TransplantTransplantsASCTPlasma cells in the bone maMesenchymal StemHaematopoietic stem cell transplant2000Person'sHSCTBiopsyPeripheral blood stemHematologyEmbryonic StemPatient's own bloodDonated stem cellsClinicalCancersBloodCells from a donorSurvivalDonor stem cellsLeukemiaAplastic anemiaYears after transplantationMyelomaRemissionPatientsProgenitor cellsLymphomaTherapiesRecipientsChemotherapy or radiationHaematologicalPediatricCancerTumorsMorbidity and mortaInvolvesSevereTissueComplicationsProliferationProcedurePatient
Transplant24
- high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
- In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
- An allogeneic transplant uses someone else's stem cells. (medlineplus.gov)
- Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
- Doctors transplant the donor's stem cells into the individual after chemotherapy or radiation therapy to replace their diseased or damaged stem cells. (medicalnewstoday.com)
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
- The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
- What is an autologous stem cell transplant? (leukaemia.org.au)
- Most people have a single autologous transplant. (leukaemia.org.au)
- It's important to realise that the processes involved in a stem cell transplant are often long and complex. (leukaemia.org.au)
- Data have been limited to this point, prompting us to take a closer look at this issue in a larger, more diverse group of autologous and allogeneic transplant survivors over an extended period. (science20.com)
- The program, which is accredited by the Foundation for the Accreditation of Cellular Therapy , has pioneered a tandem stem cell transplant for Hodgkin lymphoma, reduced intensity conditioning treatments utilizing the drug mitoxantrone, ara-C and pentostatin and refrigerated marrow storage techniques that have led to wide acclaim. (nymc.edu)
- A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
- In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
- When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
- When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
- Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
- However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
- Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
- Impact of Genetic Diagnosis on the Outcome of Hematopoietic Stem Cell Transplant in Primary Immunodeficiency Disorders. (cdc.gov)
Transplants8
- Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
- Learn more about stem cell transplants here. (medicalnewstoday.com)
- In autologous stem cell transplants, the patient is their own stem cell donor. (leukaemia.org.au)
- Autologous transplants are used to treat a number of different blood cancers. (leukaemia.org.au)
- Autologous transplants allow the use of high-dose chemotherapy, which provides some patients with a better chance of cure or long-term control of their disease. (leukaemia.org.au)
- Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health. (science20.com)
- Bone marrow transplantation, begun in 1983, and stem cell transplantation have grown to encompass allogeneic, unrelated, cord blood, autologous transplants and mini-allogeneic (reduced intensity conditioning) transplantation strategies. (nymc.edu)
- The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)
ASCT6
- OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
- High-dose melphalan and autologous stem cell transplantation (HDM/ASCT) is widely used in immunoglobulin light chain (AL) amyloidosis, but the benefit is debated mainly because of the high treatment-related mortality (24% in a randomised study comparing HDM/ASCT with oral melphalan/dexamethasone). (lu.se)
- The occurrence of varicella zoster virus (VZV) reactivation is increased after allogeneic transplantation, whereas limited data are available for herpes zoster (HZ) after autologous SCT (ASCT). (nature.com)
- Lower specific antibody titers at transplantation were observed in patients with HZ after ASCT than in those without reactivation ( P =0.009). (nature.com)
- High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
Plasma cells in the bone ma2
- Multiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. (medlineplus.gov)
- The prevalence production, lytic lesions and increased of leptomeningeal infiltration in breast can- plasma cells in the bone marrow [ 1 ]. (who.int)
Mesenchymal Stem1
- This type of cartilage repair technique is often fortified by bone marrow acquired autologous mesenchymal stem cell support. (ivis.org)
Haematopoietic stem cell transplant1
- His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
20002
- Bone Marrow Transplantation (2000) 26, 877-880. (nature.com)
- Malignant plasma cells in meningeal MM out of 2000 patients with bone marrow produce an immunoglobulin, MM, was reported was by Schluterman et al. (who.int)
Person's6
- An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)
- Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
- From there, they travel to the bone marrow and multiply, rebuilding a person's immune system . (medicalnewstoday.com)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- Stem cells harvested from a person's own bone marrow or blood, can safely slow progression of the most common form of the autoimmune disease, multiple sclerosis, or MS as it's usually known, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry. (news-medical.net)
- Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment. (news-medical.net)
HSCT9
- Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Biopsy1
- If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
Peripheral blood stem4
- In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
- Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
- Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
- In autologous stem cell transplantation, stem cells are collected (or "harvested") from either the bone marrow , bloodstream (called a peripheral blood stem cell harvest), or sometimes a combination of both. (leukaemia.org.au)
Hematology1
- 8 The BD ® Stem Cell Enumeration Kit incorporates BD Trucount™ tubes to determine the absolute cell count, thereby eliminating variability associated with hematology-derived absolute counts. (bdbiosciences.com)
Embryonic Stem3
- Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
- Nevertheless, the use of autologous bone marrow-derived SCs does not face ethical, political, biological and regulatory hurdles, like embryonic stem cells does. (parentsguidecordblood.org)
- These cells are called adult (non-embryonic) stem cells. (webrn-maculardegeneration.com)
Patient's own blood1
- The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
Donated stem cells1
- Allogeneic stem cell transplantation uses donated stem cells. (clevelandclinic.org)
Clinical5
- Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
- To our knowledge, this is the first reported case of primary pituitary lymphoma that relapsed exclusively in the bone marrow and presented with clinical findings of idiopathic anasarca. (karger.com)
- At 7 months after surgery, radiographs demonstrated complete bone repair, and no clinical problems were observed two years postoperatively. (hindawi.com)
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
- This success opens the door to a phase II clinical trial that can test the efficacy of autologous bone marrow SCs. (parentsguidecordblood.org)
Cancers5
- Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
- What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
- Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
- Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
- This was the first example of a successful SC therapy, and is still commonly used today for blood and bone-marrow-related cancers such as leukemia and myeloma. (parentsguidecordblood.org)
Blood36
- The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
- A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitory cell transplantation. (nature.com)
- The bone marrow makes blood cells. (medlineplus.gov)
- It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
- These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
- 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
- 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- These new stem cells produce healthy new blood cells. (clevelandclinic.org)
- These stem cells may come from a family member, from someone you don't know or from umbilical cord blood. (clevelandclinic.org)
- An autologous stem cell transplantation uses your own blood stem cells. (clevelandclinic.org)
- While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
- Allogeneic stem cell transplantation may cure some blood disorders FA causes. (clevelandclinic.org)
- Allogeneic stem cell transplantation replaces damaged white blood cells. (clevelandclinic.org)
- Healthcare providers consider several factors before recommending allogeneic stem cell transplantation to treat blood disorders or cancer. (clevelandclinic.org)
- Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
- In the meantime, we believe that patients with cerebral palsy can be treated with their own bone marrow SCs when their cord blood SCs were not preserved. (parentsguidecordblood.org)
- They then injected the patients with their own immune stem cells, obtained from the patients' blood before the chemotherapy, to create a new immune system. (scienceblog.com)
- G-CSF promotes the production of stem cells in the bone marrow which then leak out into your normal blood circulation in your veins. (leukaemia.org.au)
- Regular blood tests will be taken over the following week to identify the best day to start collecting your stem cells. (leukaemia.org.au)
- Stem cells are collected from your bloodstream by passing all your blood through a special machine called a cell separator (or apheresis machine). (leukaemia.org.au)
- The apheresis machine draws blood from the body, spins the blood very quickly, collects the part that contains the blood stem cells , and returns the rest of the blood back to the body. (leukaemia.org.au)
- From here the stem cells make their way to your bone marrow where they become re-established and start making new blood cells. (leukaemia.org.au)
- They further say that this study is one of the longest and is the most inclusive to date evaluating sexual well-being in blood or bone marrow transplantation (stem cell transplantation, SCT) survivors using rigorous, well-validated sexual function assessment tools. (science20.com)
- Stem cell transplantation is an increasingly effective form of treatment for patients with blood cancer such as leukemia, lymphoma, and myeloma. (science20.com)
- As blood or bone marrow transplantation survival rates have steadily increased, researchers are seeking to study and maximize survivors' quality of life. (science20.com)
- A patient's own skin or blood cells can be reprogrammed to become what is called induced Pluripotent Stem cells (iPSC). (webrn-maculardegeneration.com)
- Cells taken from the patient's blood will be converted to what are called induced pluripotent stem cells (iPs). (webrn-maculardegeneration.com)
- The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
- Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
- When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
- The stem cells are not administered directly back into the bone, but travel to the bones from the blood stream. (ucsfhealth.org)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Cells from a donor2
- Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
- For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
Survival5
- Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
- In the last decade, the availability of autologous stem cell transplantation and combination therapies consisting of immunomodulatory drugs, proteasome inhibitors, and other chemotherapeutics has improved median 5-y survival from 34.6% in 2004 to 49.6% in 2013 ( 3 , 4 ). (snmjournals.org)
- The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
- Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
- Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium. (cdc.gov)
Donor stem cells1
- Strikingly, 12 cases occurred in 1997 with the majority in recipients of allogeneic matched sibling donor stem cells. (nih.gov)
Leukemia4
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
- Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
- Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Aplastic anemia2
- Healthcare providers may recommend allogeneic stem cell transplantation for severe forms of aplastic anemia. (clevelandclinic.org)
- It has also been used as a therapy for disorders like aplastic anemia, which are associated with bone marrow failure. (ucsfhealth.org)
Years after transplantation2
- [ 7 ] of 798 patients who survived more than 5 years after transplantation, 328 were children. (medscape.com)
- After an average follow-up of three years after transplantation, 17 patients (81 percent) improved by at least one point on a disability scale. (scienceblog.com)
Myeloma7
- In people with multiple myeloma, abnormal plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. (medlineplus.gov)
- Background Thalidomide is active in multiple myeloma and is associated with minimal myelosuppression, making it a good candidate for induction therapy prior to high-dose therapy with autologous stem-cell transplantation. (haematologica.org)
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- Multiple myeloma (MM) is a cancer of terminally differentiated plasma B cells that originates in the hematopoietic bone marrow and accounts for 15%-20% of all hematologic malignancies ( 1 , 2 ). (snmjournals.org)
- In general, the first decision made in the management of patients with myeloma who require systemic therapy is whether stem cell transplantation is part of the strategy. (medscape.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Remission2
- People in remission from AML may be candidates for allogeneic stem cell transplantation. (clevelandclinic.org)
- Stem cells are usually collected when the patient's disease is in remission or their disease is in a more stable state. (leukaemia.org.au)
Patients10
- High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
- In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
- [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
- The patients enrolled in our trial received a subcutaneous medication for 4 consecutive days to stimulate their bone marrow to produce SCs, their bone marrow was then harvested, SCs were concentrated at the laboratory, and then they were delivered through the patient's cerebrospinal fluid on the fifth day of the procedure. (parentsguidecordblood.org)
- Researchers from Northwestern University's Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies and thereby "resetting" their immune systems. (scienceblog.com)
- The patients in the small phase I/II trial continued to improve for up to 24 months after the transplantation procedure and then stabilized. (scienceblog.com)
- In previous studies, Burt had transplanted immune stem cells into late-stage MS patients. (scienceblog.com)
- Does Transplantation Induce Aging In Patients? (medicaldaily.com)
- Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
- To describe the psychological suffering developed by patients transplanted with hematopoietic stem cells from a referral service in the state of Rio Grande do Norte. (bvsalud.org)
Progenitor cells4
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- 1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Lymphoma4
- Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
- High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
- High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
- In the present study, the case of a patient diagnosed with diffuse large B‑cell lymphoma, who received chemotherapy and autologous hematopoietic stem cell transplantation is presented. (spandidos-publications.com)
Therapies2
- The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
- The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
Recipients4
- It reportedly occurs primarily in autologous recipients. (nih.gov)
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
- Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Chemotherapy or radiation3
- The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
- The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
- For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
Haematological1
- MM is considered relative paucity of CNS invasion by MM an incurable disease despite various meth- in comparison with other tumours, whether ods of treatment, including autologous bone solid or haematological, remain unknown, marrow transplantation [ 3 ]. (who.int)
Pediatric1
- To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
Cancer5
- As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
- We focus on destroying only the immune component of the bone marrow and then regenerate the immune component, which makes the procedure much safer and less toxic than traditional chemotherapy for cancer," Burt said. (scienceblog.com)
- Conditioning therapy is used to help destroy any leftover cancer cells in your body and to make or create a space in your bone marrow for the new stem cells to grow. (leukaemia.org.au)
- When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
Tumors1
- The growth of these bone tumors weakens the bones. (medlineplus.gov)
Morbidity and morta1
- 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
Involves1
- This process is called stem cell mobilisation and usually involves the use of chemotherapy in combination with colony stimulating growth factor injections - usually G-CSF. (leukaemia.org.au)
Severe1
- Providers may use allogeneic stem cell transplantation to treat severe forms of thalassemia. (clevelandclinic.org)
Tissue3
- Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
- Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
- Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Complications2
- Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
- They are most often given to prevent complications such as bone fractures and kidney damage. (medlineplus.gov)
Proliferation1
- There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
Procedure2
- The present report shows a minimally invasive procedure, which could facilitate bone union in incomplete AFF. (hindawi.com)
- The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion. (scienceblog.com)
Patient3
- The present report describes an incomplete atypical femoral fracture (AFF) patient who underwent simultaneous autogenous bone transplantation to the resected fracture region during intramedullary nail fixation. (hindawi.com)
- To the best of our knowledge, this is the first report in which autogenous bone marrow transplantation, noninvasive to the iliac crest, was performed in an incomplete AFF patient. (hindawi.com)
- This is the first time in the United States that patient derived induced pluripotent stem cells were used. (webrn-maculardegeneration.com)