Autoimmune or lymphoproliferative disorder. Medical search. Frequent questions

Autoimmune disorders typically develop several years later, most frequently as a combination of hemolytic anemia and thrombocytopenia, also called Evans syndrome. (medlineplus.gov)
Autoimmune manifestations include hemolytic anemia and thrombocytopenia. (lu.se)
The prevalence of ITP in non-Hodgkin's lymphoma patients is lower compared to autoimmune hemolytic anemia, occurring in only up to 1.8% of cases ( 3 ). (spandidos-publications.com)
Cold agglutinin disease or syndrome is a relatively uncommon autoimmune hemolytic anemia presenting in the middle aged or elderly (1). (ispub.com)
The most common autoimmune conditions in patients with common variable immunodeficiency are cytopenia, idiopathic thrombocytopenic purpura (ITP) in particular, and hemolytic anemia or, more rarely, autoimmune neutropenia. (medscape.com)
Autoimmune cytopenias (hemolytic anemia, thrombocytopenia, or neutropenia) AND elevated immunoglobulin G levels (polyclonal hypergammaglobulinemia) is part of the revised diagnostic criteria for APLS. (thebloodproject.com)

Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). (medlineplus.gov)
Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of lymphocyte homeostasis. (medscape.com)
Autoimmune Lymphoproliferative Syndrome is a disease of the immune system which can cause the lymph nodes to become severely enlarged. (wisdompanel.com)
Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare, severe disorder that has been described in British Shorthair cats. (wisdompanel.com)
A carrier cat with one copy of the Autoimmune Lymphoproliferative Syndrome mutation can be safely bred with a clear cat with no copies of the Autoimmune Lymphoproliferative Syndrome mutation. (wisdompanel.com)
About half of the kittens will have one copy (carriers) and half will have no copies of the Autoimmune Lymphoproliferative Syndrome mutation. (wisdompanel.com)
Please note: It is possible that disease signs similar to the ones caused by the Autoimmune Lymphoproliferative Syndrome mutation could develop due to a different genetic or clinical cause. (wisdompanel.com)
2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. (wisdompanel.com)
1 A review in 1984 of 230 patients found that 69% were due to lymphoproliferative or myeloproliferative disorders, 7% granulomatous disorders, 6% postrenal transplant, and 4% occurred in patients with the acquired immunodeficiency syndrome (AIDS). (bmj.com)
Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. (ersjournals.com)
Going back to 1998 it was observed "Germline mutations in the Fas gene have been associated with autoimmune lymphoproliferative syndrome, and somatic Fas mutations have been found in multiple myeloma. (anti-agingfirewalls.com)
The associated conditions were primary Sjögren's syndrome (21.1%), SLE (10.9%), other autoimmune disorders (10.9%), lymphoproliferative diseases (6.8%), solid tumours (2.3%) and HBsAg positivity (8.6%), whereas 69 patients (39.4%) had essential CV. (clinexprheumatol.org)
Lymph node biopsy findings are unique in autoimmune lymphoproliferative syndrome (ALPS), and hematologists, surgeons, and pathologists involved in performing and interpreting biopsy results should be familiar with these findings and include the diagnosis of ALPS if these findings are present on biopsy. (medscape.com)
Primary and accessory diagnostic criteria for autoimmune lymphoproliferative syndrome (ALPS). (medscape.com)
Sjögren syndrome is a systemic autoimmune disease that affects 0.5 to 1% of the general population. (bmj.com)
Detection and evolutionary dynamics of somatic FAS variants in autoimmune lymphoproliferative syndrome : Diagnostic implications / Batlle-Masó, Laura (Hospital Universitari Vall d'Hebron. (uab.cat)

white blood cells (autoimmune neutropenia), or platelets (autoimmune thrombocytopenia). (medlineplus.gov)
There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated destruction and impaired production of platelets, with isolated thrombocytopenia. (spandidos-publications.com)
Some of the many underlying disorders that are associated with immune thrombocytopenia are also lymphoproliferative disorders. (spandidos-publications.com)
Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities and absent, or severely decreased marrow megakaryocytes. (checkorphan.org)

The CD5+ popuation is expanded in some autoimmune disorders (rheumatoid arthritis, etc. (exbio.cz)
SS can occur as a primary disease (primary SS (pSS)) or be associated with another autoimmune disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), dermatomyositis, or systemic sclerosis (SSc) [ 1 ]. (ersjournals.com)
One specificity of LGLL is its frequent association with auto-immune disorders, among them first and foremost rheumatoid arthritis, and other hematologic diseases, including pure red cell aplasia and bone marrow failure. (nih.gov)

The constellation of lymphadenopathy, splenomegaly, and autoimmune cytopenias necessitating long-term immunosuppressive treatment with mycophenolate mofetil makes diagnosis and management of these patients quite challenging. (medscape.com)

6 months) non-malignancy and non-infectious uncontrolled proliferation of lymphocytes commonly accompanied by autoimmune manifestations, lymphadenopathy, splenomegaly, and susceptibility to malignancies. (medscape.com)
Patients present nonmalignant lymphadenopathy and splenomegaly, autoimmune phenomena and in some cases even malignancy. (lu.se)
Splenomegaly is almost always secondary to other disorders. (msdmanuals.com)
RALD is characterized by splenomegaly, persistent monocytosis, hypergammaglobulinemia and cytopenia, but can also include autoimmune features and lymphadenopathy. (biomedcentral.com)
This case of idiopathic splenomegaly in childhood due to a somatic variant in KRAS expands our understanding of the clinical spectrum of RAS-associated autoimmune leukoproliferative disorder and emphasizes the value of securing a molecular diagnosis in children with unusual early-onset presentations with a suspected monogenic origin. (biomedcentral.com)

Autoimmune disorders are also common in ALPS. (medlineplus.gov)
Less commonly, autoimmune disorders that affect other organs and tissues occur in people with ALPS. (medlineplus.gov)
In most people with ALPS, including the majority of those with FAS gene mutations, this condition is inherited in an autosomal dominant pattern, which means one copy of an altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
[ 1 ] ALPS is the first disease known to be caused by a primary defect in programmed cell death and the first description of a monogenic cause of autoimmune disease. (medscape.com)
[ 2 ] Other ALPS-associated genetic defects in the apoptotic pathway and ALPS-like disorders (ALPS-related syndromes) have subsequently been identified. (medscape.com)

Clinical manifestations of common variable immunodeficiency (CVID) include recurrent infections, autoimmune disease, lymphoid hyperplasia, granulomatous diseases, and malignancy. (medscape.com)
The patient had an unremarkable bone marrow biopsy, flow cytometry showed no indication of expanded double negative T-cells, while malignancy and storage disorders were also excluded. (biomedcentral.com)

In contrast to X-linked agammaglobulinemia (XLA), common variable immunodeficiency is associated with a high frequency of autoimmune manifestation. (medscape.com)
Other solid organ-specific autoimmune diseases (eg, pernicious anemia, thyroid diseases, vitiligo) have prevalence rates of more than 5% in patients with common variable immunodeficiency, which is higher than in the general population. (medscape.com)
Patients who have common variable immunodeficiency and autoimmune conditions appear to have very low numbers of isotype-switched memory B cells in peripheral blood and are more likely to have a mutation in the gene that encodes TACI ( TNFRST13B ). (medscape.com)

In a similar way, HCV infection may also be involved in the pathogenesis of other autoimmune (glomerulonephritis, thyroiditis, lung fibrosis, autoimmune hepatitis, porphyria cutanea tarda) and lymphoproliferative disorders (monoclonal gammopathies, B-cell lymphomas). (unimore.it)

[ 1 ] Acquired hemophilia can arise in the context of a variety of disorders, including autoimmune diseases and malignancies, or be due to medications, but approximately half of cases are idiopathic. (medscape.com)
Is most commonly associated with liver disease, acute or chronic inflammation, autoimmune disorders and certain malignancies. (thebloodproject.com)

The initial recognition of autoimmune diseases dates back to the early 1900s, and since then, advancements in understanding and management of these conditions have been substantial, though much more is needed to fully unravel their complex etiology and pathophysiology. (wikipedia.org)

AAE type I is most commonly associated with B-cell lymphoproliferative disorders and consumption of C1-INH. (checkorphan.org)
Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc. (exbio.cz)
MC is a both autoimmune and B-cell lymphoproliferative disorder characterized by immune complexes that reversibly precipitate at low temperature (cryoglobulins). (biomedcentral.com)

Bilateral and symmetric lymph node abnormalities are concerning for lymphoproliferative disorders such as leukemia/lymphoma. (uclahealth.org)

It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions. (wikipedia.org)

Autoimmune diseases are a separate class from autoinflammatory diseases. (wikipedia.org)
A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the adaptive immune system. (wikipedia.org)

Cold agglutinin disease (CAD) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment for CAD patients. (nature.com)
Iatrogenic immunosuppression in post-transplant patients and patients undergoing cancer chemotherapy, as well as those with autoimmune disorders, is also a risk factor. (bmj.com)
Patients may also present with a dementing disorder with focal neurological signs. (bmj.com)
It is evaluating its lead candidate, tabelecleucel in Phase III clinical trials for the treatment of Epstein Barr virus associated post-transplant lymphoproliferative disorder (EBV+ PTLD) following hematopoietic cell transplant and solid organ transplant in patients who refracted rituximab. (pharmaceutical-technology.com)
Another 2008 study, Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis , looked at whether whether "the Fas system apoptotic molecules are differentially expressed in Graves' disease (GD) and Hashimoto's thyroiditis (HT), the two opposite phenotypes of autoimmune thyroid disease (AITD). (anti-agingfirewalls.com)
Acquired hemophilia is a spontaneous autoimmune disorder in which patients with previously normal hemostasis develop autoantibodies against clotting factors, most frequently FVIII. (medscape.com)
Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors. (mdpi.com)

Non-malignant somatic KRAS variants underlie a subset of RAS-associated autoimmune leukoproliferative disorders (RALD). (biomedcentral.com)

A failure of apoptosis leads to inappropriate cell survival and diseases associated with excessive accumulations of cells such as cancer, chronic inflammatory conditions, and autoimmune diseases. (medscape.com)
Symptoms that are commonly associated with autoimmune diseases include: fatigue low-grade fever malaise (a general feeling of discomfort or unease) muscle aches joint pain skin rashes These symptoms often reflect the body's systemic inflammatory response. (wikipedia.org)
Secondary vasculitis may be triggered by an infection, a drug, or a toxin or may occur as part of another inflammatory disorder or cancer. (merckmanuals.com)
Synthetic glucocorticoids are the most potent agents used in the treatment of inflammatory, autoimmune and lymphoproliferative disorders. (eurospe.org)
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. (bvsalud.org)

This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
Finally, unanswered questions and potentially informative future research directions are highlighted to speed delivery of etiology-based strategies to reduce autoimmune disease. (frontiersin.org)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
Autism spectrum disorder (ASD) is a neurodevelopmental condition with a so far unknown etiology. (uab.cat)

The patient also had a history of poorly controlled diabetes mellitus type 2, arterial hypertension, and depressive disorder. (spandidos-publications.com)
If you are under medical supervision, or have an autoimmune disease, diabetes, a depressive disorder, a thyroid condition, epilepsy, leukemia, or a lymphopro-liferative disorder, or are taking MAO inhibitor drugs or cor-ticosteroids such as cortisol or prednisone, consult your physician before taking this product. (vitanetonline.com)

An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. (wikipedia.org)
Symptoms of autoimmune diseases can significantly vary, primarily based on the specific type of the disease and the body part that it affects. (wikipedia.org)
Treatment modalities for autoimmune diseases vary based on the type of disease and its severity. (wikipedia.org)
In terms of prevalence, a UK study found that 10% of the population were affected by an autoimmune disease. (wikipedia.org)
However, due to the broad range of autoimmune diseases, the specific presentation of symptoms can significantly vary based on the type of disease, the organ systems affected, and individual factors such as age, hormonal status, and environmental influences. (wikipedia.org)
An individual may simultaneously have more than one autoimmune disease (known as polyautoimmunity), further complicating the symptomatology. (wikipedia.org)
Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
The focus of my laboratory is the molecular and cellular mechanisms of autoimmune disease and inflammation. (harvard.edu)
This includes functional(recruitment, adherence, activation, phagocytosis) and gene expression studies, and impact on inflammation and autoimmune disease associated with lymphoproliferative disorders. (harvard.edu)
Autoimmune pancreatitis (AIP) is now considered a pancreatic manifestation of a newly proposed disease condition, IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced IgG4 antibody responses and multiple organ involvements. (go.jp)
Acitretin is an aromatic retinoid analog of vitamin A. Acitretin embryopathy has been known only in fetuses and the cause of this disease is a teratogenic disorder. (checkorphan.org)
Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders. (ersjournals.com)
Cold agglutinin disease can also be associated with lymphoproliferative disorders and multiple myeloma. (ispub.com)
New targeted agents, some of which are currently approved in autoimmune diseases, appear to be relevant therapeutic strategies to treat LGLL, by targeting key activated pathways involved in the pathogenesis of the disease, including JAK-STAT signaling. (nih.gov)
Mixed cryoglobulinemia (MC) is a HCV-related lymphoproliferative disorder generally associated with advanced liver disease. (biomedcentral.com)
Gaucher Disease Gaucher disease is a sphingolipidosis, an inherited disorder of metabolism, resulting from glucocerebrosidase deficiency, causing deposition of glucocerebroside and related compounds. (msdmanuals.com)
d) Autoimmune disease (eg, Hashimoto thyroiditis, systemic lupus erythematosus, or mixed connective tissue disease). (empendium.com)
Introduction: Familial hypercholesterolaemia(FH) is a genetic disorder affecting approximately 1 in 250 people, resulting in high levels of low-density lipoprotein Cholesterol(LDL-C), increasing the likelihood of developing cardiovascular disease(CVD) at a younger age. (eurospe.org)

More than 100 autoimmune syndromes exist ( 1 ). (frontiersin.org)

Epstein-Barr virus (EBV) is a chronic viral infection associated with a heterogeneous group of lymphoproliferative disorders (LPD) and non-Hodgkin lymphomas (NHL). (clinicaltrialsgps.com)
Immunodeficiency-related lymphoproliferative disorders (LPDs) form a heterogeneous group that ranges from self-limiting hyperplasias to aggressive lymphomas. (medscape.com)

The majority of CGs are "mixed" Type 2 & 3 associated with infections and autoimmune dz. (asn-online.org)
Some of the underlying conditions that are associated with ITP are lymphoproliferative disorders and infections, especially viral ones. (spandidos-publications.com)
The company uses its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop therapies for the treatment of cancers, other autoimmune diseases, and severe viral infections. (pharmaceutical-technology.com)

Interference with apoptosis allows cells to multiply without control, leading to the lymphomas that often occur in people with this disorder. (medlineplus.gov)

Large granular lymphocyte leukemia (LGLL) is a chronic lymphoproliferative disorder characterized by the proliferation of T or NK cytotoxic cells in the peripheral blood, the spleen and the bone marrow. (nih.gov)

Progressive multifocal leucoencephalopathy (PML) has been described as a complication in various conditions which result in impaired cellular immunity-these include lymphoproliferative disorders and chronic granulomatous disorders such as sarcoidosis. (bmj.com)

Severe autoimmune manifestation can be treated with steroids and cyclophosphamide. (lu.se)
Resnick reported autoimmunity in about 28.6% with one or more autoimmune manifestation. (medscape.com)

Erythrocytes in these disorders are likely to be immature and express more big "I" and little "I" antigens, the target antigens for cold agglutinins. (ispub.com)
Conceivably, the increased expression of "I" and "I" in sickle cell disorders, thalassemia and HbE and polycythemia vera might render the erythrocytes in these disorders more vulnerable to cold agglutinins and hemolysis. (ispub.com)

However, carriers of some complex variants grouped in this category may be associated with a low risk of developing the disorder. (wisdompanel.com)

As a result, excess lymphocytes accumulate in the body's tissues and organs and often begin attacking them, leading to autoimmune disorders. (medlineplus.gov)
The disorder is caused by the inability of the body to destroy unneeded T-lymphocytes, which leads to massive accumulation of T-lymphocytes within lymph nodes. (wisdompanel.com)

However, the risk of primary cancer clinically as an immunosuppressant maceutical drugs ciclosporin and in the transplant recipient increases to treat certain autoimmune diseas- azathioprine. (who.int)

Autoimmune diseases represent a failure of self-identification leading to an immune-mediated assault on host tissues. (frontiersin.org)

Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (checkorphan.org)

For autosomal recessive disorders, cats with two copies of the variant are at risk of developing the condition. (wisdompanel.com)

Type 1 cryoglobulinemia is from a paraprotein produced by a plasma cell dyscrasia or a lymphoproliferative disorder. (asn-online.org)

Autoimmune diseases represent a vast and diverse category of disorders that, despite their differences, share some common symptomatic threads. (wikipedia.org)

A rare non-histaminic angioedema characterized by potentially life-threatening episodes of edema of subcutaneous and/or mucosal tissues without urticaria, caused by excessive consumption of C1 esterase inhibitor (C1-INH) in the context of lymphoproliferative or autoimmune diseases. (cdc.gov)

Background: Tissue sensitivity to glucocorticoids is characterized by significant inter-individual variation in terms of therapeutic response and susceptibility to several stress-related disorders. (eurospe.org)

On the other hand, type 1 diabetes, which results from an autoimmune attack on the insulin-producing cells of the pancreas, primarily presents with symptoms related to high blood sugar, such as increased thirst, frequent urination, and unexplained weight loss. (wikipedia.org)
The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) ( 2 , 3 ), type 1 diabetes (T1D) ( 4 ), and other autoimmune diseases. (frontiersin.org)

Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. (medlineplus.gov)
that occur early in embryonic development in people with no history of the disorder in their family. (medlineplus.gov)

However, some autoimmune diseases may present with more specific symptoms such as joint pain, skin rashes (e.g., urticaria), or neurological symptoms. (wikipedia.org)

Acquired hemophilia is a rare but potentially life-threatening bleeding disorder caused by the development of autoantibodies (inhibitors) directed against plasma coagulation factors, most frequently factor VIII (FVIII). (medscape.com)

Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction( ref ). (anti-agingfirewalls.com)

these mutations are associated with the classic form of the disorder. (medlineplus.gov)

Anatomy14

Organisms3

Diseases58

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology10

Phenomena and Processes16

Disciplines and Occupations1

Information Science3

Health Care5

Hemolytic6

Syndrome16

Thrombocytopenia5

Rheumatoid3

Cytopenias1

Splenomegaly5

ALPS5

Malignancy2

Common variable immunod3

Hepatitis1

Malignancies2

Pathophysiology1

Cell lymphoproliferative3

Lymphoma1

Recognized autoimmune diseases1

Autoinflammatory diseases2

Patients7

Somatic1

Inflammatory5

Etiology5

Depressive disorder2

Disease20

Syndromes1

Heterogeneous group2

Infections3

Apoptosis1

Proliferation1

Granulomatous1

Manifestation2

Cold agglutinins2

Variants1

Lymphocytes2

Transplant1

Immune-mediated1

Severe1

Autosomal1

Cryoglobulinemia1

Diseases represent1

Inhibitor1

Therapeutic1

Type 1 diabet2

Occur2

Urticaria1

Hemophilia1

Malfunction1

Mutations1