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  • regenerate
  • ESCs possess many of the same therapeutic properties as MSCs, including the ability to self-regenerate and differentiate into a number of cell lineages. (wikipedia.org)
  • Reports of the heart's ability to repair itself have started to appear in peer reviewed journals and a paper has been published that has shown the potential of bone marrow cells to regenerate myocardium (myogenesis). (wikipedia.org)
  • treatment
  • This research investigates the use of autologous bone marrow stem cells for the treatment of medically refractory temporal lobe epilepsy patients. (clinicaltrials.gov)
  • C-kit positive cell density in kidneys post-IRI and laser-treatment was (p = 0.05) 2.4-fold higher compared to that of the non-laser treated group. (sigmaaldrich.com)
  • Stem cell based therapies for the treatment of Duchenne muscular dystrophy (DMD) can proceed via two strategies. (clinicaltrials.gov)
  • This pilot study is to determine whether it would be safe and feasible to inject CD34+ stem cells from bone marrow into the eye as treatment for patients who are irreversibly blind from various retinal conditions. (clinicaltrials.gov)
  • Therefore, an ideal treatment must possess both immunomodulating properties to control irregular autoimmune responses to prevent further damage and regenerative properties to stimulate natural repair mechanisms and replace damaged cells. (wikipedia.org)
  • The exact therapeutic mechanisms of MSCs in the treatment of MS are still very much up to debate among stem cell researchers. (wikipedia.org)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • antigen
  • MSCs can also produce an immunomodulating effect by stimulating the maturation of antigen presenting cells. (wikipedia.org)
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (wikipedia.org)
  • myocardium
  • There were no periprocedual complications such as sustained ventricular arrhythmias and pericardial effusions, nor did any significant adverse effects such as bone formation in the myocardium at the 2-month follow-up. (ahajournals.org)
  • tendon
  • When the tendon tears, it can break a piece of the bone off of the kneecap. (wikipedia.org)
  • A partial tear is when some of the fibers of the patellar tendon are torn but the majority of the tendon is still attached to the soft tissue located at the posterior end of the patella bone. (wikipedia.org)
  • It is thought to be caused by microtears in the connective tissue in and around the tendon, leading to an increase in tendon repair cells. (wikipedia.org)
  • MSCs
  • By suppressing the unregulated proliferation of T and B cells, MSCs can potentially minimize and control on-going damage to the CNS. (wikipedia.org)
  • MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
  • precursors
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes. (wikipedia.org)
  • CD34
  • This will be the first human trial to determine and compare favourable and unfavourable effects of bone marrow mononuclear cells(mainly CD34) in acute ischamic stroke and also the first multi-centric study with potential to achieve a reasonable sample size in a relatively short time. (clinicaltrials.gov)
  • CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. (wikipedia.org)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration. (wikipedia.org)
  • The presence of CD34 on non-hematopoietic cells in various tissues has been linked to progenitor and adult stem cell phenotypes. (wikipedia.org)
  • citation needed] CD34 is expressed in roughly 20% of murine hematopoietic stem cells, and can be stimulated and reversed. (wikipedia.org)
  • clinical
  • The administration of cells via an infusion through the infarct related artery appears to be feasible and result in a clinical effect in some studies. (clinicaltrials.gov)
  • injections
  • Intraspinal injections of bone marrow mononuclear cells (MNC) have been able to ameliorate the course of ALS in murine models, acting as pumps of trophic factors that keep the motoneurons functional. (clinicaltrials.gov)
  • Twenty small injections of cellular suspension were directly made through a 21F butterfly needle(total=5 ml), in the anterior, lateral, posterior and apical faces of the left ventricle(average 9.6 ± 2.6 x 107 cells). (clinicaltrials.gov)
  • vivo
  • MicroRNA-155 regulates the proliferation and growth of WM cells in vitro and in vivo, by inhibiting MAPK/ERK, PI3/AKT, and NF-κB pathways. (wikipedia.org)
  • gene
  • Duplicated segments of the LMO1 gene within neuroblastoma tumor cells have been shown to increase the risk of developing an aggressive form of the cancer. (wikipedia.org)
  • WM cells show only minimal changes in cytogenetic and gene expression studies. (wikipedia.org)
  • Neurodegenerative
  • Research is underway to develop various sources for stem cells, and to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes, heart disease, and other conditions. (wikipedia.org)
  • The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders with pathological phenotypes that auto fluorescent lipopigments present in neurons and other cell types. (wikipedia.org)
  • endogenous
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • IL-1α is also known as fibroblast-activating factor (FAF), lymphocyte-activating factor (LAF), B-cell-activating factor (BAF), leukocyte endogenous mediator (LEM), epidermal cell-derived thymocyte-activating factor (ETAF), serum amyloid A inducer or hepatocyte-stimulating factor (HSP), catabolin, hemopoetin-1 (H-1), endogenous pyrogen (EP), and proteolysis-inducing factor (PIF). (wikipedia.org)
  • involves
  • The WM spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms. (wikipedia.org)
  • disease
  • Eligibility for selecting studies Randomised controlled trials evaluating the effect of autologous bone marrow stem cells for heart disease on mean left ventricular ejection fraction. (bmj.com)
  • The disease is caused when a person's antibody-producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains. (wikipedia.org)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration, such as in Parkinson's, Amyotrophic lateral sclerosis, and Alzheimer's disease. (wikipedia.org)
  • Stems cells are being studied in those with severe heart disease. (wikipedia.org)
  • WM is characterized by having high levels of a circulating antibody, immunoglobulin M (IgM), which is made and secreted by the cells involved in the disease. (wikipedia.org)
  • A diagnosis of Waldenström's macroglobulinemia depends on a significant monoclonal IgM spike evident in blood tests and malignant cells consistent with the disease in bone marrow biopsy samples. (wikipedia.org)