Autologous cells hematopoietic cells bone marrow transplantation. Medical search. Frequent questions

An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
If your child received bone marrow from someone else, look for signs of graft-versus-host disease ( GVHD ). (medlineplus.gov)
Gene delivery through stem cells using specific viral vectors are also utilised to confer lineage specificity of transducedautologous or allogeneic stem cell gene expressionin the recipient while addressing graft versus host disease. (hoajonline.com)

Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. (qxmd.com)
high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
Hematopoietic stem cell transplant. (mayoclinic.org)
http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
Hepatosplenic T-cell lymphoma is a rare form of lymphoma that is generally incurable, except in the case of an allogeneic stem cell transplant. (wikipedia.org)
Your child had a bone marrow transplant. (medlineplus.gov)
Tell your child's dentist that your child has had a bone marrow transplant. (medlineplus.gov)
What is an Autologous bone marrow transplant? (gomedii.com)
An autologous stem cell transplant is the process where healthy blood stem cells from your own body are used to replace your damaged bone marrow. (gomedii.com)
An autologous stem cell transplant is also called an autologous bone marrow transplant. (gomedii.com)
For example, there is no "rejection " factor for your own cells if you have an autologous stem cell transplant. (gomedii.com)
Allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace bone marrow that's not producing enough healthy blood cells. (gomedii.com)
Thomas has been diagnosed with sickle cell disease which affects the red blood cells and needs an urgent Stem cell transplant but it was not available in his country. (gomedii.com)
Wondering how an Autologous bone marrow transplant can help you solve the treatment options for multiple myeloma? (gomedii.com)
In a stem cell transplant, the patient gets high-dose of chemotherapy. (gomedii.com)
When stem cell transplants were first developed, the new stem cells came from bone marrow, and so this was known as a bone marrow transplant. (gomedii.com)
Now, stem cells are more often collected from blood (a peripheral blood stem cell transplant). (gomedii.com)
Stem cell transplant is commonly used to treat multiple myeloma. (gomedii.com)
Before the transplant, drug treatment is used to reduce the number of myeloma cells in the patient's body. (gomedii.com)
What are the types of matches in an Autologous bone marrow transplant? (gomedii.com)
What can be the Autologous bone marrow transplant cost? (gomedii.com)
Get your low-cost package and estimation of Autologous bone marrow transplant in India with GoMedii. (gomedii.com)
Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
In research presented in Bone Marrow Transplantation , investigators examined whether the time interval from ending induction therapy to receiving an autologous hematopoietic stem cell transplant (AHSCT) impacted outcomes in patients with multiple myeloma (MM). Lead author, Charalampos Charalampous, MD, noted that the last cycle of induction therapy is typically completed two to four weeks before transplantation. (bloodcancerstoday.com)
Bone marrow transplant also referred to as hematopoietic stem cell. (powershow.com)
The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders. (cdc.gov)

Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
mesenchymal stem cells - placenta) differentiate into multipotency as precursors to formation of the cellular components. (hoajonline.com)
These CD4+ CD25+ T regulatory cells can be isolated from mesenchymal stem cells and CD34+ hematopoietic stem cells. (hoajonline.com)
Bone marrow mononuclear cells (BMMNCs) consist of hemopoietic stem cells and mesenchymal stem cells together with progenitors of endothelial cells or somatic cells [ 1 , 2 ]. (biomedcentral.com)
While mesenchymal stem cells represent an interesting cell source for regenerative medicine, several points have to be investigated to improve their use in clinical, and in particular in the elderly population. (foreverlabs.com)
This work studied the proliferation capacity of mesenchymal stem cells isolated from human bone marrow in function of donor's age. (foreverlabs.com)
In conclusion, this study showed an effect of donor's age on the proliferation capacity of mesenchymal stem cells isolated from bone marrow that was correlated to a decrease in clonogenicity. (foreverlabs.com)
The comprehension of molecular mechanism involved in this process could help to improve the clinical application of mesenchymal stem cells. (foreverlabs.com)
Here, we provide a critical review of current clinical trials using either mesenchymal or neural stem cells to treat ALS patients. (csnn.eu)
In this post, I will explain mesenchymal stem cells and the MESCAMS study in particular, in the hopes of clarifying any misconceptions surrounding this promising therapy. (mssociety.ca)
What are mesenchymal stem cells? (mssociety.ca)
The more specialized adult stem cells (a category to which mesenchymal stem cells belong), on the other hand, are more limited in the types of cells they can differentiate into, and are generally involved in repairing damaged tissues or replacing aging cells. (mssociety.ca)
Mesenchymal stem cells are a type of adult stem cell found predominantly in the bone marrow, but have also been reported to reside in muscle, fat, and umbilical cord blood. (mssociety.ca)
Although mesenchymal stem cells have traditionally been investigated by researchers for their regenerative potential for bone and cartilage injuries, they also hold promise for people living with MS due to their capacity to suppress inflammation and assist in the repair of damaged nervous tissue. (mssociety.ca)
Studies exploring the therapeutic benefits of mesenchymal stem cell therapies for MS are in their infancy, but the results to date have been so encouraging so as to warrant a concerted, international effort in the scientific community to accelerate research into testing the safety and feasibility of this therapy in people living with MS. (mssociety.ca)
Take a look at our MS Society Fact Sheet for more information about mesenchymal stem cells. (mssociety.ca)
MESCAMS is a randomized, double-blind, cross-over, phase II clinical trial (that's quite a mouthful, but I'll explain what that means in a moment) investigating the safety and therapeutic potential of mesenchymal stem cell therapy for people with MS. The study will involve40 patients who will receive the treatment one at two sites - The Ottawa Hospital and Health Sciences Centre (HSC) Winnipeg . (mssociety.ca)
It comprises of two types of stem cells, that are hematopoietic and mesenchymal stem cells. (powershow.com)
Mesenchymal stem cells (MSCs) are ASCs, and were first described in 1966 by Friedenstein et al. (bvsalud.org)

Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
Hematopoietic stem cell transplantation (HSCT) is a therapy utilizing wholesome blood or bone marrow stem cells. (getnom.net)
HSCT is at the moment used to deal with male germ cell tumors , also called testicular tumors. (getnom.net)
As well as, HSCT is a therapy choice for sure blood-related illnesses, together with lymphoma , leukemia , and sickle cell illness . (getnom.net)
Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)

Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
Reduced mortality after allogeneic hematopoietic-cell transplantation. (nature.com)

Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
National Marrow Donor Program. (mayoclinic.org)
In such cases, there are cells from your own body and hence have certain advantages over stem cells from a donor. (gomedii.com)
Based on the report Thomas will either go through Allogenic (related Donor) or Autologous (healthy cells from their own body) donor selection. (gomedii.com)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
Results showed an increase in the doubling time for cell coming from old donor compared to cells coming from young ones. (foreverlabs.com)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Other treatments are allogeneic, meaning the stem cells are from a donor. (mssociety.ca)

Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)

For this research, Prof. Inglese and her staff examined the information of 79 individuals with lively secondary progressive MS who acquired autologous hematopoietic stem cell transplants (AHSCT). (getnom.net)
Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment. (news-medical.net)

Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion. (scienceblog.com)

To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)

Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
Binds to cell surface receptors on hematopoietic cells and stimulates proliferation, differentiation, and some end-cell functional activation. (hemonc.org)

Blood-forming stem cell transplants. (mayoclinic.org)
Conditions like bone marrow transplants or stem cells were difficult to get treated. (gomedii.com)
We know that Bone marrow transplants can help solve many problems. (gomedii.com)
Researchers from the College of Genoa discovered hematopoietic stem cell transplants assist delay incapacity longer in individuals with lively secondary progressive MS than some MS drugs. (getnom.net)
Now a staff of researchers from the College of Genoa in Italy discovered hematopoietic stem cell transplants utilizing an individual's wholesome blood stem cells assist delay incapacity longer in individuals with lively secondary progressive MS than some MS drugs. (getnom.net)
After 10 years of therapy, scientists discovered individuals who acquired stem cell transplants decreased their rating by a median of 0.01 factors per 12 months, exhibiting a lower in incapacity. (getnom.net)

2 Evaluation of harvest adequacy requires the use of reliable progenitor cell assays and this is usually achieved by CD34 cell counting using flow cytometry. (bdbiosciences.com)
Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)

We assessed late mortality in 854 individuals who had survived 2 or more years after autologous hematopoietic cell transplantation (HCT) for hematologic malignancies. (qxmd.com)
High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)

Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. (myeloma.org.uk)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)

Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being. (qxmd.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)

For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Thus homeostasis of T regulatory cells is an overbearing requirement for prevention of autoimmune disorders arising from uncontrolled self-tolerance which also permits malignancies to occur. (hoajonline.com)
A preclinical model of CD38-pretargeted radioimmunotherapy for plasma cell malignancies. (fredhutch.org)

In this study, we aimed to identify the concentrations of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of these patients and their correlation with treatment outcomes. (biomedcentral.com)
Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)

Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)

Impact of the time interval between end of induction and autologous hematopoietic transplantation in newly diagnosed patients with multiple myeloma. (bloodcancerstoday.com)

This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)

OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. (fredhutch.org)
The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium. (cdc.gov)

Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
After the transplantation, the patient's new lymphocytes or immune cells are self-tolerant and do not attack the immune system. (scienceblog.com)

Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)

The cell of origin for this disease is an immature cytotoxic T-cell clonally expressing the γδ T-cell receptor. (wikipedia.org)
Symptoms related to bone marrow dysfunction, such as anemia, leukopenia, or thrombocytopenia, are rare at presentation but can also be observed in the later stages of the disease. (medscape.com)
The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
Therapeutic regeneration of molecularly engineered and transplanted autologous stem cells in neurological and cardiovascular diseases due to inability of self-regeneration or repair of endogenous stem cells at sites of inflammation or disease at various stages of progress for regeneration of the damaged tissue depending upon the sites and nature of degeneration. (hoajonline.com)
Cancer stem cellsand their susceptibility over their expected to be "downstream or progeny" cancer cells represent a target for therapeutic interventions to prevent latency and consequently relapse or metastasis of the malignant disease. (hoajonline.com)
Transient activation of CD4+ CD25+ T regulatory cells is required for autoimmune disease containment since their chronic activation leads to deleterious self-tolerance and infection or disease reactivation or tumour development as well as occurrences of relapse. (hoajonline.com)
The time from disease onset to stem cell application ranged from 1 to 36 months. (biomedcentral.com)
Myeloma bone disease: Progress in pathogenesis. (myeloma.org.uk)
In order to provide robust assessment of the efficacy of stem cells, it will be essential to standardize administration protocols, identify the most suitable cell type as well as to validate more reliable biomarkers of disease progression in longitudinal clinical studies. (csnn.eu)
Recognizing that most of the global burden of hemoglobin disorders exists in low- and middle-income countries, we review the increasingly available array of point-of-care-tests (POCT), which have an increasingly important role in expanding early diagnosis programs to address the global burden of sickle cell disease, including Sickle SCAN, HemoTypeSC, Gazelle Hb Variant, and Smart LifeLC. (bvsalud.org)
Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry. (news-medical.net)
Involvement of other organs, such as spleen, liver, or bone marrow is an indication of advanced disease. (vin.com)
Prognostic factors include stage and substage of disease, histologic type, immunophenotype (B-cell versus T-cell), presence of hypercalcemia, response to therapy, pre-treatment steroid therapy, and possibly gender. (vin.com)
Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)

This reduced differentiation of CD34+ hematopoietic progenitor stem cells could occur due to both infectious and non-communicable diseases and also due to their drug induced treatments. (hoajonline.com)
Retention of cellular phenotype is the hallmark of differentiation of pluripotent stem cells. (hoajonline.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor. (dukecancerinstitute.org)
The use of ASCs in regenerative medicine and tissue engineering research has important advantages in comparison with ESCs, since there are no ethical complications and the process of differentiation of these cells is better controlled. (bvsalud.org)
8,9 Because dental stem cells (DSCs) are easy to obtain and present a great potential of differentiation, there has been a growing interest in their use in regenerative medicine for treatment of various human diseases. (bvsalud.org)

High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)

Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater at Vinmec Times City International Hospital. (biomedcentral.com)

The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
Tumors contain a minority population of cancer stem cells that maintain the tumor. (hoajonline.com)
In marked contrast to the cancer stem cells, the tumor cells without "stemness" have either no capacity or a markedly diminished capacity, to form new tumors. (hoajonline.com)
Therefore, to treat cancer effectively, the cancer stem cell must be eliminated. (hoajonline.com)
The tumor will rapidly recur if the therapy eliminates cancer cells but spares a significant population of the cancer stem cells. (hoajonline.com)
Since the initial discovery of the self-renewing properties of stem cells in the early 1960s - pioneered by a small team of researchers at the Ontario Cancer Institute [3] - the understanding of the power and diversity of stem cells has increased rapidly. (articlecity.com)
This complex treatment offers a huge benefit for patients: even more resistant cancer cells are killed by the more intensive treatment process. (leading-medicine-guide.com)
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy for cancer," Burt said. (scienceblog.com)

Nonrelapse-related mortality was increased after carmustine (RR = 2.3) and with use of peripheral blood stem cells (RR = 2.4). (qxmd.com)
Cells of a similar morphology observed in solid organs are observed in peripheral blood. (wikipedia.org)
A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)
2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
Thomas decided to travel to India where he will go through pre-treatment procedures of Blood tests and stem cell biopsy. (gomedii.com)
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Inhibition of hematopoiesis results in reduced populations of blood forming cells. (hoajonline.com)
mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)
Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
An important focal point of Professor Graeven's range of services is haematology, i.e. the diagnosis and treatment of all conditions of the blood, the hematopoietic organs and the lymphatic system. (leading-medicine-guide.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Bendamustine, etoposide and dexamethasone to mobilize peripheral blood hematopoietic stem cells for autologous transplantation in patients with multiple myeloma. (fredhutch.org)
The second is to transform and mature into specialized cell types with certain functions (for example, a blood cell or a nerve cell). (mssociety.ca)
There's scientific proof that the transplantation of autologous hematopoietic stem cell transplantation after intense immune suppression can induce a resetting of the autoreactive blood white cells (lymphocytes) chargeable for the illness pathogenesis, that are changed by new and self-tolerant white cells. (getnom.net)
Bone marrow is mainly responsible for the haematopoiesis, (formation of blood cells), production of lymphocytes, and the storage of fats. (powershow.com)
They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)

[ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
After an average follow-up of three years after transplantation, 17 patients (81 percent) improved by at least one point on a disability scale. (scienceblog.com)

WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
Bone Marrow Transplantation 51(1):67-71, 2016. (fredhutch.org)

1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)

[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)

Pathology and genetics of tumours of haematopoietic and lymphoid tissues. (wikipedia.org)
Stem cells are the engines of the body that give rise to tissues and organs, as well as maintain and repair certain tissues when they become damaged. (mssociety.ca)
Adult stem cells exist in many adult tissues and although some go on to develop into tissues, others stay as stem cells which makes them easier to extract from the body. (mssociety.ca)
These stem cells can give rise to certain tissues of the body, including cells making up cartilage, bone and fat. (mssociety.ca)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Due to the ability to self-renew and to differentiate into cells that are found throughout the body, there is a great interest in using stem cells for the regeneration of injured tissues as well as to develop tissue-engineered implants and bio-hybrid organs, in order to restore tissue function. (bvsalud.org)
MSCs can be isolated from different locations, such as bone marrow, umbilical cord, placenta, adipose and dental tissues. (bvsalud.org)
In human postnatal dental tissues, five main sources of DSCs have been identified: dental pulp stem cells (DPSCs), 11 stem cells from human exfoliated deciduous teeth (SHEDs), 12 periodontal ligament stem cells (PDLSCs), 13 dental follicle stem cells (DFSCs) 14 and stem cells from apical papilla (SCAPs). (bvsalud.org)

The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)

The best hope for regeneration of these permanently damaged cells is optic stem cell therapy combined with continued drug treatments or other exogenous biomaterial implants depending upon the relevant ophthalmological condition. (hoajonline.com)
I hear a lot of questions about stem cell therapy, such as "what is the source of stem cells used in MS research? (mssociety.ca)
and, "what are the risks and benefits of stem cell therapy? (mssociety.ca)

Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)

Embryonic stem cells which are characteristic of totipotency differentiate into generations of the multiple organs. (hoajonline.com)
The totipotentstem cells differentiate further into pluripotency thatpopulate the organs with different sub-divisional components of the various individual organs. (hoajonline.com)

Stem cells exist both in embryos and adult cells. (articlecity.com)
Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
1,2 Regarding the origin, they can be classified as embryonic stem cells (ESCs) and adult stem cells (ASCs). (bvsalud.org)

High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
For example, they often use high-dose chemotherapy with special hematopoietic stem cell transplantation. (leading-medicine-guide.com)

The method involves microinjecting heterologous mitochondria into an oocyte or embryonic cell wherein the heterologous mitochondria are capable of achieving at least normal levels of mitochondrial membrane potential in the oocyte or embryonic cell. (justia.com)
WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
Embryonic stem cells, which as the name suggests are derived from an embryo, can differentiate into nearly any kind of cell type and are the building blocks for the entire body during development. (mssociety.ca)
Embryonic stem cells only exist in the developing embryo for a short period of time, which makes it difficult to access these stem cells. (mssociety.ca)
3,4 The zygote and cells derived from the first two cellular divisions constitute the most primitive cells (totipotent cells) that are capable of forming the embryo and the embryonic annexes (e.g. placenta, amniotic membranes etc). (bvsalud.org)

The growing amount of bone marrow diseases will help in escalating the growth of the bone marrow market. (powershow.com)
[ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)

It is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show significant sinusoidal infiltration in the liver, spleen, and bone marrow. (wikipedia.org)
The spleen and liver are always involved, and bone marrow involvement is common. (wikipedia.org)

Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)

Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)

Most of the identifiable cells are lymphocytes or plasma cells. (medscape.com)

The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)

On the other hand, elimination or escape of Treg cells also causes the reactivation and induction of tumors and relapse. (hoajonline.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)

Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)

Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
Monotypic plasma cell interstitial nephritis as the only clinical manifestation in a patient with previously undiagnosed indolent multiple myeloma: A case report. (myeloma.org.uk)
A 78-year-old woman with lung adenocarcinoma and multiple bone metastases received maintenance therapy with pemetrexed + pembrolizumab for a year. (journaltocs.ac.uk)
A Randomized Study of Melphalan 200 mg/m2 v. 280 mg/m2 as a Preparative Regimen for Patients with Multiple Myeloma undergoing Autologous Stem Cell Transplantation. (fredhutch.org)
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)

The bone marrow market is expected to gain market growth in the forecast period of 2021 to 2028. (powershow.com)

8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)

The typical clinical finding in a patient with hepatosplenic T-cell lymphoma is hepatosplenomegaly. (wikipedia.org)

Anatomy32

Organisms13

Diseases57

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology2

Phenomena and Processes42

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Named Groups3

Health Care11

Graft-versus-5

Transplant34

Mesenchymal19

HSCT15

Allogeneic hematopoietic-cell transplantation2

Donor9

Umbilical-cord2

AHSCT2

Myeloablative3

Pediatric1

Proliferation3

Transplants6

Progenitor cell10

Hematologic2

Acute4

Long-term survivors2

Malignancies3

Outcomes2

Peripheral blood progenitor cells1

Newly diagnosed1

Mobilization2

Survival6

Patient's3

Patients undergoing1

Disease16

Differentiation7

Chemotherapy followed1

Aspiration3

Cancer11

Blood23

Years after transplantation2

20162

Morbidity and morta1

Severe1

Tissues10

Apheresis1

Stem Cell Th3

Stromal cells2

Organs2

Adult3

High-dose chemotherapy2

Embryonic7

Diseases2

Liver2

Diagnosis2

Multipotent cells1

Lymphocytes1

Immunology1

Tumors2

Donors2

Multiple7

20211

Hematology1

Clinical1