Aurora a kinase controls spindle. Medical search. Frequent questions

Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
Mitosis is usually a dynamic process controlled by the activity of multiple kinases with attendant modification of proteins facilitating rigid checkpoint control. (ap26113.com)
GSK1904529A Aurora A is found at centrosomes in early mitosis and controls centrosome maturation centriole separation and chromosome alignment (33) whereas accurate targeting of Aurora B to the chromosomes and then to the spindle midzone and midbody is essential for maintaining microtubule/kinetochore attachments and therefore faithful chromosomal segregation (34). (ap26113.com)
GR phosphorylation by an Aurora kinase-dependent pathway provides the mechanism explaining the tight coupling GSK1904529A of ligand-independent GR phosphorylation to cell cycle phase because the maximal activity of these kinases occurs in mitosis. (ap26113.com)
To examine the functional role of GR during mitosis we performed GR knockdown studies tracking cell division in real time and observed increased chromosome segregation errors with evidence of spindle defects. (ap26113.com)
However multipolarity occurs after normal bipolarization of GSK1904529A the spindle (Movies S4-S6) suggesting normal centrosome number at the onset of mitosis. (ap26113.com)
At the onset of mitosis, centrosomes become the core structures of spindle poles and direct the formation of mitotic spindles. (biomedcentral.com)
In early mitosis, the cohesion between the two pairs of centrioles is broken and each of them participates in the formation of the mitotic spindle pole. (biomedcentral.com)
During mitosis the two centrosomes are present and form the mitotic spindle poles. (biomedcentral.com)
Our recent studies have shown that haspin, a protein kinase imperative for mitosis, is engaged in the interphase progression of HeLa and U2OS cancer cells. (bvsalud.org)
When reduction in ATP concentration was moderate, chromosome movements in mitosis were barely affected, while the metaphase-anaphase transition was significantly prolonged due to reduced tension between the sister-kinetochores, which delayed the satisfaction of the spindle assembly checkpoint. (bvsalud.org)
The dynamic crosstalk between kinases and phosphatases is essential to ensure faithful mitosis. (ed.ac.uk)
PP2A(B56), together with Shugoshin1 (Sgo1), opposes Aurora B during early mitosis to protect cohesin from being disassembled at the inner centromere. (ed.ac.uk)
The Ska complex is a key protein assembly -consisting of Ska1, Ska2 and Ska3- essential for stabilising load-bearing end-on kinetochore-microtubule attachments, and it is also found in the central spindle and midbody at the end of mitosis. (ed.ac.uk)
These unusual changes in command, never observed among any other eukaryotes previously, prompted us to examine some of the protein kinases in T. brucei known to control both mitosis and cytokinesis in other eukaryotes. (ucsf.edu)
This ready change of command on cell division in the same organism has never been observed previously, because cell division is always tightly controlled by mitosis in other organisms. (ucsf.edu)
We have since examined in T. brucei the Polo-like kinase (TbPLK) and Aurora-like kinase (TbAUK1), known to play pivotal roles in controlling both mitosis and cell division in other organisms, to find out how they function in T. brucei. (ucsf.edu)
TbAUK1 resides in a novel protein complex and trans-localizes at the completion of mitosis from the nuclear spindle to the dorsal side of the cell and transcends down from the anterior to the posterior end of the cell to divide it into two. (ucsf.edu)
Focal adhesions control cleavage furrow shape and spindle tilt during mitosis. (syracuse.edu)
Aurora kinase A (AURKA), which is a member of serine/threonine kinase family, plays a critical role in regulating mitosis. (encyclopedia.pub)
The typical period of mitosis in DMSO-treated control cells was 64±28 min (n=23, Fig. 4C). (mirnamimics.com)
Eupatorin affects spindle formation, spindle integrity and centrosome separation To know why cells uncovered to eupatorin at G2 were postponed in mitosis we looked into when the flavonoid intervenes using the spindle dynamics, structure and/or MT polymerization. (mirnamimics.com)
Cells were blocked in mitosis with monastrol which induces monopolar spindles because of Eg5 inhibition.After that cells were launched either into normal or eupatorin-that contains culture medium both compounded with MG132 to avoid anaphase onset. (mirnamimics.com)
These mitotic kinesins are spatially and temporally regulated to stringently control their localized activity towards both ends of MTs at each stage of mitosis, thereby ensuring mitotic fidelity [ 3 ]. (biomedcentral.com)
Development through mitosis depends upon three major regulatory systems, each involving several serine/threonine kinases, referred to as mitotic kinases. (survivinpathway.com)
Within this review, we summarize the functions that all of the Aurora kinases has in cancer biology and mitosis, and discuss the binding modes of Aurora A kinase inhibitors, the spot elements in the binding sites and the fortunate inhibitor components. (survivinpathway.com)
The first of these is Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. (rupress.org)
Contrary to cells treated with a siRNA, cells treated with siRNAs against Bora often displayed multipolar spindles in mitosis, a phenotype that is also seen upon TPX2 RNAi Geneticin distributor and after injection of antibodies blocking Aurora A function. (others-signal.com)
Aurora A is involved with centrosome readiness, spindle assembly, and uneven protein localization throughout mitosis. (others-signal.com)

Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. (unibas.ch)
A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)

The onset of anaphase is triggered by activation of the anaphase promoting complex/cyclosome (APC/C), following silencing of the spindle assembly checkpoint (SAC). (warwick.ac.uk)
HSP90AA1 Aurora kinases are grasp regulators of both centrosome and checkpoint control function. (ap26113.com)
We have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines. (biomedcentral.com)
Previous evidence points to numerous components of the spindle assembly checkpoint and mitotic regulation playing a major role in several cancers [ 11 , 12 ]. (biomedcentral.com)
Lastly, through gene expression profiling we have demonstrated disruption of the spindle assembly checkpoint in the paclitaxel resistant cell lines, indicating a potential therapeutic pathway. (biomedcentral.com)
2004). Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells . (up.pt)
PP2A(B56) and Aurora B also act antagonistically in controlling the processes of error correction and activation of the Spindle Assembly Checkpoint, both of which are essential to achieve chromosome biorientation. (ed.ac.uk)
The bloodstream form is thus apparently lacking the spindle assembly checkpoint, which is present and functioning in the procyclic form. (ucsf.edu)
Such dynamism is essential for assembling and positioning the bipolar spindle, searching for and docking with kinetochores, congressing and segregating chromosomes, and governing the spindle checkpoint [ 1 ]. (biomedcentral.com)

In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator of Aurora A. Without ALADIN, Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators and slows spindle assembly and chromosome alignment. (mblwhoilibrary.org)
These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)
Protein phosphatases PP2A(B55) and PP2A(B56), and the Chromosomal Passenger Complex -CPC, containing Aurora B kinase-, establish a signalling network that controls sister chromatid cohesion, kinetochore-microtubule attachments, and timely chromosome segregation. (ed.ac.uk)
Depletion of PIP4KIIγ enhanced the spindle pole accumulation of mitotic centromere-associated kinesin (MCAK), a microtubule (MT)-depolymerizing kinesin, and resulted in a less stable spindle pole-associated MT. Depletion of MCAK can ameliorate PIP4KIIγ depletion-induced spindle abnormalities. (biomedcentral.com)
The spindle microtubule (MT) exhibits highly regulated dynamic instability, with frequent polymerization and depolymerization occurring at both the plus and minus ends. (biomedcentral.com)
Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
TPX2/ Aurora A binding is stimulated by the little GTPase Ran, which in turn is activated by RCC1, an exchange factor that is found on condensed chromatin and is involved with microtubule nucleation and spindle formation. (others-signal.com)

Treating SCCHN cell lines with a pan-Aurora kinase inhibitor resulted in defective cytokinesis, polyploidy and apoptosis, which was effective irrespective of the EGFR status. (oncotarget.com)
For example, patients with metastatic melanoma who carry a mutation in BRAF kinase respond dramatically well to treatment with vemurafenib, a BRAF-kinase inhibitor. (ispo.ee)
Hence, Rucaparib kinase inhibitor it can be assumed that if expressed in any respect, the guinea pig Survivin variants seem to get expressed at rather very low ranges. (mirnamimic.com)

Here, we report an unexpected, kinase-independent function for AURKA in DNA replication initiation whose inhibition through a class of allosteric inhibitors opens avenues for cancer therapy. (bvsalud.org)
Indeed, allosteric but not catalytic AURKA inhibitors sensitize cancer cells to inhibition of the CDC7 kinase subunit of the replication-initiating factor DDK. (bvsalud.org)
AZD6244 In relaxation from the cells, cleavage furrow formation was started but cytokinesis was soon aborted leading to fusion of two daughter cells into one polyploid cell (Figs. 4A, B). These results indicate that eupatorin impairs normal SAC signaling and suppresses normal cytokinesis when put on otherwise unperturbed mitotic cells, which fits using the phenotype caused by Aurora B kinase inhibitors. (mirnamimics.com)
Our report on the reported chemical scaffolds of Aurora A kinase inhibitors and their binding modes could give a of good use Letrozole ic50 framework from which new design strategies for inhibitors may be evaluated or produced. (survivinpathway.com)
In addition, we review the main pre-clinical and clinical studies concerning Aurora kinase inhibitors currently under investigation. (survivinpathway.com)
The extensive pre-clinical data supports the develop-ment of focused Aurora kinase inhibitors in certain tumefaction types. (survivinpathway.com)
Kinase selectivity studiesshowed that AP24534 does not inhibit Aurora kinases, clearly distinguishing it from other T315I inhibitors in development. (others-signal.com)
Modifications Inhibitors,Modulators,Libraries in the phosphorylation state of the DAT by kinases causes alterations in the function and location of the DAT. (inhibitorkit.com)

2013). Aurora B and Cyclin B have opposite effects on the timing of cytokinesis abscission in drosophila germ cells and in vertebrate somatic cells . (up.pt)
Right chromosome segregation is closely controlled by mitotic kinases such as cyclin dependent NIMA related kinase 2, Pololike kinase, kinase 1 and Aurora kinases. (survivinpathway.com)

Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase. (wikipedia.org)
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A". Mol. (wikipedia.org)
Treatment of HeLa cells with paclitaxel induces phosphorylation of Aurora A at Thr288 while treatment with hydroxyurea ablates phosphorylation. (cellsignal.com)
The biochemical response for phosphorylation practice is given as From the phosphorylation response, the Signal may very well be an upstream kinase or other activators that triggers M3K phosphorylation. (smadsignaling.com)
As discussed in detail below, biochemical, biophysical, structural, and cellular evidences have shown that the redox modification of the cysteine residues of AURKA affects both the phosphorylation state of Thr288 and the conformation state of structural elements critical for the kinase activity, leading to the regulation of AURKA activity. (encyclopedia.pub)
Indeed, the phosphorylation level of Thr288 of AURKA was significantly elevated when the mammalian cells were treated with H 2 O 2 , suggesting that the hyperphosphorylation of AURKA induces mitotic delay and abnormal spindle formation [ 17 ] . (encyclopedia.pub)
In addition, PIP2 binds to polo-like kinase (PLK1) and reduces PLK1-mediated phosphorylation of MCAK. (biomedcentral.com)

Multipolar spindles can arise as a consequence of failure of cytokinesis centrosome amplification or loss of spindle pole integrity (35). (ap26113.com)
Due to the presence of a single mitochondrion in each cell, the nuclear cycle and mitochondrial cycle in T. brucei have to be coordinated for a fruitful cell division, suggesting also that cytokinesis could be controlled by either of the two cycles. (ucsf.edu)
The Polo-like kinase (TbPLK) turns out regulating only cytokinesis and localizing to the flagellum attachment zone (FAZ) in T. brucei. (ucsf.edu)

This promotes relocalisation of Aurora B kinase, and other components of the chromosome passenger complex (CPC), from centromeres to the spindle midzone. (warwick.ac.uk)
The Aurora-like kinase (TbAUK1) resides in a novel chromosomal passenger complex (CPC) that trans-localizes from the central spindle midzone in late anaphase across the nuclear envelope to the FAZ and then transcends down from the anterior to the posterior end along the FAZ to separate the cell into two. (ucsf.edu)
The INCENP N-terminus forms a triple-helix pack using the C-terminus of survivin and N-terminus of borealin (9) that's needed is for CPC localization towards the centromere anaphase spindle midzone and telophase midbody (9-12). (pkc-inhibitor.com)

Aurora kinases control multiple events during cell cycle progression and are essential for mitotic and meiotic bipolar spindle assembly and function. (cancer-research-network.com)
Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)

Regulation by mitotic kinases controls this entire process. (mblwhoilibrary.org)
Current research suggests that mitotic kinases have a key role in regulating the cell cycle. (survivinpathway.com)

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases. (liverpool.ac.uk)
Some kinases are essential scientific objectives of imatinib, nilotinib, and/or dasatinib, although only dasatinib has been reported to inhibit all SRC family kinases. (others-signal.com)
This feature probably contributes to the relatively wide kinase specificity profile of AP24534, including VEGFR and FGFR family kinases, receptors perhaps not restricted by the three currently authorized BCR ABL drugs. (others-signal.com)

Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. (nih.gov)
The catalytic activity of human AURORA-A kinase (AURKA) regulates mitotic progression, and its frequent overexpression in major forms of epithelial cancer is associated with aneuploidy and carcinogenesis. (bvsalud.org)
Strict localization of AURKB by CPC means that the kinase which includes >50 substrates (8) phosphorylates the Col4a6 right targets at the correct guidelines in cell routine progression. (pkc-inhibitor.com)
It has been demonstrated that members of the PIP5KI and PIP4KII families are specifically phosphorylated at the mitotic stage [ 9 ], suggesting that they may contribute to the control of mitotic progression. (biomedcentral.com)

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)

Though it continues to be unclear the way the aberrant mitotic phenotype takes place a model for the era of multipolar spindles indie of centrosome GSK1904529A amplification has been advanced which lists most likely causes as cohesion exhaustion fragmentation of pericentriolar materials or centriole disengagement (35). (ap26113.com)

ALADIN interacts with inactive Aurora A and is recruited to the spindle pole after Aurora A inhibition. (mblwhoilibrary.org)
Loss of GR drives a significant delay in metaphase accompanied by the acquisition of tripolar or tetrapolar spindles determining lack of spindle pole integrity just as one consequence of decreased GR expression. (ap26113.com)
We statement a novel connection between nuclear pore complexes (NPCs) and spindle pole bodies (SPBs) revealed by our research from the gene. (bioinf.org)
PIP4KIIγ accumulates at the spindle pole before anaphase, and is required for the assembly of functional bipolar spindles. (biomedcentral.com)
Consequently, depletion of PLK1 has been shown to counteract the PIP4KIIγ depletion-induced instability of spindle pole-associated MT and cell resistance to arsenite. (biomedcentral.com)
Our current results imply that PIP4KIIγ may restrain MT depolymerization at the spindle pole through attenuating PLK1-mediated activation of MCAK before anaphase onset. (biomedcentral.com)

Disturbed CPC function can also be due to overexpression of CPC subunits and by deregulation of its regulatory JNJ-26481585 kinases and phosphatases. (pkc-inhibitor.com)

Anaphase-promoting complex that intertwine with fields like Immunoprecipitation, Activator, Cdc20 Proteins and Polo kinase. (research.com)

Combined Aurora kinase and EGFR targeting using a monoclonal anti-EGFR antibody was more effective compared to single EGFR and Aurora kinase inhibition. (oncotarget.com)

Here we show that human Aurora-A binds to TPX2, a prominent component of the spindle apparatus. (unibas.ch)
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)

Binding studies demonstrated that the NH2 terminus of TPX2 can directly interact with the COOH-terminal catalytic domain of Aurora-A. Although kinase activity was not required for this interaction, TPX2 was readily phosphorylated by Aurora-A. Upon siRNA-mediated elimination of TPX2 from cells, the association of Aurora-A with the spindle microtubules was abolished, although its association with spindle poles was unaffected. (unibas.ch)

So far, several lines of evidence have shown that H 2 O 2 -induced regulation of the AURKA activity, possibly through direct oxidation of Cys290 present in the activation segment of the kinase domain. (encyclopedia.pub)
As the spindle formation is the process that is mainly governed by the kinase activity of AURKA, these observations led to the hypothesis that H 2 O 2 regulates the activity of AURKA [ 27 ] [ 28 ] . (encyclopedia.pub)

Conversely, depletion of Aurora-A by siRNA had no detectable influence on the localization of TPX2. (unibas.ch)
Because the members of the PIP5KI and PIP4KII families exhibit specific and distinct subcellular localization patterns, it has been postulated that local increases in PIP2 concentration by a specific kinase member may underlie its diverse signaling functions [ 5 , 8 ]. (biomedcentral.com)
Immune system Nevertheless, nuclear launch of Bora isn't the only system by which its service of Aurora A is controlled since the bora mutant phenotype can be rescued by Bora fused to a signal, which keeps the protein in the cytoplasm, or fused to a localization signal, which maintains the protein in the nucleus until nuclear envelope breakdown. (others-signal.com)
Amphetamine, a psychostim ulant, also causes reversal and altered cellular location of the DAT which is known to be regulated by kinases, phos phatases, and Ca2 localization and association. (inhibitorkit.com)

Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. (rupress.org)

In this study, we explored how PIP4KIIγ regulates the assembly of mitotic spindles. (biomedcentral.com)

More over, TPX2 is only necessary for a part of Aurora A dependent processes: TPX2 inactivation by RNAi causes spindle problems and reduction of Aurora A from the mitotic spindle, but centrosome maturation is normal, and the centrosome pool of the kinase is unchanged. (others-signal.com)

Finally, we evaluate a functional interaction between Fry and NDR1 kinase, providing evidence of an evolutionarily conserved complex required for morphogenesis. (nature.com)

His research in Establishment of sister chromatid cohesion intersects with topics in Meiosis II, Spindle apparatus and Kinetochore. (research.com)

In turn, Aurora-A might regulate the function of TPX2 during spindle assembly. (unibas.ch)
The MTOC is responsible to direct the assembly and the orientation of MTs and to control MT-dependent processes such as trafficking of cytoplasmic vesicles and orientation of cellular organelles. (biomedcentral.com)
Therefore, unlike Bora, TPX2 appears to be specifically in charge of the spindle assembly purpose of Aurora A. To date, no TPX2 homolog has been discovered in Drosophila. (others-signal.com)

Our results demonstrate that combined targeting of EGFR and Aurora kinases represents a therapeutic means to activate cell cycle checkpoints and apoptosis in SCCHN. (oncotarget.com)

By analysing tum/RacGAP50C mutant Drosophila embryos we show that cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase, Diaphanous, Pav-KLP and Anillin. (biologists.com)
Taken together, our findings suggest that Bora is just a important activator of Aurora A that is functionally conserved between Drosophila and vertebrates. (others-signal.com)
We show here that the conserved binding partner Bora is essential for Aurora A to perform these functions in Drosophila. (others-signal.com)
Although in Drosophila, Bora so far may be the only known activator of Aurora A, many in vitro activators of Aurora A have now been discovered in other creatures. (others-signal.com)

Cysteine Modification in Aurora Kinase A" Encyclopedia , https://encyclopedia.pub/entry/45170 (accessed December 08, 2023). (encyclopedia.pub)

A previous screen of a human kinase and phosphatase shRNA library to select genes that mediate arsenite induction of spindle abnormalities resulted in the identification of phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (PIP4KIIγ), a phosphatidylinositol 4,5-bisphosphate (PIP2)-synthesizing enzyme. (biomedcentral.com)

Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
In mammalian cells, the oxidative stress induced by the additional H 2 O 2 results in the mitotic delay and abnormal mitotic spindle formation [ 17 ] . (encyclopedia.pub)

Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)

The formation of the mitotic spindle is a complex process that requires massive cellular reorganization. (mblwhoilibrary.org)
Our research interests include understanding the interface between cytoskeletal dynamics and membrane transport and defining how they co-regulate one another to control essential cellular processes such as cell division, fate, and polarity. (syracuse.edu)

TPX2 was identified by mass spectrometry as a major protein coimmunoprecipitating specifically with Aurora-A from mitotic HeLa cell extracts. (unibas.ch)
The relationship between lysate protein concentration from paclitaxel-treated and hydroxyurea-treated HeLa cells and the absorbance at 450 nm using the PathScan ® RP Phospho-Aurora A (Thr288) Sandwich ELISA Kit #41333 is shown in the upper figure. (cellsignal.com)

Conversely, Aurora-A could be detected in TPX2 immunoprecipitates. (unibas.ch)
In vertebrates, TPX2 prevents PP1 dependent dephosphorylation and therefore AZD5363 locks the kinase in its active conformation. (others-signal.com)
The service of Aurora A by Cdc2 is PP1 independent, and, for that reason, TPX2 is impossible to participate in this particular function. (others-signal.com)

One of these mitotic controllers is Aurora A kinase, which is itself highly regulated. (mblwhoilibrary.org)

Ongoing efforts in human cell lines aim to explain how this interaction controls the localisation and function of the Ska complex during late mitotic events. (ed.ac.uk)
A comprehensive kinase interaction map for dasatinib was recently described, though assay differences preclude direct comparison of the kinase users of AP24534 and dasatinib. (others-signal.com)

Hung H, Hehnly H¥ , Doxsey S ¥ . The mother centriole protein, cenexin, modulates symmetric lumen formation through spindle orientation. (syracuse.edu)

DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. (wikipedia.org)
To look at if eupatorin can perturb spindle dynamics at M phase, we examined the cells' capability to convert the spindle architecture from monopolar to bipolar structure. (mirnamimics.com)
The instability of MT dynamics depends heavily on mitotic kinesins, a class of molecular motors, which use the energy from ATP hydrolysis to translocate along the MT or control MT dynamics by facilitating MT polymerization and depolymerization at both ends. (biomedcentral.com)

Together this signifies that exposure Bicalutamide recently G2 cells to eupatorin causesdefects in spindle formation.To review the result of eupatorin on spindle maintenance, we treated MG132 blocked metaphase cells with eupatorin for just two h within the ongoing presence of MG132. (mirnamimics.com)
In addition, coordination of MT polymerization/depolymerization at both ends to maintain the size and shape of mitotic spindles is also critical for the proper formation and function of the mitotic spindle. (biomedcentral.com)

Anatomy11

Organisms2

Chemicals and Drugs50

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes23

Information Science2

MITOSIS32

Serine-threon3

Checkpoint9

Microtubule7

Inhibitor3

Inhibitors8

Cyclin2

Phosphorylation7

CYTOKINESIS3

Midzone3

Bipolar spindle assembly2

Mitotic kinases2

Family kinases3

Progression4

Protein kinase2

Multipolar spindles1

Pole6

Phosphatases1

Proteins1

Inhibition1

Binds3

Microtubules1

AURKA2

Localization4

Depletion1

Regulates1

Maturation1

Evolutionarily conserved1

Apparatus1

Assembly3

Cell cycle1

Drosophila4

20231

Phosphatase1

Mammalian2

Centrosome amplification1

Cellular2

HeLa2

TPX23

Highly regulated1

Interaction2

Centriole1

Dynamics3

Formation2