Attenuated dengue virus dengue vaccines. Medical search. Frequent questions

Similar to the ubiquitous dengue virus (DENV), which occurs as 4 distinct serotypes, Zika virus is a flavivirus ( 14 ). (cdc.gov)
However, antibody-dependent enhancement was not observed in experimentally Zika virus-infected nonhuman primates ( 22 ) and during pivotal epidemiologic studies from Brazil that assessed neither individual DENV serotypes nor microcephaly cases ( 5 , 9 , 23 ). (cdc.gov)
QDENGA® (TAK-003) is a dengue vaccine that is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four dengue virus serotypes and is designed to protect against any of these serotypes. (newswire.co.kr)
Over the past 15 years epidemics caused by all four dengue virus serotypes have occurred with increasing frequency in the Caribbean Basin. (cdc.gov)
The increased disease incidence, combined with the increased frequency of epidemic dengue caused by multiple virus serotypes, has increased the risk of epidemic DHF. (cdc.gov)
There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
The 4 dengue serotypes are serologically and genetically distinct, although they share several of their structural antigens. (cdc.gov)
Dengue fever is caused by four different serotypes of the dengue virus, and recovery from one serotype does not provide immunity against the others. (thaimedicalnews.com)
The prevalence of these serotypes varies geographically, making dengue a complex challenge to combat. (thaimedicalnews.com)
Takeda Pharmaceuticals' QDENGA is a tetravalent vaccine designed to provide protection against all four serotypes of the dengue virus. (thaimedicalnews.com)
The vaccine is based on a live-attenuated dengue serotype 2 virus, which serves as the genetic "backbone" for all four serotypes. (thaimedicalnews.com)
Achieving uniform protection across all dengue virus serotypes is a complex task, and ensuring equitable access to the vaccine, particularly in low-resource settings, is crucial. (thaimedicalnews.com)
GMTs of neutralizing antibodies for each of the 4 dengue serotypes were measured by microneutralization test 50% [MNT50]. (clinicaltrials.gov)
The 4 dengue virus serotypes were DENV-1, DENV-2, DENV-3, and DENV-4. (clinicaltrials.gov)
Seropositivity rates were assessed for the four dengue serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. (clinicaltrials.gov)
The dengue virus serotypes are DENV-1, DENV-2, DENV-3 and DENV-4. (clinicaltrials.gov)
Seropositivity for multiple dengue serotypes was summarized in the following categories: tetravalent and at least trivalent. (clinicaltrials.gov)
In this work we examined whether the combination of TV005, a LATV-derived formulation, with Tetra DIIIC, a subunit vaccine candidate based on fusion proteins derived from structural proteins from all four DENV serotypes, can overcome the respective limitations of these two vaccine approaches. (bvsalud.org)
Meanwhile, attenuated vaccine strains serotypes 1, 3, and 4 were made by substituting the pre-membrane (prM) and envelope (E) gene structures of TDV-2 with the prM and E genes for Dengue virus type 1, Dengue virus type 3, and Dengue virus type 4. (indonesiawindow.com)
Dengvaxia is based on an existing live-attenuated vaccine for yellow fever virus (YFV) and consists of four YFV genomes that have been chimerized by replacing the YFV pre-membrane and envelope structural genes with those of the four respective DENV serotypes. (virology.ws)
An effective DENV vaccine would generate a robust tetravalent response to all four serotypes at the same time, thus avoiding issues of antibody-dependent enhancement. (virology.ws)
Each component represents one of the four DENV serotypes and consists of a DENV genome containing a 30 nucleotide deletion in the 3′ untranslated region, for the purpose of attenuating virulence. (virology.ws)
Development of vaccines for dengue has been complicated, since disease can be caused by any of four dengue virus serotypes and the vaccine must be tetravalent, providing equal protection against all four serotypes. (uvm.edu)
Robust and balanced immune responses to all four dengue serotypes following a single dose of a live-attenuated tetravalent vaccine administered to healthy flavivirus-naïve adults. (uvm.edu)
The primary cause of Dengue Hemorrhagic Fever (DHF) is infection by one of the four dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). (tanzirislambritto.com)
To sum up, the cause of DHF is multi-factorial, involving not only the dengue virus and its serotypes but also the human immune response, the vector mosquito species, and various ecological factors. (tanzirislambritto.com)
The 3 UTR is nearly 400 bases in length and is predicted to contain several stem-loop structures conserved among dengue virus serotypes (3, 9, 14, 17). (antiviralbiologic.com)
Based on the success of this vaccine candidate, a strategy for the development of additional vaccine candidates representing the other three DEN virus serotypes was foreseen in which wild-type (wt) dengue viruses could be similarly attenuated for vaccine use by incorporation of mutations in the 3 UTR. (antiviralbiologic.com)
Although the individual nucleotides are not well conserved in the TL2 region of each of the four DEN virus serotypes, appropriate base pairing preserves the stem-loop structure for DEN1 and DEN4 (Fig. (antiviralbiologic.com)
7] Clinical Phase 2 data in children and adolescents showed that TAK-003 induced immune responses against all four dengue serotypes, in both seropositive and seronegative participants, which persisted through 48 months after vaccination. (sagunin.com)
The double-blind, randomized, placebo-controlled Phase 3 TIDES trial is evaluating the safety and efficacy of two doses of TAK-003 in the prevention of laboratory-confirmed symptomatic dengue fever of any severity and due to any of the four dengue virus serotypes in children and adolescents. (sagunin.com)
A live attenuated vaccine for serotypes 1-4 is undergoing clinical trails. (stanford.edu)
The tetravalent live attenuated vaccine Demgvaxia from Sanofi Pasteur, which protects against dengue virus serotypes 1-4, is recommended for people between 9 and 45 years old, which live in endemic regions and had a dengue infection in the past. (european-biotechnology.com)
The drug prevents against dengue caused by any of the four existing serotypes of this virus, which usually generates more serious cases when a person is bitten by mosquitoes with two different serotypes. (antiguanewsroom.com)
The vaccine is composed of live attenuated virus and was developed from dengue serotype 2, which forms the genetic basis for offering protection against the four serotypes, "activating multiple arms of the immune system that contribute to protection against infection and dengue disease," it was expplained. (antiguanewsroom.com)

A dengue vaccine is now approved for use in children aged 9-16 years with laboratory-confirmed previous dengue virus infection and living in dengue-endemic areas (where dengue occurs frequently or continuously). (cdc.gov)
The U.S. Food and Drug Administration approved Dengvaxia for use in children and adolescents 9-16 years old with laboratory-confirmed evidence of a previous dengue virus infection and living in areas of the United States where dengue is common. (cdc.gov)
In June 2021, the Advisory Committee on Immunization Practices recommended the use of Dengvaxia to prevent dengue in children aged 9-16 years, with laboratory-confirmed previous dengue virus infection and living in areas where dengue is endemic. (cdc.gov)
Before vaccination with Dengvaxia, children need to have laboratory evidence of a previous dengue infection. (cdc.gov)
Healthcare providers can confirm a previous dengue infection with results from a specific type of laboratory test (dengue RT-PCR rest or dengue NS1 antigen test). (cdc.gov)
In children who have not already had a dengue infection, Dengvaxia increases the risk of hospitalization and severe illness if the child gets dengue after vaccination. (cdc.gov)
A person's second dengue infection is most likely to lead to severe illness. (cdc.gov)
Children are at the highest risk of hospitalization with a second dengue infection. (cdc.gov)
Every dengue infection has a risk of hospitalization and severe illness. (cdc.gov)
Vaccines can be prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic (to fight a disease that has already occurred, such as cancer). (wikipedia.org)
Some vaccines offer full sterilizing immunity, in which infection is prevented completely. (wikipedia.org)
In some cases vaccines may result in partial immune protection (in which immunity is less than 100% effective but still reduces risk of infection) or in temporary immune protection (in which immunity wanes over time) rather than full or permanent immunity. (wikipedia.org)
Dengue is a public health concern because most of the population in tropical America is susceptible to infection. (medscape.com)
Go to Dengue and Severe Dengue Infection for complete information on these topics. (medscape.com)
Zika virus infection can also be enhanced by DENV antibodies in vitro ( 17 , 18 ) and in mice ( 19 ). (cdc.gov)
Infection with one results in immunity to that specific virus but not to the other 3. (nih.gov)
Studies have found that infection with one virus type increases the risk for severe dengue fever from a different dengue virus. (nih.gov)
KENILWORTH, N.J.-( BUSINESS WIRE )-Merck (NYSE:MRK), known as MSD outside the United States and Canada, and Instituto Butantan, Sao Paulo, Brazil, a non-profit producer of immunobiologic products for Brazil today announced a collaboration agreement to develop vaccines to protect against dengue virus disease, the mosquito-borne infection. (merck.com)
By investigating two of these receptors during infection by dengue and Zika viruses, scientists from the Institut Pasteur discovered that a precise region of the viral genome was recognized by a receptor known as RIG-I. Their discovery paves the way for the future development of vaccines for these diseases. (pasteur.fr)
Vaccination is the primary intervention used to curb influenza virus infection, and the WHO recommends immunization for at-risk individuals to mitigate disease. (mdpi.com)
We discuss the different vectored vaccines that have been or are currently in clinical trials, with a forward-looking focus on immunogens that may be protective against seasonal and pandemic influenza infection, in the context of viral-vectored vaccines. (mdpi.com)
Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
Dengue is a major public health problem with more than 3.6 billion people at risk for dengue virus (DENV) infection and an estimated 390 million infections annually in over 120 tropical and sub-tropical countries. (fondation-merieux.org)
The WHO recommended a pre-vaccination screening as the preferred strategy as with such a strategy predominantly persons with evidence of a prior dengue infection would be selected to be offered vaccination (based on serological test, or documentation of laboratory confirmed dengue infection in the past. (fondation-merieux.org)
To date, no RDT has been licensed for the indication of prior dengue infection status. (fondation-merieux.org)
The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection. (cdc.gov)
In May 2019, Dengvaxia® was approved by the U.S. Food and Drug Administration (FDA) in the United States for use in children 9-16 years old living in an area with endemic dengue with laboratory confirmed prior dengue virus infection. (cdc.gov)
Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
Zika virus (ZIKV) infection usually is mild and self-limited. (medscape.com)
There are no specific FDA-approved treatment options or vaccines for treatment and prevention of Zika virus infection. (medscape.com)
Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with unconfirmed Zika virus infection should be avoided since the use of such drugs in dengue fever is associated with hemorrhagic risk and risk for Reye syndrome in the pediatric population. (medscape.com)
Expert consultation with a maternal-fetal medicine and infectious diseases specialists is advised for management of Zika virus infection during pregnancy. (medscape.com)
The best method for preventing Zika virus infection is to avoid travel to areas with active Zika virus transmission. (medscape.com)
The methods and compositions of this invention provide a means for prevention of ZIKV infection by immunization with live attenuated, immunogenic viral vaccines against ZIKV and/or Dengue virus. (justia.com)
Zika virus infection continues to be a global concern for human health due to the high-risk association of the disease with neurological disorders and microcephaly in newborn. (bvsalud.org)
This response can also avoid severe manifestations of dengue disease, associated to the antibody-dependent enhancement of the infection. (bvsalud.org)
This is because naïve vaccine recipients who have not had a prior natural infection with DENV can experience enhanced dengue disease if they are naturally infected after vaccination. (virology.ws)
An initial infection with any of these viruses can range from asymptomatic to severe, with symptoms such as skin rash, fever, headache, vomiting, muscle and joint pains often collectively referred to as "breakbone fever. (virology.ws)
For many viruses, antibodies are sufficient to protect against infection and/or disease. (virology.ws)
That is, by eliciting a strong response to all four DENV types, there wouldn't be the possibility of a weakly neutralizing antibody for one serotype causing a severe infection by that virus. (virology.ws)
A reported 40 percent of the world's population is at risk for dengue infection, with a rising number of home-grown cases occurring in the U.S. Dengue infection is caused by any of four related flaviviruses. (uvm.edu)
To date, the team's research has shown that the antibodies produced by the vaccines can block infection of cells in a laboratory culture dish. (uvm.edu)
However, other recent clinical trials of a different dengue vaccine candidate have revealed that vaccinated individuals can have a high level of antibodies in their bloodstream without being adequately protected from dengue infection. (uvm.edu)
The team's latest research, published in Science Translational Medicine (March 2016), reported promising results from clinical trials on a new tetravalent vaccine (TV003) that is very effective at preventing dengue infection and is likely to require only a single dose. (uvm.edu)
Approximately 40 percent of the world's population - 2.5 billion people - are at risk of contracting dengue, a viral infection spread by mosquitos in tropical and subtropical regions of the world. (uvm.edu)
To investigate how prior WNV exposure would influ-ence USUV infection, we used an attenuated WNV vaccine that contains the surface proteins of WNV in the backbone of a dengue virus 2 vaccine strain and protects against WNV disease. (cdc.gov)
Future studies will investigate the immune mechanisms responsible for the protection against USUV infection induced by WNV vaccination, providing critical insight that will be essential for USUV and WNV vaccine development. (cdc.gov)
For this study, instead of looking only at antibodies, the researchers looked for the evidence of actual infection: virus in the blood, rash and low white blood cell count. (jhu.edu)
None of the 21 people who had received the vaccine had any evidence of infection in their blood, nor did they develop a rash or have low white blood cell counts. (jhu.edu)
While people who were vaccinated there developed antibodies, those antibodies did not protect against dengue 2 infection and could have played a role in causing more serious disease. (jhu.edu)
The live attenuated tetravalent dengue vaccine TV003 elicits complete protection against dengue virus serotype 2 infection in a human challenge mode. (uvm.edu)
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. (bvsalud.org)
Interestingly, it's not the first infection with the dengue virus that usually causes DHF but rather a subsequent infection with a different dengue serotype. (tanzirislambritto.com)
In ADE, antibodies from a first dengue infection fail to neutralize a second dengue virus of a different serotype during re-infection. (tanzirislambritto.com)
These antibodies will neutralize the virus and aid in its clearance, thus resolving the infection. (tanzirislambritto.com)
For instance, infants born to dengue-immune mothers are at a higher risk of severe disease due to the presence of maternal antibodies, which can enhance viral infection. (tanzirislambritto.com)
Although vaccines have been developed against dengue, the first of these (DengvaxiaÒ) is recommended only for people who have previously been infected with dengue, or in highly endemic territories where prior infection may be assumed. (prfire.co.uk)
Recently it was also demonstrated (Katzelnick et al PMID 32855339) that Zika infection (like dengue infection) can prime for severe dengue and, so far, the priming effect of prior Zika vaccination on the risks of dengue vaccination (helpful or otherwise) is not known. (prfire.co.uk)
These results indicate that dengue virus-specific CD4+ CD8- CTL are generated in short-term bulk cultures as well as in long-term-cultured cell lines, and support the concept that CD4+ CTL may be generated in vivo during infection. (umassmed.edu)
Nipah virus infection causes febrile encephalitis and aseptic meningitis. (stanford.edu)
A relativiely quick virus, clinical manifestations of Nipah infection occur shortly after handling infected pigs. (stanford.edu)
A post-exposure rabies vaccine can be given after infection. (stanford.edu)
VLPs self-assembled into empty shells can be used safely as vaccines without the risk of replication or infection due to the lack of viral nucleic acid. (nature.com)
When the Zika epidemic spread through the American continent and then later to Africa and Asia in 2015, researchers compared the characteristics of the Zika infection to Dengue, considering both these viruses were transmitted primarily through the same vector, the Aedes aegypti female mosquitoes. (frontiersin.org)
The main symptoms that could lead to suspect the presence of a dengue infection include acute and non-specific febrile symptoms, severe headache, pain behind the eyes, muscle and joint pain, sometimes diarrhea or vomiting, and sometimes skin rashes. (antiguanewsroom.com)
In June 2021, ACIP voted to recommend Dengvaxia for routine use in children age 9 through 16 years with laboratory-confirmed previous dengue virus infection and living in areas where CDC has classified dengue as endemic. (immunize.org)
The recommendation is only for persons with confirmed previous DENV infection because Dengvaxia is associated with an increased risk for severe dengue in those who experience their first natural infection (i.e., primary infection) after vaccination. (immunize.org)
Yellow fever never occurred in either Axis or Allied troops during the subsequent war years, but tropical disease experts argued for the use of the vaccine, resulting in tens of thousands of cases of HBV infection. (jphmpdirect.com)
Concerns are that children, not pre-immune to dengue, vaccinated with a live-attenuated dengue virus, that vaccination would act like a first infection and result in enhanced disease when the child was infected with the real virus. (isv-online.org)
Epidemiology of Zika virus infection. (springer.com)
Guillain-Barre syndrome after Zika virus infection in Brazil. (springer.com)
Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. (springer.com)
Guillain-Barré syndrome associated with Zika virus infection. (springer.com)
Acute myelitis due to Zika virus infection. (springer.com)
The reason is that children without previous dengue infection are at increased risk for severe dengue disease and hospitalization if they get dengue after they are vaccinated with Dengvaxia. (cdc.gov)
Therefore, healthcare providers should check for evidence of a laboratory-confirmed previous dengue infection before vaccination. (cdc.gov)
The dengue vaccine is approved for use in children 9 through 16 years of age of who have a previous history of laboratory-confirmed dengue infection. (cdc.gov)
Only children with laboratory-confirmed evidence of previous dengue infection should be vaccinated. (cdc.gov)
Vaccine providers should consider the risk of dengue virus infection when making a recommendation for vaccination for pregnant people. (cdc.gov)
Vaccine providers should consider the developmental and health benefits of breastfeeding as well as the risk of dengue virus infection to the breastfeeding person and infant. (cdc.gov)
Children under 9 years of age are less likely to have had a prior dengue infection. (cdc.gov)
Children who have not had a prior dengue infection. (cdc.gov)
The Dengvaxia vaccine will be available starting in 2022 for use in children 9 through 16 years old with laboratory-confirmed evidence of a previous dengue virus infection and living in areas where dengue is common (occurs frequently or continuously). (cdc.gov)
Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Інфекція вірусом імунодефіциту людини (ВІЛ) Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
Психосоціальний підхід до дітей із ВІЛ-інфекцією Human immunodeficiency virus (HIV) infection is caused by the retrovirus HIV-1 (and less commonly by the related retrovirus HIV-2). (msdmanuals.com)
Weinberg GA, Siberry GK: Pediatric human immunodeficiency virus infection. (msdmanuals.com)
These febrile diseases result from infection by viruses from 4 viral families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. (medscape.com)

To confirm our findings, we performed serotype-specific DENV neutralization tests in a case-control framework in northeastern Brazil among 29 Zika virus-seropositive mothers of neonates with CZS and 108 Zika virus-seropositive control mothers. (cdc.gov)
OSAKA, JAPAN & CAMBRIDGE, MASS.--( Business Wire / Korea Newswire ) August 23, 2022 -- Takeda (TSE:4502/NYSE:TAK) today announced the company's dengue vaccine, QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003), was approved by the Indonesia National Agency for Drug and Food Control, Badan Pengawas Obat dan Makanan (BPOM), for the prevention of dengue disease caused by any serotype in individuals six years to 45 years of age. (newswire.co.kr)
In Indonesia, QDENGA is indicated for the prevention of dengue disease caused by any dengue virus serotype in individuals six years to 45 years of age and should be administered subcutaneously as a 0.5 mL dose at a two-dose (0 and 3 months) schedule pursuant to approved dosing regimen. (newswire.co.kr)
Qdenga vaccine is a type of Live Attenuated Tetravalent Dengue Vaccine (TDV) consisting of four dengue virus strains, namely attenuated dengue serotype 2 strain (TDV-2), recombinant dengue serotype 2/1 (TDV-1), recombinant dengue serotype 2/3 strain (TDV-3), and recombinant dengue strain serotype 2/4 (TDV-4). (indonesiawindow.com)
Because vaccine efficacy against DENV-2 has been historically poor, the genome representing this serotype is actually a DENV-2/DENV-4 chimera and consists of a DENV-4 backbone harboring the DENV-2 pre-membrane and envelope genes. (virology.ws)
When a person is infected with the dengue virus for the first time, the immune system responds by producing antibodies specific to that serotype. (tanzirislambritto.com)
However, problems arise when the person is later infected with a different dengue serotype. (tanzirislambritto.com)
DHF and DSS are also influenced by various other factors, such as the strain and serotype of the dengue virus, age, genetic predisposition, and the individual's immune status. (tanzirislambritto.com)
Participants presenting with febrile illness were tested for virologically confirmed dengue (VCD) by serotype-specific RT-PCR. (edu.ph)
In timeframes beginning 30 days post-second dose, the primary endpoint (overall vaccine efficacy) was assessed in the first 11 months, and the secondary endpoints (efficacy by baseline serostatus, serotype, hospitalised dengue, and severe dengue) in the first 17 months. (edu.ph)
Vaccine efficacy varied by serotype, warranting continued follow-up to assess longer-term vaccine performance. (edu.ph)
PBMC cultured with dengue 1 Ag lysed autologous lymphoblastoid cell line (LCL)3 pulsed with noninfectious dengue 1 Ag, but did not lyse LCL pulsed with Ag of other dengue serotype, West Nile virus, or yellow fever virus, or control Ag. (umassmed.edu)
In October 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended the approval of Takeda's dengue vaccine candidate, TAK-003, for the prevention of dengue disease caused by any serotype in individuals four years of age and older in Europe and in dengue-endemic countries participating in the parallel EU-M4all procedure. (sagunin.com)
Takeda's tetravalent dengue vaccine candidate (TAK-003) is based on a live-attenuated dengue serotype 2 virus, which provides the genetic "backbone" for all four vaccine viruses. (sagunin.com)

The administration of vaccines is called vaccination. (wikipedia.org)
The terms vaccine and vaccination are derived from Variolae vaccinae (smallpox of the cow), the term devised by Edward Jenner (who both developed the concept of vaccines and created the first vaccine) to denote cowpox. (wikipedia.org)
Sometimes, protection fails for vaccine-related reasons such as failures in vaccine attenuation, vaccination regimens or administration. (wikipedia.org)
Vaccination will offer health care providers in Indonesia a welcomed advancement in dengue prevention, along with vector control, allowing us to reduce the burden of dengue and protect the broader population. (newswire.co.kr)
The approval of QDENGA is based on results through three years after vaccination from the ongoing Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial that enrolled over 20,000 healthy children and adolescents ages four to 16 years living in dengue-endemic areas in Asia and Latin America. (newswire.co.kr)
QDENGA demonstrated continued overall protection against dengue illness and hospitalization three years after vaccination, regardless of an individual's previous dengue exposure. (newswire.co.kr)
Using an RLR-purification technique in conjunction with high-throughput sequencing and bioinformatics analysis, "we demonstrated that a precise region of the genomes of the dengue and Zika viruses (known as the 5' untranslated region) was recognized by RIG-I," explains Nolwenn Jouvenet, a scientist in the Viral Genomics and Vaccination Unit at the Institut Pasteur and last author of the paper. (pasteur.fr)
There are a number of alternate vaccination strategies in current development which may circumvent the need for annual re-vaccination, including new platform technologies such as viral-vectored vaccines. (mdpi.com)
The Partnership for Dengue Control (PDC) organized a workshop on pre-vaccination screening for the use of dengue vaccines with differential performance dependent on serostatus: vaccine clinical updates, rapid diagnostic tests and implementation strategies, at Les Pensières Center for Global Health, January 20-22, 2020. (fondation-merieux.org)
The vaccine is recommended for children aged six to 16 years, and the vaccination schedule consists of two doses administered three months apart. (thaimedicalnews.com)
We hypothesized that vaccination with this attenuated WNV vaccine would protect against USUV in-fection. (cdc.gov)
That vaccine produced antibodies against the dengue in a clinical trial and protected against dengue during the first year after vaccination. (jhu.edu)
But two years after vaccination, children who were under the age of nine when they received the vaccine were hospitalized for dengue at a significantly higher rate than those who received the placebo. (jhu.edu)
Vaccination of volunteers with low-dose live attenuated dengue viruses leads to distinct immunologic and virologic profiles. (uvm.edu)
Primary Vaccination with Low Dose Live Dengue 1 Virus Generates a Pro-inflammatory, Multifunctional T Cell Response in Humans. (uvm.edu)
These are compelling reasons for the development of improved point-of-care antibody tests (as advocated by WHO) that may inform vaccination practice with dengue (and Zika) vaccines. (prfire.co.uk)
5,6] In addition, TAK-003 met its secondary endpoint by preventing 90.4% of hospitalizations at 18 months, and in an exploratory analysis, it demonstrated protection against dengue fever through 4.5 years (54 months) after vaccination. (sagunin.com)
While elimination of smallpox from the human population was one of the greatest achievements for vaccines and vaccination, there are many challenges ahead for effective vaccine development to be addressed in 2020. (isv-online.org)
5. Receipt of previous vaccination against dengue virus. (who.int)
CDC recommends dengue vaccination for children 9 through 16 years old, but only when they have been previously infected with dengue and living in areas where dengue is common. (cdc.gov)
For this reason, if your child is under the age of 9, they are not eligible for dengue vaccination. (cdc.gov)
Overall, Dengvaxia protects children from dengue illness, hospitalizations, and severe dengue 8 out of 10 times (80%) in children who had dengue before vaccination. (cdc.gov)
The presenters will share AAP and CDC recommendations about influenza vaccination and antiviral treatment, including updated recommendations for the use of intranasal live attenuated influenza vaccine (LAIV4) in children. (cdc.gov)

The Zika virus outbreak in Latin America resulted in congenital malformations, called congenital Zika syndrome (CZS). (cdc.gov)
Two of these protein receptors, RIG-I and MDA5, had previously been identified as playing a key role in the innate response against the replication of flaviviruses, a family of mosquito-borne viruses that includes dengue, yellow fever and Zika. (pasteur.fr)
There is currently no specific treatment or effective vaccine for dengue or Zika . (pasteur.fr)
RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes, Cell Reports , July 10, 2018. (pasteur.fr)
Associated with Zika virus, Japanese encephalitis virus, West Nile virus dengue viruses, and live attenuated yellow fever vaccine. (standardofcare.com)
Patients infected with arboviruses such as Zika virus should be advised to limit activity during symptomatic illness in order to avoid exposure to mosquitoes and potential risk for human-to-arthropod transmission and subsequent local spread of disease. (medscape.com)
The prospective exclusive licensed territory may be limited to the United States of America, Canada, Mexico, Brazil and Colombia, and the field of use may be limited to: ''Monovalent live attenuated Zika vaccines and multivalent live attenuated flavivirus vaccines. (justia.com)
Zika virus (ZIKV) is an emerging infectious disease that was first identified in 1947, and that has more recently become a major public health threat around the world. (justia.com)
In this study, we obtained a novel subunit vaccine that combines two regions of zika genome, domain III of the envelope and the capsid, in a chimeric protein in E. coli bacteria. (bvsalud.org)
In this study, we propose a novel vaccine candidate against the zika disease based on a recombinant protein that can stimulate both arms of the immune system. (bvsalud.org)
July 23, 2021, doi: 10.3389/fimmu.2021.703887) which demonstrates the unique performance advantages and versatility of its novel antigen and device design innovations embodied in the form of lateral flow antibody tests for dengue and Zika. (prfire.co.uk)
Currently there is no licensed Zika vaccine. (prfire.co.uk)
We set out to develop novel antibody diagnostic tests for prior dengue and Zika based on our proprietary glycan-cloaked envelope proteins from dengue and Zika, which deliver improved specificity by concealing the highly cross-reactive fusion loop. (prfire.co.uk)
Previously, lateral flow antibody tests had been designed to diagnose ongoing dengue and Zika infections, at which time antibody levels are high. (prfire.co.uk)
Excivion's granted patents in Europe and the USA (Granted European Patent No. EP3458471B1, Granted US Patent No. 11,028,133 B2) provide composition of matter coverage for glycan-cloaked flavivirus antigens covering all positions in the fusion loop which is 100% conserved across all major human flavivirus pathogens (Zika, dengue 1-4, Japanese encephalitis virus and yellow fever virus). (prfire.co.uk)
Yellow fever virus (YFV) belongs to the group of flaviviruses (such as Zika virus, Dengue virus, Japanese Encephalitis virus) that are all transmitted via mosquito bites ( Aedes aegypti ). (escoaster.com)
An important difference to note, however, was that the Zika epidemic diffused in a shorter time span compared to the persisting feature of Dengue infections, which is endemic in many Asian countries. (frontiersin.org)
Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
This review discusses similarities between Dengue and Zika infections, comparing their disease transmissions and vectors involved, and both the innate and adaptive immune responses in these infections. (frontiersin.org)
Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
Finally, a summary of the immune biomarkers that have been reported for dengue and Zika viral infections are discussed which may be useful indicators for future anti-viral targets or predictors for disease severity. (frontiersin.org)
Together, this information appraises the current understanding of both Zika and Dengue infections, providing insights for future vaccine design approaches against both viruses. (frontiersin.org)
According to the World Health Organization, dengue fever, chikungunya and zika viruses can also present with fever and rash…and test positive for measles - due to " non-specific reactions or formation of immune complexes that can produce a false positive IgM result in measles or rubella IgM assays [6]. (theothersideofvaccines.com)
Zika virus (ZIKV) is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. (springer.com)
Structure of the thermally stable Zika virus. (springer.com)
The emergence of Zika virus as a global health security threat: a review and a consensus statement of the INDUSEM joint working group (JWG). (springer.com)
Zika virus in Gabon (Central Africa) - 2007: a new threat from Aedes albopictus? (springer.com)
Zika virus replication in the mosquito Culex quinquefasciatus in Brazil. (springer.com)
Potential sexual transmission of Zika virus. (springer.com)
Davidson A, Slavinski S, Komoto K, Rakeman J, Weiss D. Suspected female-to-male sexual transmission of Zika virus - new York City, 2016. (springer.com)
Male-to-male sexual transmission of Zika virus--Texas, January 2016. (springer.com)
Epidemiological and ecological determinants of Zika virus transmission in an urban setting. (springer.com)
Zika virus disease: interim case definitions. (springer.com)

Dengue fever is a mosquito-borne viral disease caused by 1 of 4 antigenically distinct dengue flaviviruses: dengue virus 1 (DEN-1), dengue virus 2 (DEN-2), dengue virus 3 (DEN-3), and dengue virus 4 (DEN-4). (medscape.com)
Dengue is a mosquito-borne viral disease that poses a significant global public health threat, with prevalence in over 125 countries. (newswire.co.kr)
Recognition of the genome of a virus initiates a signaling cascade that results in the expression of several hundreds of genes that are capable of blocking various stages of viral replication. (pasteur.fr)
Unraveling the molecular mechanisms used by human cells to detect viral infections will help improve understanding of the diseases caused by these viruses. (pasteur.fr)
These findings could also pave the way for the development of viral strains that induce a robust innate response and thus could be used as live attenuated vaccines. (pasteur.fr)
Unfortunately, influenza vaccine composition needs to be updated annually due to antigenic shift and drift in the viral immunogen hemagglutinin (HA). (mdpi.com)
Based on the state-of-play in Belgium, this chapter discusses examples of regulatory journeys of applications with genetically modified viral vectors and novel vaccine candidates that have been reviewed by GMO national competent authorities in Belgium and in Europe. (intechopen.com)
Dengue is currently the most important vector-borne viral disease afflicting humanity, in terms of both morbidity and mortality (1, 2). (cdc.gov)
Dengue fever , a viral disease transmitted by mosquitoes, has been recognized by the World Health Organization (WHO) as one of the top 10 threats to global health. (thaimedicalnews.com)
Vaccine development approaches for ZIKV include but are not limited to inactivated virus (dead virus), live attenuated virus (weakened virus), recombinant viral vectors (weakened virus with target genes added), and subunit (portion of a virus) as well as mRNA- and DNA-based (gene-targeted). (justia.com)
Although the two evaluated prime-boost regimes were equivalent to a single administration of TV005 in terms of the development of virus-binding and neutralizing antibodies as well as the protection against viral challenge, both regimes reduced vaccine viremia to undetectable levels. (bvsalud.org)
Instead, they facilitate and enhance entry of the heterotypic virus into host cells, resulting in increased viral replication and disease. (virology.ws)
This leads to increased viral replication, a higher viral load, and a much more severe disease, resulting in DHF or even more severe dengue shock syndrome (DSS). (tanzirislambritto.com)
Over one hundred vaccines using varied approaches including protein subunit, viral vector, RNA, DNA, inactivated virus, attenuated virus, and virus like particles (VLPs) platforms are in clinical trials. (nature.com)
Among these, viral vector and RNA vaccines are currently in use. (nature.com)
These protein subunits can assemble into virus particles without viral RNA genome in mammalian cells to study virus-cell entry 2 and to develop vaccines 3 . (nature.com)
Therefore, there is a high interest to develop an efficient cell culture-based option for viral vaccine production. (escoaster.com)
Can engineering subdue viral vaccine reversion? (microbe.tv)
A, B, C, D, E: It's a short, menacing alphabet representing the five types of virus causing viral hepatitis, a sickness afflicting some 400 million people around the world today. (gavi.org)
Initially, people in the viral hepatitis field invited us to meetings, but because we were doing work on the related virus, yellow fever, not because we were considered majors player in the field. (gavi.org)
Although it is not currently epidemic, there is a concern that the virus can still reemerge since the male genital tract might harbor persistent reservoirs that could facilitate viral transmission over extended periods, raising concerns among public health and assisted reproductive technologies (ART) experts and professionals. (springer.com)
With the exception of a vaccine for yellow fever and ribavirin, which is used as a drug treatment for some arenaviral infections, no cures or drug treatments for viral hemorrhagic fever exist. (medscape.com)
Not all viruses in these families cause viral hemorrhagic fever. (medscape.com)
Viral hemorrhagic fevers share certain clinical manifestations, regardless of the virus that causes the disease. (medscape.com)
However, different viruses can cause a range of various clinical problems in addition to viral hemorrhagic fever. (medscape.com)
Despite the diverse taxonomy of the four virus families involved in viral hemorrhagic fevers (VHFs), they share some common characteristics. (medscape.com)

The goal of the trial is to determine the efficacy of the vaccine for preventing dengue, and importantly to provide additional information about its safety. (merck.com)
The US Advisory Committee on Immunization Practices (ACIP) Dengue Vaccine Work Group reviewed Dengvaxia ® safety and efficacy data in a systematic literature review in 2018. (cdc.gov)
The second part of this phase II clinical trial will yield additional insight about the vaccine's safety and immunogenicity in children as young as 18 months and will set the stage for future vaccine efficacy studies. (pharmabiz.com)
SAGE reviewed data from 19 clinical trials involving over 28,000 participants, including the pivotal Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES). (thaimedicalnews.com)
The TIDES trial demonstrated the efficacy of QDENGA in preventing dengue fever and hospitalization due to the virus. (thaimedicalnews.com)
The vaccine has also shown long-term protection, with substantial efficacy even after 54 months. (thaimedicalnews.com)
The document defines international norms and standards to assure the quality, safety and efficacy of each of these approaches, so as to facilitate national authorities' decision-making on the suitability of candidate dengue vaccines for testing in their own populations. (who.int)
In particular, its observations, conclusions and recommendations provide timely recommendations and reference preparations for assuring the quality, safety and efficacy of vaccines, and the provision of reference materials for standardizing essential diagnostic assays for the detection of virological contaminants in blood products. (who.int)
Dengvaxia, licensed in several countries where DENV is endemic, has shown low efficacy profiles and there are safety concerns prohibiting its administration to children younger than 9 years old, and the live-attenuated tetravalent vaccine (LATV) developed by NIAID has proven too reactogenic during clinical trialing. (bvsalud.org)
The Qdenga dengue vaccine shows good efficacy in seropositive subjects (having antibodies to the Dengue virus) and seronegative subjects (not yet having antibodies to the Dengue virus). (indonesiawindow.com)
The overall efficacy of the Qdenga vaccine for the prevention of dengue fever was 80.2 percent, while the efficacy rate for preventing hospitalization was 95.4 percent. (indonesiawindow.com)
Currently, there is no data on the efficacy of Qdenga for people over 45 years of age, so the efficacy of this vaccine in this group is uncertain. (indonesiawindow.com)
The SPC also provides more complete information about the safety and efficacy of Qdenga, as well as precautions in the use of vaccines, including monitoring for possible side effects or adverse event following immunization (AEFI) and how to report these conditions. (indonesiawindow.com)
In February, based on the new findings, researchers in Brazil began administering the new single-dose vaccine in a large Phase 3 clinical trial designed to look at vaccine efficacy against naturally occurring dengue. (jhu.edu)
Efficacy of a tetravalent dengue vaccine in healthy children aged 4-16" by Shibadas Biswal, Charissa Borja-Tabora et al. (edu.ph)
We aimed to assess the efficacy, safety, and immunogenicity of a live attenuated tetravalent dengue vaccine (TAK-003) in healthy children aged 4-16 years. (edu.ph)
In the secondary endpoint assessment timeframe, an overall vaccine efficacy of 73·3% (95% CI 66·5 to 78·8) was observed. (edu.ph)
The TAK-003 BLA is supported by safety and efficacy data from the pivotal Phase 3 Tetravalent Immunization against Dengue Efficacy Study (TIDES) trial, where the dengue vaccine candidate met its primary endpoint by preventing 80.2% of symptomatic dengue cases at 12 months. (sagunin.com)
8] The pivotal Phase 3 TIDES trial met its primary endpoint of overall vaccine efficacy (VE) against virologically confirmed dengue (VCD) at 12 months follow-up and all secondary endpoints at 18 months follow-up for which there were a sufficient number of dengue cases, including VE against hospitalized dengue and VE in baseline seropositive and baseline seronegative individuals. (sagunin.com)
A new JAMA Viewpoint by Shah, Marks, and Hahn provides some reassurance that the FDA is aware of these concerns and has issued guidance, summarized below, to help ensure the safety and efficacy of any new COVID-19 vaccine that will be used widely in the US. (jphmpdirect.com)

To date, we know that the vaccine can provide protection against dengue for at least 6 years. (cdc.gov)

A severe form of dengue fever, (dengue hemorrhagic fever) can cause severe bleeding, a sudden drop in blood pressure and death. (merck.com)
The ongoing resurgence of Aedes aegypti in the Americas-- abetted by poor mosquito control, urbanization, and increased air travel--has led to dengue hyperendemicity, more frequent dengue epidemics, and the emergence of dengue hemorrhagic fever (DHF). (cdc.gov)
Repeated epidemics of dengue and dengue hemorrhagic fever (DHF) involving up to several million people occur annually in tropical areas of Asia, Africa, the Pacific, and the Americas and may extend into temperate areas inhabited by the Aedes aegypti mosquito vector (3). (cdc.gov)
Although some dengue infections are asymptomatic, severe infections of this flavivirus can cause hemorrhagic fever and dengue shock syndrome and have a higher risk of complications and death. (uvm.edu)
While most of those who are infected with dengue survive with few or no symptoms, more than two million people annually develop what can be a dangerous dengue hemorrhagic fever, which kills more than 25,000 people each year. (jhu.edu)
Dengue hemorrhagic fever occurs when blood leaks from the blood vessels into other parts of the body, which can lead to failure of the circulatory system and shock, and possibly death, without prompt, appropriate treatment. (jhu.edu)
Dengue Hemorrhagic Fever (DHF) is an acute and potentially lethal complication of dengue fever, a tropical disease caused by the dengue virus. (tanzirislambritto.com)
What Causes Dengue Hemorrhagic Fever? (tanzirislambritto.com)
The Aedes mosquito, mainly Aedes aegypti and, to a lesser extent, Aedes albopictus, plays a crucial role in transmitting the dengue virus, which causes Dengue Hemorrhagic Fever. (tanzirislambritto.com)

one potential explanation is that dengue virus (DENV)-mediated immune enhancement may promote CZS development. (cdc.gov)
Secondary DENV infections can be more severe than primary infections because of antibody-dependent enhancement (i.e., heterotypic subneutralizing antibodies enhancing virus entry into poorly susceptible cells) ( 15 , 16 ). (cdc.gov)
Four related viruses can cause dengue fever: DENV-1, DENV-2, DENV-3, and DENV-4. (nih.gov)
Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
The development of live-attenuated vaccines against Dengue virus (DENV) has been problematic. (bvsalud.org)
Tetra DIIIC is a vaccine candidate against dengue virus (DENV) composed by four chimeric proteins that fuse the domain III of the envelope protein of each virus to the corresponding capsid protein. (bvsalud.org)
Dengue fever, caused by dengue virus (DENV), is of substantial public health significance in the tropics, where the virus is spread by Aedes mosquitoes. (virology.ws)
The use of this vaccine is restricted to individuals who were previously infected with DENV. (virology.ws)
However, because the DENV epitopes that the CD8+ T lymphocytes would recognize are absent in this vaccine, Dengvaxia does not confer any CD8-mediated immunity against DENV. (virology.ws)
Dengue virus (DENV) is an enveloped, single-stranded RNA virus belonging to the Flaviviridae family. (frontiersin.org)

Dengvaxia is approved for the prevention of dengue caused by all four dengue viruses. (cdc.gov)
the live attenuated recombinant tetravalent vaccine CYD-TDV (Dengvaxia). (fondation-merieux.org)
A vaccine to prevent dengue (CYD-TDV, Dengvaxia®) is licensed and available in 20 countries for people ages 9-45 years old. (cdc.gov)
Qdenga is the second dengue vaccine to receive distribution authorization from BPOM after Dengvaxia which is registered under the name of PT Aventis Pharma. (indonesiawindow.com)
The vaccine approved by the FDA is Dengvaxia, a live-attenuated formulation manufactured by Sanofi Pasteur that is administered in three doses, at six month intervals. (virology.ws)
As discussed in two previous posts and at least one episode of TWiV (links available here , here , and here ), Dengvaxia is only moderately effective and is unsuitable for children under the age of 9, a demographic that is in dire need of a dengue vaccine in endemic countries. (virology.ws)
A three-dose vaccine called Dengvaxia received limited licensure in 2016 in Mexico, the Philippines, and Brazil. (jhu.edu)
Is Dengvaxia included in the Vaccines For Children (VFC) program? (immunize.org)

Dengue is spread by Aedes species mosquitoes like Aedes aegypti . (cdc.gov)
The Aedes aegypti mosquito transmits the virus while ingesting a blood meal. (medscape.com)
An economic evaluation from the societal perspective is salient, comparing the regular control program for dengue prevention versus an intervention of environmental management strategy by covering the most Aedes aegypti productive breeding sites with insecticide covers and additional activities. (medscape.com)
This workshop was developed with the Global Dengue & Aedes -Transmitted Diseases Consortium (GDAC) Advisory Committee as a continuation of the workshop held in January 2019. (fondation-merieux.org)
The four dengue viruses (DEN-1, DEN-2, DEN-3 and DEN-4) are spread by the mosquito, Aedes aegypti, which is found throughout tropical and subtropical regions. (pharmabiz.com)
Spreading of these viruses has been re-emerging in the last decade due to weather and climate variability that increased further geographical expansion of Aedes vectors. (escoaster.com)
Dengue is a disease transmitted by mosquitoes, with the primary vector being the Aedes Aegypti mosquito. (frontiersin.org)
The Aedes Aegypti mosquito transmitting the disease can survive in weather cooler than previously thought due to climate change and urbanization, which means the virus can reach further south, although the vaccine is in principle is designed for regions with a high burden of dengue and high transmission. (antiguanewsroom.com)
2 The virus is transmitted between epidemic, China developed a national yellow fever control humans, or from monkeys to humans, through the bite and prevention protocol, 6 and took steps to strengthen of infected mosquitoes belonging to the Aedes and surveil ance at airports and health-care facilities and to Haemogogus genera, respectively. (who.int)

3,4] In the first half of 2022 alone, Indonesia reported over 63,000 dengue cases and nearly 600 deaths spread across 455 cities in 34 provinces. (newswire.co.kr)
The Qdenga dengue vaccine for ages 6-45 years received a distribution permit from Indonesia's National Agency of Drug and Food Control (BPOM) on Friday (September 9, 2022). (indonesiawindow.com)
Vaccine 2022;40:1143-1151. (cdc.gov)
OSAKA, Japan and CAM--( 뉴스와이어 ) 2022년 11월 23일 -- Takeda (TSE:4502/NYSE:TAK) today announced that the U.S. Food and Drug Administration (FDA) has accepted and granted priority review of the Biologics License Application (BLA) for TAK-003, the company's investigational dengue vaccine candidate. (sagunin.com)

Blood tests can confirm if someone has had previous dengue infections. (cdc.gov)
The World Health Organization (WHO) reports that licensed vaccines are currently available for twenty-five different preventable infections. (wikipedia.org)
The World Health Organization has estimated that up to 400 million dengue infections occur annually, resulting in 500,000 hospitalizations. (merck.com)
Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
No vaccine exists today to prevent ZIKV infections. (justia.com)
The Vaccine Testing Center and laboratories are dedicated to improving global health through the development and study of new vaccines and by improving our understanding of how humans respond immunologically to infections and vaccines. (uvm.edu)
The goal of this work is to gain a better understanding of immunologic responses to vaccines as well as natural infections. (uvm.edu)
An estimated 105 million dengue infections occur each year, resulting in 500,000 hospitalisations and 44,000 deaths. (prfire.co.uk)
This year, of the 888 dengue infections in the U.S., 96% were a result of travel to dengue endemic areas. (sagunin.com)
Of the 316 dengue infections in U.S. endemic territories, 97% were locally transmitted. (sagunin.com)
A slow virus, BK establishes latent infections in B-lymphocytes and attacks an immunosuppressed host upon reactivation. (stanford.edu)
Despite revised clinical classifications of dengue infections by the World Health Organization, the wide spectrum of the manifestations of dengue illness continues to pose challenges in diagnosis and patient management for clinicians. (frontiersin.org)
Most of the deaths are from cirrhosis of the liver or hepatic cancer due to chronic infections with hepatitis viruses B or C, picked up through contact with contaminated blood. (gavi.org)
SCD patients should also receive counselling on hygiene, barrier protection against vectors, routine chemoprophylaxis for locally endemic diseases, and immunization for vaccine-preventable infections as a long-term preventive strategy against IAH. (bvsalud.org)
Other flaviviral infections include dengue, Japanese encephalitis, and tick-borne encephalitis. (medscape.com)

Dengue can affect anyone living in or traveling to endemic areas - regardless of age, health and socio-economic circumstances," said Gary Dubin, president of Takeda's Vaccine Business Unit. (newswire.co.kr)
The completion of the first stage of this phase II study is an important milestone for Inviragen, as it represents the first comprehensive safety evaluation of the vaccine in individuals of various ages who live in dengue endemic areas," said Dr Dan Stinchcomb, CEO of Inviragen. (pharmabiz.com)
Last week the FDA announced its approval of a first vaccine for the prevention of dengue disease in endemic areas. (virology.ws)

A Single Dose of Any Four Different Live Attenuated Tetravalent Dengue Vaccines is Safe and Immunogenic in Flavivirus-naïve Adults: A Randomized, Double Blind Clinical Trial. (uvm.edu)
These viruses are members of the Flavivirus genus. (tanzirislambritto.com)
Esco Aster, a leading independent contract development and manufacturing organization underpinned by its patent Tide Motion bioreactor technology, has signed a cooperation agreement with the Max Planck Institute (MPI) for Dynamics of Complex Technical Systems, Magdeburg, Germany to develop new techniques for cell-culture based virus production of human flavivirus vaccines. (escoaster.com)
The Flavivirus genus is composed of more than 70 arthropod-transmitted viruses, of which 30 are known to cause human disease. (medscape.com)

Scientists in the Laboratory of Infectious Diseases at the NIAID of the NIH engineered a candidate live attenuated tetravalent vaccine against the dengue virus. (merck.com)
The Expert Committee also adopted new guidelines for the production and quality control of candidate live attenuated tetravalent dengue vaccines, and revised recommendations for the preparation, characterization and establishment of international and other biological reference standards. (who.int)
The guidelines on dengue vaccines were developed in response to interest from many countries in the development of candidate live attenuated tetravalent dengue vaccines. (who.int)

What is promising about TV003 is that it elicited solid antibody responses after just one dose," explains NIAID's Dr. Stephen Whitehead, who led development of the vaccine candidates. (nih.gov)
Instituto Butantan's dengue vaccine candidate, TV003, is currently being evaluated in a large Phase 3 study in Brazil. (merck.com)
Instituto Butantan will retain responsibility for the manufacturing and commercialization of their investigational vaccine, TV003, in Brazil. (merck.com)
TV003, a live-attenuated tetravalent formulation developed by the National Institutes of Health, is currently being evaluated in phase 2 and phase 3 clinical trials. (virology.ws)
The TV003 vaccine, as it is known, was already in pretty good shape in preventing dengue 1, 3 and 4 viruses, but the portion of the vaccine that was designed to prevent dengue 2 did not induce as strong an immune response in people as the other three components. (jhu.edu)
In the investigation, researchers from the Bloomberg School and the University of Vermont administered the TV003 dengue vaccine to 24 healthy adults, while 24 others received a placebo. (jhu.edu)

The endorsement of QDENGA by the WHO's Strategic Advisory Group of Experts on Immunization (SAGE) is a significant step forward in dengue prevention. (thaimedicalnews.com)
Two modelling systems are used: Lives Saved Tool (LiST) is used increasingly by donor organizations, and the WHO/IVB model used by the World Health Organization's Department of Immunization, Vaccines and Biologicals. (theothersideofvaccines.com)
Refer to https://www.who.int/teams/immunization-vaccines-and-biologicals/policies/position-papers for most recent version of this table and position papers. (who.int)
List key recommendations in the AAP influenza policy statement, "Recommendations for Prevention and Control of Influenza in Children, 2018-2019" and in the CDC Advisory Committee on Immunization Practices' document, "Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices-United States, 2018-2019 Influenza Season. (cdc.gov)

Seropositivity rate was defined as the percentage of participants being seropositive, derived from titers of dengue- neutralizing antibodies. (clinicaltrials.gov)
Rhesus macaques were first primed with one or two doses of Tetra DIIIC and then boosted with TV005, following the time course of the appearance of virus-binding and neutralizing antibodies, and evaluating protection by means of a challenge experiment with wild-type viruses. (bvsalud.org)
This enhanced disease, known as antibody-dependent enhancement, is a hallmark of dengue disease and is a phenomenon in which antibodies against a heterotypic virus bind it but don't neutralize (i.e., inactivate) it. (virology.ws)
In addition to UVM VTC investigators, the research team includes researchers from the Johns Hopkins Bloomberg School of Public Health, the National Institute of Allergy and Infectious Disease (NIAID), the La Jolla Institute for Allergy and Immunology , the University of North Carolina , and Atreca, Inc. A major focus of this study is the antibodies and T-cell responses produced in the blood in response to the dengue. (uvm.edu)
For this reason, the researchers, led by Anna P. Durbin, MD, an associate professor in International Health at the Bloomberg School, were concerned that measuring antibodies alone may not truly indicate the ability of the vaccine to protect against dengue. (jhu.edu)
Often, vaccine trials are looking to see whether a person has developed antibodies to the virus. (jhu.edu)
During this SARS-CoV-2 pandemic, many studies on the development of plant-derived vaccines and antibodies are underway. (nature.com)

Diseases (NIAID), part of the United States National Institutes of Health (NIH), for the development of live attenuated tetravalent vaccines (LATV). (merck.com)

Dengue is transmitted to humans through the bite of infected A aegypti mosquitoes. (medscape.com)
Dengue fever occurs in tropical and subtropical areas of the world, where it is spread by mosquitoes. (nih.gov)
These mosquitoes are highly adaptive to the human environment, coupled with increasing urbanization and inadequate vector control, which has led to a surge in dengue transmission in urban and semi-urban settings. (tanzirislambritto.com)
In addition, the 30 mutation was shown to restrict the capacity for dissemination of DEN4 virus from the EDC3 midgut to the head of mosquitoes (20). (antiviralbiologic.com)
As a first step, we introduced the 30 mutation into the homologous region of the 3 UTR of DEN1 virus and evaluated the level of replication of the resulting virus in rhesus monkeys and mosquitoes. (antiviralbiologic.com)

Protection against virologically confirmed dengue, severe dengue, and hospitalization for dengue. (cdc.gov)

The immune system recognizes vaccine agents as foreign, destroys them, and "remembers" them. (wikipedia.org)
Those who are older often display less of a response than those who are younger, a pattern known as Immunosenescence.Adjuvants commonly are used to boost immune response, particularly for older people whose immune response to a simple vaccine may have weakened. (wikipedia.org)
Just one dose of a low-cost vaccine proved safe and stimulated a strong immune response against the dengue virus in most participants in an early-stage clinical trial. (nih.gov)
These vaccines contain weakened viruses that don't cause illness but can still induce an immune response. (nih.gov)
All 4 vaccine combinations successfully produced immune responses without any serious side effects. (nih.gov)
Both biopharmaceuticals are regarded as vaccines because they elicit an immune response, either against a pathogenic microorganism or against the host's own tumour cells. (intechopen.com)
Inviragen's DENVax vaccine, invented by researchers at the Division of Vector-Borne Diseases of the Centres for Disease Control and Prevention, is based on an attenuated DEN-2 virus that generates long-lasting anti-dengue immune responses. (pharmabiz.com)
The team is examining how the immune system recognizes dengue virus in an effort to confirm the protective effects of new vaccines in development. (uvm.edu)
Instead, they form complexes with the virus that are more readily taken up by cells involved in the immune response. (tanzirislambritto.com)
As a post-doctoral fellow, he developed a program to study medically importantflaviviruses (West Nile and dengue virus) and their interaction with the innate immune signaling pathway. (scitechnol.com)
His main focus is investigating the role of West Nile and dengue virus proteins in abrogating the response to the antiviral innate immune molecule Interferon. (scitechnol.com)

Because we have limited tools to control dengue, having a safe and effective vaccine available to protect children is a step in the right direction in our fight against this mosquito-borne disease. (cdc.gov)
Dengue fever is a mosquito-borne disease that occurs in tropical and subtropical areas of the world. (merck.com)
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. (curehunter.com)
In a small clinical trial led by the Johns Hopkins Bloomberg School of Public Health, researchers say that a promising single-dose dengue vaccine, developed by scientists at the National Institutes of Health, was 100 percent effective in preventing human volunteers from contracting the virus, the most prevalent mosquito-borne virus in the world. (jhu.edu)
Dengue is a mosquito-borne virus endemic in more than 125 countries, including the U.S. territories of Puerto Rico, the U.S. Virgin Islands and American Samoa. (sagunin.com)

We're proud to introduce QDENGA as a new dengue prevention tool to the people of Indonesia, and we will continue to work with additional regulatory agencies to make QDENGA available globally. (newswire.co.kr)
QDENGA is currently undergoing regulatory review for the prevention of dengue in children and adults in the European Union (EU) and in dengue-endemic countries outside the EU through the EU-M4all (previously Article 58) procedure. (newswire.co.kr)
The 2012 WNV season in the United States saw a massive spike in the number of neuroinvasive cases and deaths similar to what was seen in the 2002-2003 season, according to the West Nile virus disease cases and deaths reported to the CDC by year and clinical presentation, 1999-2012, by ArboNET (Arboviral Diseases Branch, Centers for Disease Control and Prevention). (mdpi.com)
In a major development in dengue prevention, the WHO has recently endorsed Takeda Pharmaceuticals' QDENGA vaccine. (thaimedicalnews.com)
The endorsement of QDENGA by the WHO brings hope for a brighter future in dengue prevention. (thaimedicalnews.com)
As QDENGA becomes available in more regions, continued vigilance in dengue prevention and ongoing research will be essential. (thaimedicalnews.com)
Qdenga is a vaccine with indications for the prevention of dengue disease caused by the dengue virus at the age of 6 to 45 years old produced by IDT Biologika GmbH Germany, and released by and registered on behalf of Takeda GmbH Germany, BPOM said in a statement received here on Friday. (indonesiawindow.com)
If approved, we believe TAK-003 has the potential to become an important dengue prevention option for healthcare providers, and we continue to be encouraged by our discussions with the FDA," said Gary Dubin, M.D., president of the Global Vaccine Business Unit at Takeda. (sagunin.com)

Persons with dengue flaviviruses in their blood can transmit the flaviviruses to the mosquito (the vector) 1 day before the onset of the febrile period. (medscape.com)
West Nile virus (WNV) and Usutu virus (USUV) are mosquitoborne flaviviruses that can cause neuroinvasive disease in humans. (cdc.gov)
They identified it as a novel virus of the family to which yellow fever virus belongs: the flaviviruses, a group of RNA viruses often transmitted through the bite of infected arthropods. (gavi.org)

In 2019, the World Health Organization identified vaccine hesitancy as one of the top ten global health threats, which makes public mistrust another concern for public health officials. (jphmpdirect.com)
The Officers and Executive Board thank the members of the International Society for Vaccines (ISV) for supporting the Society on a successful 2019. (isv-online.org)

Shortage of the vaccine supply is a major issue, especially when sudden outbreaks occur ( Brazil 2017 ). (escoaster.com)

Each year, dengue fever affects 50 million to 100 million people and hospitalizes nearly 500,000, according to the World Health Organization. (nih.gov)

Researchers at the University of Vermont (UVM) Vaccine Testing Center, along with collaborators at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health and Johns Hopkins Bloomberg School of Public Health, have been working since 2008 to develop a dengue vaccine that will protect against all four dengue strains. (uvm.edu)
For this reason, a good dengue vaccine needs to protect against all four dengue viruses, the researchers say. (jhu.edu)

Dengue hemmorhagic fever (DHF) is a more severe form of dengue fever associated with thrombocytopenia and hemoconcentration. (medscape.com)

TV003's inexpensive production cost - less than $1 per dose - is critical to its potential use in developing countries where dengue is prevalent. (nih.gov)
a retrospective analysis of clinical trial data, stratifying participants according to their dengue serostatus before the first vaccine dose, revealed an excess risk of severe dengue in seronegative vaccine recipients, while in seropositive vaccine recipients, the vaccine was efficacious and safe. (fondation-merieux.org)
The DSMB determined that the first dose of the vaccine is well tolerated in adults, adolescents and children, some of whom were pre-exposed to dengue viruses. (pharmabiz.com)
Following the assessment of an independent monitoring board, the study was designed to enter its second stage, in which it will enroll approximately 200 children aged 18 months to 11 years to further test the safety and immunogenicity of the two-dose DENVax vaccine. (pharmabiz.com)
Only a single dose of the vaccine was necessary and while researchers believe the effects will be long lasting, they only tested it after six months. (jhu.edu)
Children who have had a severe (life-threatening) allergic reaction to a previous dose of the vaccine. (cdc.gov)
Vaccine providers give three doses administered subcutaneously and each dose given 6 months apart (at 0, 6, and 12 months) for full protection. (cdc.gov)

Currently, the live-attenuated yellow fever vaccine is produced in embryonated chicken eggs. (escoaster.com)
The Yellow Fever Vaccine Misadventure of 1942 by Dr. John Marr in the Journal of Public Health Management and Practice . (jphmpdirect.com)
The currently available yellow fever vaccine confers near lifelong immunity in 95% of patients. (medscape.com)

Mild symptoms can be treated at home, but severe dengue requires hospitalization. (cdc.gov)

In the new study, the scientists tested tetravalent combinations of the most effective vaccine candidates against each of the 4 viruses. (nih.gov)

Influenza-virus-mediated disease can be associated with high levels of morbidity and mortality, particularly in younger children and older adults. (mdpi.com)
Associated with a small but significant risk following administration of influenza vaccines. (standardofcare.com)
certolizumab pegol decreases effects of influenza virus vaccine quadrivalent, intranasal by pharmacodynamic antagonism. (medscape.com)
The CHMP also recommended to approve the cell culture-derived influenza vaccine Flucelvax Tetra developed by Swquirus Netherlands BV which includes an inactivated influenza surface antigen. (european-biotechnology.com)
Outline background information about updated recommendations for the use of intranasal live attenuated influenza vaccine (LAIV4) in children. (cdc.gov)

TAK-003 was well tolerated and efficacious against symptomatic dengue in children regardless of serostatus before immunisation. (edu.ph)
The TIDES exploratory analyses showed that throughout the 4.5-year study follow-up, TAK-003 prevented 84% of hospitalized dengue cases and 61% of symptomatic dengue cases in the overall population, including both seropositive and seronegative individuals. (sagunin.com)
It consists of 2 doses, applied at an interval of 3 months, which reduces 84% of hospitalizations and 61% of symptomatic dengue cases. (antiguanewsroom.com)

Inviragen, Inc., a company focused on developing vaccines to protect against infectious diseases worldwide, has begun the second stage of an ongoing phase II, randomized, double-blind, placebo-controlled study of DENVax, the company's investigational dengue vaccine. (pharmabiz.com)

ZIKV has recently been shown to cause devastating neurological damage in infants and serious complications in adults in some cases, and may have other effects that have not yet been identified or definitively linked to the virus. (justia.com)
A Phase II, Randomized, Safety and Immunogenicity Trial of a Re-Derived, Live-Attenuated Dengue Virus Vaccine in Healthy Children and Adults Living in Puerto Rico. (ouhsc.edu)
While two vaccine companies have tested new dengue vaccines in the last 2 years, early results have indicated that vaccinated children may have complications to the vaccine, but the vaccine appears effective in adults. (isv-online.org)
To assess the safety profile of Dengue Tetravalent Vaccine (TDV) administered as 2 doses given 3 months apart in healthy adults, adolescents, and children. (who.int)

Children need three doses of the dengue vaccine, given at six-month intervals, for full protection. (cdc.gov)
Other vaccines in development require 2 or 3 injections at higher doses to achieve similar results. (nih.gov)
The Qdenga vaccine is given in two doses with an interval of three months, through injection of drugs or vaccines into the hypodermis, which is the layer of skin under the dermis, in the upper arm muscles," Head of BPOM Penny K Lukito explained. (indonesiawindow.com)

With further development, the vaccine may help ease the burden of dengue fever in developing countries. (nih.gov)

In addition, the establishment and recent spread of lineage II WNV virus strains into Western Europe and the presence of neurovirulent and neuroinvasive strains among them is a cause of major concern. (mdpi.com)
This innovative approach aims to offer comprehensive protection against the diverse strains of the virus. (thaimedicalnews.com)
There are four very different strains of dengue that circulate and a successful vaccine must prevent all four strains. (jhu.edu)

A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. (wikipedia.org)

Analysis of secondary endpoints showed efficacies of 76·1% (95% CI 68·5 to 81·9) in individuals who were seropositive at baseline, 66·2% (49·1 to 77·5) in individuals who were seronegative at baseline, 90·4% (82·6 to 94·7) against hospitalised dengue, and 85·9% (31·9 to 97·1) against dengue haemorrhagic fever. (edu.ph)

There is overwhelming scientific consensus that vaccines are a very safe and effective way to fight and eradicate infectious diseases. (wikipedia.org)
The vaccines - developed by scientists at NIH's National Institute of Allergy and Infectious Diseases (NIAID) - were live-attenuated vaccines. (nih.gov)
Infectious diseases before and after a vaccine was introduced. (webot.org)
The NIH dengue vaccine was designed by Stephen Whitehead, Ph.D., a senior scientist and virologist at the Laboratory of Infectious Diseases at the NIAID. (uvm.edu)
The ISV is a global not-for-profit organization that aims to encourage, establish, and promote the development and use of vaccines to prevent and control infectious and non-infectious diseases in humans and animals. (isv-online.org)

Dengue fever is another disease that effects 100 million people living in tropical areas where dengue viruses are easily transmitted by mosquitos. (isv-online.org)
Children must also be living in areas where dengue occurs frequently or continuously, which include American Samoa, Puerto Rico, and the U.S. Virgin Islands, and the freely associated states of the Federated States of Micronesia, the Republic of Marshall Islands, and the Republic of Palau. (cdc.gov)
Travelers and non-residents of areas where dengue is common. (cdc.gov)

As a vaccine candidate, rDEN430 (also referred to as 2A30) was administered to 20 adult human volunteers and shown to be highly immunogenic and well tolerated without causing systemic illness (5). (antiviralbiologic.com)

NIAID then supported the development of the candidate vaccine through a series of clinical trials. (merck.com)
Dr Gilad Gordon, Inviragen's CMO added, "In completed and on-going phase I and II studies, we have enrolled over 400 subjects in DENVax clinical trials and more than 300 have received the vaccine. (pharmabiz.com)
2020 will bring new dengue vaccines to clinical trials that may overcome these issues in children. (isv-online.org)

Do not administer live vaccines 30 days before or concurrently with belimumab. (medscape.com)
Do not give live vaccines concurrently with certolizumab. (medscape.com)
A licensed vaccine within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to TDV or placebo administration. (who.int)

Anatomy2

Organisms10

Diseases4

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes6

Information Science2

Health Care3

Geographicals2

Serotypes35

Infection88

Serotype14

Vaccination23

Zika33

Viral26

Efficacy20

Protection against dengue1

Hemorrhagic fever9

DENV10

Dengvaxia8

Aedes9

20224

Infections15

Endemic areas3

Flavivirus4

Candidate live attenuated tetravalent3

TV0036

Immunization4

Antibodies7

Development of live attenuated1

Mosquitoes5

Virologically confirmed dengue1

Immune11

Mosquito-borne5

Prevention8

Flaviviruses3

20192

20171

World Health Organ1

Protect against all four dengue2

Severe form of dengue fever1

Dose7

Yellow fever vaccine3

Hospitalization1

Effective vaccine1

Influenza5

Symptomatic3

Company's1

Adults4

Doses3

Burden of dengue1

Strains3

Proteins1

Seronegative1

Infectious Diseases5

Areas where dengue3

Illness1

Clinical trials3

Live vaccines3