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Live attenuatedNasalImmune responsesInfectionsProteinHumanHostStudies
Live attenuated2
  • This application claims live attenuated Zika viruses and vaccines, attenuated chimeric Zika viruses and vaccines, and multivalent immunogenic compositions comprising Zika vaccines and vaccines for other flaviviruses. (nih.gov)
  • We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters nasal inflammatory and antiviral responses to live attenuated influenza virus (LAIV). (nih.gov)
Nasal2
  • Virus RNA and inflammatory factors were measured in nasal lavage fluids (NLF) serially after LAIV inoculation. (nih.gov)
  • Exposure to cigarette smoke was associated with suppression of specific nasal inflammatory and antiviral responses, as well as increased virus quantity, after nasal inoculation with LAIV. (nih.gov)
Immune responses1
  • The present disclosure also claims methods of inducing immune responses, as well as preventing ZIKV and another flavivirus, e.g. , dengue virus. (nih.gov)
Infections1
  • The detection of two human infections by avian H3N8 viruses in April and May of 2022 raised pandemic concerns. (researchgate.net)
Protein2
  • The chimeric Zika viruses claimed include a first nucleotide sequence encoding at least one structural protein from a Zika virus (ZIKV), a second nucleotide sequence encoding at least one nonstructural protein from a first flavivirus, and a third nucleotide sequence of a 3' untranslated region from a second flavivirus. (nih.gov)
  • Virus RNA in NLF cells was significantly increased in smokers, as were interferon-inducible protein 10:virus ratios. (nih.gov)
Human1
  • We therefore sought to develop a protocol for the study of human airway responses to virus in the intact human respiratory tract. (nih.gov)
Host2
  • Thus, available evidence suggests that the effects of cigarette smoke on susceptibility to influenza infection may involve elements of early or innate host defense against viruses. (nih.gov)
  • Virus emergence may occur through interspecies transmission and recombination of viruses coinfecting a host, with potential to pair novel and adaptive gene combinations. (researchgate.net)
Studies1