• In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. (biomedcentral.com)
  • Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
  • Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
  • In the past, many clinical efforts have been made to attenuate skin toxicity in radiation therapy or to delay its onset, but in many countries there is no "gold standard" in skin care during and after radiation treatment. (biomedcentral.com)
  • To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)
  • We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
  • Supporting the notion of noncanonical autophagy, we found that ATRA-induced autophagy was Beclin1-independent compared to starvation- or arsenic trioxide- (ATO-) induced autophagy. (hindawi.com)
  • The ULK1 protein complex including ULK1, ATG13, and FIP200 coordinates the autophagy initiation from different upstream signaling pathways to induce autophagy [ 6 , 7 ]. (hindawi.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
  • An alcohol-free fermented blueberry and blackberry beverage extract attenuates diet-induced obesity and blood glucose in mice. (greenmedinfo.com)
  • The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity. (greenmedinfo.com)
  • Thus, treatment targeting mitochondrial-induced oxidative stress is very crucial in suppressing DCM. (encyclopedia.pub)
  • The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue - Evid Based Complement Alternat Med. (qualitycounts.com)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • Ferroptosis was shown to be involved in 5-FU-induced intestinal mucositis, and TBHQ markedly hampered its activation. (biomedcentral.com)
  • The onset of DOX-induced cardiotoxicity can be acute, occurring within 2-3 days or be chronic until several months after the end of chemotherapy [ 3 ]. (hindawi.com)
  • Current studies pay more attention to DOX-related chronic cardiomyopathy but lose sight of the clinical importance of DOX-induced acute cardiotoxicity. (hindawi.com)
  • Currently, there are no molecules with an actual cardioprotective effect on DOX-induced acute cardiotoxicity. (hindawi.com)
  • Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
  • Additionally, in the current study, glycogen synthase kinase appears to attenuate tau pathology. (neurofit.com)
  • In the model with pathogenic SOD1 mutation, ALS iPSC-CM attenuated all examined hallmarks of ALS pathology, rescued human ALS-MNs from denervation and death, restored mitochondrial health, and reduced the expression of inflammatory genes. (springer.com)
  • DOX-induced oxidative damage and cardiomyocyte loss have been recognized as the potential causative mechanisms of this cardiac toxicity. (hindawi.com)
  • We analyzed the effects of a new purine derivative drug, PDD005, in attenuating mechanisms involved in the pathogenesis of neurodegenerative diseases, using both in vivo and in vitro models. (neurofit.com)
  • In conclusion, Mul treatment attenuated DOX-induced cardiac toxicity via activation of the AKT signaling pathway. (hindawi.com)
  • Mul might be a promising therapeutic agent against DOX-induced cardiac toxicity. (hindawi.com)
  • This Funding Opportunity Announcement (FOA) by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) is intended to stimulate research on new preventive and therapeutic approaches to alcohol- and antiretroviral drug- induced liver disease in patients with AIDS. (nih.gov)
  • This FOA emphasizes the need to explore new targets and encourages the development of novel preventive and therapeutic interventions that protect the liver from alcohol and antiretroviral drug- induced liver injury. (nih.gov)
  • There are also reports of animals fed with a high-fat diet to induce nonalcoholic steatohepatitis (NASH) and evaluate its efficacy in the progression of liver cancer [37] . (researchgate.net)
  • 36] High-fat diet-induced liver cancer H2-rich water showed carcinogenic effects in an experimental system that progressed from NASH to fibrosis and liver cancer. (researchgate.net)
  • Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
  • In the past, many clinical efforts have been made to attenuate skin toxicity in radiation therapy or to delay its onset, but in many countries there is no "gold standard" in skin care during and after radiation treatment. (biomedcentral.com)
  • Activated protein kinase B (AKT) activation was essential for the protective effects of Mul against DOX-induced cardiac toxicity, and AKT inactivation abolished Mul-mediated protective effects against DOX cardiotoxicity. (hindawi.com)
  • Doxorubicin (DOX) is a widely used chemotherapy drug. (hindawi.com)
  • The aim of this study was to investigate the effect of Mul on DOX-induced heart injury and to clarify the underlying mechanism. (hindawi.com)
  • The incidence of DOX-induced cardiac injury ranges from 11% to 18%, as estimated by previous studies [ 2 , 3 ]. (hindawi.com)
  • Based on these reports, we speculated that Mul might protect against DOX-related cardiac injury in mice. (hindawi.com)
  • ALS patient-derived human-induced pluripotent stem cells (ALS hiPSCs, harboring the SOD1 AV4 mutation), were differentiated to MNs (ALS-MNs). (springer.com)
  • To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)