Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
Osteochondral Autograft Transplantation: Healthy cartilage tissue (graft) is taken from the bone that bears less weight and is transferred to the injured joint place. (randyclarkmd.com)
One ACI treatment, called MACI (autologous cultured chondrocytes on a porcine collagen matrix), is indicated for healthy patients 18-55 with medium to large sized damage to their cartilage. (wikipedia.org)
This procedure to grow new cartilage, also known as matrix-induced autologous chondrocyte implantation (MACI) , is a two-step process. (healthline.com)
Alternative therapies, including autologous chondrocyte implantation (ACI), matrix-induced ACI (MACI), and stem cell transplantation, are also available commercially or are in the clinical study phase. (biomedcentral.com)
Matrix-assisted autologous chondrocyte implantation (MACI) is a variation of ACI that involves seeding the expanded chondrocytes onto a biocompatible scaffold before implantation. (surgeonsync.com)
Microfracture3
The successful protocol involved arthroscopic microdrilling/ microfracture surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPCs) and hyaluronic acid. (wikipedia.org)
In this interview, Dr. Katz discusses why third-generation autologous chondrocyte implantation (ACI) is superior to microfracture for focal chondral defects of the knee joint - a topic applied to the generation of thought provoking NBME style questions for self-evaluation. (finfactbuddy.com)
Various surgical techniques and interventions are utilized to achieve this goal, including autologous chondrocyte implantation (ACI), microfracture, osteochondral grafting, and other emerging technologies. (finfactbuddy.com)
Defects3
For extended osteochondral defects new types of osteochondral allograft transplantation are recommended. (ivis.org)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Allograft3
Autologous Chondrocyte Implantation and Osteochondral Allograft Transplantation Render Comparable Outcomes in the Setting of Failed Marrow Stimulation. (rush.edu)
Topographic Matching of Osteochondral Allograft Transplantation Using Lateral Femoral Condyle for the Treatment of Medial Femoral Condyle Lesions: A?Computer-Simulated Model Study. (rush.edu)
Topographic Analysis of the Distal Femoral Condyle Articular Cartilage Surface: Adequacy of the Graft from Opposite Condyles of the Same or Different Size for the Osteochondral Allograft Transplantation. (rush.edu)
Differentiate into chondrocytes2
When cartilage is damaged, MSCs derived from synovial fluid can partially move to the injured site and differentiate into chondrocytes to repair the defect, and IGF-1 induces chondrogenic differentiation [ 11 , 12 , 13 ]. (biomedcentral.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
Articular cartilage8
Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a collagen membrane. (wikipedia.org)
Elbow cartilagetransplantation is a surgical procedure that repairs damaged articular cartilage in the elbow joint by transplanting cartilage to the defected area to relieve pain and restore normal function of the elbow. (chrisjoycemd.com)
EN] Articular cartilage is a tissue with low capacity for self-restoration due to its avascularity and low cell population. (upv.es)
Transplantation of autologous chondrocytes has been proposed to regenerate articular cartilage but this therapy fails mainly to the absence of a material support (scaffold) for the adequate stimulation of cells. (upv.es)
Their three-dimensionality plays a critical role in articular cartilagetissue engineering to maintain chondrocyte function, since monolayer culture of chondrocytes makes them dedifferentiate towards a fibroblast-like phenotype secreting fibrocartilage. (upv.es)
Tissue2
The implanted chondrocytes then divide and integrate with surrounding tissue and potentially generate hyaline-like cartilage. (wikipedia.org)
Usually, OCD surgery consists of removing the loose cartilage and bone, but newer procedures may also involve implantation of scaffolds or bone-derived stem cells to replace the lost tissue and reduce later risk of arthritis, especially in the knees. (orthopaedic-surgery-md.com)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
Mesenchymal2
Because mesenchymal stem cells may regenerate cartilage, cartilage growth in human knees using autologous cultured mesenchymal stem cells is under research and preliminary clinical use, and appears to be safe as of 2016. (wikipedia.org)
This type of cartilage repair technique is often fortified by bone marrow acquired autologous mesenchymal stem cell support. (ivis.org)
Procedure2
Implantation of the new cartilage cells is performed through an open surgical procedure called arthrotomy. (jonathanmyermd.com)
ACI is a two-step surgical procedure which necessitates chondral harvesting from a non-weight-bearing area of the knee and external chondrocytes expansion in a dedicated laboratory [ 9 , 10 ]. (springer.com)
Mosaicplasty1
Autologous osteochondral mosaicplasty and autologous chondrocyte implantation are the oldest modern cartilage repair options. (ivis.org)
Involves3
The first step involves growing new cartilage cells followed by the implantation of these new cells into the defect. (jonathanmyermd.com)
Autologous chondrocyte implantation (ACI) involves harvesting healthy cartilage cells from the patient, which are then cultured and expanded in the laboratory. (surgeonsync.com)
Autologous chondrocyte implantation (ACI) involves the removal of cartilage cells from your own body. (activeoa.com)
Apoptosis2
Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. (wikipedia.org)
IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. (biomedcentral.com)
MSCs can be differentiated along different cell lineages of mesodermal origin including osteoblasts, chondrocytes, skeletal myocytes or visceral stromal cells 9 . (nature.com)
Thus, chondrocyte metabolism in the adjacent cartilage is relatively low, and these cells cannot easily migrate to the damaged site [ 2 ]. (biomedcentral.com)
Patient's1
The patient's chondrocytes are removed arthroscopically from a non load-bearing area from either the intercondylar notch or the superior ridge of the medial or lateral femoral condyles. (wikipedia.org)
Replacement2
One cell-based replacement technique is called autologous chondrocyte implantation (ACI) or autologous chondrocyte transplantation (ACT). (wikipedia.org)
Insulin-like growth factor-1 (IGF-1), a member of a family of growth factors that are structurally closely related to pro-insulin, has shown profound effects on chondrocyte biological behavior and fundamentally regulates cartilage matrix metabolism during cartilage repair. (biomedcentral.com)
Technique1
Another ACI technique, using "chondospheres", uses only chondrocytes and no matrix material. (wikipedia.org)