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  • embryos
  • Previous reports have described the generation of bovine ES-like cells ( 4 ) and mouse ES cells from the ICMs of cloned blastocysts ( 5 - 7 ) and the development of cloned human embryos to the 8- to 10-cell stage ( 8 , 9 ). (sciencemag.org)
  • Secrets to Living Longer, " which aired last night and was hosted by Barbara Walters, highlighted the role that the company ' s blastomere program for creating human embryonic stem cell (hESC) lines without impacting the developmental potential of embryos could play in extending life and slowing down the aging process. (opednews.com)
  • In August 2006, Advanced Cell Technology reported in the journal Nature that company scientists had successfully generated hESCs using its blastomere technology, an approach that does not destroy the developmental potential of embryos. (opednews.com)
  • Embryonic stem cells are derived from embryos that develop from eggs that have been fertilized in vitro. (slideserve.com)
  • transplant
  • For example, consider an autologous bone marrow transplant, wherein a patient's bone marrow is harvested prior to chemotherapy, and then reintroduced back into the patient with no negative immunological consequence. (wordpress.com)
  • Here we describe, for the first time, the multi-disciplinary post-operative rehabilitation and outcome of a patient with chronic cervical SCI after autologous human embryonic stem cell transplant. (scielo.org.za)
  • A 33 year old male, American Spinal cord Injury Association (ASIA) Grade A, C4 chronic SCI patient received glial scar resection and Autologous Human Embryonic Stem Cell (AHESC) transplant, 6 years after injury, and thereafter had intensive interdisciplinary rehabilitation comprising occupational, biokinetic and physiotherapy, for an average of 17 hours per week over the course of 12 months. (scielo.org.za)
  • These are cells obtained from bone marrow, usually autologous or from the same person that will receive the transplant. (rutgers.edu)
  • Here we report accumulated safety and imaging data from the 1st and 2nd cohorts of patients, who received a subretinal transplant of 50k or 200k OpRegen cells in suspension, with up to 1 year follow up. (arvojournals.org)
  • hESC
  • Moreover, we focus on the reciprocal paracrine signals within the in vitro hESC niche allowing for the maintenance and/or expansion of the hESC colony-initiating cell (CIC). (springer.com)
  • In June 2007, ACT announced at the fifth annual meeting of the International Society for Stem Cell Research in Cairns, Australia, that it had reproduced its work by successfully producing an hESC line without destroying an embryo at its lab in Worcester, Massachusetts. (opednews.com)
  • placenta
  • They do not contribute to the extra-embryonic membranes or the placenta. (euvolution.com)
  • A part of the placenta called the amnion, or the outer membrane of the amniotic sac, is comprised of cells that have strikingly similar characteristics to embryonic stem cells, including the ability to express two key genes that give embryonic stem cells their unique capability for developing into any kind of specialized cell, the researchers report. (bio-medicine.org)
  • For each discarded placenta, the researchers calculate there are about 300 million amniotic epithelial cells that potentially could be expanded to between 10 and 60 billion cells relatively easily. (bio-medicine.org)
  • Only cells from an earlier stage of the embryo, known as the morula , are totipotent, able to become all tissues in the body and the extraembryonic placenta. (wikipedia.org)
  • Only the morula's cells are totipotent, able to become all tissues and a placenta. (thefullwiki.org)
  • pluripotency
  • Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA (2000) Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. (springer.com)
  • Mouse and human embryonic stem cells are in different states of pluripotency (naive/ground and primed states). (springer.com)
  • Mechanisms of signaling regulation in cells with ground and primed states of pluripotency are considerably different. (springer.com)
  • In order to understand the contribution of endogenous and exogenous factors in the maintenance of a metastable state of the cells in different phases of pluripotency, we examined the expression of TGFβ family factors (ActivinA, Nodal, Lefty1, TGFβ1, GDF3, BMP4) and FGF2 initiating the appropriate signaling pathways in mouse and human embryonic stem cells (mESCs, hESCs) and supporting feeder cells. (springer.com)
  • Activin A Maintains Pluripotency of Human Embryonic Stem Cells in the Absence of Feeder Layers, Stem Cells , 2005, vol. 23, pp. 489-495. (springer.com)
  • epithelial
  • And according to the results of their studies, these so-called amniotic epithelial cells could in fact be directed to form liver, pancreas, heart and nerve cells under the right laboratory conditions. (bio-medicine.org)
  • Yet the authors are careful to point out that despite their remarkable similarities to embryonic stem cells, amniotic epithelial cells are not stem cells per se, because they can't grow indefinitely. (bio-medicine.org)
  • Perhaps it's to their advantage that the amnion epithelial cells lack telomerase expression, because telomerase is associated with many cancers and one of the main concerns about stem cell therapies is that transplanted stem cells would replicate in the recipient to form tumors," noted Toshio Miki, M.D., Ph.D., first author of the paper and an instructor in the department of pathology at the School of Medicine. (bio-medicine.org)
  • While amniotic epithelial cells do not share the same capacity for unlimited replication as do embryonic stem cells, they still can double in population size about 20 times over without needing another cell type serving as a feeder cell layer. (bio-medicine.org)
  • Amniotic epithelial cells, on the other hand, create their own feeder layer, with some cells choosing to spread out at the bottom of the culture dish thereby giving those cells just above them the best environment for replicating and for retaining their stem cell characteristics. (bio-medicine.org)
  • The company published positive data from animal studies for its RPE (retinal pigment epithelial) cell program for the treatment of retinal degenerative disorders completed in collaboration with the Casey Eye Institute at Oregon Health and Science University. (opednews.com)
  • endothelial
  • 2006) report that human monocyte derived multipotential cells are expressed CD31, CD144, vascular endothelial growth factor (VEGF) type 1 and 2 receptors, Tie-2, von Willebrand factor (vWF), endothelial nitric oxide synthase, and CD146, but CD14/CD45 expression was markedly down-regulated. (rutgers.edu)
  • spinal cord
  • The healing effects of stem cells in spinal cord injury can be aided by their ability to hitch intercellular rides to specific anti-inflammatory cells called M2 macrophages, Yale researchers report. (medicalxpress.com)
  • The spinal cord consists of multiple neuronal cell types that are critical to motor control and arise from distinct progenitor domains in the developing neural tube. (pnas.org)
  • blastocysts
  • These are cells that are derived from blastocysts, a very early stage of development that occurs during the first two weeks after fertilization. (rutgers.edu)
  • clinical
  • For instance, bone marrow aspiration may yield low numbers of stem cells on processing, which necessitates an ex vivo expansion step to obtain sufficient cell numbers for clinical application. (ahajournals.org)
  • We're not diminishing the importance of embryonic or IPS research/clinical trials. (cosmeticsurg.net)
  • In actuality, there's a wide variation in stem cell risk profiles and clinical trial development. (cosmeticsurg.net)
  • A big misconception is how far along adult stem cells are in their clinical trial development. (cosmeticsurg.net)
  • Safety and tolerability of this cell product, OpRegen, is now being evaluated in a dose-escalating Phase I/IIa clinical study in patients with advanced dry AMD accompanied by geographic atrophy (NCT02286089). (arvojournals.org)
  • research
  • S.C.B. and M.H.S are supported by CIHR Canada Graduate Scholarship Doctoral awards, M. Bhatia by the Canadian Chair Program who holds the Canada Research Chair in human stem cell biology and Michael G. DeGroote Chair in Stem Cell Biology. (springer.com)
  • Research into stem cells grew out of findings by Ernest A. McCulloch and James E. Till at the University of Toronto in the 1960s. (euvolution.com)
  • ALL stem cell research is important and findings in one field have helped the other fields. (cosmeticsurg.net)
  • Research in the stem cell field grew out of findings by Canadian scientists Ernest A. McCulloch and James E. Till in the 1960s. (medicalxpress.com)
  • Stem cell research" redirects here. (wikipedia.org)
  • For the journal, see Stem Cell Research (journal) . (wikipedia.org)
  • The research team, including senior author Dr. Charles Vacanti of Brigham and Women's Hospital, says their findings may one day lead to the creation of embryonic stem cells specific to each individual without the need for genetic manipulation. (medicalnewstoday.com)
  • Other research has detailed the use of stem cells for the treatment of cardiovascular disease, brain disorders and blood diseases. (medicalnewstoday.com)
  • Stem cell research has raised ethical concerns in the past, as extracting human embryonic stem cells from a 4- or 5-day-old embryo can lead to its destruction. (medicalnewstoday.com)
  • The research team was inspired by the ability of a plant callus - a collection of plant cells that grow into a new plant after being injured on an existing plant. (medicalnewstoday.com)
  • The report, which included an interview with Dr. Robert Lanza, MD, Chief Scientific Officer at Advanced Cell Technology, featured the company ' s research platforms and included a discussion of the role that the company ' s stem cell science could play in treating various diseases. (opednews.com)
  • In addition, the NIH announced in 2007 that it would begin implementing President George W. Bush ' s Executive Order to explore methods to expand the number of approved pluripotent stem cell lines " without creating a human embryo for research purposes or destroying, discarding, or subjecting to harm a human embryo or fetus. (opednews.com)
  • But here is why many may disagree with embryonic stem cell research. (thisisms.com)
  • Science has used the time of the ban to do more research, and can now make stem cells from adult sources. (thisisms.com)
  • Until now, it has been generally believed that embryonic stem cells had a greater capacity to multiply than post-natal stem cells, making them more desirable to research as a potential treatment, according to Johnny Huard, PhD, director of the Growth and Development Laboratory at Children's Hospital of Pittsburgh. (scienceblog.com)
  • The entire world is closely following the advances in stem cell research, and everyone is interested in the potential of stem cells to treat everything from diabetes to Parkinson's disease. (scienceblog.com)
  • Previous research has found that embryonic stem cells could undergo more than 200 population doublings before the cells began to die. (scienceblog.com)
  • Dr. Deasy, a research assistant professor in the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine, discovered that a unique population of muscle-derived stem cells was able to undergo more than 200 population doublings, as well. (scienceblog.com)
  • findings
  • The findings are published in the July 1, 2005, issue of Molecular Biology of the Cell, published by the American Society for Cell Biology. (scienceblog.com)
  • adipose
  • The aim of this study was to establish a culture protocol for obtaining and characterizing adipose-derived stem cells (ADSCs) from C57BL/6 J mice. (biomedcentral.com)