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  • vitro
  • An in vitro examination demonstrated TCchem attenuated nitric oxide production and PPARα activity in HUVECs, which was partially improved by bezafibrate. (nii.ac.jp)
  • Biochemical profiling demonstrates that G1T28-1 is a competitive inhibitor of CDK4/6 at low nanomolar concentrations, and that G1T28-1 is highly selective for CDK4/cyclin D1 and CDK6/cyclin D3 as compared to CDK2/cyclin A or CDK2/cyclin E. G1T28-1 induces a clean G0/G1 arrest in CDK4/6 dependent cell lines in vitro. (aacrjournals.org)
  • And in vitro, FZE was also found to protect Schwann cells against high glucose injury. (jove.com)
  • alleviate
  • Inhibition of the glial enzyme glutamate carboxypeptidase II (GCPII) has been shown to selectively dampen excessive glutamate transmission and alleviate neuropathic pain and protect peripheral nerves from the functional and histological deficits induced by chemotherapeutic agents. (grantome.com)
  • drugs
  • In pre-clinical rodent testing, Epidiferphane™, in conjunction with a nutritional ketosis, has been shown to double the mean life expectancy, increase the effectiveness of chemotherapy, and sensitize chemotherapy resistant tumors to standard of care drugs. (yahoo.com)
  • As a class, thiol drugs have a risk of inducing hypersensitivity reactions. (grantome.com)
  • inflammatory
  • HO-1 itself and the by-products of heme degradation play a crucial role in maintaining cellular homeostasis, protecting cells from oxidative damage, attenuating inflammatory response and inhibiting cytokine production [ 11 ]. (ijbs.com)
  • The MSCs mitigated the gonadotoxicity induced by cisplatin through antioxidative, anti-inflammatory, and antiapoptotic mechanisms. (biomedcentral.com)
  • pharmacology
  • G1T28-1 was specifically designed with high potency, exquisite selectivity, and favorable pharmacology to induce a predictable and well-defined transient arrest of HSPC as compared to less potent and selective CDK4/6 inhibitors. (aacrjournals.org)
  • prevent
  • A study reported in the Journal of Nutrition demonstrated the promise of green tea polyphenols as anticarcinogenic agents to prevent the development of solar ultraviolet radiation induced skin cancer. (herbs.org)
  • Phosphodiesterase (PDE) 5 inhibitors, which prevent cGMP degradation and therefore elevate its level in the heart, have been shown to protect the myocardium in several animal models of heart failure and in human trials. (biomedcentral.com)
  • treatment
  • Prana Therapeutics is a biotech company focused on developing targeted therapeutics for prevention of the negative side effects of chemotherapy, management of rheumatoid arthritis, and treatment of brain cancer. (yahoo.com)
  • This study enrolled 45 gynecological cancer patients who underwent surgical treatment followed by TC-chemotherapy. (nii.ac.jp)
  • To date, there are no effective and well-tolerated cytostatics for the palliative treatment of patients who are not suitable for aggressive anthracycline-based chemotherapy. (spandidos-publications.com)
  • In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. (ijbs.com)
  • Responses
  • Although strong humoral responses are induced by VL infection, antibodies play no role in protection and are often associated with disease exacerbation [ 5 ]. (hindawi.com)
  • symptoms
  • Although there are several protocols to minimize the side effects associated with chemotherapy, there is currently no protocol that prevents these symptoms. (yahoo.com)
  • Methods
  • The Patent protects the use of suspending both phytocannabinoids and cannabinoids with specific combinations of cannabis derived terpenes in liquid forms with an array of delivery methods including capsule, sublingual, topical, oral, suppository, and vaporization. (fintel.io)
  • data
  • These data suggest that PKG Iα disulfide formation transduces oxidant signals that arise in the heart during DOX chemotherapy into a pro-apoptotic signal, leading to cardiomyopathy. (biomedcentral.com)
  • drug
  • Countries all over the world, and especially the developing world, are taking a different approach to their herbal traditions than the American approach, which seems focused primarily on protecting the medical monopoly of doctors, drug companies and insurance companies. (herbs.org)
  • several
  • The cytoprotective function of HO-1 has been regarded as a shied from radiotherapy, chemotherapy, photodynamic therapy and other adjuvant therapy in several malignant diseases [ 12 - 14 ]. (ijbs.com)