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  • apoptosis
  • Multipolar spindles were induced in these ZM-treated G(2)/M-arrested cells with accumulation of 4N/8N DNA, similar to cells with genetically suppressed Aurora-B. Cells subsequently underwent apoptosis, as assessed by cleavage of critical apoptotic associated protein PARP. (nih.gov)
  • instability
  • Genetic instability and cellular proliferation have been associated with aurora kinase expression in several cancer entities, including multiple myeloma. (nih.gov)
  • Myeloma cell samples with detectable versus absent aurora-A expression show a significantly higher proliferation rate, but neither a higher absolute number of chromosomal aberrations (aneuploidy), nor of subclonal aberrations (chromosomal instability). (nih.gov)
  • cells
  • Therefore, the expression of aurora-A, -B, and -C was determined by Affymetrix DNA microarrays in 784 samples including 2 independent sets of 233 and 345 CD138-purified myeloma cells from previously untreated patients. (nih.gov)
  • We found aurora-A and -B to be expressed at varying frequencies in primary myeloma cells of different patient cohorts, but aurora-C in testis cell samples only. (nih.gov)
  • Shown are the blots of 10 cell lines for Aurora-A and -B with β-actin as loading control and HELA cells as positive control, respectively. (nih.gov)
  • Aurora Kinase 2 is reported to be expressed at high levels in testis and various proliferating cell lines, including HeLa cells. (leicabiosystems.com)
  • When inactive kinase is expressed, however, the cells eventually die and do not become immortalized, unlike with the active kinase. (leicabiosystems.com)
  • Patients
  • Presence of aurora-A expression delineates significantly inferior event-free and overall survival in 2 independent cohorts of patients undergoing high-dose chemotherapy, independent from conventional prognostic factors. (nih.gov)
  • role
  • The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway has a fundamental role in cell growth proliferation and survival and when altered tumorigenesis (1-3). (exposed-skin-care.net)