• Disorders caused by organ specific autoantibodies, those that primarily target a single organ, (such as the thyroid in Graves' disease and Hashimoto's thyroiditis), are often the easiest to diagnose as they frequently present with organ related symptoms. (wikipedia.org)
  • It is speculated that progression to β-cell loss and clinical onset of type 1 diabetes is reflected in a developing pattern of epitope-specific autoantibodies. (diabetesjournals.org)
  • Among the remarkable advances in neurology in the last 2-3 decades has been identification of highly specific autoantibodies and their molecular targets. (aacc.org)
  • Currently two principal causes are accepted: In NMO-IgG positive patients, the cause of the neuromyelitis optica (understood as the syndrome) is an autoimmune aquaporin-4 channelopathy, due to these specific autoantibodies. (wikipedia.org)
  • The presence of these autoantibodies provides early evidence of autoimmune disease activity, and their measurement can be useful in assisting the physician with the prediction, diagnosis, and management of patients with diabetes. (labcorp.com)
  • See Milatuzumab#CD74 Autoantibodies against CD74 have been identified as a promissing biomarkers in the early diagnosis of the autoimmune disease called axial spondyloarthritis (non-radiographic axial Spondyloarthritis and radiographic axial Spondyloarthritis / Ankylosing spondylitis). (wikipedia.org)
  • Autoantibodies to DSP are a hallmark of the autoimmune disease paraneoplastic pemphigus. (wikipedia.org)
  • 6. Greenbaum CJ, Palmer JP, Kuglin B, Kolb H. Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: Results of the Fourth International Workshop on the Standardization of Insulin Autoantibody Measurement. (labcorp.com)
  • In this issue of the Journal of Clinical Investigation , Jordan Price and colleagues at Stanford University developed a microarray to identify cytokines, chemokines, and other circulating proteins as potential targets of the autoantibodies produced by SLE patients. (medicalxpress.com)
  • One or more autoantibodies may be produced by a person's immune system when it fails to distinguish between 'self' and 'non-self' proteins. (labtestsonline.org.au)
  • Anti-tumor and anti-ovarian autoantibodies in women with ovarian cancer," American Journal of Reproductive Immunology , vol. 57, no. 4, pp. 243-249, 2007. (hindawi.com)
  • Samples that are devoid of autoantibodies, and are therefore suitable for valid thyroglobulin determinations, bind less than 6% of the radiolabeled thyroglobulin. (biomedsearch.com)
  • Anette-G Ziegler at the Diabetes Research Institute in Munich and her colleagues reported that of the 1,610 at-risk infants enrolled in the BABYDIAB trial, those given gluten-containing cereal prior to age 3 months were over five times as likely to develop pancreatic islet autoantibodies as those children first exposed to gluten-based cereals between 3 and 6 months of age. (thefreedictionary.com)
  • Some disorders, such as SLE may be more likely if several autoantibodies are present, while others, such as MCTD (mixed connective tissue disease) may be more likely if a single autoantibody, RNP - ribonucleic protein is the only one present. (wikipedia.org)
  • Tests may include: blood tests to detect inflammation, autoantibodies, and organ involvement x-rays and other imaging scans to detect changes in bones, joints, and organs biopsies to look for pathologic changes in tissue specimens Autoantibody tests may be ordered as part of an investigation of chronic progressive arthritis type symptoms and/or unexplained fevers, fatigue, muscle weakness and rashes. (wikipedia.org)
  • blood tests to detect autoantibodies, inflammation, and organ involvement/damage. (labtestsonline.org.au)
  • Patients with paraneoplastic cerebellar degeneration, paraneoplastic encephalomyelitis, multiple sclerosis, celiac disease, and cerebellar ataxia with polyendocrine autoimmunity can be characterized by the presence of circulating autoantibodies. (aacc.org)
  • In the present article, we will discuss the mechanisms by which the autoantibodies to GAD65 (GAD65Ab), IA-2 (IA-2Ab), and insulin (IAA) appear, pathways of formation, shift between isotypes and subtypes, epitope recognition, and detection, as well as the potential usefulness of epitope-specific autoantibody tests to improve prediction and classification of autoimmune diabetes. (diabetesjournals.org)
  • This chapter outlines the autoantibodies found in pSS and discusses their importance in clinical practice. (intechopen.com)
  • Study Selection: English-language original articles and critical reviews concerning ZnT8 and the clinical applications of islet autoantibodies in diabetes were reviewed. (thefreedictionary.com)
  • Although there are few clinical implications resulting from this classification, autoantibody profiles indicate that AIH is a heterogenous group of entities. (omicsonline.org)
  • The type of autoimmune disorder or disease that occurs and the amount of destruction done to the body depends on which systems or organs are targeted by the autoantibodies, and how strongly. (wikipedia.org)
  • Prediction of IDDM in the general population: Strategies based on combinations of autoantibody markers. (labcorp.com)
  • Some autoantibodies do not cause tissue injury directly but are thought to be part of an overall immune response that can cause inflammation and damage. (labcorp.com)
  • Autoantibodies and their corresponding autoantigens are intensively studied to provide clues to the understanding of disease initiation, tissue specificity, and propagation of hepatic autoimmune diseases. (omicsonline.org)
  • Because autoantibodies recognize unique autoantigens, it was reasoned that standard immunoprecipitation tests followed by a biochemical analysis of the purified immune complexes should make it possible to identify islet autoantigens recognized by immunoglobulin in sera from newly diagnosed diabetic children. (diabetesjournals.org)
  • Disorders caused by autoantibodies that primarily affect a single organ, such as the thyroid in Graves disease or Hashimoto thyroiditis, are often easier to diagnose. (labcorp.com)
  • Sometimes, the immune system ceases to recognize one or more of the body's normal constituents as "self," leading to production of pathological autoantibodies. (wikipedia.org)