Autologous cell suspension transplantation. Medical search. Frequent questions

Appropriately, cell therapy with autologous bone tissue marrow concentrates or aspirates, which includes both hematopoietic and mesenchymal stromal cells (BM-MSCs) furthermore to various other cell types that may are likely involved in tissues regeneration, represents a practical choice for osteonecrosis in SCD [6, 7]. (azd1152.com)
Approval was based on the multicenter ELARA trial (ClinicalTrials.gov identifier NCT03568461) in patients who were refractory or relapsed within 6 months after completion of at least two lines of systemic therapy (including an anti-CD20 antibody and an alkylating agent) or who relapsed after autologous hematopoietic stem cell transplantation. (ascopost.com)
C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. (edu.pl)
To overcome this problem, methods of ex vivo treatment ('purging') of autologous marrow must be developed that optimally eradicate AML cells but spare normal hematopoietic stem cells. (arizona.edu)
CFU-Leuk), which we have shown are predictive for hematopoietic engraftment and AML log-kill in rats given syngeneic marrow and/or AML cells incubated ex vivo with selected chemotherapeutic agents, will be used in these dose-response studies. (arizona.edu)
After incubation, cells will be plated for CFU-GM and CFU-Leuk assays to determine survival of committed hematopoietic progenitors and log-kill of AML cells, and optimal conditions for antileukemic effect with stem-cell sparing. (arizona.edu)

While cells could survive as grafts for several months, there was little evidence for true integration into host tissue and immature photoreceptors did not mature into fully functional structures ( 5 , 6 ). (amegroups.org)
transplantation of early tissue leads to the formation of self-contained mini-retinas. (amegroups.org)
The tissue source issue has been overcome with the introduction of stem cell lines, particularly induced pluripotential stem cells (iPSCs) that can be produced from adult tissues. (amegroups.org)
Such treatments include allogeneic and xenogeneic transplants and skin substitutes such as tissue-engineered skin, cultured cells, and stem cells. (biomedcentral.com)
The aim of this paper is to discuss the general overview of the quality assurance and quality control implemented in the manufacturing of cell and tissue product, with emphasis on our experience in the manufacturing of MyDerm ® , an autologous bilayered human skin substitute. (biomedcentral.com)
Manufacturing MyDerm ® requires multiple high-risk open manipulation steps, such as tissue processing, cell culture expansion, and skin construct formation. (biomedcentral.com)
In recent years, the development in cell therapy and stem cell research has led scientist to engage in the production of cells and tissue product that is of clinical grade. (biomedcentral.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
White blood cells formed in the body's lymphoid tissue. (lookformedical.com)
Other properties than tissue replacement, for example their capability to inhibit pathogenic T and B cell responses and on the release of neuroprotective and pro-oligodendrogenic molecules favoring tissue protection and repair [1]. (ephb4inhibitor.com)
and 5) autologous tissue composite. (ersjournals.com)
Currently, an autologous tissue composite, with or without a tracheal allograft, is the only long-term working solution for every aetiology, despite its technical complexity and setbacks. (ersjournals.com)
During the use of PSI Pentastarch Solution, follow the details of your institution's instructions for the processing of Human Cells, Tissues, and Cellular Tissue-Based Products (HCT/Ps), in compliance with the applicable Current Good Tissue Practice regulations, during the use of PSI Pentastarch Solution. (preservationsolutions.com)
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
This leads to hypoxia and tissue damage as a consequence of the build up of waste metabolites and may result in cell death [ 1 ]. (biomedcentral.com)
Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)
In particular, chimeric antigen receptor (CAR) - patient T cells genetically engineered to express antigen receptors targeting cancer cells - and organoid technologies (tiny, self-organized three-dimensional tissue cultures derived from stem cells) will continue to disrupt the cell and gene therapy and regenerative medicine fields, translating early successes with liquid cancers to solid tumors and beyond. (corning.com)
Organoids are generated using tissue-specific stem cells, which are typically undifferentiated epithelial cells. (corning.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
In order to reduce morbidity associated with STSG harvesting, researchers have developed autologous dermo-epidermal substitutes (DESs) using cell culture, tissue engineering, and, more recently, bioprinting approaches. (frontiersin.org)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
[5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
The aim of this study is to evaluate the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization. (unav.edu)
Stem cells are known to work via a variety of methods to heal tissue depending on where the stem cells come from and into which tissue it is being placed. (drcremers.com)
Here is a general list of all the Ways Stem Cells heal tissues or create new tissue. (drcremers.com)
1. Stem cells have long been known to have the ability to differentiate (ie become/transform) into "good/normal" tissue. (drcremers.com)
Embryonic stem cells have been fraught with difficulties in coaxing them into "good/normal" tissue and there are major ethical issues. (drcremers.com)
This strategy, in fact, has shown the potential to generate both functional cardiac tissue substitutes for use in the failing heart, and biological in vitro model systems to investigate the cardiac tissue-specific development and diseases, allowing to perform accurate and controlled in vitro tests for cell and tissue-based therapies, drug screening, predictive toxicology and target validation. (polito.it)
3) biomimetic in vitro culture environments, designed to replicate the in vivo milieu by using biologically inspired requirements, influence and drive cells to differentiate towards the desired phenotype and to express their functions, promoting extracellular matrix formation and tissue maturation. (polito.it)
Starting from a wide and in-depth review of the state of the art of bioreactors for cardiac TE (Chapter I), two bioreactor prototypes were developed (Chapter II and III), firstly, as model systems to investigate in vitro the effects of biophysical stimuli on cardiac cell culture and cardiac tissue formation and maturation. (polito.it)
The success of stem cell transplantation pivots on the identification of a donor possessing either a fully-matched or partially-matched tissue group with the patient. (medistateinternational.com)

Allogeneic pancreas islet transplantation involves isolating islet cells from the pancreas of a cadaver donor, which are then purified and transplanted into the recipient via the portal vein or one of the tributaries of the liver where they take up residence and resume function. (bcbsnd.com)
Programs that perform fewer than 35 annual autologous or 35 annual allogeneic transplants will be required to submit data from the immediately preceding year's transplants in order to obtain a statistically significant number of transplant cases (35). (humana.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)
Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
Furthermore, a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells. (nature.com)
Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)

The group, led by Sheraz Daya, was able to successfully use adult stem cells obtained from the patient, a relative, or even a cadaver. (wikipedia.org)
In the present studies we have examined the ability of adult glial cells, either as suspension of mixed glial cells or as 01 positive oligodendrocytes purified by cell sorting, to myelinate md rat axons following transplantation. (karger.com)
Mixed glial cell preparations from adult rats myelinated large areas of either, dorsal, lateral or ventral columns. (karger.com)
FDA approved polatuzumab vedotin-piiq (Polivy, Genentech, Inc.) with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for adult patients who have previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS), or high-grade B-cell lymphoma (HGBL) and who have an International Prognostic Index (IPI) score of 2 or greater. (org.in)
FDA granted accelerated approval to mosunetuzumab-axgb (Lunsumio, Genentech, Inc.), a bispecific CD20-directed CD3 T-cell engager for adult patients with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. (org.in)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
[3] Today, patients take insulin shots and pharmaceuticals to control their diabetes, and adult stem cell transplants have shown success at ameliorating the condition. (lozierinstitute.org)
In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
Methods: A phase I multicentre clinical trial (ClinicalTrials.gov NCT01919827) with a single endobronchial administration of autologous adult BM-MSCs in patients diagnosed with mild-to-moderate IPF. (unav.edu)
Adult stem cells turn out to be a more robust and reliable source of cell to heal damaged cells. (drcremers.com)
These adult stem cells, such as from fat (adipose derived) or bone marrow, have the ability to transform into different cells. (drcremers.com)

In this interview, Dr. Katz discusses why third-generation autologous chondrocyte implantation (ACI) is superior to microfracture for focal chondral defects of the knee joint - a topic applied to the generation of thought provoking NBME style questions for self-evaluation. (finfactbuddy.com)
Various surgical techniques and interventions are utilized to achieve this goal, including autologous chondrocyte implantation (ACI), microfracture, osteochondral grafting, and other emerging technologies. (finfactbuddy.com)
Tomeglovir showed that BM-MNCs from SCD sufferers had been practical lately, proliferative highly, and in a position to differentiate into useful bone-forming osteoblastic cells in ectopic implantation murine versions [8]. (azd1152.com)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
15. Erggelet C, Sittinger M., Lahm A. The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. (genescells.ru)
However, current therapeutic cardiac strategies, e.g., transplantation of autologous and donor grafts, and implantation of artificial prostheses or devices as left ventricular assist devices, suffer from limitations. (polito.it)

Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)
Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
Mesenchymal stromal cells (MSCs) have shown benefit in other inflammatory diseases. (unav.edu)

Dermabrasion versus microneedling in transplantation of autologous noncultured melanocyte-keratinocyte cell suspension in patients with vitiligo. (medscape.com)
This randomized comparative study aimed to assess the efficacy of transplanting autologous melanocyte-keratinocyte suspension in patients with stable vitiligo and to compare site preparation using dermabrasion vs microneedling. (medscape.com)
Conclusion: Since we did not find any reports of serious complications for fibroblast, keratinocyte and melanocyte cells, especially about their in-vivo uncontrolled proliferation, it is possible to give ethical approval for research in these fields (considering all ethical codes and principles). (ac.ir)
Noble Vitiligo and Aesthetic Clinic was established in 1997 in Bangalore-India and was the first clinic to start treating Vitiligo patients with melanocyte transplantation. (mediescapes.com)
He has undergone training in Autologous melanocyte transplantation in Sweden in 1997. (mediescapes.com)
Noble Clinic is the first clinic in India to start with melanocyte transplantation for Vitiligo, Is the first clinic, in south India to start laser Lipolysis for body sculpting. (mediescapes.com)
Dr. Vivekanand Bhat received his training in Autologous Melanocyte Transplantation a ( SWEDISH PROCEDURE ) in 1997. (mediescapes.com)

Following lymphodepleting chemotherapy, tisagenlecleucel was given via a single intravenous infusion with a target dose of 0.6 to 6.0 × 10 8 chimeric antigen receptor (CAR)-positive viable T cells. (ascopost.com)
Axicabtagene ciloleucel injection is used to treat a certain type of non-Hodgkin's lymphoma (cancer that begins in white blood cells that normally fight infection) that has returned or is unresponsive to other treatment(s) in people who have already been treated with at least two other chemotherapy medications. (medlineplus.gov)
Stem cell transplantation is a promising strategy for delayed wound healing caused by chemotherapy. (ijbs.com)
However, the fate of stem cells under chemotherapy has not been fully elucidated. (ijbs.com)
Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
It permits the administration of exceedingly high doses of chemotherapy, a practice that becomes viable due to the subsequent infusion of the patient's own stem cells. (medistateinternational.com)
This twofold approach not only harnesses the power of potent chemotherapy but also safeguards against bone marrow deficiency by replenishing the patient's stem cell count following the chemotherapy phase. (medistateinternational.com)
Altogether, fewer than 30 to 40% of patients with NB survive despite aggressive treatment combinations that involve multiagent chemotherapy, surgery, autologous bone marrow transplantation, and radiation ( 3 - 5 ). (iiarjournals.org)

Chen FK, Uppal GS, MacLaren RE, Coffey PJ, Rubin GS, Tufail A, Aylward GW, Da Cruz L. (2009) Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration. (wikipedia.org)
The largest need for transplants in AMD is for the two cell types most affected, namely cone photoreceptors and retinal pigment epithelium (RPE). (amegroups.org)

It is highly recommended to perform cell manufacturing for therapeutic use in a well-designed GMP-compliant cleanroom facility. (biomedcentral.com)
However, BTC may also be used in the manufacture of advanced therapy medicinal products (ATMPs), cell and gene therapy medicinal products with ground-breaking therapeutic potential. (bristows.com)
Recently, there has been growing interest in the therapeutic potential of using a cell-based approach to treat vasodegenerative disorders. (biomedcentral.com)
In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
Both in animal models and humans, it has been shown that cell therapy can induce therapeutic angiogenesis, making mesenchymal stromal cell-based therapy one of the most promising therapeutic alternatives. (unav.edu)
However, the presence of residual occult viable leukemic cells in the marrow autograft limits the therapeutic effectiveness of ABMT in AML. (arizona.edu)
Eisenbud D. Founding and growth of a start-up company in the cell-based therapeutic arena. (genescells.ru)
While alternative therapeutic techniques persist, bone marrow/peripheral stem cell transplantation emerges as a transformative option, particularly when other methods display limited efficacy. (medistateinternational.com)
Another report described the intravenous ( i.v. ) injection of NB cell lines into NSG, SCID-beige, and nude mice, and demonstrated that the use of NSG mice was advantageous in therapeutic and survival studies ( 35 ). (iiarjournals.org)
However, the metastatic potential of free NB cells injected into NSG mice needs to be investigated further in order to validate the use of these mice as a relevant xenograft model of human NB and as a preclinical model for the development of new therapeutic strategies. (iiarjournals.org)

It is a relatively avascular structure, and the dense extracellular matrix located between chondrocytes prevents movement of these cells and nutrients to the defect site. (finfactbuddy.com)
Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)

Autologous RPE transplantation is conventionally done employing two techniques, namely, RPE suspension and autologous full-thickness RPE-choroid transplantation. (wikipedia.org)
An autologous split-thickness skin graft (STSG) is a standard treatment for coverage of full-thickness skin defects. (frontiersin.org)

CD19-directed genetically modified autologous T cell immunotherapy. (empr.com)
Axicabtagene ciloleucel injection is in a class of medications called autologous cellular immunotherapy, a type of medication prepared using cells from the patient's own blood. (medlineplus.gov)
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. (edu.pl)
Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)

However, indigenous BM-MSCs are used without the product quality assessment before transplantation usually. (azd1152.com)
Typically, BM-MSCs could be discovered by their plastic material adherence and capability to type colony-forming device fibroblasts (CFU-Fs) = 32) and from nonsickle cell disease sufferers (NS group, = 19), going through orthopedic medical procedures for principal osteoarticular problems. (azd1152.com)
At 6 months since the 1st infusion, remedy was reversed (i.e., sufferers who received initial suspension media received cryopreserved MSCs and vice versa). (ephb4inhibitor.com)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Objectives: To evaluate the safety and feasibility of endobronchial administration of bone marrow autologous MSCs (BM-MSC) in patients with mild-to-moderate IPF. (unav.edu)

Later, allogenic fetal RPE cell transplantation was tried in which immune rejection of the graft was a major problem. (wikipedia.org)
Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Therefore, fetal stem cells are suitable cells for clarifying the influences of CTX on cell functions. (ijbs.com)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

In addition, preparations containing over 90% 01 positive oligodendrocytes were also capable of myelinating large numbers of axons upon transplantation. (karger.com)

The team used iPS cells made from the patient's own skin cells. (wikipedia.org)
The isolated cells (2.5-7.5×10(5)) were resuspended in 300 microL of the patient's cerebrospinal fluid, and implanted in motor cortexes using a Hamilton syringe. (cellsurgicalnetwork.com)
Autologous bone marrow transplantation (ABMT), whereby the patient's own marrow is used as the source of stem cell rescue, is potentially curative in patients with acute myeloid leukemia (AML). (arizona.edu)
In cases where such donors are not available, the process can extend to non-related donors or even a patient's own cells, demonstrating the flexibility and innovation inherent in this field. (medistateinternational.com)

A central aspect is then the ability to optimize the functional properties with high spatial resolution, creating materials that are able to control the interaction with the biological surrounding at the nanoscale thus guiding the responses of biomolecules, cells and tissues. (european-mrs.com)
At the end of 2020, the European Commission (EC) announced plans to revise and update the existing European legislation governing the quality and safety of human blood, tissues and cells (BTC) intended for clinical application. (bristows.com)
It works by causing the body's immune system (a group of cells, tissues, and organs that protects the body from attack by bacteria, viruses, cancer cells, and other substances that cause disease) to fight the cancer cells. (medlineplus.gov)
The evaluation of the most suitable timing of cell delivery as well as the number of cells needed to integrate into resident vasculature and promote revascularisation of specific tissues requires careful optimisation and evaluation. (biomedcentral.com)

The study was conducted from March 2020 to September 2022 and included 40 patients with 40 stable vitiligo lesions that were managed by suspension transplants of melanocytes. (medscape.com)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)

2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. (lu.se)
We provide detailed protocols for lentiviral transduction, neural differentiation, and subsequent analysis of human embryonic stem cells. (lu.se)

and (3) types of outcomes - the primary outcome was total efficacy rate, which was ≥ 50% repigmentation rate, and the secondary outcomes were cure rate (proportion of patients achieving 100% repigmentation of the lesion), serum cytokine levels, and blood ratio of CD4 + /CD8 + T cells. (medscape.com)
Cell therapy Ophthalmology Stem cell therapy Macular degeneration Gene therapy for color blindness Gene therapy of the human retina Atala, A. Human embryonic stem cells: early hints on safety and efficacy. (wikipedia.org)

Then in March 2017 team carried out the world's first successful transplant of retinal cells created from donor iPS cells into the eye of a patient with advanced wet age-related macular degeneration. (wikipedia.org)
Time and cost used in the surgery has been significantly reduced by using super donor cells, cells derived from people with special white blood cell types that aren't rejected by the immune systems of receiving patients. (wikipedia.org)
During the surgery the patient received a transplant of approximately 250,000 retinal pigment epithelial cells into the eye generated from donor-derived iPSCs. (wikipedia.org)
However, the worldwide shortages of corneal donor material generate a strong demand for personalized stem cell-based alternative therapies. (lww.com)
The principal contraindications in using autologous grafts are identified in donor site morbidity, limited availability, risk of infection, and secondary surgical wounds. (polito.it)
In such cases, the transplantation procedure is prioritized during the early stages, provided a suitable donor is identified. (medistateinternational.com)
The decision to proceed with stem cell transplantation for these conditions hinges on a comprehensive evaluation of the disease's course, severity, donor-related attributes, and procedural risks. (medistateinternational.com)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

Autologous pancreas islet transplantation is performed during the pancreatectomy procedure. (bcbsnd.com)
A suspension of isolated islet cells is created from the recipients resected pancreas specimen and then injected in the portal vein of the liver where the cells function as a free graft. (bcbsnd.com)
Autologous pancreas islet transplantation may be considered medically necessary as an adjunct to a total or near total pancreatectomy in individuals with chronic pancreatitis. (bcbsnd.com)
Autologous pancreas islet transplantation not meeting the criteria indicated in this policy is considered not medically necessary. (bcbsnd.com)
Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes. (edu.pl)

In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. (wikipedia.org)
PSI Pentastarch Solution is a liquid product intended for use as a component in cryopreservation media for human ex vivo cells, as part of cell culture processing. (preservationsolutions.com)
2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
Hopkins Oncology Center (JHOC), Baltimore, MD, will evaluate novel ex vivo marrow purging regimens by comparison of the effects of incubation with graded concentrations of immunologic and/or pharmacologic agents on the growth of normal marrow and leukemic cells, using an authentic animal model of human AML (the LBN hybrid rat). (arizona.edu)
Transplantation of ex vivo expanded LSCs to the LSCD eye has been reported as a successful therapy to treat LSCD [ 5 , 11 , 12 ]. (drcremers.com)

CD133(+) stem cells are known to have the capacity to differentiate into neural lineages. (cellsurgicalnetwork.com)
Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)

To optimize the ASC-supported culture, freshly isolated limbal epithelial cells in the form of single cells (SC-ASC) or cell clusters (CC-ASC) were cultured using three different methods: LSCs seeded directly on feeder cells, a 3-dimensional (3D) culture system and a 3D culture system with fibrin (fibrin 3D). (drcremers.com)
CC-ASC generated epithelial cells with undifferentiated morphology in all culture methods, among which CC-ASC in 3D culture supported the highest cell doubling (cells doubled 9.0 times compared to cells doubled 4.9 times in control) while maintained the percentage of putative limbal stem/progenitor cells compared to the control. (drcremers.com)

Stem cell therapy for macular degeneration is the use of stem cells to heal, replace dead or damaged cells of the macula in the retina. (wikipedia.org)
For years, stem cell assisted therapy has been accepted as a standard treatment method for the management of some diseases. (ac.ir)
One of the main concerns in the field of stem cell therapy research is the safety of these cells. (ac.ir)
FDA granted accelerated approval to elranatamab-bcmm (Elrexfio, Pfizer, Inc.), a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager, for adults with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. (org.in)
FDA granted accelerated approval to glofitamab-gxbm (Columvi, Genentech, Inc.) for relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS) or large B-cell lymphoma (LBCL) arising from follicular lymphoma, after two or more lines of systemic therapy. (org.in)
FDA granted accelerated approval to epcoritamab-bysp (Epkinly, Genmab US, Inc.) for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma after two or more lines of systemic therapy. (org.in)
FDA granted accelerated approval to pirtobrutinib (Jaypirca, Eli Lilly and Company) for relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a BTK inhibitor. (org.in)
Relapsed/refractory after 1 line of therapy: give a single dose of 90-110×10 6 CAR-positive viable T cells (consisting of 1:1 CD8 and CD4 components), with each component supplied separately. (empr.com)
On May 27, 2022 , tisagenlecleucel, a CD19 chimeric antigen receptor (CAR) T-cell therapy, was granted accelerated approval for adults with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy. (ascopost.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
The use of cell therapy for vascular regeneration offers an exciting new prospect in regenerative medicine. (biomedcentral.com)
Finally, one should consider cell choice, a critical aspect of any cell therapy. (biomedcentral.com)
Corneal transplantation is currently the only therapy for severe corneal disorders. (lww.com)
Also, the multidisciplinary coordination exercise needed to develop this clinical trial protocol will undoubtfully be useful to conduct academic clinical trials in the field of cell therapy in the near future. (unav.edu)
The decision to proceed with transplantation hinges on a thorough assessment of patients' chances for successful results, along with a comprehensive understanding of therapy-related risks. (medistateinternational.com)
Cell Therapy for Parkinsons Disease: What Next? (lu.se)

Encouraging clinical outcomes has already been reported with the transplantation of the autologous RPE choroid from the periphery of the eye to a disease affected portion. (wikipedia.org)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)

Follicular unit hair transplantation in England. (mediescapes.com)

Danbury, Connecticut, 28th June 2023, ZEX PR WIRE , Dr. Richard Katz has in-depth knowledge of regenerative-biological cell-based therapies. (finfactbuddy.com)

Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Mei H, González S, Nakatsu MN, Baclagon ER, Chen FV, Deng SX (2017) Human adipose-derived stem cells support the growth of limbal stem/progenitor cells. (drcremers.com)
The scientists at the University of California San Diego report on a method of removing cataracts while preserving epithelial stem/progenitor cells (LECs), which have an important role in lens regeneration. (medscape.com)

[ 8 ] Piebaldism results from mutations of the KIT proto-oncogene, which encodes the cell surface receptor transmembrane tyrosine kinase for an embryonic growth factor, steel factor. (medscape.com)
iPS cells are created by removing mature cells from an individual and reprogramming these cells back to an embryonic state. (wikipedia.org)
Development of human embryonic stem cell therapies for age-related macular degeneration. (wikipedia.org)
Spits C, Mateizel I, Geens M, Mertzanidou A, Staessen C, Vandeskelde Y, Van der Elst J, Liebaers I and Sermon K (2008) Recurrent chromosomal abnormalities in human embryonic stem cells. (miekegeens.be)
Geens M, Mateizel I, Sermon K, De Rycke M, Spits C, Cauffman G, Devroey P, Tournaye H, Liebaers I, Van de Velde H (2009) Human embryonic stem cell lines derived from single blastomeres of two 4-cell stage embryos. (miekegeens.be)
Given this, human pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripo- tent stem cells (hiPSCs), have become a unique cell source for study- ing early human brain development. (lu.se)

During prenatal development and postnatal cyclic hair regeneration, hair follicle morphogenesis is triggered by reciprocal interactions and the organization of the epithelial and mesenchymal cell po. (researchgate.net)
Hair regeneration using hair follicle stem cells (HFSCs) and dermal papilla cells is a promising approach for the treatment of alopecia. (researchgate.net)
Dermal papilla cells (DPCs) play critical roles in hair follicle development, but the underlying mechanisms that contribute to hair regeneration have yet to be fully elucidated, particularly in terms of alterations in androgenetic alopecia patients. (researchgate.net)
These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
Commenting on the study in a statement, Dr Dusko Ilic, reader in stem cell science at King's College London, says: "The basic science research led to the hypothesis that preserving and stimulating autologous stem cells in the eye might promote regeneration of a surgically removed lens. (medscape.com)

Stem cell based therapies using bone marrow stem cells as well as retinal pigment epithelial transplantation are being studied. (wikipedia.org)
Gagliardi G, Ben M'Barek K, Goureau O. Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: A pluripotent stem cell-based approach. (amegroups.org)
The advantages of a dividing stem cell pool are well known and include and essentially unlimited supply of cells and the possibility of deriving iPSCs from patients and thus avoiding graft rejection problems. (amegroups.org)
Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients. (cellsurgicalnetwork.com)
CONCLUSIONS: Stem-cell transplantation in the motor cortex delays ALS progression and improves quality of life. (cellsurgicalnetwork.com)
Stem Cell Res. (sciendo.com)
Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
Geens M, Goossens E, De Block G, Ning L, Van Saen D, Tournaye H. (2008) Autologous spermatogonial stem cell transplantation in man: current obstacles for a future clinical application. (miekegeens.be)
An update on spermatogonial stem cell banking and transplantation. (miekegeens.be)
3. New research shows that the mere fact that a stem cell touches or even pass by another cell, stimulates the other cell or damaged cell to behave better. (drcremers.com)
Loss of LSCs or their dysfunction may lead to limbal stem cell deficiency (LSCD) which present with corneal opacity, vascularization and conjunctivalization. (drcremers.com)
9. Stem Cell Summit. (genescells.ru)
In the last decade, a great deal of progress was made in this field due to new advances in interdisciplinary areas such as biology, genetic engineering, biomaterials, polymer science, bioreactor engineering, and stem cell biology. (polito.it)
The procedure of bone marrow / peripheral stem cell transplantation serves as a pivotal treatment avenue for patients contending with a spectrum of medical challenges. (medistateinternational.com)
Stem cell transplantation is considered when these approaches prove ineffective, emphasizing the importance of exhausting all available options. (medistateinternational.com)
While stem cell transplantation often finds its place in addressing leukemia and cancer cases, its scope extends far beyond these realms, particularly in childhood ailments. (medistateinternational.com)
For conditions affecting the bone marrow-the essential hub for blood cell production-stem cell transplantation emerges as a potential avenue for patients grappling with insufficient or impaired blood production. (medistateinternational.com)
Furthermore, stem cell transplantation proves invaluable in addressing various familial diseases, each marked by distinct trajectories that primarily manifest during childhood. (medistateinternational.com)
Hereditary diseases encompass a vast spectrum, with differing suitability for stem cell transplantation. (medistateinternational.com)
However, for certain hereditary diseases characterized by severe, life-threatening, or progressive courses, stem cell transplantation may present a lifeline. (medistateinternational.com)
Often, conventional medical treatment options are limited, leaving stem cell transplantation as a potential game-changer. (medistateinternational.com)
This improved immunodeficient profile has established NSG mice as the new 'gold standard' for human haematopoietic stem cell ( 23 - 25 ) and cancer research. (iiarjournals.org)

An autologous split-thickness skin graft (STSG) is the reference treatment for skin coverage, especially when the defect is large and reaches the hypodermis. (frontiersin.org)

Even with the availability of inbred mouse strains transplantation studies have shown only modest success. (amegroups.org)
However, all these mouse strains display residual immune functions, in particular, natural killer (NK) cells that can inhibit tumor formation and metastatic spread of cancer cells ( 20 , 21 ). (iiarjournals.org)

The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
Recently, NSG mice have been used in an NB xenograft model for studying tumor-infiltrating human lymphocytes in subcutaneous ( s.c. ) tumors of NB cells embedded in Matrigel® ( 32 ). (iiarjournals.org)

Most piebald patients have the above-described mutation of the KIT gene encoding a tyrosine kinase receptor involved in pigment cell development. (medscape.com)

In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. (edu.pl)
To reduce possible xenobiotic contamination from 3T3s, primary human adipose-derived stem cells (ASCs) were examined as feeder cells to support the expansion of LSCs in vitro . (drcremers.com)
Therefore, we developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. (nature.com)

The Food and Drug Administration (FDA) has received reports of T-cell malignancies, including chimeric antigen receptor CAR-positive lymphoma, in patients who received treatment with BCMA- or CD19-directed autologous CAR T cell immunotherapies such as axicabtagene ciloleucel injection. (medlineplus.gov)
γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)

RESULTS: The autologous transplantation of CD133(+) stem cells into the frontal motor cortex is a safe and well-tolerated procedure in ALS patients. (cellsurgicalnetwork.com)
Tracheal reconstruction and replacement is a complex and vital surgical procedure with several indications, including primary tracheal neoplasm (adenoid cystic carcinoma and squamous cell carcinoma), thyroid cancer, extensive tracheoesophageal fistulas, unsuccessful previous surgery for benign tracheal diseases (re-stenosis, long-term stenosis that has been dilated or been non-surgically repaired) and, rarely, congenital tracheal stenosis. (ersjournals.com)
Before your dose of axicabtagene ciloleucel injection is to be given, a sample of your white blood cells will be taken at a cell collection center using a procedure called leukapheresis (a process that removes white blood cells from the body). (medlineplus.gov)

Ten patients with confirmed ALS without transplantation were used as a control group. (cellsurgicalnetwork.com)
If these statistics are not submitted by Oct. 1 of each year, the result will be immediate suspension of referrals and authorization of new patients. (humana.com)
Since 1997 more than 4500 patients have undergone melanocycle transplantation in our clinic. (mediescapes.com)
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual β cell mass. (edu.pl)
Ninety eligible patients will be randomly assigned at a ratio 1:1:1 to one of the following: control group (n = 30), low-cell dose treatment group (n = 30), and high-cell dose treatment group (n = 30). (unav.edu)
In a first escalating-dose phase, three patients were included sequentially in three dose cohorts (10×106, 50×106 and 100×106 cells). (unav.edu)
Geens M, Van de Velde H, De Block G, Goossens E, Van Steirteghem A, Tournaye H. (2007) The efficiency of magnetic-activated cell sorting and fluorescence-activated cell sorting in the decontamination of testicular cell suspensions in cancer patients. (miekegeens.be)
furthermore, the expanded γδ T cells were adoptively transferred into late-stage liver and lung cancer patients. (nature.com)
In addition, tumor growth rates and organ infiltration patterns associated with injected NB cell lines correlated with the in vitro proliferation properties and genetic markers of poor prognosis in NB patients. (iiarjournals.org)

Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)

However, easy BM-MSC quantification and practical home assays are essential factors for cell-based therapies yet to be optimized. (azd1152.com)
Collectively, this work provides important data for the suitable measurement and development of BM-MSC in support to advanced cell-based therapies for SCD individuals with osteonecrosis. (azd1152.com)

Since 2003, researchers have successfully transplanted corneal stem cells into damaged eyes to restore vision. (wikipedia.org)

Background: Autologous noncultured cell suspension transplantation is an effective treatment for repigmentation in segmental vitiligo and piebaldism. (amsterdamumc.org)
present a comprehensive review of the current efforts to obtain and use transplantable photoreceptors through the controlled treatment of stem cells. (amegroups.org)
Stem cells may provide an alternative treatment for ALS and other neurodegenerative diseases. (cellsurgicalnetwork.com)
Product labeling provides instructions on lymphodepleting treatment, premedication, and management of adverse reactions including cytokine-release syndrome and neurologic toxicity including immune effector cell-associated neurotoxicity syndrome. (ascopost.com)
It is important to be on time and to not to miss your scheduled cell collection appointment(s) or to receive your treatment dose. (medlineplus.gov)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Variables to be examined include agent concentrations, incubation duration and temperature, cell density, sequence of treatment, and number of cycles of in vitro treatment. (arizona.edu)
He adds: "Because the new treatment doesn't involve introducing any new or non-native cells but simply seeks to preserve those normally found in the eye through delicate surgical technique, such an early trial was ethically justified. (medscape.com)

They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)

Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)
The most efficient method to expand limbal stem cells (LSCs) in vitro for clinical transplantation is to culture single LSCs directly on growth-arrested mouse fibroblast 3T3 cells. (drcremers.com)

They may also serve as an unlimited source of therapeutically active cells for regenerative medi- cine. (lu.se)

Dietary manipulation of β-cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study. (edu.pl)
No effect of the 1 alpha, 25-dihydroxyvitamin D3 on β-cell residual function and insulin requirement in adults with new-onset type 1 diabetes. (edu.pl)
Maternal intake of vitamin D during pregnancy and risk of advanced β cell autoimmunity and type 1 diabetes in offspring. (edu.pl)
Β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. (edu.pl)

Scientists have described a cure for cataracts that involves regrowing the lens in the eye using stem cells. (medscape.com)

Peripheral blood mononuclear cells were obtained after admission by leukapheresis. (cellsurgicalnetwork.com)

Axicabtagene ciloleucel injection comes as a suspension (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a doctor's office or infusion center. (medlineplus.gov)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Subcutaneous injection of cell lines induced tumor formation only in NSG mice and was accompanied by metastasis to the liver, adrenal glands, skull and bone marrow. (iiarjournals.org)

This article assessed the safety of using mesenchymal fibroblasts, keratinocytes, melanocytes and skeletal myoblasts in clinical trials.Methods: A systematic search of reliable electronic databases was performed in order to find all articles related to safety of the mentioned cells. (ac.ir)
However, according to serious complications reported for skeletal myoblast cells transplantation, giving ethical approval for using this cell type in human research requires strict commitment to precise methods (such as inclusion criteria, patient follow-up methods, and prophylactic treatments). (ac.ir)

Each CD8 or CD4 component is packed in a carton containing up to 4 vials, depending upon the concentration of the cryopreserved drug product CAR-positive viable T cells. (empr.com)
The recommended tisagenlecleucel dose is 0.6 to 6.0 × 10 8 CAR-positive viable T cells. (ascopost.com)

Anatomy34

Organisms12

Diseases39

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment103

Phenomena and Processes31

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Named Groups2

Health Care21

Hematopoietic6

Tissue37

Allogeneic8

Adult11

Implantation7

Stromal cells6

Melanocyte7

Chemotherapy8

Retinal pigment ep2

Therapeutic10

Chondrocytes2

Full-thickness2

Immunotherapy5

MSCs6

Fetal4

Upon transplantation1

Patient's4

Tissues4

Transplants2

Differentiation5

Efficacy2

Donor8

Islet5

Vivo5

Differentiate3

Epithelial cells2

Therapy20

Clinical outcomes3

Follicular1

20231

Progenitor4

Embryonic6

Regeneration5

Stem cell22

Graft1

Mouse strains2

Tumors2

Pigment1

Expansion4

Antigen2

Procedure3

Patients9

Endothelial cells2

Therapies2

Corneal1

Treatment8

Proliferation1

Vitro2

Regenerative1

Type 1 Diabet4

Involves1

Peripheral1

Injection4

Skeletal2

Viable T cells2