Autoinducer cell communication. Medical search. Frequent questions

Essentially, certain signaling molecules named autoinducers with specific bacterial receptors become activated when the population density of bacteria is high enough. (wikipedia.org)
QS involves the synthesis of small signaling molecules, called autoinducers (AI), which are secreted by individual bacteria but serve to coordinate their responses. (umd.edu)
Bacterial communication relies on versatile chemical signaling molecules called autoinducers, which regulate bacterial gene expression in a process known as quorum sensing. (asm.org)
Bacteria communicate with each other through a process known as quorum sensing (QS), which uses signaling molecules, like the 'universal' signaling molecule autoinducer-2 (AI-2), to coordinate actions such as virulence and pathogenicity. (aminzargar.com)
Individual microbial cells synthesize and release signaling molecules at a basal rate. (peerj.com)

QS relies on the production, accumulation, detection, and population-wide response to extracellular signal molecules called autoinducers (AI). (wadsworth.org)
This process, known as quorum sensing, relies on the secretion and detection of signalling molecules called autoinducers. (princeton.edu)
Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. (absin-reagent.com)
Meanwhile, bacteria have been "talking" to each other for billions of years by exchanging chemical messages via hormone-like molecules called autoinducers. (phys.org)

Another possible reason bacteria use luminescence reaction is for quorum sensing, an ability to regulate gene expression in response to bacterial cell density. (wikipedia.org)
Thus, bacterial bioluminescence is regulated by means of chemical communication referred to as quorum sensing. (wikipedia.org)
In 1993-94, we reported that a bacterium could have multiple quorum-sensing systems, and that distinctly different mechanisms had evolved to enable cell-cell communication. (shawprize.org)
At high cell density the accumulation of two quorum-sensing autoinducers represses these traits. (princeton.edu)
Vibrio cholerae, the causative agent of the disease cholera, uses a cell to cell communication process called quorum sensing to control biofilm formation and virulence factor production. (princeton.edu)
CqsA couples SAM and decanoyl-coenzyme A to produce a previously unknown but potent quorum-sensing molecule, 3-aminotridec-2-en-4-one (Ea-CAI-1). (princeton.edu)
Quorum sensing (QS) is a phenomenon which refers to bacterial cell-to-cell communication in a population manner. (um.edu.my)
In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. (elsevierpure.com)
In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinducers, signal to eukaryotic cells, mimicking hormones. (elsevierpure.com)
Department of Chemical and Biomolecular Engineering sophomore Apoorv Gupta has been awarded a Howard Hughes Medical Institute (HHMI) Undergraduate Research Fellowship for his proposed study of a form of intercellular communication known as quorum sensing. (umd.edu)
Gupta is part of Bentley's ongoing research on quorum sensing, a cell-to-cell communication process that allows groups of single celled bacteria to act as multicellular entities, in some cases allowing them to become pathogenic. (umd.edu)
A signaling molecule emitted by single celled bacteria, known as autoinducer-2 (AI-2), is believed to be the key facilitator of quorum sensing. (umd.edu)
Monitoring these special cells will allow Gupta to track and analyze quorum sensing activity. (umd.edu)
Quorum sensing är bakteriers förmåga att kommunicera med varandra och ger dem möjligheten att uppvisa en form av multicellularitet. (slu.se)
Men det krävs vidare forskning och en djupare förståelse för hur quorum sensing kan användas som måltavla för läkemedel på ett säkert sätt för patienten och miljön innan det kommer tas i bruk. (slu.se)
Quorum sensing is a type of bacterial communication that occurs via the secretion of autoinducer molecules (5). (kenyon.edu)
Like others in the field, Bentley and members of his Biomolecular and Metabolic Engineering Lab previously investigated quorum sensing (QS) - a bacterial form of cell-to-cell communication - to engineer communication circuits amongst and between bacterial strains in order to coordinate their behaviors. (umd.edu)
Once the AI level reaches a threshold - signaling a "quorum" of cells - the AI signals are transported intracellularly, where they activate gene expression and enable coordinated responses. (umd.edu)
Quorum sensing in the gut microbiota involving autoinducers is a key issue [9]. (fortunepublish.com)
Specifically, engineered cell populations are triggered by a quorum sensing (QS) signal molecule, autoinducer-2, to express surface-displayed fusions consisting of a fluorescent marker and an affinity peptide. (pharmaceuticalintelligence.com)
The appearance of multiple virulence and success genes in is normally cell density reliant and uses cell-cell communication program termed CD24 quorum sensing. (technuc.com)
This universal term is currently commonly used to spell it out the sensation whereby the deposition of the diffusible, low-molecular-weight indication molecule (occasionally known as a pheromone or autoinducer) allows specific bacterial cells to feeling when the minimal people device or quorum of bacterias has been attained for the concerted people response to become initiated (15). (technuc.com)
uses and and systems are program regulates the machine straight, thus providing general coordination of quorum sensing and temporal gene appearance in Colchicine supplier response to cell-to-cell conversation (31, 67). (technuc.com)
Subramani (2019) said that Quorum sensing (QS) is a process of intercellular signaling or cell-cell communication and a vital regulatory mechanism for coordinating biofilm formation including common activities and physiological processes such as symbiosis, formation of spores or fruiting bodies, antibiotics synthesis, genetic competence, apoptosis, and virulence in many bacterial species using extracellular QS signaling molecules, which is often referred to as autoinducers. (learnlifescience.com)
Quorum sensing is normally an over-all cell-cell communication system in the bacterial kingdom taking place via small chemical substance substances termed autoinducers as chemical substance "dialects" to organize bacterial people behaviors. (palomid529.com)
Quorum quenching (QQ) is the disruption of bacterial cell-to-cell communication (known as quorum sensing), which has previously been described in mesophilic bacteria. (northumbria.ac.uk)
N-(β-ketocaproyl)-L-Homoserine lactone is a component of quorum regulatory sensing which is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. (absin-reagent.com)
Many pathogenic bacteria rely on a communication system known as quorum sensing to help them establish infection in a host," Meschwitz said. (salve.edu)
This quorum sensing communication system is controlled by small molecules called auto-inducers, which coordinate collective behaviors and allow the bacteria to attack as a group rather than as a single cell, thus overpowering the host immune system. (salve.edu)
A cell density-dependent regulatory network termed quorum sensing (QS) is pivotal in the control of P. aeruginosa pathogenicity, and the signal molecules employed are N-acyl-L-homoserine lactones (AHLs) and the Pseudomonas quinolone signal (PQS). (nottingham.ac.uk)
But when it comes to communication skills, unicellular microbes are just as chatty, and studying quorum sensing (QS) in bac-teria is among the more fascinating topics in today's mi-cro-bi-o-lo-gy. (asmblog.org)
Through next-generation RNA sequencing and bioinformatics, our work indicated for the first time that quorum sensing impacts the behavior of human intestinal epithelial cells (IECs) through the 'universal' QS molecule AI-2 ( mBio 2015). (aminzargar.com)
Through a model-based design, we developed a suite of well-characterized controller cells that have elucidated the kinetics behind the signal transduction of the quorum sensing molecule AI-2. (aminzargar.com)
This microbial decision-making process called "quorum sensing (QS)" was originally understood as a cell-to-cell communication to identify conspecific population density and accomplish cooperative behaviors ( Fuqua, Winans & Greenberg, 1994 ). (peerj.com)

Small talk: cell-cell communication in bacteria. (microbiologyresearch.org)
They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
Bacteria that possess QS activity communicate through secreted signal molecules or autoinducer. (um.edu.my)
The Gram-negative bacteria and archaeon use acyl homoserine lactones (AHLs) as a QS signal to achieve regulation through the luxI-luxR homolog system, wheareas Gram-positive bacteria use small peptides as autoinducers. (um.edu.my)
Some of these autoinducers activate epithelial cells to induce generation of neutrophil chemotatic factors and then, these migrated factors will be triggered to produce toxin which are detrimental to the bacteria [ 2 ]. (biomedcentral.com)
Strictly by the numbers, the vast majority - estimated by many scientists at 90 percent - of the cells in what you think of as your body are actually bacteria, not human cells. (spectrevision.net)
Until the 1970s, archaea and bacteria were classed together, but the chemistry of archaean cell walls and other features are quite different from bacteria, enabling them to live in extreme environments such as Yellowstone's mud pots and hyperacidic mine tailings. (spectrevision.net)
Gupta will use microarray analysis to study the effect of AI-2 on gene expression in human intestinal cells in order to understand the interactions between bacteria and their hosts. (umd.edu)
This literature study aims to summarize how communication takes place in Gram-negative and Gram-positive bacteria. (slu.se)
The general understanding is that the cell density of the bacteria leads to the activated genes resulting in the luminescent ability. (slu.se)
The response itself is dependent on communication between the bacteria. (slu.se)
It is done by chemical transmitters called autoinducers, which differ between gram-negative and grampositive bacteria based on the molecular structure of the autoinducer. (slu.se)
The autoinducers gives the bacteria its species specificity when it comes to communication. (slu.se)
Gram-negative bacteria use homoserine lactones, while gram-positive bacteria use peptides as autoinducers to start the gene activation. (slu.se)
Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells (Romling et al, 2013). (learnlifescience.com)
Gram-negative bacteria produce acyl-homoserine lactone autoinducers that can passively diffuse through their thin cell wall. (asm.org)
For many bacteria, the change in gene expression includes downregulation of autoinducer synthesis in a negative feedback loop. (asm.org)
Numerous other species of bacteria also employ N-(β-ketocaproyl)-L-homoserine lactone in cell-to-cell communication. (absin-reagent.com)
As bacteria are in an environment they are all releasing these molecules, they measure those molecules, and they use that as a proxy to know that there are other cells around. (asmblog.org)
Growing λ-ly-so-ge-nic host bacteria led to accumulation of free phages in the culture due to spontaneous prophage induction in a small percentage of the cells, i.e., the production and re-lease of progeny phages into the medium by host cell lysis. (asmblog.org)
Interkingdom cell-to-cell signaling involves small molecules, such as hormones that are produced by eukaryotes and hormone-like chemicals that are produced by bacteria. (aminzargar.com)
2015). Using harmless probiotic bacteria to interfere with communication molecules provides a potent tool to stop bacterial infections without causing a resistance mechanism. (aminzargar.com)
Bacteria have evolved multiple strategies for causing infections that include producing virulence factors, undertaking motility, developing biofilms and invading host cells. (nature.com)
For example, bacteria may only invade a cell if enough neighboring bacteria are releasing autoinducers. (phys.org)
Bacteria also communicate with the cells of other species, including ours. (phys.org)
Studies into premature babies have shown the relationship between gut bacteria and human cells are crucial for cognitive development. (phys.org)

however, the levels of extracellular autoinducer-2 decline (Glucose Retention of AI-2 Levels: GRAIL). (microbiologyresearch.org)
Aggregate of microorganisms in which cells that are frequently embedded within a self-produced matrix of extracellular polymeric substances (EPSs) adhere to each other and/or to a surface. (wikipedia.org)
[2] [3] These adherent cells become embedded within a slimy extracellular matrix that is composed of extracellular polymeric substances (EPSs). (wikipedia.org)
[2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
INTRODUCTION Bacterias in organic and commercial environments mainly grow as biofilms mounted on surfaces or connected with interfaces where bacterial cells are encased within a self-produced extracellular matrix referred to as extracellular polymeric chemicals (EPS) made up of polysaccharides DNA protein and lipids (1). (palomid529.com)
As V. cholerae reproduces, the extracellular concentration of autoinducers increases and eventually exceeds each bacterium's intracellular autoinducer concentration. (asm.org)
A biofilm is an assemblage of surface-associated microbial cells that form an extracellular polymeric substance, named EPS-matrix. (maritech.org)

Vibrio cholerae, the causative agent of the human disease cholera, uses cell-to-cell communication to control pathogenicity and biofilm formation. (princeton.edu)
Cell-Cell Communication natural context: Cuttlefish and Vibrio harveyi. (vdocuments.net)
Mechanism of Vibrio cholerae autoinducer-1 biosynthesis. (princeton.edu)
Genom att studera symbiosförhållandet mellan bläckfisken Euprymna scolope och bakterien Vibrio fisheri, ökade förståelsen kring hur celldensiteten hos bakterierna ledde till det aktiverade gensvaret, vilket visade sig i en självlysande förmåga hos den typen av bakterier. (slu.se)

We showed that V harveyi had two autoinducers, two cognate receptors, and a protein linking the two systems. (shawprize.org)
Once intracellular concentration increases, autoinducers bind to their receptors, triggering signaling cascades that alter transcription factor activity and therefore, gene expression. (asm.org)
When the intracellular concentration of autoinducers is low, autoinducer receptors act as kinases , transferring phosphate to LuxO (LuxO~P). LuxO~P promotes the expression of proteins used for building biofilms. (asm.org)
Intracellular autoinducer concentration in turn increases, autoinducers bind their receptors and change receptor activity from kinase to phosphatase. (asm.org)
For example, some species cannot produce their own autoinducers, but have receptors for the autoinducer molecules of other species, allowing them to sense and respond to others in their environment. (asm.org)

The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). (absin-reagent.com)

QS is a process of bacterial cell-cell communication that controls virulence and biofilm formation in many bacterial species. (wadsworth.org)
A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. (wikipedia.org)
The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)
[10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)
Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)
Till följd av kommunikationen kan de med en hög grad av samordning och på ett energieffektivt sätt uttrycka virulensfaktorer som biofilm, motilitet, toxiner eller bioluminiscens som möjliggör infektion. (slu.se)
In addition, there is also communication between species, which is essential in biofilm formation. (slu.se)
Biofilm formation represents a protected mode of growth that not only allows cells to survive in hostile environments but also to colonize new niches by dispersal of microorganisms from the microbial clusters. (learnlifescience.com)
In a biofilm, microbial cells stick to each other and often also to a surface. (learnlifescience.com)
In many biofilm systems however EPS still present a challenge limiting the bactericidal aftereffect of phages (13 14 One technique followed by phages through the phage-bacterium evolutionary hands race (15) may be the creation of polysaccharide depolymerases to degrade EPS and invite phages to gain access to encased bacterial cells. (palomid529.com)
For instance, one exciting study demonstrated that overloading V. cholerae with its autoinducer can halt the process of biofilm formation completely, and potentially delay the infectious process enough for our immune systems to catch up. (asm.org)
At elevated cell densities, microorganisms need to efficiently coordinate the expression of energetically expensive phenotypes, such as biofilm development, exoenzyme production and microbial dispersal. (peerj.com)
Biofilm formation requires three different stages: cell attachment to a solid substrate, adhesion, and growth. (intechopen.com)
In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
Therefore, a biofilm consists of highly hydrated and immobilized cells that stick to a substratum. (maritech.org)
Intercellular communications within a biofilm and rapidly enabling temporal adaptation. (maritech.org)

At low cell density V. cholerae activates the expression of virulence factors and forms biofilms. (princeton.edu)
These two autoinducers, cholerae autoinducer-1 (CAI-1) and autoinducer-2 (AI-2), function synergistically to control gene regulation, although CAI-1 is the stronger of the two signals. (princeton.edu)
It can be difficult to detect the presence of V. cholerae in water sources, due to the bacterium's ability to aggregate into of conditionally viable environmental cells (CVECs) (3). (kenyon.edu)
Individual V. cholerae produce species-specific autoinducers as they reproduce. (asm.org)
V. cholerae regulates its response to autoinducers via LuxO. (asm.org)

For instance, Pseudomonas aeruginosais, a symbiotic gram-negative bacterium, can produce HSL autoinducers to modulate gene expression in humans [ 2 ]. (biomedcentral.com)
During their reproductive cycle, individual bacterium synthesize autoinducers. (asm.org)
After determining the effects of AI-2 on epithelial cells, I genetically engineered a bacterium that disrupts bacterial communication by the rapid consumption of AI-2. (aminzargar.com)

We found that E. coli secretions have an inflammatory effect in epithelial cells, and that specifically IECs 'listen in' on bacterial communication mediated by AI-2. (aminzargar.com)

EPS VX-765 in biofilms give a regional environment that protects the bacterial cells against damage from antibiotics and various other antimicrobial treatments. (palomid529.com)
Biofilms are an ensemble of microbial cells irreversibly associated with a surface and enclosed in an essentially self-produced matrix. (intechopen.com)

Cell age group and thickness from the lifestyle are recognized to have an effect on lectin synthesis, and the creation of PA-IL and PA-IIL lectins which of other virulence elements have already been reported to become coregulated (23, 25), recommending the life of common regulatory systems. (technuc.com)

For years, scientists have explored ways to alter the cells of microorganisms in efforts to improve how a wide range of products are made - including medicines, fuels, and even beer. (umd.edu)
Microorganisms preferentially reside on solid surfaces, which often leads to a closer proximity of neighboring cells than when in a planktonic form ( Donné & Dewilde, 2015 ). (peerj.com)

To create an autonomous system, Bentley and his team rewired the bacterial QS systems at play in two strains of E. coli so that the growth rate of communicating cell subpopulations within the consortia would be dictated by signaling between the cells. (umd.edu)
The second E. coli strain, considered the"controller" strain, is engineered to carry out a signal-driven, tunable growth rate of the consortia cells, regulated by none other than the AI-1 produced by the first strain. (umd.edu)
Heterologous gene expression in E. coli confirmed its functions for hydrolysis of AHLs, and the gene was designated as aidP (autoinducer degrading gene from Planococcus sp. (northumbria.ac.uk)
Production of foreign QSSM synthases had a knock-on effect on the native E. coli QSSM, autoinducer-2 (AI-2). (nottingham.ac.uk)
The lab of Sine Lo Svenningsen at the University of Copenhagen, Denmark showed in a recent study that E. coli respond to high cell density by turning off - or at least reduce - the synthesis of the lambda phage (λ) receptor, LamB. (asmblog.org)

Complementation of growth by exogenously added metabolites confirmed our hypothesis that QSSM synthesis creates a drain on metabolite levels with consequences for cell fitness. (nottingham.ac.uk)

That threshold makes it energetically unfavorable for intracellular autoinducers tocontinue to leave the cell (whether through diffusion or transport), resulting in an increase in their intracellular concentration. (asm.org)

To address this problem, William E. Bentley , a University of Maryland bioengineering professor and director of the Robert E. Fischell Institute for Biomedical Devices , is working with a team of researchers to focus on engineering microbial consortia, wherein cell subpopulations are engineered to work together to carry out a desired function. (umd.edu)
Now, we could guide one cell subpopulation to produce a product and another subpopulation to produce another, which is the major advantage of microbial consortia. (aminzargar.com)
These empirical relationships, which predict the distribution of dissolved solutes along pore channels, allow to quantitatively estimate the effective communication distances amongst multiple microbial aggregates without further numerical simulations. (peerj.com)

The tradeoff is that driving a consortium to carry out a specific set of tasks requires engineers to somehow regulate how many of each cell subpopulation are present. (umd.edu)

Silverman, with graduate student Joanne Engebrecht and collaborator Ken Nealson, discovered, and cloned the genes underpinning the V fischeri cell-cell communication mechanism as well as the luciferase genes required for light production. (shawprize.org)

Useful in many infections, these cells are retained within the capsule, while AI-2 is small enough to freely diffuse into the capsule and be consumed. (aminzargar.com)

Cell communication can cross species through transmitting signals such as hormones, cytokines and small RNAs (sRNAs) [ 1 ]. (biomedcentral.com)
Such a cross-species communication also exists in virus-host interaction. (biomedcentral.com)
Disrupting the bacterial communication structure is an exciting innovation and practical response to the sharp rise of antibiotic resistance across bacterial species. (asm.org)

We have merged cells with nanotechnology for an integrated molecular processing network. (pharmaceuticalintelligence.com)
The resultant nano-guided cell network assesses QS activity and conveys molecular information as a 'bio-litmus' in a manner read by simple optical means. (pharmaceuticalintelligence.com)
Specifically, through engineered design, cell-based molecular processing can be further coupled to enable external abiotic responses. (pharmaceuticalintelligence.com)
We posit the use of cell populations assembled in parallel¸ where multiple microbes with distinct molecular recognition capabilities work congruently. (pharmaceuticalintelligence.com)
The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction. (screeninglibraries.com)
Members of the institute have published in a wide range of peer-reviewed journals, including Nature, Molecular Cell, Angewandte Chemie, JACS, Science Advances, Proceedings of the National Academy of Sciences USA, Nucleic Acids Research, Chemical Science and many others. (le.ac.uk)

Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. (goethe-university-frankfurt.de)
Gene regulation involves a complex web of interactions within a given cell among signals from the cell's environment, signalling molecules within the cell, and the cell's DNA. (pressbooks.pub)
While individual cells have inherent adaptive capability, in certain cases, the adaptation to a given stimulus occurs at the population level via detection and processing of chemical signals. (frontiersin.org)

Accumulation of AI occurs in a cell-density-dependent manner until a thresh-old level is reached. (asmblog.org)

An advantage is that populations, as opposed to few cells, can facilitate thorough sampling since the presence of many cells increases their spatial breadth and per-cell data contributions ( Fig. 1a ). (pharmaceuticalintelligence.com)

Conversely, host hormones can signal to bacterial cells through converging pathways to autoinducer signaling. (elsevierpure.com)
It broadly indicates cell population density, and is considered to be an important signal in naturally occurring consortia and microbiomes. (umd.edu)

Here we showed that deletion of Roquin-encoding alleles specifically in regulatory T (Treg) cells also caused the activation of conventional T cells. (cipsm.de)
But, altering the genetic and regulatory processes that take place within cells presents challenges. (umd.edu)
QS in Gram-negative organisms in-vol-ves two regulatory components: the tran-scrip-tio-nal activator protein (receptor protein) and the autoinducer (AI) molecule produced by the AI-synthase. (asmblog.org)

Chemical communication between cells ensures coordination of behavior. (elsevierpure.com)
Here we show that an engineered cell consortium autonomously generates feedback to chemical cues. (pharmaceuticalintelligence.com)

In contrast, gram-positive bacterial autoinducers are made of peptide and must be actively transported through their peptidoglycan cell wall using the ATP-binding cassette (ABC) transporter system . (asm.org)

For example, blocking the signalling protein FAK, a so-called kinase, causes breast cancer cells to become less mobile and thus less likely to metastasise. (goethe-university-frankfurt.de)

As such, Bentley and his team realized that a more powerful approach would be to reengineer the cells themselves to coordinate their subpopulation densities autonomously. (umd.edu)

pfs -dependent regulation of autoinducer 2 production in Salmonella enterica serovar typhimurium. (microbiologyresearch.org)
We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. (cipsm.de)

The first strain senses AI-2 and, in response, yields an output of autoinducer-1 (AI-1). (umd.edu)

Most often, such studies require engineers to rely on manual or user-controlled techniques to strike a balance among cell subpopulations. (umd.edu)
By minimally interacting with the cell population, the device was not only able to quench QS, but could also tune the phenotypes of QS subpopulations. (aminzargar.com)

In both cases, each genetically identical cell does not turn on, or express, the same set of genes. (pressbooks.pub)

Each nucleated cell in a multicellular organism contains copies of the same DNA. (pressbooks.pub)
If each cell in a multicellular organism has the same DNA, then how is it that cells in different parts of the organism's body exhibit different characteristics? (pressbooks.pub)
It is (almost boringly) obvious that cell-to-cell com-mu-ni-ca-tion is vital in multicellular organisms. (asmblog.org)

Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)
Similarly, all cells in two pure bacterial cultures inoculated from the same starting colony contain the same DNA, with the exception of changes that arise from spontaneous mutations. (pressbooks.pub)

Anatomy4

Organisms11

Diseases1

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology6

Phenomena and Processes15

Information Science9

Health Care4

Signaling molecules5

Molecules called autoinducers4

Quorum34

Bacteria26

Extracellular7

Vibrio4

Receptors5

Homoserine lactones1

Biofilm17

Cholerae5

Bacterium3

Epithelial cells1

Biofilms2

Virulence1

Microorganisms2

Coli5

Synthesis1

Intracellular1

Microbial3

Regulate1

Mechanism1

Diffuse1

Species3

Molecular6

Signals3

Accumulation1

Increases1

Signal2

Regulatory3

Chemical2

Cassette1

Kinase1

Coordinate1

Regulation2

Response1

Subpopulations2

Genetically1

Multicellular3

Spontaneous2