• Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Due to its high antioxidant content, GSE can help prevent disease and protect against oxidative stress, tissue damage, and inflammation. (healthline.com)
  • An alcohol-free fermented blueberry and blackberry beverage extract attenuates diet-induced obesity and blood glucose in mice. (greenmedinfo.com)
  • In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications. (researchgate.net)
  • As the heart contains a high amount of mitochondria, cardiac mitochondrial dysfunction can lead to cardiac oxidative stress which aggravates the development of DCM. (encyclopedia.pub)
  • Thus, treatment targeting mitochondrial-induced oxidative stress is very crucial in suppressing DCM. (encyclopedia.pub)
  • Additionally, a study in 87 people undergoing heart surgery found that taking 400 mg of GSE the day before surgery significantly reduced oxidative stress. (healthline.com)
  • This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
  • The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)
  • Secondary outcomes included other pulmonary variables, the incidence of in-hospital complications, markers of oxidative stress, and inflammatory response. (silverchair.com)
  • The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
  • The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity. (greenmedinfo.com)
  • Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff served as RIPC stimulus. (silverchair.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • Finally, oxidative phosphorylation is a good candidate to play a dual role by decreasing or increasing the risk of lung cancer and glioblastoma in Alzheimer's disease. (nature.com)
  • In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
  • One method comprises starving the subject for 24-60 (e.g., 48) hours and administering to the subject a chemotherapy agent. (justia.com)
  • Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
  • Another method of the invention comprises reducing the caloric intake or the glucose intake by the subject and administering to the subject a chemotherapy agent. (justia.com)
  • Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
  • Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
  • By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)
  • DOX-induced oxidative damage, inflammation accumulation, and myocardial apoptosis were largely attenuated by the treatment of Mul. (hindawi.com)
  • Several mechanisms are involved in the process of DOX-related toxicities including mitochondrial dysfunction, oxidative stress, inhibition of autophagy, and myocardial apoptosis [ 4 ]. (hindawi.com)
  • DOX-dependent oxidative damage induced the release of cytochrome C and subsequent activation of caspase 3, causing myocardial apoptosis [ 9 ]. (hindawi.com)
  • The attenuation of DOX-induced myocardial apoptosis could protect against DOX-induced cardiotoxicity [ 10 ]. (hindawi.com)
  • Mul reduced spinal cord injury-induced apoptosis and inflammation and attenuated hepatic fibrosis by targeting nuclear factor E2-related factor 2 (Nrf2) in mice [ 11 , 12 ]. (hindawi.com)
  • Plasma alanine aminotransferase levels, hepatic expression of tumor necrosis factor-α, interleukin-6, fatty acid synthesis-related genes, oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis marker terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the liver were decreased in the HW and PGZ groups. (researchgate.net)
  • Conclusion: Consumption of hydrogen-rich water may be an effective treatment for NASH by reducing hepatic oxidative stress, apoptosis, inflammation, and hepatocarcinogenesis. (researchgate.net)
  • WSPF induced mitochondrial-mediated apoptosis of MDA-MB-231 cells via extensive reactive oxygen species generation, dysregulation of Bax/Bcl-2, loss of mitochondrial membrane potential and caspase-3 activation. (salviaparadise.cz)
  • Compared side by side, cyclosporine (CsA), a mitochondrial membrane blocker that prevents the leakage of mitochondrial DNA, failed to avert the death of ALS-MNs, although CsA and ALS iPSC-CM equally stabilized MN mitochondria and attenuated inflammatory genes. (springer.com)
  • In the model with pathogenic SOD1 mutation, ALS iPSC-CM attenuated all examined hallmarks of ALS pathology, rescued human ALS-MNs from denervation and death, restored mitochondrial health, and reduced the expression of inflammatory genes. (springer.com)
  • In conclusion, Mul treatment attenuated DOX-induced cardiac toxicity via activation of the AKT signaling pathway. (hindawi.com)
  • found that Mul attenuated Parkinson's disease by activating the β -catenin signaling pathway in mice [ 13 ]. (hindawi.com)
  • DOX-induced oxidative damage and cardiomyocyte loss have been recognized as the potential causative mechanisms of this cardiac toxicity. (hindawi.com)
  • Activated protein kinase B (AKT) activation was essential for the protective effects of Mul against DOX-induced cardiac toxicity, and AKT inactivation abolished Mul-mediated protective effects against DOX cardiotoxicity. (hindawi.com)
  • Mul might be a promising therapeutic agent against DOX-induced cardiac toxicity. (hindawi.com)
  • Melatonin and its metabolites possess free-radical scavenging activity and it has been shown that they protect against cisplatin toxicity. (medscape.com)
  • Conclusions: Our results show that oral exposure to PCBs can induce substantial changes in the gut microbiome, which may then influence their systemic toxicity. (nih.gov)
  • Cisplatin chemotherapy induces a reduction in the antioxidant status, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drugs. (medscape.com)
  • A decrease in mitochondrial fusion promotes fission-induced mitochondrial fragmentation, but a reduction in mitochondrial fission produces excessive mitochondrial elongation. (krcp-ksn.org)
  • However, the mechanism of the protective effects of melatonin against cisplatin-induced nephrotoxicity is still essentially unknown. (medscape.com)
  • We therefore designed this study to investigate the underlying mechanism of the protective effect of melatonin against cisplatin-induced renal damage in a rat nephrotoxicity model in vivo. (medscape.com)
  • DOX treatment leads to the production of free oxygen radicals and antioxidant deficiency, which causes oxidative stress in the heart [ 1 , 4 ]. (hindawi.com)
  • Overexpression of antioxidant enzymes can ameliorate DOX-induced cardiotoxicity in mice [ 7 , 8 ]. (hindawi.com)
  • Cisplatin-induced oxidative stress in the kidney was partially prevented by antioxidant treatments using superoxide dismutase, glutathione, selenium and flavonoids. (medscape.com)
  • The aim of this study was to investigate the effect of Mul on DOX-induced heart injury and to clarify the underlying mechanism. (hindawi.com)
  • This Funding Opportunity Announcement (FOA) by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) is intended to stimulate research on new preventive and therapeutic approaches to alcohol- and antiretroviral drug- induced liver disease in patients with AIDS. (nih.gov)
  • This FOA emphasizes the need to explore new targets and encourages the development of novel preventive and therapeutic interventions that protect the liver from alcohol and antiretroviral drug- induced liver injury. (nih.gov)
  • There are also reports of animals fed with a high-fat diet to induce nonalcoholic steatohepatitis (NASH) and evaluate its efficacy in the progression of liver cancer [37] . (researchgate.net)
  • 36] High-fat diet-induced liver cancer H2-rich water showed carcinogenic effects in an experimental system that progressed from NASH to fibrosis and liver cancer. (researchgate.net)
  • The onset of DOX-induced cardiotoxicity can be acute, occurring within 2-3 days or be chronic until several months after the end of chemotherapy [ 3 ]. (hindawi.com)
  • Current studies pay more attention to DOX-related chronic cardiomyopathy but lose sight of the clinical importance of DOX-induced acute cardiotoxicity. (hindawi.com)
  • These findings highlighted the importance of finding a promising therapeutic strategy to inhibit oxidative damage and apoptotic cell death in DOX-related cardiotoxicity. (hindawi.com)
  • The incidence of DOX-induced cardiac injury ranges from 11% to 18%, as estimated by previous studies [ 2 , 3 ]. (hindawi.com)
  • Based on these reports, we speculated that Mul might protect against DOX-related cardiac injury in mice. (hindawi.com)