AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowTransplantation, AutologousBone Marrow CellsTransplantation, HomologousBone Marrow PurgingBone and BonesWhole-Body IrradiationGraft vs Host DiseaseCombined Modality TherapyCyclophosphamideHematopoietic Stem Cell TransplantationBone Marrow DiseasesHematopoietic Stem CellsTransplantation ConditioningLymphoma, Non-HodgkinCarmustineLeukemiaBusulfanAnemia, AplasticGraft SurvivalHematopoiesisRemission InductionMelphalanLeukemia, Myeloid, AcuteBone Marrow ExaminationTransplantation ChimeraAntineoplastic Combined Chemotherapy ProtocolsBone RemodelingColony-Forming Units AssayRecurrenceTreatment OutcomeBone Marrow NeoplasmsEtoposideTissue DonorsLiver TransplantationHodgkin DiseaseTransplantation, IsogeneicLeukemia, MyeloidPrecursor Cell Lymphoblastic Leukemia-LymphomaTime FactorsHistocompatibility TestingCytarabineStem Cell TransplantationMice, Inbred C57BLHistocompatibilityBone DensityRadiation ChimeraSurvival AnalysisActuarial AnalysisLeukemia, Myelogenous, Chronic, BCR-ABL PositiveAcute DiseaseHepatic Veno-Occlusive DiseaseHematologic DiseasesMyelodysplastic SyndromesBone ResorptionKidney TransplantationLymphomaImmunosuppressive AgentsT-LymphocytesMultiple MyelomaGranulocyte Colony-Stimulating FactorFollow-Up StudiesBone TransplantationCell DifferentiationLeukocyte CountDrug EvaluationImmunosuppressionHematologic NeoplasmsThiotepaVincristineSurvival RateRetrospective StudiesDisease-Free SurvivalAntigens, CD34PodophyllotoxinGraft RejectionCells, CulturedGranulocytesSalvage TherapyFlow CytometryBone NeoplasmsGraft vs Host ReactionLymphocyte DepletionTransplantation ImmunologyCell SeparationCyclosporineChimeraLeukocyte TransfusionPrognosisAntibodies, MonoclonalGranulocyte-Macrophage Colony-Stimulating FactorBlood Cell CountSevere Combined ImmunodeficiencyPlatelet CountHLA AntigensStromal CellsPancytopeniaSpleenBone Development
TransplantMultiple myelomaTransplantsCell transplantationPatient'sMesenchymal stemHSCTProgenitorRegenerativeDonorClinicalHigh dose chemotherapyASCTStem cell therapiesChondrocyte implantationPerson'sAdipose TissueBiopsySurvivalCellsCellular therapiesEngraftmentCancerEfficacyCancersAllograftDiseasesCancerousNeuroblastomaPulmonaryCord bloodLiverImmunotherapyLymphSpongyMyelodysplasticTreatmentRadiation therapySpinal cordNovel therapiesSymptomaticComplicationsRefractory
Transplant31
Multiple myeloma8
Transplants9
  • Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
  • Bone marrow transplantation, begun in 1983, and stem cell transplantation have grown to encompass allogeneic, unrelated, cord blood, autologous transplants and mini-allogeneic (reduced intensity conditioning) transplantation strategies. (nymc.edu)
  • Due to the affiliation with the medical team at the top hospitals in Ghana for bone marrow transplants, they can provide excellent results. (bonemarrowtransplantations.com)
  • They helped many people in Ghana who needed bone marrow transplants, and these patients were successfully treated. (bonemarrowtransplantations.com)
  • It was suggested that a combination of bone marrow transplants and very high doses of anticancer drugs could pulverise breast cancer into submission. (healthy.net)
  • In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
  • Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
  • Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
  • Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
Cell transplantation35
Patient's3
  • The patient's clinical condition deteriorated over the next 36 hours despite steroid and antibiotic therapy, and the patient had to undergo a total colectomy and ileostomy. (medscape.com)
  • After potassium replacement therapy, the patient's pseudo-obstruction completely resolved. (medscape.com)
  • The patients enrolled in our trial received a subcutaneous medication for 4 consecutive days to stimulate their bone marrow to produce SCs, their bone marrow was then harvested, SCs were concentrated at the laboratory, and then they were delivered through the patient's cerebrospinal fluid on the fifth day of the procedure. (parentsguidecordblood.org)
Mesenchymal stem2
  • This type of cartilage repair technique is often fortified by bone marrow acquired autologous mesenchymal stem cell support. (ivis.org)
  • NEURONATA-R also uses autologous bone marrow mesenchymal stem cell therapy. (geneonline.com)
HSCT5
  • this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
  • The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. (ox.ac.uk)
  • METHODS: Patients received 666 MBq/kg of 131I-mIBG and single HDC and HSCT from autologous or allogeneic stem cell sources. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
Progenitor9
  • Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
  • Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
  • For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
  • For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
  • For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
  • Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
Regenerative4
  • Beside unique operative techniques adjuvant regenerative therapies may improve clinical results. (ivis.org)
  • Salewski RPF, Eftekharpour E, Fehlings MG. Are induced pluripotent stem cells the future of cell-based regenerative therapies for spinal cord injury? (elearnsci.org)
  • Conclusion: Dentin-pulp complex shows regenerative capacity, but the literature lacks evidence to validate the regenerative therapies in endodontic practice. (bvsalud.org)
  • The basis of regenerative medicine is the use of tissue regenerative therapies 14 . (bvsalud.org)
Donor4
  • National Marrow Donor Program. (mayoclinic.org)
  • Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
  • Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
Clinical9
  • Treatment options for refractory ALL may include high dose chemotherapy, targeted therapy, immunotherapy, clinical trials , or palliative care to manage symptoms and improve quality of life. (medicalnewstoday.com)
  • This success opens the door to a phase II clinical trial that can test the efficacy of autologous bone marrow SCs. (parentsguidecordblood.org)
  • Her main area of research interest is cellular therapy, in which she has clinical trials running and listed in ClinicalTrials.gov. (parentsguidecordblood.org)
  • Most data regarding the impact of age on survival mainly come from clinical trials developed before the current therapy choices were in use. (scielo.br)
  • The study aimed to evaluate the short-term clinical effect, therapeutic response rate (TRR%), and therapy safety of a single intra-articular autologous MFAT injection for symptomatic knee OA. (mdpi.com)
  • Furthermore, because Ghana offers European-standard cancer care and medical therapy, along with highly competent employees in continuously well-maintained contemporary clinical facilities, medical professionals from all over West Africa chose Ghana as their patients' preferred treatment location. (bonemarrowtransplantations.com)
  • Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials. (ox.ac.uk)
  • The main clinical problem in treating NB is metastasis, specifically metastatic stages III and IV according to the International Neuroblastoma Staging System ( 1 , 2 ), because metastatic lesions are often resistant to current therapies. (iiarjournals.org)
  • These data further validate the efficacy of gene therapy for MSUD opening perspectives towards clinical translation. (stanford.edu)
High dose chemotherapy2
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
ASCT2
  • Progression-free survival for people who have received an HDT-ASCT combination therapy is around 3.5 years. (janssen.com)
  • The role of ASCT consolidation after salvage therapy remains controversial and may benefit only a subset of patients with relapsed MCL. (medscape.com)
Stem cell therapies2
  • Will stem cell therapies be safe and effective for treating spinal cord injuries? (elearnsci.org)
  • Other types of laboratory-based dental stem cell therapies are under development. (bvsalud.org)
Chondrocyte implantation2
  • Autologous osteochondral mosaicplasty and autologous chondrocyte implantation are the oldest modern cartilage repair options. (ivis.org)
  • Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Person's2
Adipose Tissue3
Biopsy1
Survival1
  • Compared with sub-lethal irradiation, Busulfan conditioning enhanced the engraftment of edited CD34+ cells in the bone marrow, as well the long-term homing and survival of bone-marrow-derived cells in viscera, and in the CNS, resulting in higher transgene expression and biochemical correction in these organs. (stanford.edu)
Cells34
Cellular therapies2
  • Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies? (bmj.com)
  • These treatments include antibodies, small molecules and CAR T-cell and other cellular therapies. (hackensackmeridianhealth.org)
Engraftment1
Cancer4
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • Few stories in medicine are as sobering as the American experience with autologous bone marrow transplantation (ABMT) for treating breast cancer. (healthy.net)
  • But legal wranglings over who should foot the bill for the high cost of this supposed treatment, as well as the findings of major randomised trials that didn't support the use of the therapy, conspired to scuttle this establishment approach to breast cancer treatment from the start. (healthy.net)
  • Past treatment with radiation therapy increases the risk for this type of cancer . (medlineplus.gov)
Efficacy4
  • In addition, high-dose corticosteroids have only limited efficacy as therapy for DAH after allotransplantation. (nih.gov)
  • Current statistics report an increase in the incidence of hematological and oncological malignancies, 1 but treatment with immune-based therapies have also risen in both use and efficacy. (bmj.com)
  • Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165. (biomedcentral.com)
  • Since the initial success of cell therapy for ischemic diseases many attempts have been made to increase its efficacy. (biomedcentral.com)
Cancers1
  • This was the first example of a successful SC therapy, and is still commonly used today for blood and bone-marrow-related cancers such as leukemia and myeloma. (parentsguidecordblood.org)
Allograft1
  • For extended osteochondral defects new types of osteochondral allograft transplantation are recommended. (ivis.org)
Diseases3
  • Cellular therapy of the injured brain has been studied in preclinical models for more than a decade, providing the basis for the development of new therapies for a broad spectrum of human neurological diseases. (parentsguidecordblood.org)
  • European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE) None. (ox.ac.uk)
  • Dr. Pasqualina Colella is a scientist with extensive expertise in cell therapy and gene therapy approaches for the treatment of inherited diseases. (stanford.edu)
Cancerous1
  • The section of solid tumor oncology has been collaborating with the hepatobiliary service and the liver surgery service to find new therapies for cancerous organs that historically have been difficult to treat with chemotherapy. (nymc.edu)
Neuroblastoma4
  • PURPOSE: Paediatric high-risk neuroblastoma has poor prognosis despite modern multimodality therapy. (bvsalud.org)
  • CONCLUSION: 131I-mIBG therapy with 666 MBq/kg followed by single HDC and autologous or allogeneic SCT is safe and efficacious in patients with high-risk neuroblastoma and has no DLT. (bvsalud.org)
  • The primary end point was response after one course by New Approaches to Neuroblastoma Therapy criteria. (bvsalud.org)
  • An additional five, five, and four patients met New Approaches to Neuroblastoma Therapy Minor Response criteria on arms A, B, and C, respectively. (bvsalud.org)
Pulmonary1
Cord blood2
  • In the meantime, we believe that patients with cerebral palsy can be treated with their own bone marrow SCs when their cord blood SCs were not preserved. (parentsguidecordblood.org)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Liver4
  • Subcutaneous injection of cell lines induced tumor formation only in NSG mice and was accompanied by metastasis to the liver, adrenal glands, skull and bone marrow. (iiarjournals.org)
  • The incidence of metastasis to various sites at diagnosis is as follows: 70.5% to bone marrow, 55.7% to bone, 30.9% to lymph nodes, 29.6% to liver, 18.2% to the cranium, 3.3% to lung, and 0.6% to the CNS ( 3 ). (iiarjournals.org)
  • As Postdoc she developed innovative in vivo AAV gene therapy approaches based on liver gene transfer or multi-tissue gene expression to target the multi-organ manifestations of Pompe disease, a LSD that presents with neuromuscular impairment. (stanford.edu)
  • Orthotopic liver transplantation is a beneficial therapeutic option, which shows that restoration of only a fraction of whole-body BCKD enzyme activity is therapeutic. (stanford.edu)
Immunotherapy1
  • These are slow growing tumors that may be treated with surgery, radiation therapy , the immunotherapy drug rituximab, or occasionally with antibiotics. (dana-farber.org)
Lymph1
Spongy1
  • Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
Myelodysplastic1
Treatment11
  • Neupogen therapy should only be given in collaboration with an oncology centre which has experience in G-CSF treatment and haematology and has the necessary diagnostic facilities. (medicines.org.uk)
  • Treatment includes induction therapy and postremission therapy (consolidation). (medscape.com)
  • As a community, we have gone from the development of a first-in-class proteasome inhibitor treatment some twenty years ago, to now exploring the ground-breaking reaches of personalised medicine through CAR-T therapy and beyond. (janssen.com)
  • Based on its pathophysiology and the resemblance of CRS to sepsis and septic shock, as well as based on the principles of initiation of continuous renal replacement therapy (CRRT) in sepsis, we propose the rationale of using CRRT therapy as an adjunct treatment in CRS where all the other approaches have failed in controlling the clinically significant manifestations. (bmj.com)
  • Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)
  • CAR T-cell therapy has shown excellent results, especially in cases where other treatment methods have failed. (bookinghealth.com)
  • Altogether, fewer than 30 to 40% of patients with NB survive despite aggressive treatment combinations that involve multiagent chemotherapy, surgery, autologous bone marrow transplantation, and radiation ( 3 - 5 ). (iiarjournals.org)
  • Successful treatment of severe MSUD in Bckdhb-/- mice with neonatal AAV gene therapy. (stanford.edu)
  • 204. Prior CD19 targeted therapy with the exception of subjects who received KTE-X19 or axicabtagene ciloleucel in this study and are eligible for re-treatment. (who.int)
  • MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
  • Endodontic treatment of teeth with open apex requires a non-conventional approach and the goals new therapies are to allow root's complete development differently from what happens with traditional apexification technique. (bvsalud.org)
Radiation therapy4
  • Learn more about the various types of radiation therapy. (medicalnewstoday.com)
  • Learn more about the side effects of radiation therapy here. (medicalnewstoday.com)
  • Radiation therapy may be used to relieve bone pain or to shrink a tumor that is pushing on the spinal cord. (medlineplus.gov)
  • Lesions that have been previously irradiated will be considered measurable only if progression has been documented following completion of radiation therapy. (who.int)
Spinal cord4
  • A systematic review of directly applied biologic therapies for acute spinal cord injury. (elearnsci.org)
  • Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial. (elearnsci.org)
  • Ruff CA, Wilcox JT, Fehlings MG. Cell-based transplantation strategies to promote plasticity following spinal cord injury. (elearnsci.org)
  • A systematic review of cellular transplantation therapies for spinal cord injury. (elearnsci.org)
Novel therapies1
Symptomatic1
  • CXCR4 mutations cause symptomatic hyperviscosity syndrome and high bone marrow activity characteristic of the disease. (wikipedia.org)
Complications1
  • They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)
Refractory3
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Combination therapies involving melphalan, a small-molecule DNA alkylating agent, are commonly prescribed to patients with relapsed or refractory MM, necessitating the stratification of responding patients to minimize toxicities and improve quality of life. (snmjournals.org)