Autologous bone marrow mononuclear cells. Medical search. Frequent questions

Whereas, cell transplantation therapy is very desirable strategy for the treatment of CSPI, though much preclinical and clinical research work remains. (openveterinaryjournal.com)
Aim: The aim of this study was to confirm an effect of the bone marrow derived mononuclear cell (BM-MNC) transplantation for CSPI of the dog. (openveterinaryjournal.com)
Methods: We test that treatment efficiency with CSPI of 12 dogs by bone marrow derived mononuclear cell (BM-MNC) transplantation. (openveterinaryjournal.com)
The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
In addition, the regenerative potential of purified stem cells was assessed 3 weeks after transplantation in immunodeficient mice which had been subjected to experimental myocardial infarction. (biomedcentral.com)
Among all, cell transplantation therapy is considered the most favourable treatment strategy for femoral head necrosis. (ijpsonline.com)
Pilot studies suggest that intracoronary transplantation of progenitor cells derived from bone marrow (BMC) or circulating blood (CPC) may improve left ventricular function after acute myocardial infarction. (pharmaceuticalintelligence.com)
The effects of cell transplantation in patients with healed myocardial infarction are unknown. (pharmaceuticalintelligence.com)
Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)

The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
Improvement in insulin sensitivity with MSCs and increase in C-peptide response with MNCs provide newer insights in cell-based therapies. (drcalapai.com)
Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)
1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)
Cytokines and growth factors (interleukin-8 transforming growth factor-beta stromal cell-derived factor-1alpha and vascular endothelial growth factor) that mediate endogenous bone regeneration were also produced by expanded MSCs from SCD patients. (bioskinrevive.com)
And for a final bit of dèja vu to start the new year, here is yet another trial showing that you can safely put transendocardial stem cells with autologous mesenchymal stem cells (MSCs) and bone marrow mononuclear cells (BMCs) into patients with ischaemic cardiomyopathy. (jwatch.org)
12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)
Ixmyelocel-T contains expanded populations of mesenchymal stromal cells (MSCs) and M2-like macrophages, as well as many of the CD45+ cells found in the bone marrow. (lonza.com)

These landmark publications have been the basis for the new field of autologous bone marrow stem cell therapy for heart disease. (wikipedia.org)
Is stem cell therapy ready for patients? (wikipedia.org)
Stem Cell Therapy for Cardiac Repair. (wikipedia.org)
However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease? (bmj.com)
In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
According to the European Medicines Agency (EMA) BM-derived CD133 + stem cells intended for the regeneration of human ischemic heart tissue are classified as an advanced therapy medicinal product (ATMP) [ 17 ]. (biomedcentral.com)
The main objective of this communication is to study the treatment of femoral head necrosis with cell replacement therapy and also its effects by focusing on the disease stages. (ijpsonline.com)
Introduction Stem cell therapy with bone marrow-derived mononuclear cells (BMMCs) is an option for improving joint function in osteonecrosis of the femoral head (ONFH). (bioskinrevive.com)
Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes. (bmj.com)
Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability. (bmj.com)
Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods, cell dosing, type of cells used, timing of delivery, infarct size and location of infarct that are likely to benefit from cell therapy. (bmj.com)
Cell therapy is one approach to enhancing recovery after stroke. (bmj.com)
9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
Ambrose Cell Therapy, Inc is a management service organization that manages Ambrose Physician Services, PC. (ambrosecelltherapy.com)
The aggressive marketing approach currently used by practitioners and clinics regarding various birth tissue products as safe and effective "stem cell therapy" is not supported by the existing scientific literature. (ambrosecelltherapy.com)
Therapeutic potential of ixmyelocel-T, an expanded autologous multicellular therapy for treatment of ischemic cardiovascular diseases. (lonza.com)
Ixmyelocel-T, an expanded autologous multicellular therapy, is manufactured from a small sample of bone marrow aspirate. (lonza.com)
In conclusion, ixmyelocel-T therapy may provide a new aspect of therapeutic angiogenesis in this patient population where expanded populations of regenerative cells might be required. (lonza.com)
So, if someone is searching for an affordable, safe, and effective treatment, they can consider choosing stem cell therapy for down syndrome in India . (viezec.com)
He has been an author in Biotechnology and is an active Diamond Member of EMT attaining ACGME certifications in Pain Management, Medical, Dermatological & Surgical Aesthetics, Laser Skin Therapy, Innovative Regenerative Biological Therapies, Autologous Fat Transfer and Anti-Aging Medicine. (regenestem.com)
Dr. Novas holds key positions in prestigious organizations related to regenerative medicine and stem cell research, including the Gene-Therapy Biomedical Research College in Wellington, Florida, and the Far Eastern University in Manila, Philippines. (regenestem.com)
She also actively participates as an academic member of the European Society of Gene and Cell Therapy and the International Society for Cellular Therapy, among others. (regenestem.com)
Subjects who relapse =12 months after therapy should have progressed after autologous transplant or been ineligible for autologous transplant. (who.int)

Professor Bodo-Eckehard Strauer (born 16 January 1943) is a German cardiologist who has made award-winning contributions to cardiovascular science including pivotal reports that transfusions of patients' own bone marrow cells into the coronary arteries can increase the pumping efficacy of a weak heart. (wikipedia.org)
To determine the safety and efficacy of intramyocardial autologous blood stem cell injection for cardiomyopathy. (tci-thaijo.org)
Ruengsakulrach P, Visudharom K, Chaothawee L, Belkin M. Safety and Efficacy of Intramyocardial Implantation of Peripheral Blood Stem Cell for Cardiomyopathy. (tci-thaijo.org)

Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
CD133 + stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. (biomedcentral.com)
INTRODUCTION: Bone marrow derived cellular therapies are an emerging approach to promoting therapeutic angiogenesis in ischemic cardiovascular disease. (lonza.com)

Adult stem cells remain of particular interest as therapeutic agents for cardiac regeneration in ischemic heart disease [ 1 - 4 ]. (biomedcentral.com)
These findings support the potential therapeutic value of autologous ADRC administration for reduction of HTS development following deep-partial cutaneous injury. (biomedcentral.com)
Therapeutic angiogenesis with autologous stem/progenitor cells is a promising novel strategy for treatment of severe ischemic diseases. (nagoya-u.ac.jp)
Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study. (nagoya-u.ac.jp)
Recently, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (EVs) have emerged as a potential new therapeutic agent for stroke treatment. (explorationpub.com)
Nonunion is a serious complication following long-bone fracture that is known as a therapeutic challenge for surgeons and is associated with significant morbidity. (ijos.ir)

Patients with TAO exhibit hypersensitivity to intradermally injected tobacco extracts, increased cellular sensitivity to collagen types I and III, elevated serum anti-endothelial cell antibody titers, and impaired peripheral endothelium-dependent vasorelaxation. (medscape.com)
Nevertheless, every effort should be made to improve distal arterial flow in patients with TAO, and autologous vein bypass of coexistent large-vessel atherosclerotic stenoses should be considered in patients with severe ischemia who have an acceptable distal target vessel. (medscape.com)
Forty patients (60 hips) with stage I, II or III (ARCO system) osteonecrosis of femoral head were treated by either core decompression and isolated mononuclear cells (group A) or core decompression and unprocessed bone marrow injection (group B). The patients were followed up clinically and radiologically for a minimum of 2 years. (nih.gov)
Conclusion The autologous BMMC implantation with a minimally invasive technique resulted in significant pain relief and halted the progression of early stages of ONFH in SCD patients. (bioskinrevive.com)
In summary our results indicate that infusion of BMMCs enriched with stem/progenitor cells is a safe and effective treatment for the early stages of ONFH in SCD patients. (bioskinrevive.com)
Depending upon the particular genotype and severity of the SCD the prevalence of ONFH ranges from 3 to 50 % among SCD patients [4 5 Osteonecrosis can be viewed as a vascular and bone disease with altered bone remodeling. (bioskinrevive.com)
10 11 Using a similar stereotactic approach implanting cells into the basal ganglia, Savitz and colleagues transplanted LGE cells (fetal porcine striatum-derived cells, Genvec) in five patients. (bmj.com)
At least 300 patients had reported bacterial infections tied to Liveyon's umbilical cord stem cell products. (ambrosecelltherapy.com)
The more FDA warns providers and patients of perinatal stem cells and their exosomes' risks, the more the fad is becoming a frenzy too. (ambrosecelltherapy.com)
Between May 2005 and February 2010, 126 consecutive patients underwent intramyocardial cell injection. (tci-thaijo.org)
After an initial pilot trial involving 17 patients, we randomly assigned, in a controlled crossover study, 75 patients with stable ischemic heart disease who had had a myo-cardial infarction at least 3 months previously to receive either no cell infusion (23 patients) or infusion of CPC (24 patients) or BMC (28 patients) into the patent coro-nary artery supplying the most dyskinetic left ventricular area. (pharmaceuticalintelligence.com)
This study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic conditions. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater. (biomedcentral.com)
The density of MNCs was 5.22 million cells per mL and 5.03% CD34+ cells in patients with three neurologic conditions. (biomedcentral.com)
The highest density of MNCs in each ml of bone marrow was found in patients with CP due to OD, whereas the percentage of CD34+ cells was the highest among patients with CP related to NI. (biomedcentral.com)
In this study, we aimed to identify the concentrations of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of these patients and their correlation with treatment outcomes. (biomedcentral.com)
Bone marrow aspiration was conducted from the patients' bilateral anterior iliac crest under general anesthesia in an operating theater at Vinmec Times City International Hospital. (biomedcentral.com)
Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis. (phosphatases.com)

Implantation of autologous bone marrow stem cells in avascular necrosis of femoral head is a safe and effective procedure and has better outcome than bone marrow for early stage of avascular necrosis of femoral head. (nih.gov)
This study demonstrated safety and feasibility of stereotactic cell implantation, although there was no significant improvement in functional outcomes. (bmj.com)
She has been instrumental in imparting knowledge and proper protocols for harvesting and isolating adipose-derived stem cells for autologous re-implantation to physicians worldwide. (regenestem.com)

en-hanced regional contractility in the area targeted by intracoronary infusion of BMC. (pharmaceuticalintelligence.com)
whether intracoronary infusion of pro-genitor cells into the infarct-related artery at least 3 months after myocardial infarction improves global and regional left ventricular function. (pharmaceuticalintelligence.com)

however, their role in β-cell regeneration remains elusive. (drcalapai.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
The regeneration potential of these cells is mainly based on their direct contribution to neovascularization and on their secretion of various paracrine factors activating pro-angiogenic mechanisms [ 13 - 16 ]. (biomedcentral.com)
In Dentistry, many studies have aimed to improve bone regeneration through the use of BMPs for bone replacement. (bvsalud.org)
Several studies demonstrate the biological advantages of rhBMP-2 on bone regeneration of the jaws. (bvsalud.org)

The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)

CONCLUSIONS: This work demonstrates that ixmyelocel-T interacts with endothelial cells in a paracrine manner, resulting in angiogenesis and endothelial protection. (lonza.com)

However, the percentage of regenerative cells in bone marrow mononuclear cells (BMMNCs) is small, and large amounts of BMMNCs are required. (lonza.com)
Bone marrow mononuclear cells (BMMNCs) consist of hemopoietic stem cells and mesenchymal stem cells together with progenitors of endothelial cells or somatic cells [ 1 , 2 ]. (biomedcentral.com)

These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)

Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)

An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)

Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
Subjects who have undergone autologous SCT with disease progression or relapse following SCT will be eligible if all other eligibility criteria are met. (who.int)

Bone marrow-derived mononuclear cells with their angiogenic and osteogenic properties appear to have the potential to halt the disease process when injected intralesionally following core decompression. (nih.gov)
The final product is called angiogenic cell precursors (ACPs). (tci-thaijo.org)

Flow cytometry analysis showed a significantly higher number of hematopoietic stem/endothelial progenitor cell markers in concentrated BMMCs when compared with bone marrow aspirate indicating an enrichment of these cell types. (bioskinrevive.com)
In this study, we aimed to treat nonunion using autologous bone marrow-derived mononuclear cell (BMDMC) aspirate as a source of osteoprogenitor cells combined with internal fixation. (ijos.ir)

The number of cells prior to injection was 46.1 ± 36.5 million cells. (tci-thaijo.org)
Combined coronary artery surgery and cell injection were performed in 33.8% of ICM cases. (tci-thaijo.org)

Comparison of NOD-like receptors in limbal stem cell-derived corneal epithelial cells and in immortalized corneal epithelial cell line. (remedicon.hu)
that binds heparin and dermatan sulfate, and facilitates binding of B. burgdorferi to epithelial cells and glial cells [50]. (phosphatases.com)
For example, Vero cells, which were derived from monkey kidney epithelium [65], can be used as a representative of epithelial cells for studying GAGs-mediated adherence. (phosphatases.com)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)

The study will test if these cells preserve injured brain tissue after traumatic injury. (childrenslearninginstitute.org)

Melero-Martin JM , Khan ZA , Picard A , In vivo vasculogenic potential of human blood-derived endothelial progenitor cells . (avma.org)
Propagation and differentiation of neural stem cells at different O2 levels: comparative studies in vitro and in vivo. (remedicon.hu)
More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell-based engineered airways and tracheal allografts implanted after heterotopic revascularization. (biomedcentral.com)

Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
In animal models, delivery of several different types of stem cells reduce infarct size and improve functional outcomes. (bmj.com)

The biological activity of automatically isolated CD133 + cells was evaluated and compared to manually isolated CD133 + cells via functional assays as well as immunofluorescence microscopy. (biomedcentral.com)

Human umbilical mesenchymal stem cell and its adipogenic differentiation: Profiling by nuclear magnetic resonance spectroscopy. (wjgnet.com)
To further determine the effects on endothelial cells, ixmyelocel-T was co-cultured with human umbilical vein endothelial cells (HUVEC) in non-contacting Transwell® inserts. (lonza.com)
The EA.hy926 cell line was derived from human umbilical vein endothelial cells, and it has been shown to express differentiated functions that are characteristics of human vascular endothelium [66, 67]. (phosphatases.com)

Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. (biomedcentral.com)
Autologous ADRCs were isolated from the inguinal fat pad and then sprayed directly onto the wound at a dose of 0.25 × 10 6 viable cells/cm 2 . (biomedcentral.com)
Human clinical trials utilizing autologous adipose-derived regenerative cells (ADRCs) have not reported treatment-related critical adverse effects thus far. (nagoya-u.ac.jp)

Edwards N , Langford-Smith AWW , Wilkinson FL , Endothelial progenitor cells: new targets for therapeutics for inflammatory conditions with high cardiovascular risk . (avma.org)

Because of persistent thrombocytopenia, a second bone marrow biopsy was performed in February 2002. (cdc.gov)

The Stem Cells Portal provides coverage of the latest research, clinical applications, policies, and developments in the stem cell and regenerative medicine fields. (stemcellsportal.com)

On December 5, 2019, the FDA warned Liveyon Labs, Inc. that they were selling unapproved, contaminated umbilical cord stem cell products. (ambrosecelltherapy.com)
Sadly, as a chiropractor's patient with long-Covid and congestive heart failure related, "I tried umbilical cord stem cells. (ambrosecelltherapy.com)
CFU-Fs, often referred to as stem cells, were not found within any of the commercial UC (umbilical cord) allograft products analyzed, and clinicians should remain wary of marketing claims stating otherwise. (ambrosecelltherapy.com)
But how does the Tide Pod eating fad relate to the umbilical cord stem cell fad? (ambrosecelltherapy.com)

Furthermore, we demonstrated that these automatically isolated cells bear proliferation and differentiation capacities comparable to manually isolated cells in vitro. (biomedcentral.com)
Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)

The wound-healing process is complex, requiring tight coordination of several cell types and numerous factors to ensure orderly, successful progression through the stages of healing leading to physiological repair [ 1 ]. (biomedcentral.com)

Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)

Over the years, she has played a pivotal role in promoting the use of stem cells for the treatment of chronic degenerative conditions. (regenestem.com)
As a pioneer in stem cell applications for aesthetic procedures and chronic degenerative conditions, she continues to inspire and empower fellow physicians globally. (regenestem.com)

Various preventive measures required to treat femoral head necrosis include revascularization, adequate supply of osteogenic cells and establishing enough strength to avoid collapse. (ijpsonline.com)

Although, a list of contributing factors such as sickle cell anaemia, use of steroids, femoral neck fractures are involved in the loss of osteogenic cells via obstructing blood supply especially in the greater trochanteric region[ 1 , 2 ]. (ijpsonline.com)

While his early research was into hypertensive heart disease, his notable contributions were his novel approach to improving cardiac function by bone-marrow derived stem cell treatment involving injections into the coronary arteries with consistent large favorable effects. (wikipedia.org)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
In Dentistry autogenous bone is the most useful tissue used in pre-prosthetic surgery and rehabilitation treatment of bone defects, thereby contributing to the function and aesthetics 8 . (bvsalud.org)
This mosaic of every day and abnormal cells is caused by the strange cellular departments after treatment. (viezec.com)

Concurrently, we performed the characterization of the transplanted cells were evaluated by quantitative real-time PCR, flow cytometry and ELISA. (openveterinaryjournal.com)
must be detected on greater than 50% of the malignant cells by immunohistochemistry or = 90% by flow cytometry. (who.int)
In general, immunohistochemistry will be used for lymph node biopsies, flow cytometry will be used for peripheral blood and bone marrow samples. (who.int)

The main indications for tracheal reconstruction include malignant tumours (squamous cell carcinoma, adenoid cystic carcinoma), tracheoesophageal fistula, trauma, unsuccessful surgical results for benign diseases and congenital stenosis. (ersjournals.com)
Tracheal reconstruction and replacement is a complex and vital surgical procedure with several indications, including primary tracheal neoplasm (adenoid cystic carcinoma and squamous cell carcinoma), thyroid cancer, extensive tracheoesophageal fistulas, unsuccessful previous surgery for benign tracheal diseases (re-stenosis, long-term stenosis that has been dilated or been non-surgically repaired) and, rarely, congenital tracheal stenosis. (ersjournals.com)

Recently, several clinical trials showed an increased left ventricular ejection fraction (LVEF) and an improved regional perfusion following intramyocardial application of cluster of differentiation (CD) 133 + stem cells [ 5 - 9 ]. (biomedcentral.com)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)

C6 glioma cells were derived from rat central nervous system and were previously shown to display glycosaminoglycans, heparan sulfate and chondroitin sulfates, on their surface [43, 61, 68]. (phosphatases.com)

Anatomy31

Organisms4

Diseases43

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes27

Technology, Industry, Agriculture1

Information Science2

Health Care11

Transplantation12

MSCs14

Therapy44

Efficacy3

Therapies3

Therapeutic6

Patients18

Implantation3

Intracoronary2

Regeneration5

Stromal2

Conclusions1

BMMNCs2

Transplant1

Allogeneic2

Ischemic stroke1

Undergone2

Angiogenic2

Aspirate2

Injection2

Epithelial cells3

Skeletal3

Traumatic injury1

Vivo3

Outcomes2

Biological1

Human umbilical3

ADRCs3

Endothelial progenitor cells1

20021

Regenerative medicine1

Umbilical cord4

Vitro2

Progression1

Cardiomyocytes1

Chronic2

Femoral head1

Osteogenic1

Treatment4

Flow cytometry3

Surgical2

Differentiation2

Glioma cells1