• The CDC has recorded 257 confirmed and 30 probable cases of MDR C. auris in the United States as of March 31, 2018. (the-hospitalist.org)
  • Although micafungin and caspofungin inhibited some of the fungus, neither worked against biofilms: voriconazole showed little activity against C auris cells, and fluconazole was altogether ineffective. (medscape.com)
  • C. auris was named because it was a yeast-like fungus with biologic properties that fit into the genus Candida and was first isolated as an infectious agent from a patient's ear ( auris means 'ear' in Latin). (medicinenet.com)
  • C. auris spread, according to the CDC, is likely due to contact with contaminated surfaces or equipment or even possibly by direct physical person-to-person contact, but the CDC is still gathering the data on the spread of this disease as some people may be carriers this fungus for many months. (medicinenet.com)
  • The best way to identify C. auris is by looking under a microscope, which often takes time because it requires doctors to grow the fungus, Chauhan said. (usatoday.com)
  • The fungus - also referred to as C. auris - is resistant to some or all antifungal medicines, which makes it harder to treat, the CDC says. (usatoday.com)
  • Five of the first seven cases had not been flagged as C. auris at the time the patients were hospitalized, underlining the difficulty of identifying the fungus. (statnews.com)
  • When a patient with C. auris is identified, implement screening of high-risk patients and patient contacts for C . auris colonization. (ca.gov)
  • These factors, together with the innate resistance of C. auris to most antifungal agents, may explain why it is an emerging pathogen. (medscape.com)
  • Dr Sherry's team concluded that antifungal stewardship strategies alone will be unlikely to control C auris ' spread, but explored what antifungal agents the pathogen might be susceptible to. (medscape.com)
  • Prevention of C. auris spread is detailed in the CDC's infection-control publications and the CDC encourages environmental cleaning with an EPA-registered hospital-grade disinfectant that is effective against fungi. (medicinenet.com)
  • Here's what we know about C. auris after talking to Neeraj Chauhan , an associate professor at Rutgers University Medical School, who has been studying Candida fungi for nearly 20 years. (usatoday.com)
  • Healos, the trial in which the drug failed to meet the main goal, was testing two doses of Auris Medical's AM-111 - 0.4 mg and 0.8 mg - in patients with severe and profound sudden deafness. (yahoo.com)
  • Auris Medical's CEO Meyer also said the company would discuss with health regulators the improvement seen in some patients on the lower dosage. (yahoo.com)
  • We are very pleased with this new addition to our patent estate in tinnitus, which remains an area of great unmet medical need", commented Thomas Meyer, Auris Medical's founder, Chairman and CEO. (yahoo.com)
  • Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Auris Medical's strategies or expectations. (yahoo.com)
  • Auris Medical is also developing treatments for a variety of inner ear disorders, including tinnitus and Meniere's disease. (yahoo.com)
  • In addition, Auris Medical has two Phase 3 programs under development: Sonsuvi ® (AM-111) for acute inner ear hearing loss and Keyzilen ® (AM-101) for acute inner ear tinnitus. (yahoo.com)
  • Even if Auris is successful in their second tinnitus trial, they'd still have to conduct another U.S. trial to win FDA approval. (reuters.com)
  • Tinnitus aurium is the technical term for ringing in the ear, although it may actually involve sounds better described as buzzing, roaring, or hissing. (portsmouthhospital.com)
  • Basel, Switzerland, Feb. 11, 2015 (GLOBE NEWSWIRE) -- Auris Medical Holding AG (Nasdaq:EARS), a clinical-stage company dedicated to developing therapeutics that address important unmet medical needs in otolaryngology, today announced that it has recently been granted a patent by the Chinese patent office covering the use of its investigational tinnitus treatment AM-101. (cnbc.com)
  • Sequence analyses of outbreak isolates revealed that C. auris has simultaneously emerged as four distinct continentally restricted clonal lineages. (asm.org)
  • Armstrong recently investigated an outbreak in Colombia, working with health authorities there to learn more about how C. auris spreads. (cnn.com)
  • Most troubling: a continuing outbreak in a hospital in Valencia, Spain, in which 17 patients have died - a 41% fatality rate among those who developed a fulminant C. auris candidemia, Javier Pemán, MD , said at the meeting. (the-hospitalist.org)
  • The disinfectant has been effective in wiping out C. difficile and disinfects surfaces contaminated with C. auris, too. (usatoday.com)
  • C. auris spreads in hospitals and health care settings via surfaces, where it persists for days, and from person to person, he said. (usatoday.com)
  • According to a Contagion Today article, a team of investigators from Northeast Ohio Veterans Affairs Healthcare System, Case Western Reserve University, University Hospital Cleveland Medical Center, and Louis Stokes Veterans Affairs Medical Center presented research on the effectiveness of disinfectant wipes in reducing C auris on surfaces. (cleanlink.com)
  • Any patient with a C. auris infection should be isolated, and their rooms should be cleaned and disinfected with EPA-registered hospital-grade disinfectant with a fungal claim, according to the alert. (statnews.com)
  • Infection-prevention measures targeting C. auris biofilms in patients, on medical devices (e.g., equipment in contact with patients), and in the hospital environment will be required. (medscape.com)
  • With supervision from an infectious disease expert, "hospital workers used a special device to spray aerosolized hydrogen peroxide around a room used for a patient with C auris, the theory being that the vapor would scour each nook and cranny. (cleanlink.com)
  • the genome sequences of the C. auris infecting the two Illinois patients, also treated at the same hospital at the same time, were also nearly identical to one another. (statnews.com)
  • C. auris is hard to remove from the hospital environment," once it becomes established, said Dr. Pemán of La Fe University and Polytechnic Hospital, Valencia. (the-hospitalist.org)
  • Jacques Meis, MD, of the department of medical microbiology and infectious diseases at Canisius Wilhelmina Hospital, Nijmegen, the Netherlands, set the stage for an extended discussion of C. auris at the meeting. (the-hospitalist.org)
  • Thus, use of this disinfectant can be advocated for topical control of C. auris at standard concentrations used for skin and wound cleansing and disinfection (0.05%-4.0%)," the authors write. (medscape.com)
  • 5 log10 colony forming units (CFU) reduction of C auris on steel and glass carriers, while non-disinfectant wipes led to a reduction of ~2 log. (cleanlink.com)
  • Ensure the laboratory notifies infection prevention immediately following a positive result for C. auris , even if preliminary. (ca.gov)
  • this requires a positive identification of the C. auris infecting strain and laboratory determination of the strain's drug susceptibility. (medicinenet.com)
  • C auris was initially discovered in 2009 in a patient's infected ear canal in Japan, and the first US cases were detected in 2013 in patients with serious preexisting medical conditions. (medscape.com)
  • So far, these yeast infections have been limited to long-term hospitalized patients, Chiller said, so the general public doesn't need to worry about getting infected with C. auris. (statnews.com)
  • Auris Medical is a biopharmaceutical company dedicated to developing therapeutics that address important unmet medical needs in neurotology and central nervous system disorders. (yahoo.com)
  • Auris Medical Holding AG is a clinical-stage biopharmaceutical company. (equities.com)
  • For this reason, it is important to quickly identify C. auris in a hospitalized patient so that healthcare facilities can take special precautions to stop its spread. (cdc.gov)
  • Due to the growing and global spread, the CDC has just added C auris to its list of "urgent threats. (cleanlink.com)
  • The global spread of C. auris has had public health officials on alert for imported cases, but all of the US cases seem to have been contracted domestically. (statnews.com)
  • These findings suggest that C. auris could be spread in healthcare settings," the CDC said. (statnews.com)
  • C. auris was first identified in 2009 in an ear infection in a Japanese woman, but the earliest known strain dates back to 1996 in South Korea, according to the New Jersey Department of Health. (usatoday.com)
  • Based on information from a limited number of patients, C. auris infections have a mortality rate of around 60 percent, double the 30 percent death rate of patients with invasive candidemia, a Candida bloodstream infection, according to the CDC . (statnews.com)
  • C. auris causes serious, hard to treat infections in hospitalized patients. (ca.gov)
  • Nov 28 (Reuters) - Auris Medical Holding AG's shares hit a record low on Tuesday after it said it would end an ongoing late-stage study testing its treatment for sudden deafness, as the drug failed to improve hearing in patients in a similar trial. (yahoo.com)
  • Despite the drug's failure, Auris Medical said it sees hope in the smaller dose, which showed improvement in some patients with profound hearing loss. (yahoo.com)
  • All seven of the patients had been hospitalized for cancer, respiratory failure, or other serious condition, so it is not clear if C. auris contributed to the deaths of four of them, the CDC said. (statnews.com)
  • After one of the Illinois patients was hospitalized for an unrelated illness, researchers found C. auris in his mattress, bedside table, bed rail, chair, and windowsill. (statnews.com)
  • Although 60 percent of people with C. auris infections outside the US have died, the CDC said, that figure is based on a small number of patients, many of whom had other severe illnesses, making it unclear how serious the infection on its own might be. (statnews.com)
  • Based on information from a limited number of patients, 30 - 60% of people with C. auris infections have died. (cbsnews.com)
  • Another concern is that testing of patients' rooms identified C. auris on mattresses, beds, windowsills, chairs, infusion pumps and countertops. (cnn.com)
  • San Diego-based Otonomy and Swiss biotech Auris propose delivering medicines using different gel-like formulations into the middle ear, for absorption by the inner ear. (reuters.com)
  • Auris Medical, which had a market cap of $36.8 million as of Monday's close, lost about $20 million in value after plummeting more than 50 percent in morning trading. (yahoo.com)
  • The shares of Auris Medical Holding Ltd. trade on the NASDAQ Capital Market under the symbol "EARS. (yahoo.com)
  • Pivotal drug-trial data from Otonomy Inc and Auris Medical Holding AG is expected to show whether two competing approaches can address ear disorders associated with hearing loss and balance. (reuters.com)
  • The passionate team and differentiated innovation from Auris will help us amplify the power of digital surgery to address unmet clinical needs and lead a transformation in surgical care and lung cancer intervention," J&J medical devices worldwide chair Ashley McEvoy said in a press release. (massdevice.com)
  • The clinical development of AM-101 was initiated by Auris Medical in 2007 and comprises three completed clinical trials to date. (cnbc.com)
  • In 2013, Auris Medical reached agreement with the US Food and Drug Administration (FDA) under a Special Protocol Assessment (SPA) for its pivotal TACTT2 study. (cnbc.com)
  • In addition, Auris Medical is pursuing early-stage research and development projects. (cnbc.com)
  • It's unclear why C. auris has emerged now, but Chiller said researchers suspect medication use may be a factor. (statnews.com)
  • It advises health care facilities and laboratories to report any suspected C. auris infections to state and local health authorities, and to the CDC. (statnews.com)
  • Health experts have issued a warning regarding C auris, which has been quietly spreading around the world. (cleanlink.com)
  • Once established in a health care setting - often an intensive care ward - C. auris poses major infection controls challenges and can be very hard to identify and eradicate, said Dr. Meis. (the-hospitalist.org)
  • Most C. auris cases in the United States have been detected in the New York City area, New Jersey, and the Chicago area," the CDC said in a statement. (cbsnews.com)
  • Most cases of C. auris that have been reported have been from the blood," Tsay wrote in an email, though she noted that it has also been seen in urine, the respiratory tract, wounds, bile fluid and the ear. (cnn.com)
  • Cases of M. auris infection have been reported in Asia and Micronesia (Saipan), causing otitis interna. (wikipedia.org)
  • What makes C. auris so deadly is that it is difficult to treat and often misidentified, the CDC says. (usatoday.com)
  • Hundreds of music lovers were seen enjoying the instrumental music sessions by Takahero Aure and Camp Zuherman of Switzerland. (thefreedictionary.com)
  • Wondering if my iFi NOS would perform well with the Aurium, I'm assuming they'd work as they are 6922s. (head-fi.org)