VEGF, produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma cells. (wikipedia.org)
Multicellular organisms use four main means of chemical signaling pathways for communication- autocrine, paracrine, endocrine, and contact-dependent. (jove.com)
These effects occur through cellular secretion and subsequent binding of BDNF to its cognate receptor, TrkB, which promotes paracrine and autocrine signaling cascades. (biomedcentral.com)
They have potent autocrine, paracrine, and endocrine functions. (bvsalud.org)
Their main role is in cell-signaling, and, because they are hydrophobic, their main actions are limited to paracrine (cell-to-cell) or autocrine (same cell), rather than systemic, effects. (medscape.com)
Secretion5
Recent research revealed that IL-6 secretion induced by HER2 overexpression activated STAT3 and altered gene expression, resulting in an autocrine loop of IL-6/STAT3 expression. (wikipedia.org)
Mesenchymal cells (MCs) derived from fibrotic lung allografts (BOS MCs) demonstrated constitutive nuclear β-catenin expression that was dependent on autocrine ATX secretion and LPA signaling. (jci.org)
LPA signaling induced NFAT1 nuclear translocation, suggesting that autocrine LPA synthesis promotes NFAT1 transcriptional activation and ATX secretion in a positive feedback loop. (jci.org)
Autocrine signaling is defined as the production and secretion of an extracellular mediator by a cell followed by the binding of that mediator to receptors on the same cell to initiate signaling. (uni-luebeck.de)
High levels of membrane WNT7b autocrine secretion predicts poor outcome in patients with CRC. (researchsquare.com)
Pathway9
De-regulation of the autocrine Wnt signaling pathway via mutations in APC and Axin have been linked to activation of various types of human cancer. (wikipedia.org)
Genetic alterations that lead to de-regulation of the autocrine Wnt pathway result in transactivation of epidermal growth factor receptor (EGFR) and other pathways, in turn contributing to proliferation of tumor cells. (wikipedia.org)
Further investigation revealed that mutant EGFR could activate the oncogenic STAT3 pathway via upregulated IL-6 autocrine signaling. (wikipedia.org)
Here, we have identified an autocrine pathway linking nuclear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and β-catenin that contributes to progression of fibrosis in lung allografts. (jci.org)
Insulin-like growth factor 2 (IGF2), produced and secreted by adult β-cells, functions as an autocrine activator of the β-cell insulin-like growth factor 1 receptor signaling pathway. (unige.ch)
GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation. (umassmed.edu)
Big'-insulin-like growth factor-II signaling is an autocrine survival pathway in gastrointestinal stromal tumors. (ru.nl)
Our data put forth the big-IGF-II/IR isoform A axis as an autocrine survival pathway and potential therapeutic target in GISTs. (ru.nl)
In summary, we demonstrated that the membrane enrichment of WNT7b autocrine probably contributes to CRC metastasis by activating EMT process through the Wnt/β‐catenin signaling pathway. (researchsquare.com)
Proliferation6
These cells express both transforming growth factor alpha and amphiregulin and require autocrine signaling through the EGFR for proliferation and migration. (nih.gov)
The cytokines are autocrine agents which bind to the receptors present on the surface of T lymphocytes and activate intracellular cascades that can induce a response, such as cellular proliferation. (jove.com)
These receptors bind to progesterone released from the cancer cells themselves, thus, acting in an autocrine manner to stimulate cell proliferation. (jove.com)
Together, these observations demonstrate that one or more Src family kinases act upstream as well as downstream of ErbB1 to promote amphiregulin-dependent autocrine stimulation of NHKs and suggest that autocrine NHK proliferation is more dependent upon ERK activation than upon Tyr 845 phosphorylation. (aspetjournals.org)
Insulin-like growth factor-I supports proliferation of autocrine thymic lymphoma cells with a pre-T cell phenotype. (aai.org)
We also show that Int 407 cells produce CysLTs and blocking this autocrine signaling using three different CysLT1 receptor antagonists for longer time points led to attenuation in cell proliferation and induction of apoptosis in the cells. (lu.se)
VEGF4
Another agent involved in autocrine cancer signaling is vascular endothelial growth factor (VEGF). (wikipedia.org)
Evidence shows that autocrine VEGF is involved in two major aspects of invasive carcinoma: survival and migration. (wikipedia.org)
However, addition of exogenous VEGF alone or blocking secreted autocrine VEGF had little or no effect on CLL-cell survival. (uhi.ac.uk)
In conclusion, our findings identify autocrine VEGF as an important mediator of the antiapoptotic effect of CD40 ligation, and thus provide new insights into CLL-cell rescue by CD154 in lymphoreticular tissues. (uhi.ac.uk)
Mediates1
Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells. (stembook.org)
Receptors5
Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell. (wikipedia.org)
Receptors, Autocrine Motility Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
This graph shows the total number of publications written about "Receptors, Autocrine Motility Factor" by people in UAMS Profiles by year, and whether "Receptors, Autocrine Motility Factor" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Receptors, Autocrine Motility Factor" by people in Profiles over the past ten years. (uams.edu)
Autocrine stimulation often operates in autocrine loops, a type of interaction, in which a cell produces a mediator, for which it has receptors, that upon activation promotes expression of the same mediator, allowing the cell to repeatedly autostimulate itself (positive feedback) or balance its expression via regulation of a second factor that provides negative feedback. (uni-luebeck.de)
Glutamate release1
Computational modelling, based on these results, predicts that NMDA Rs in cancer cells could be strongly activated in the tumour microenvironment by both autocrine glutamate release and necrosis. (cam.ac.uk)
Receptor6
These results show that IL-8 induces autocrine signalling via an apical CXCR1 in Caco-2 BBE intestinal epithelial cells and that this receptor is also expressed on the apical surface of differentiated human intestinal epithelial cells in vivo , suggesting an autocrine function for IL-8 secreted in the lumen. (biomedcentral.com)
Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
Insulin-like growth factor (IGF)-II acts as an autocrine factor in several tumor types by binding to IGF receptor type 1 (IGF-1R) and/or the insulin receptor (IR) isoform A. The aim of the present study was to investigate the putative role of unprocessed pro-IGF-II, called 'big'-IGF-II, in GISTs. (ru.nl)
In advanced fibrosis, we found that an autocrine HSC signaling circuit emerged that was composed of 68 receptor-ligand interactions conserved between murine and human NASH. (mssm.edu)
As proof of principle, pharmacological inhibition of one such autocrine interaction, neurotrophic receptor tyrosine kinase 3-neurotrophin 3, inhibited human HSC activation in culture and reversed advanced murine NASH fibrosis. (mssm.edu)
A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line. (rush.edu)
Integrin1
Autocrine transforming growth factor-{beta}1 activation mediated by integrin {alpha}V{beta}3 regulates transcriptional expression of laminin-332 in Madin-Darby canine kidney epithelial cells. (uchicago.edu)
Induce2
Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)
We report here that NC cells themselves express and release SLF protein, which in turn acts as an autocrine factor to induce melanogenesis in nearly NC cells. (elsevierpure.com)
Tumors2
One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. (wikipedia.org)
Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
Epidermal1
Biomimetic autocrine waxy materials (AWMs) inspired by renewable epidermal waxes are attracting increasing attention . (bvsalud.org)
Signaling12
Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. (wikipedia.org)
Their research showed that autocrine IL-6 signaling induced malignant features in Notch-3 expressing mammospheres. (wikipedia.org)
One study showed that autocrine PDGFR signaling plays an essential role in epithelial-mesenchymal transition (EMT) maintenance in vitro, which is known to correlate well with metastasis in vivo. (wikipedia.org)
Many of their antimetastatic effects could be the result of their ability to inhibit autocrine signaling through the EGFR. (nih.gov)
Autocrine signaling is a form of communication where a cell interacts with itself. (jove.com)
In this type of signaling, the cell secretes a chemical messenger called an autocrine agent. (jove.com)
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. (jove.com)
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. (jove.com)
Autocrine signaling is also a major signaling mechanism in cancer cells. (jove.com)
We show, analytically and by simulation, that autocrine signaling suffices to cause both strong and weak Allee effects. (chalmers.se)
Autocrine signaling loops with positive or negative feedback are an important feature in cancer, where they enable context-dependent cell signaling in the regulation of growth, survival, and cell motility. (uni-luebeck.de)
This review surveys the many observations of autocrine TGF-β signaling in tumor biology, including data from cell culture and animal models as well as from patients. (uni-luebeck.de)
Activation4
Blocking release of EGFR ligands also strongly inhibited autocrine activation of the EGFR and reduced both the rate and persistence of cell migration. (nih.gov)
Activating NMDA Rs is shown to cause excitation and intracellular calcium elevation, and intracellular perfusion with physiological levels of glutamate leads to a VGLUT -dependent autocrine NMDAR activation. (cam.ac.uk)
50%, suggesting that the release of preformed mast cell-associated TNF-α acts as a positive autocrine feedback signal to augment NF-κB activation and production of further cytokine, including GM-CSF and IL-8. (soton.ac.uk)
We then examined the hypothesis that when mast cells are stimulated immunologically, the release of preformed TNF-α acts as a positive autocrine feedback signal to augment NF-κB activation. (soton.ac.uk)
Survival2
A BDNF/TrkB autocrine loop has been implicated in the survival of cells representing several human cancers and is associated with poor prognosis. (biomedcentral.com)
Together these results suggest that HBZ activates a BDNF/TrkB autocrine loop that enhances survival of HTLV-1-infected cells. (biomedcentral.com)
Mediator1
We propose that lcn2 is an autocrine mediator of reactive astrocytosis based on the multiple roles of lcn2 in the regulation of cell death, morphology, and migration of astrocytes. (jneurosci.org)
Physiological1
Whether this autocrine activity of IGF2 plays a physiological role in β-cell and whole-body physiology is not known. (unige.ch)
A study demonstrates how the autocrine production of the IL-7 cytokine mediated by T-cell acute lymphoblastic leukemia (T-ALL) can be involved in the oncogenic development of T-ALL and offer novel insights into T-ALL spreading. (wikipedia.org)
Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB. (ox.ac.uk)
Factor3
Here, we formulate and analyze an individual-based model of cancer, in which cell division rates are increased by the local concentration of an autocrine growth factor produced by the cancer cells themselves. (chalmers.se)
A growth factor that is intimately involved in tumor development and progression and often produced by the cancer cells in an autocrine manner is transforming growth factor-β (TGF-β). (uni-luebeck.de)
However, they do proliferate in response to insulin-like growth factor I (IGF-I) and to a small autocrine peptide distinct from IGF-I, which we term lymphoma growth factor. (aai.org)
Thus, the autocrine action of IGF2 regulates adult β-cell mass and function to preserve in vivo GSIS in aging and to adapt β-cell mass in response to metabolic stress, pregnancy hormones, and acute induction of insulin resistance. (unige.ch)
Autocrine human growth hormone up-regulates two poly(C)-binding proteins, αCP1 and αCP2, which bind to these cis-regulatory elements and stabilize hTERT mRNA. (uaeu.ac.ae)
Cell1
Cancerous cells secrete a variety of self-sustaining growth signals that act as autocrine mediators and control cell division rates. (jove.com)
Cells3
NF-κB and TNF-α: A positive autocrine loop in human lung mast cells? (soton.ac.uk)
We herein demonstrate that autocrine human growth hormone production in human mammary carcinoma cells results in increased telomerase activity as a result of specific up-regulation of telomerase catalytic subunit (human telomerase reverse transcriptase (hTERT)) mRNA and protein. (uaeu.ac.ae)
Furthermore, autocrine GH increases the oncogenicity of EA cells and is considered fu. (endocrine-abstracts.org)
Systemic1
MGF is thought to have an autocrine function while IGF-1 has a systemic function. (cdc.gov)
Cellular1
We also provide the reader with a critical discussion on the various experimental approaches employed to identify and prove the involvement of autocrine TGF-β in a given cellular response. (uni-luebeck.de)