• Resting-state functional connectivity (FC) analyses have shown atypical connectivity in autism spectrum disorder (ASD) as compared to typically developing (TD). (biorxiv.org)
  • Neuroimaging studies of functional connectivity (FC) in autism have been hampered by small sample sizes and inconsistent findings with regard to whether connectivity is increased or decreased in individuals with autism, whether these alterations affect focal systems or reflect a brain-wide pattern, and whether these are age and/or sex dependent. (kcl.ac.uk)
  • The study included resting-state functional magnetic resonance imaging and clinical data from the EU-AIMS LEAP (European Autism Interventions Longitudinal European Autism Project) and the ABIDE (Autism Brain Imaging Data Exchange) 1 and 2 initiatives of 1824 (796 with autism) participants with an age range of 5-58 years. (kcl.ac.uk)
  • In functional neuroimaging studies, when performing theory of mind and facial emotion response tasks, the median person on the autism spectrum exhibits less activation in the primary and secondary somatosensory cortices of the brain than the median member of a properly sampled control population. (wikipedia.org)
  • Increased functional connectivity within the left hemisphere which directly correlates with severity of autism. (wikipedia.org)
  • Despite ample behavioral evidence of atypical facial emotion processing in individuals with autism (IwA), the neural underpinnings of such behavioral heterogeneities remain unclear. (biorxiv.org)
  • A critical question, however, is whether the atypical facial emotion recognition broadly reported in individuals with autism (IwA) arises purely from differences in sensory representations (i.e., purely perceptual alterations 16 , 17 ) or is due to a primary (but not mutually exclusive) variation in the development and function of specialized affect processing regions (e.g., atypical amygdala development leading to specific differences in encoding emotion). (biorxiv.org)
  • Converging evidence indicates that brain abnormalities in autism spectrum disorder (ASD) involve atypical network connectivity, but it is unclear whether altered connectivity is especially prominent in brain networks that participate in social cognition. (autismsciencefoundation.org)
  • Atypical functional connectome hierarchy in autism. (mpg.de)
  • Bin Wan and Sofie Valk from the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig and Forschungszentrum Jülich (Germany), together with international researchers from South Korea, UK, Switzerland, and Canada, have now investigated in a study whether such functional asymmetries in autism are indicative of altered systematic organisation in the brain in general. (mpg.de)
  • The widespread behavioural alterations observed in people with autism are accompanied by reports of structural and functional changes in the sensory and associative regions of the brain. (mpg.de)
  • When segregating unimodal and transmodal systems, reduced left-directed functional asymmetry of language network organisation was observed in individuals with autism compared to non-autistic individuals. (mpg.de)
  • This may suggest that the atypical functional laterality in autism results from altered developmental trajectories. (mpg.de)
  • Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). (lu.se)
  • A favorable 3-year outcome of kidney transplantation in atypical hemolytic uremic syndrome associated with a factor H mutation: case report. (lu.se)
  • Complement factor H-associated atypical hemolytic uremic syndrome in monozygotic twins: concordant presentation, discordant response to treatment. (lu.se)
  • Posttransplantation cytomegalovirus-induced recurrence of atypical hemolytic uremic syndrome associated with a factor H mutation: successful treatment with intensive plasma exchanges and ganciclovir. (lu.se)
  • Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15. (lu.se)
  • Atypical relapse of hemolytic uremic syndrome after transplantation. (lu.se)
  • Signs of critical illness in older adults may be subtle or atypical, meaning that their presentation often deviates from typical "illness scripts", which represent the patterns in history or physical exam associated with a specific disease process. (saem.org)
  • Neuroendocrine Tumors of the Bronchopulmonary System (Typical and Atypical Carcinoid Tumors): Current Strategies in Diagnosis and Treatment. (karger.com)
  • Copies of these "typical" data were deliberately analyzed incorrectly to assess feasibility of identifying them as "atypical. (uni-regensburg.de)
  • Results TMA identified all atypical activity maps for both tasks, at the cost of incorrectly classifying 3.6 (VG)-6.5% (FT) of typical maps as atypical. (uni-regensburg.de)
  • We used site-directed mutagenesis of conserved residues in transmembrane 3 (TMIII), a key region involved in G protein-coupled receptor activation, to probe the binding and function of prototypical orthosteric mAChR agonists, allosteric modulators, and "atypical" agonists. (aspetjournals.org)
  • Contrasting with most extant literature in the present study, we investigated precisely how age and disease phenotypes factors into dynamic changes in functional connectivity of TD and ASD using resting-state functional magnetic resonance imaging (rs-fMRI) data stratified into three cohorts: children (7-11 years) and adolescents (12-17 years), and adults (18+) for the analysis. (biorxiv.org)
  • Conclusion This study supports feasibility of TMA for objective identification of atypical activation patterns for motor and verb generation fMRI protocols. (uni-regensburg.de)
  • In a clinical setting, this method could be applied to automatically flag fMRI scans showing atypical activation patterns for further investigation to determine whether atypicality is caused by poor scan data quality or abnormal functional topography. (uni-regensburg.de)
  • The participants underwent 2 functional magnetic resonance imaging (fMRI) brain scans spaced a year apart. (nih.gov)
  • Graph-theoretical analyses have shown that the functional connectivity in the human brain is divided into well-organized modules or subnetworks which are densely connected within themselves and sparsely connected to each other. (biorxiv.org)
  • For patients, the average TMA was significantly higher than atypical healthy scans, despite localized anatomical abnormalities caused by a tumor. (uni-regensburg.de)
  • A few studies have found somatosensory abnormalities in atypical odontalgia (AO) patients. (hindawi.com)
  • The cognitive phenotype of ASD includes atypical executive functioning (EF) [ 2 , 3 ], which comprises a range of cognitive processes that are necessary for concentrating and paying and/or switching attention [ 4 ]. (biomedcentral.com)
  • Long-range functional connections mirror and link microarchitectural and cognitive hierarchies in the human brain. (mpg.de)
  • Sofie Valk, head of the Cognitive Neurogenetics research group at MPI CBS, classifies: 'Taken together, our work shows that there are subtle differences in the asymmetry of functional organisation in autistic and non-autistic individuals. (mpg.de)
  • The course includes individual differences from various perspectives: biological (genes/environment), assessment (personality structure), cognitive (intelligence), functional (dark traits), motivational (self-concept), mental health (well-being), and societal (ethics) perspectives. (lu.se)
  • Researchers locate one cause in altered patterns of brain asymmetry, possibly related to atypical lateralisation of functional processes. (mpg.de)
  • With very little "innate" functional neural circuits, the model acquired various behavior patterns that comply with its embodiment, and the neural model self organizes to capture the embodied information structure. (upenn.edu)
  • Several studies on neurocognitive diseases have reported atypical fluctuation in modularity. (biorxiv.org)
  • Atypical Parkinsonism disorders are a group of diseases linked to a lack of dopamine in the brain. (parkinson.ca)
  • For the first time, the atypical strains BTV-25-GER2018 and BTV-33-MNG3/2016 as well as the re-emerged classical strain BTV-8-GER2018 were evaluated comparatively in a pathogenesis study in goats-the natural host of atypical BTV. (mdpi.com)
  • To compare the consequences of a guided discontinuation strategy and maintenance treatment in remitted first-episode psychosis in terms of relapse rates and functional outcome. (psychiatrist.com)
  • This atypical clinical course should be known in order to improve the outcome of adverse events due to antituberculosis treatment. (who.int)
  • Even so, the long-term outcome of early treatment of women with asymptomatic or atypical PID on important clinical outcomes is unknown. (cdc.gov)
  • This atypical clinical ties, 4/5 in the shoulders and elbows and consisted of articular mobilization course should be known in order to and 2/5 in the 2 wrists and hands. (who.int)
  • Here, I have used brain-tissue mapped artificial neural network (ANN) models of primate vision to probe candidate neural and behavior markers of atypical facial emotion recognition in IwA at an image-by-image level. (biorxiv.org)
  • Furthermore, in silico experiments revealed how learning under noisy sensory representations could lead to atypical facial emotion processing that better matches the image-level behavior observed in IwA. (biorxiv.org)
  • To investigate whether adolescents with ASD show altered functional connectivity in 2 brain networks putatively impaired in ASD and involved in social processing, theory of mind (ToM) and mirror neuron system (MNS). (autismsciencefoundation.org)
  • Statistical parametric maps testing the degree of whole-brain functional connectivity and social functioning measures. (autismsciencefoundation.org)
  • Adolescents with ASD showed atypically increased functional connectivity involving the mentalizing and mirror neuron systems, largely reflecting greater cross talk between the 2. (autismsciencefoundation.org)
  • The lack (deficiency) of functional complement factor I protein allows uncontrolled activation of the complement system. (medlineplus.gov)
  • Atypical haemolytic uraemic syndrome associated with a hybrid complement gene. (lu.se)
  • The human complement factor H: functional roles, genetic variations and disease associations. (lu.se)
  • These recommendations are based in part on the fact that diagnosis and management of other common causes of lower abdominal pain (e.g., ectopic pregnancy, acute appendicitis, and functional pain) are unlikely to be impaired by initiating empiric antimicrobial therapy for PID. (cdc.gov)
  • This type of depression is considered to cause more serious functional impairment compared with other ones. (depressionhelps.com)
  • Here we report a case of acute isoniazid-induced peripheral neuropathy with predominant motor functional impairment associated with tetraplegia. (who.int)
  • Although numerous mutations affected signaling, we did not identify amino acids that were important for the functional activity of any one class of agonist (orthosteric, allosteric, or atypical) to the exclusion of any others, suggesting that TMIII is key for the transmission of stimulus irrespective of the agonist. (aspetjournals.org)
  • Jie Song et al (2014) reported that modularity decreases with aging, suggesting less distinct functional divisions and specialization across whole brain networks. (biorxiv.org)
  • Under placebo, compared to controls, individuals with ASD had atypical brain activation in response inhibition regions including the inferior frontal cortex, premotor regions and cerebellum. (biomedcentral.com)
  • Also, within ASD individuals, brain functional differences were shifted significantly towards control levels during response inhibition in the inferior frontal and premotor cortices. (biomedcentral.com)
  • Our findings provide the first evidence that tianeptine can shift atypical brain activation during EF in adults with ASD towards control levels. (biomedcentral.com)
  • Thus, compared to non-autistic individuals, they show subtle changes in the asymmetry of the brain structure and a lower laterality of functional activation, in terms of the use of the left or right hemisphere in the brain. (mpg.de)
  • Asymmetry is a key feature of brain organisation, supporting flexible interplay between local neuronal modules linked to the functional specialisation that underlies human cognition,' explains Bin Wan, lead author of the study. (mpg.de)
  • Atypical BTV strains are phylogenetically distinct from the classical BTV serotypes 1-24 and differ in terms of several biological features. (mdpi.com)
  • Changes of hormonal levels are classified as biological causes of atypical depression. (depressionhelps.com)
  • There were no advantages of the discontinuation strategy regarding functional outcome. (psychiatrist.com)
  • and actively assisted muscle strengthen- improve the outcome of adverse events There were no deglutition or sphinc- ing and functional work. (who.int)
  • The researchers found that there are large differences in the asymmetry of functional organization in autistic and non-autistic individuals. (mpg.de)
  • Atypical Odontalgia (AO) is a persistent pain condition located in the teeth and jaws. (hindawi.com)
  • We previously showed that cyclin I does not regulate proliferation, but rather controls survival of podocytes, terminally differentiated epithelial cells that are essential for the structural and functional integrity of kidney glomeruli. (jci.org)
  • Cross-sectional study using resting-state functional magnetic resonance imaging involving 25 adolescents with ASD between the ages of 11 and 18 years and 25 typically developing adolescents matched for age, handedness, and nonverbal IQ. (autismsciencefoundation.org)
  • Atypical presentations occur for many reasons, including the physiological changes of aging, medication effects, and factors that limit history or physical exam (Table 1). (saem.org)
  • But factors that cause other types of depression are known to cause atypical depression, too. (depressionhelps.com)
  • 20 are likely to affect FI function, and that monitoring iC3b in a degradation assay is a useful tool to establish the pathogenicity of CFI variants in functional studies. (lu.se)
  • Pathogenicity prediction and a yeast-functional assay suggested p.Gly116Arg impaired m-AAA (ATPases associated with various cellular activities) complex function. (uni-koeln.de)
  • Because of the difficulty of diagnosis and the potential for damage to the reproductive health of women even by apparently mild or atypical PID, experts recommend that providers maintain a low threshold of diagnosis for PID. (cdc.gov)
  • Treatment of atypical depression has been improved due to creation of mood-stabilizers and new antidepressants. (depressionhelps.com)
  • Maintenance treatment was carried out according to American Psychiatric Association guidelines, preferably using low-dose atypical antipsychotics. (psychiatrist.com)
  • Functional MRI of disease progression in Parkinson disease and atypical parkinsonian syndromes. (nih.gov)
  • and persons with functional or anatomic asplenia (including persons with sickle cell disease). (cdc.gov)
  • Also, by changing the model parameters, we can simulate "atypical" development. (upenn.edu)
  • People suffering from atypical depression more often suffer from personality disorder and social phobia. (depressionhelps.com)
  • Recent work indicates that the plates had a keratinous horny covering (they were not just skin-covered): the idea that they functional primarily in thermoregulation isn't supported by their histology (Main et al . (scienceblogs.com)
  • The functional regulation of cells is a complex and dynamic process. (nature.com)
  • Cyclin I is an atypical cyclin because it is most abundant in postmitotic cells. (jci.org)
  • The US and the whole world are attending one of the most atypical, controversial and contested presidential races in recent times. (realinstitutoelcano.org)
  • In recent years, numerous atypical Bluetongue virus (BTV) strains have been discovered all around the world. (mdpi.com)
  • They will offer an atypical design and receive a special chip. (gizchina.com)
  • As any mental disorder, atypical depression is usually treated with help of psychotherapy and medications. (depressionhelps.com)