxicity. (aacrjournals.org)
He has built a prototype of AI with neural network analysis for patients with chronic myeloid leukemia in chronic phase (CML-CP) for the best treatment decision. (mdanderson.org)

Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)

Moreover, she underwent effective double transplantations and was eventually found to be cured despite accompanying complications. (bvsalud.org)
[ 1 ] Some patients die within several years of diagnosis, usually due to complications from CLL, but most patients survive for at least five years. (medscape.com)
Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT. (stembook.org)
[ 1 ] Some patients die rapidly, within 2-3 years of diagnosis, because of complications from CLL, but most patients live 5-10 years. (medscape.com)

rather, the comorbidities and functional status of the older patient are likely better predictors of toxicity than chronologic age in both the autologous and allogeneic setting. (nccn.org)
Critically ill cancer patients have lower survival rates compared with patients without comorbidities. (springeropen.com)

There is an increased risk of multiple myeloma in certain occupations. (wikipedia.org)
3.5 mg/L, albumin ≥ 3.5 g/dL, normal cytogenetics, no elevated LDH Stage II: Not classified under Stage I or Stage III Stage III: β2M ≥ 5.5 mg/L and either elevated LDH or high-risk cytogenetics [t(4,14), t(14,16), and/or del(17p)] The risk of multiple myeloma can be reduced slightly by maintaining a normal body weight. (wikipedia.org)

Therapeutic Candidate or Device The therapeutic product candidate is autologous CD34+ hematopoietic stem/progenitor cells (HSPC) transduced with the G1XCGD lentiviral vector. (ca.gov)

Normally, potentially malignant cells are continuously eliminated by the immune system, but cancer cells can accumulate certain mutations, which allow them to escape these mechanisms [ 2 ]. (nature.com)
CAR-modified immune cells are expanded until sufficient cell numbers are attained and are adoptively transferred into the patient to fight malignant cells. (nature.com)
Minimal residual disease (MRD) refers to the small number of malignant cells that remain after therapy when the patient is in remission and shows no symptoms or overt signs of disease. (smw.ch)
As MRD reflects the nature of the malignant disease itself, including its sensitivity to the drug regimens applied, it constitutes the ideal method for surveillance and patient follow-up. (smw.ch)

The CRAB criteria were formerly the benchmark used to establish presence of active multiple myeloma (as opposed to an earlier, generally asymptomatic, "smoldering" form of the disease). (wikipedia.org)

The main objective of the study was to assess the safety and efficacy of allotransplantation in elderly AML.Forty nine patients (33 males) at median age of 68 years were identified. (bvsalud.org)
In the CLL5 study comparing fludarabine with chlorambucil (median age 70 y), while there was significantly higher response rate with fludarabine, progression-free survival was similar (19 vs 18 mo). (medscape.com)
With a median follow-up of 23 months (range = 1-43 months), the overall response rate was 38% for patients receiving azacitidine, 49% for azacitidine plus lenalidomide (P = .14 vs azacitidine), and 27% for azacitidine plus vorinostat (P = .16 vs azacitidine). (ascopost.com)
The median age among the 270 patients who received treatment with liso-cel was 63 years (range, 18-86), with 41% of patients 65 years of age or older and 10% who were 75 years of age or older. (onclive.com)
The median number of prior lines of systemic therapy received was 3 (range, 1-8), 33% received prior autologous transplant, 3% had prior allogeneic transplant, and 59% received bridging therapy. (onclive.com)
Twenty-six patients were infused with CART cells (median 81 days after leukapheresis) and were analyzed for the overall response (OR) 3 months later. (frontiersin.org)

Therapeutic Candidate or Device Tumor stem cell-targeted immunotherapy. (ca.gov)
Novel understanding in the interaction between immune system and cancer cells of the patient holds great promise for immunotherapy development [ 4 - 6 ]. (hindawi.com)
Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. (aacrjournals.org)
The immunotherapy module will review the mechanism of action, toxicities, dose adjustments, and important monitoring parameters of immunotherapy agents in the treatment of cancer patients. (hoparx.org)
Finally, essential information will be covered so the participant can effectively counsel patients on immunotherapy agents. (hoparx.org)

Therapeutic Candidate or Device Rebecsinib is a novel small molecule inhibitor of ADAR1 splicing that selectively eradicates therapy-resistant cancer stem cells in blood cancers. (ca.gov)
These cells can self-renew and the patient can enjoy a long-term cure from blood cancer. (parkwaycancercentre.com)
Almost every year new genes were detected being targetable, and drugs have been developed and provided for those patients being diagnosed with such a lung cancer. (deepdyve.com)
This activity has been designated to meet the educational needs of physicians and nurses involved in the management of patients with cancer. (nccn.org)
Interventions The patients were categorised into subgroups based on cancer-related symptoms using a latent class analysis. (bmj.com)
A latent class analysis was used to categorise cancer-related symptoms in Chinese patients undergoing treatment for multiple myeloma (MM). (bmj.com)
Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
As multi-modality approaches to cancer continue to improve patient outcomes, limiting treatment related morbidity is essential. (mdanderson.org)
A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. (springeropen.com)
In this review, we will appraise the prognostic factors and discuss the overall perspective related to the management of critically ill patients with cancer. (springeropen.com)
Because of the overall increased survival that has been reported in critically ill patients with cancer, we outline an easy-to-use and evidence-based ICU admission triage criteria that may help avoid depriving life support to patients with cancer who can benefit. (springeropen.com)
Managing organ dysfunction in critically ill cancer patients requires specialized skills by the intensivist and close collaboration between the intensivist and oncologist. (springeropen.com)
Healthcare providers and patients often discuss the merits of providing mechanical ventilation, vasoactive agents, renal replacement therapy, or other life-sustaining treatments in patients with cancer [ 19 ]. (springeropen.com)
Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus. (uchicago.edu)
We work with our communities and patients to remove access barriers to cancer prevention, screening, treatment and survivorship services. (columbia.edu)
Before coming to Columbia, Dr. Mapara was Associate Professor of Medicine (with tenure) at the University of Pittsburgh Cancer Institute and served as the Director of the Adult Hematopoietic Stem Cell Transplantation Program. (columbia.edu)

Transplant Cell Ther 2021. (harvard.edu)
There were 3468 patients screened at the time of the data cutoff of August 13, 2021, and 539 underwent randomization. (oncnursingnews.com)

Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. (uchicago.edu)
Since the recent data do not clearly support the benefit of ICU support to unselected critically ill allogeneic BMT recipients, more outcome research is needed in this subgroup. (springeropen.com)

Peripheral blood stem cells are the preferred source of HSCs because of the relative ease of collection. (parkwaycancercentre.com)
The authors collected peripheral blood stem cells that were shipped to a manufacturing facility to be gene edited. (healthcare.pro)

Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)

All patients received reduced-intensity conditioning (RIC). (bvsalud.org)
While the doctor-patient relationship is one of potential intensity and privacy, the best patient care comes from teamwork, which values all who contribute to achieving high-quality care with compassion. (rochester.edu)
Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis. (stembook.org)

Title: Impact of Induction Therapy with VRD vs. VCD on Outcomes in Patients with Multiple Myeloma in Partial Response or Better Undergoing Upfront Autologous Stem Cell Transplantation. (stembook.org)

It is a bispecific humanized monoclonal antibody against CD3, a T-cell surface antigen, and GPRC5D (human G-protein coupled receptor family C group 5 member D), a tumor-associated antigen with potential antineoplastic activity. (medscape.com)

05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
Moreover, none of the patients with an EF less than 50% developed cardiac toxicity. (slideshare.net)
Although the occurrence of cardiac toxicity is correlated with a reduction of EF before BMT, life-threatening cardiac toxicity cannot be predicted in individual patients [33]. (slideshare.net)
Further research is needed to establish the utility of CGA in predicting toxicity and to evaluate the quality of survival in older adults undergoing HCT. (nccn.org)
In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)
CONDITIONING: Patients receive fludarabine intravenously (IV) once daily (QD) on days -7 to -5, and undergo TMLI twice daily (BID) on days -4 to 0 in the absence of disease progression or unacceptable toxicity. (survivornet.com)
GVHD PROPHYLAXIS: Patients receive cyclophosphamide IV QD on days 3-4 in the absence of disease progression or unacceptable toxicity. (survivornet.com)

Background: In our country, transplantation centers differ in the age limit for allogeneic hematopoietic transplantation (ALOHT). (scielo.org)
Safe administration of CAR-T cell therapy requires thorough patient selection and patient care in qualified CAR-T cell centers. (deepdyve.com)

Therapeutic Candidate or Device Cryopreserved autologous TRAC locus 1XX BCMA-CAR T cells Indication Relapsed and Refractory Multiple Myeloma Therapeutic Mechanism Engineered T cells target and kill BCMA+ Myeloma cells Unmet Medical Need No durable treatments are available for RRMM and only ~30% of patients can access current BCMA CAR therapies. (ca.gov)
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma. (dukecancerinstitute.org)

Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
Lately, CAR-NK cell therapies have also come into focus as novel therapeutic options to address hurdles related to CAR-T cell therapies, such as therapy-induced side effects. (nature.com)

After PET-positive disease was reconfirmed, patients received a lymphodepletion regimen comprised of fludarabine at 30 mg/m2 and cytarabine at a dose of 300 mg/m2 for 3 days. (onclive.com)

High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)
Fludarabine and Melphalan Compared with Reduced Doses of Busulfan and Fludarabine Improves Transplant Outcomes in Older MDS Patients. (stembook.org)
Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. (uchicago.edu)

Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience. (uchicago.edu)

The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
Now, 15 years after stem cell transplantation and 8 years after kidney transplantation, the patient remains in good condition overall, presenting with symptoms of limited cGvHD. (bvsalud.org)

One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
The chimeric antigen receptor-intensive care unit (CAR-ICU) initiative: Surveying intensive care unit practices in the management of CAR T-cell associated toxicities. (stembook.org)

SummaryChimeric antigen receptor (CAR) T cells are genetically engineered cells containing fusion proteins combining an extracellular epitope-specific binding domain, a transmembrane and signaling domains of the T cell receptor. (deepdyve.com)

Validation and refinement of the disease risk index for allogeneic stem cell transplantation: a study from the CIBMTR. (stembook.org)

Given the high transplant-related morbidity, these treatment strategies were initially restricted to younger patients, but are increasingly being used in older adults. (nccn.org)
Here's the truth - stem cell transplant-related deaths are relatively rare. (medical-definitions.net)

elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)

Adoptive transfer of expanded natural killer cells inhibited the growth of established OPM2 and high-risk primary myeloma tumors grown in the murine model. (haematologica.org)
Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor. (dukecancerinstitute.org)

Because many organs can be affected by myeloma, the symptoms and signs vary greatly. (wikipedia.org)
Conclusions Patients with MM experienced varying degrees of symptoms during treatment. (bmj.com)
Patients with CLL present with a wide range of signs and symptoms. (medscape.com)
Enlarged lymph nodes are the most common presenting symptom, but patients may present with a wide range of symptoms and signs. (medscape.com)
This has resulted in definite benefit for the seven patients with Ã -thalassemia, making them transfusion-independent, and for the three patients with sickle cell disease who remain without symptoms of vaso-occlusive crisis," Frangoul said. (healthcare.pro)

Anatomy33

Organisms12

Diseases51

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Psychiatry and Psychology2

Phenomena and Processes34

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups6

Health Care19

Geographicals1

Lymphoma27

Graft-versus-8

Chemotherapy29

Transplants9

Reduced-intensity allogeneic3

Bone38

20231

Patient's4

Relapse12

Relapsed or refractory3

Malignancies16

Plasma cell my2

HSCT10

Donor17

Clinical24

Mortality10

Engraftment3

Donors5

Aplastic anemia1

ASCT11

Acute14

Myelofibrosis5

Prognosis4

Overall survival10

Leukemia4

Marrow Transplant1

Complications4

Comorbidities2

Risk of multiple myeloma2

Progenitor1

Malignant4

Active multiple myeloma1

Median6

Immunotherapy5

Cancer24

20212

Recipients2

Peripheral blood stem cells2

Umbilical cord2

Intensity3

Outcomes in Patients1

Humanized monoclon1

Toxicity7

Centers2

Refractory multiple2

Therapies3

Regimen1

Melphalan3

Renal cell carc1

Kidney transplantation2

Chimeric2

Antigen receptor1

CIBMTR1

Transplant-related2

Tumor cells1

Murine2

Symptoms5