Autologous gbm tumor cells expressing endogenous immunologic antigen of tumor. Medical search. Frequent questions

In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)

Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)

The G2 M checkpoint is especially important in protecting normal cells from tumor formation driven by the accumulation of mutations. (hsp90-inhibitors.com)
Therefore, elimination of the checkpoint increases the sensitivity of human tumor cell lines to anticancer agents. (hsp90-inhibitors.com)
HLA-G is considered as an immune checkpoint protein and a tumor-associated antigen. (bvsalud.org)

Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)

Farnesyltransferase inhibitor tipifarnib is well leurocristine tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic tumor survival pathways in patients with advanced multiple myeloma. (hsp90-inhibitors.com)

Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Both in vivo and in vitro experiments reveal that the Nb-CAR.BiTE-Î³Î´T cells could effectively eliminate PD-L1 and/or HLA-G-positive solid tumors. (bvsalud.org)

Increased JNK activity is important for the dissociation of p21 and JNK, following which cells enter into the S phases. (hsp90-inhibitors.com)
These results indicate that JNK activity may regulate cell proliferation through the regulation of cell cycles. (hsp90-inhibitors.com)

Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. (lookformedical.com)

We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)

Therefore, the upregulation of p21 expression may contribute to G2 M arrest in the early stages, and then Cdk2 may regulate endoreduplication by treating leukemia cells in the middle stages in the presence of SP600125. (hsp90-inhibitors.com)

Expression of NKG2D ligands on cancer cells can be boosted or reduced using a range of drugs, providing opportunities for therapeutic intervention. (mdpi.com)
Interestingly, NBEAL2 deficiency leads to low CTLA-4 expression in patient-derived effector T cells, while their regulatory T cells appear unaffected. (bvsalud.org)
Knocking-down NBEAL2 in healthy primary T cells recapitulates the low CTLA-4 expression observed in the T cells of GPS patients. (bvsalud.org)
Our results thus show that NBEAL2 is involved in the regulation of CTLA-4 expression in conventional T cells and provide a rationale for considering CTLA-4-immunoglobulin therapy in patients with GPS and autoimmune disease. (bvsalud.org)
Methods: In this current study, we used cytometry time-of-flight (CyTOF), bulk RNA sequencing on sorted T cells, and single-cell RNA (scRNA) sequencing to interrogate expression of CD38 and its correlation with T cell exhaustion in HCC samples. (bvsalud.org)

NKG2D ligands are generally absent from the surfaces of healthy cells. (mdpi.com)