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  • allele
  • In fact, the null allele of the HLA-DRB4 gene ( DRB4*0103102N ) is transcribed, but it is an aberrant protein due to the lack of splicing out of the first exon 11 . (dorak.info)
  • The null allele DRB4*0103102N has been found on HLA-DRB1*04:01, *04:02 and *04:04 haplotypes 13;14 . (dorak.info)
  • In addition, with the advance of the next generation sequencing (NGS) technologies, HLA typing by NGS seems to be a promising approach for HLA sequencing and allele assignment owing to its efficiency and cost effectiveness. (biomedcentral.com)
  • In renal dialysis patients, HLA-A*02 was the most frequent allele in both carriers (25.5%) and non-carriers (21.2%) of S. aureus . (biomedcentral.com)
  • For example, hypersensitivity to abacavir, a drug used for treating of human immunodeficiency virus (HIV) infection, has been proposed to be associated with allele 57:01 of HLA-B gene (terms HLA-B 57:01 ). (hindawi.com)
  • immunogenetic basis
  • All patients were subjected to serologic testing for herpes virus (IgG and IgM) and to HLA (A, B, C) and HLA-DR-DQ tissue typing to see if there was any correlation between the emergence of CNS pathology and these various antigens, thus to show a possible autoimmune-type immunogenetic basis for demyelination processes. (healthy.net)
  • gene
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • A total of more than 1500 alleles of HLA-B gene have been identified [ 2 ]. (hindawi.com)
  • type 1 diabet
  • Type 1 diabetes is a chronic autoimmune disease associated with destruction of the pancreatic islet beta cells, resulting in loss of insulin production. (springer.com)
  • Among environmental factors, viral infections have frequently been proposed as triggers of the autoimmune reaction resulting in type 1 diabetes. (springer.com)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • peptide
  • Disclosed herein is a reductionistic system incorporating known participants of MHC class II antigen processing in solution to generate peptide pools from antigens, including those for which no immunodominant epitope has yet been identified, that are highly enriched for proteolytic fragments containing their immunodominant epitopes. (freepatentsonline.com)
  • Editing of the HLA-DR-peptide repertoire by HLA-DM," The EMBO Journal, 15(22):6144-6154 (1996). (freepatentsonline.com)
  • epitope
  • To date, linear or conformational epitopes of TSHR-ECD, as well as the molecular structure of the epitope-binding groove in HLA-DR, were reported to be related to the pathogenesis in GD. (frontiersin.org)
  • We review and update the role of immunogenic TSHR epitopes and HLA in GD, and offer perspectives on TSHR epitope specific treatments. (frontiersin.org)
  • Interaction by the complex of TSHR epitope, HLA-class II molecule, and T-cell receptor (TCR) is modified through binding of CD40 ligand to CD40 and of CTLA-4 to B7 ( 3 - 6 ). (frontiersin.org)
  • glycoprotein
  • It was found that of the structural proteins, El glycoprotein was the dominant antigen recognized by the study population sampled from normal individuals with no history of rubella associated conditions. (ubc.ca)
  • fetal
  • It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
  • Several reports based on serologic HLA typing have pointed out the positive association between patients with recurrent fetal miscarriage who are positive for antiphospholipid antibodies and specific HLA alleles (13, 14). (healthdocbox.com)
  • tissue
  • All the patients were subjected to tissue typing for HLA (A, B, C) and HLA DR-DQ with the aim of defining the relative immunogenetic order. (healthy.net)
  • Auto-antibodies to brain antigens, of several natures (N-methyl-d-aspartate glutamate receptor, gangliosides, brain tissue extract, synaptic membrane, and others), were described in epileptic patients and in epileptic syndromes. (eurekaselect.com)
  • accurately
  • The B-cell antigen D8/17 accurately identifies Australians with a past history of RF, and the assay is feasible in remote settings with access to facilities capable of performing D8/17 staining within half a day of sample collection. (mja.com.au)
  • mechanisms
  • Murine models of GD and HLA-transgenic mice have played a pivotal role in elucidating the immunological mechanisms. (frontiersin.org)
  • occur
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • sequences
  • It was showed that the four major NGS platforms, Roche GS 454 FLX, Illumina MiSeq/HiSeq, PGM Ion Torrent and Pacific Biosciences SMRT (PacBio), were all capable of producing sequences suitable for the resolution of HLA genotyping. (biomedcentral.com)
  • marker
  • To test the B-cell antigen D8/17 as a marker of past rheumatic fever (RF) in a predominantly Aboriginal Australian population, and to evaluate technical modifications to allow its use in remote settings. (mja.com.au)
  • Anti-Kv1.4 antibody is a useful marker for the potential development of lethal autoimmune myocarditis and response to calcineurin inhibitors. (hindawi.com)
  • patients
  • In addition, HLA-A*68 (dialysis patients) and HLA-A*03 and HLA-B*15 (transplant patients) appear to be associated with increased resistance to S. aureus nasal carriage. (biomedcentral.com)
  • major
  • Central nervous system (CNS) myelin, the likely major target of autoimmune attack in multiple sclerosis (MS), contains a number of unique components that are potential targets of the attack. (hindawi.com)