Mesenchymal stemChemotherapyHematopoietic cell transplantationProgenitor CellsASCTTransplantPatients2000Plasma cells in the bone maMultiple myelomaMononuclearLymphoidPeripheral-bloodBiopsyIntra-articularOrgan transplantationDiseaseHSCTChondrocytesCellsStromalTransplantsCytokineTumorsLeukemiaEfficacyTherapiesHuman TissueSpongySpinal1991AcuteLymphomasTreatmentSUPPL2021Stem cellDiseasesSurvivorsTherapyOrgansTissuesImmuneABSTRACTFractures
Mesenchymal stem3
- The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
- Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
- Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Chemotherapy16
- Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
- METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
- During this time, she is undergoing a costly treatment, which includes chemotherapy and autologous bone marrow transplantation. (gofundme.com)
- High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
- High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. (semanticscholar.org)
- Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
- Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
- We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
- Saja received her initial chemotherapy in Rabat, before returning home to Gaza in February 2020 to continue her treatment and undergo bone marrow transplantation in the occupied Palestinian territory. (who.int)
- Throughout efforts to refer Saja for bone marrow transplant, she has been receiving chemotherapy at Rantisi Hospital in Gaza City. (who.int)
Hematopoietic cell transplantation2
- Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. (qxmd.com)
- We assessed late mortality in 854 individuals who had survived 2 or more years after autologous hematopoietic cell transplantation (HCT) for hematologic malignancies. (qxmd.com)
Progenitor Cells3
- The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
- Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
ASCT3
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- High-dose melphalan and autologous stem cell transplantation (HDM/ASCT) is widely used in immunoglobulin light chain (AL) amyloidosis, but the benefit is debated mainly because of the high treatment-related mortality (24% in a randomised study comparing HDM/ASCT with oral melphalan/dexamethasone). (lu.se)
Transplant7
- Bone marrow transplant also referred to as hematopoietic stem cell. (powershow.com)
- The bone marrow transplant is the last alternative generally recommended by the physicians in the cases of fatal bone marrow diseases and bone or skin cancer. (powershow.com)
- She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
- An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
- 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
Patients9
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
- Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
- Gaston-Jahansson J. M, Evelin M. Lachica M.S, Fall-Dickson J.M,, Kennedy J (2004) Psychological Distress, Fatigue, Bourden of Care, and Quality of Life in Primary caregivers of Patients with breast cancer undergoing autologous bone marrow transplantation. (bvsalud.org)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
- Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
20001
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
Plasma cells in the bone ma2
- Multiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. (medlineplus.gov)
- The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)
Multiple myeloma4
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
- In people with multiple myeloma, abnormal plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. (medlineplus.gov)
Mononuclear3
- Aim: The aim of this study was to confirm an effect of the bone marrow derived mononuclear cell (BM-MNC) transplantation for CSPI of the dog. (openveterinaryjournal.com)
- Methods: We test that treatment efficiency with CSPI of 12 dogs by bone marrow derived mononuclear cell (BM-MNC) transplantation. (openveterinaryjournal.com)
- In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
Lymphoid1
- Lymphoid leukemia (lymphoid or lymphoblastic leukemia) arises from the lymphoid line of cells in the bone marrow. (medicinenet.com)
Peripheral-blood2
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
Biopsy1
- If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
Intra-articular3
- The study aimed to evaluate the short-term clinical effect, therapeutic response rate (TRR%), and therapy safety of a single intra-articular autologous MFAT injection for symptomatic knee OA. (mdpi.com)
- The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
- Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Organ transplantation2
- In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
- Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
Disease7
- CXCR4 mutations cause symptomatic hyperviscosity syndrome and high bone marrow activity characteristic of the disease. (wikipedia.org)
- The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
- Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. (cdc.gov)
- Many affected individuals have widespread disease at diagnosis, with involved regions often including multiple lymph nodes, the spleen, and, potentially, the bone marrow, the liver, and/or regions of the digestive (gastrointestinal) tract. (rarediseases.org)
- MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
- Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
HSCT3
- The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
- This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
- Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Chondrocytes1
- Autologous chondrocytes implantation and osteochondral autograft transplantation are limited by scarce cartilage production, low proliferative capacity of chondrocytes, chondrocyte de-differentiation and complications due to donor site morbidity 5 . (nature.com)
Cells18
- Preliminary Study of Autologous Bone Marrow Nucleated Cells Transplantation in Children With Spinal Cord Injury. (stembook.org)
- Bone marrow is mainly responsible for the haematopoiesis, (formation of blood cells), production of lymphocytes, and the storage of fats. (powershow.com)
- The bone marrow makes blood cells. (medlineplus.gov)
- It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
- As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
- An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)
- Lymphatic tissues also include the thymus, a relatively small organ behind the breastbone that is thought to play an important role in the immune system until puberty, as well as the bone marrow, which is the spongy tissue inside the cavities of bones that manufactures blood cells. (rarediseases.org)
- Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
- Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
- Blood platelets are generated from bone marrow stem cells, serving not only to control normal bleeding, but involved also in excessive clotting that may predispose to pathological disorders such as heart attacks and stroke. (ny.gov)
- For our NYSTEM proposal, we have developed novel means of infecting bone marrow stem cells to specifically target the deficient protein (factor VIII) in bone marrow stem cells that are the precursors for circulating blood platelets. (ny.gov)
- Leukemia is a cancer of the blood cells and bone marrow. (medicinenet.com)
- It is slow-growing cancer that begins in the lymphocyte cells present in the bone marrow. (medicinenet.com)
- The bone marrow produces a high number of B-Cells, a type of white blood cell that fights against infection-causing a decrease in healthy blood cells. (medicinenet.com)
- A group of closely related diseases in which the bone marrow produces very few healthy, functioning red blood cells , white blood cells, platelets, or any combination of the three. (medicinenet.com)
- and those transplanted with autologous hematopoietic stem cells. (cancernetwork.com)
- Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathy]. (bvsalud.org)
- The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
Stromal2
- Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
- Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
Transplants1
- It was suggested that a combination of bone marrow transplants and very high doses of anticancer drugs could pulverise breast cancer into submission. (healthy.net)
Cytokine1
- Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
Tumors1
- The growth of these bone tumors weakens the bones. (medlineplus.gov)
Leukemia1
- I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Efficacy1
- This study aims to examine the efficacy and safety of ABM-MSC and ABM-MNC transplantation in T2DM and explores alterations in glucose-insulin homeostasis by metabolic studies. (drcalapai.com)
Therapies1
- The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
Human Tissue2
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Spongy1
- Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
Spinal1
- Radiation therapy may be used to relieve bone pain or to shrink a tumor that is pushing on the spinal cord. (medlineplus.gov)
19911
- A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
Acute1
- For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
Lymphomas1
- Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
Treatment2
- Whereas, cell transplantation therapy is very desirable strategy for the treatment of CSPI, though much preclinical and clinical research work remains. (openveterinaryjournal.com)
- Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
SUPPL1
- Bone Marrow Transplantation , 5 (SUPPL. (tau.ac.il)
20211
- The bone marrow market is expected to gain market growth in the forecast period of 2021 to 2028. (powershow.com)
Stem cell1
- The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
Diseases1
- The growing amount of bone marrow diseases will help in escalating the growth of the bone marrow market. (powershow.com)
Survivors1
- Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being. (qxmd.com)
Therapy1
- 1 ] reported that long-term alendronate therapy could cause severely suppressed bone turnover (SSBT), resulting in delayed healing of nonspinal fractures. (hindawi.com)
Organs3
- This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
- In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Tissues1
- Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
Immune1
- Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
ABSTRACT1
- abstract = "Although high-dose chemoradiotherapy used for conditioning prior to autologous bone marrow transplantation (BMT) represent an effective tool for eradication of certain malignant hematological disorders, relapses indicate that the last tumor cell is unlikely to be completely eradicated. (tau.ac.il)
Fractures3
- You may develop broken bones (bone fractures) just from doing normal activities. (medlineplus.gov)
- Bone x-rays, CT scans, or MRI may show fractures or hollowed out areas of bone. (medlineplus.gov)
- They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)