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  • Focal Adhesi
  • This study identified HEF1/NEDD9 as an interactive partner for focal adhesion kinase (FAK), connecting it to integrin signaling. (wikipedia.org)
  • cyclin depend
  • The essential mechanism of MAPK cascade for phragmoplast expansion is suppressed by cyclin dependent kinase (CDK) activity before telophase. (wikipedia.org)
  • Kinome Cyclin-dependent kinase Signal transduction Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras come into view. (wikipedia.org)
  • Nek2
  • In the case of the former, it has been suggested that Aurora A cooperates with the kinase Nek2 in Xenopus to dissolves the structure tethering the cell's centrosomes together. (wikipedia.org)
  • histone
  • The Aurora enzymes are particularly significant because they are involved in a direct path to the nucleosome by phosphorylating histone H3. (wikipedia.org)
  • tumors
  • Aurora A expression in tumors is often associated with gene amplification, genetic instability, poor histologic differentiation, and poor prognosis. (aacrjournals.org)
  • Aurora B is frequently expressed at high levels in a variety of tumors, often coincidently with aurora A, and expression level has also been associated with increased genetic instability and clinical outcome. (aacrjournals.org)
  • centrosomes
  • γ-tubulins, the base structure from which centrosomal microtubules polymerize, are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase. (wikipedia.org)
  • Therefore, without proper expression of Aurora A, the cell's centrosomes are never able to separate. (wikipedia.org)
  • For example, deletion of Aurora A in C. elegans results in an initial separation of the cell's centrosomes followed by an immediate collapse of the asters. (wikipedia.org)
  • Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al. (wikipedia.org)
  • Intriguingly
  • Intriguingly, abolishment of Aurora A through RNAi interference results in different mutant phenotypes in different organisms and cell types. (wikipedia.org)
  • cell
  • Finally, a portion of the tagged Aurora B localized to the equatorial cell cortex, having been transported to this location by astral microtubules. (wikipedia.org)
  • The problem with K562 cells, and many other cancer cell types, is an overabundance of Aurora kinases. (wikipedia.org)
  • Abnormally elevated levels of Aurora B kinase, cause unequal chromosomal separation during cell division, resulting in the formation of cells with abnormal numbers of chromosomes, which are both a cause and driver of cancer. (wikipedia.org)
  • Drugs
  • Drugs that target this interaction are under development, and are designed to change the conformation of aurora A. Conformational change in Aurora A leads to release of N-Myc, which is then degraded in a ubiquitin-dependent manner. (wikipedia.org)
  • focal adhesi
  • Objective Enhanced adhesive signaling including activation from the focal adhesion kinase (FAK) can be a hallmark of fibroblasts from lung fibrosis patients, and FAK continues to be therefore hypothesized to be always a key mediator of the disease. (biomasswars.com)
  • This study identified HEF1/NEDD9 as an interactive partner for focal adhesion kinase (FAK), connecting it to integrin signaling. (wikipedia.org)
  • atypical
  • Purpose Review aberrations of insulin signaling to atypical proteins kinase C (aPKC) in muscles and liver that generate cardiovascular risk elements, including, weight problems, hypertriglyceridemia, hypercholesterolemia, insulin level of resistance and blood sugar intolerance in type 2 diabetes mellitus (T2DM), and obesity-associated metabolic symptoms (MetSyn). (biomasswars.com)
  • In both invertebrates and mammals, Numb is localized using the Pins/GαI complex and the PAR complex of Bazooka (Par3 in mammals), Par6, and aPKC (atypical protein kinase C). In the sensory organ precursor (SOP) cell, the PAR proteins localize to the posterior pole of the cell, and the Pins/GαI complex is localized to the anterior pole of the cell. (wikipedia.org)
  • Mps1
  • He is best known for his work on Mad1/Mad2 complexes, which led to the formulation of the template model, and for his contributions to the understanding of the role of the kinase Aurora B, Mps1 and Haspin in mitosis. (wikipedia.org)
  • MPS1 is a protein kinase that is essential to the spindle assembly checkpoint, and may remodel an SAS6-cored intermediate between severed mother and daughter centrioles into a pair of cartwheel protein complexes onto which procentrioles assemble. (wikipedia.org)
  • tumor
  • Methodology/Principal Findings: In this study, we report that the expression of Sphingosine Kinase 1 (SphK1) protein was preferentially elevated in MPM tumor tissues (49 epithelioid and 13 sarcomatoid) compared to normal tissue (n = 13). (docplayer.net)
  • potent
  • Purpose: Next generation Abl and Src kinase inhibitors (including dasatinib, AP23464, and AMN107) have demonstrated potent activity against some clinically relevant BCR-ABL mutants that lead to imatinib resistance. (aacrjournals.org)
  • processes
  • SU6656 has been used primarily as a research tool to investigate the function of Src family kinases in cellular signal transduction processes and biology. (wikipedia.org)
  • plays
  • Conclusions/Significance: The lipid kinase SphK1 plays a positive and essential role in the growth and development of malignant mesothelioma and is therefore a likely therapeutic target. (docplayer.net)
  • Shugoshin is a crucial target of Bub1 kinase that plays a central role in the cohesion of chromosomes during cell division. (wikipedia.org)
  • functional
  • Sphingosine kinase (SphK) is a lipid kinase that phosphorylates sphingosine to sphingosine-1-phosphate (S1P) and mammals express two functional SphK isoenzymes, SphK1 and SphK2. (docplayer.net)
  • region
  • Chk1 has a N-terminal kinase domain, a linker region, a regulatory SQ/TQ domain and a C-terminal domain. (wikipedia.org)
  • different
  • Intriguingly, abolishment of Aurora A through RNAi interference results in different mutant phenotypes in different organisms and cell types. (wikipedia.org)