Attachment monomeric gtp binding proteins. Medical search. Frequent questions

Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (lookformedical.com)

They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION. (lookformedical.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)

An actin protein is the monomeric subunit of two types of filaments in cells: microfilaments, one of the three major components of the cytoskeleton, and thin filaments, part of the contractile apparatus in muscle cells. (wikipedia.org)
The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (lookformedical.com)

Many membrane-associated proteins were found to stably integrate in the rafts, which is critical for their biological function. (typeset.io)
This behavior, however, has never been reproduced in vitro in model bilayers with recombinant proteins, and therefore has been attributed to action of other proteins binding Ras at the membrane surface. (typeset.io)
In a cell, many membrane proteins permanently reside in raft membrane domains, which is essential for their function5, 15-19. (typeset.io)
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. (lookformedical.com)
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE. (lookformedical.com)
They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. (lookformedical.com)
A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane. (lookformedical.com)
The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)

However, it has become evident that substantial posttranslational modifications of many of these proteins are required for the development and progression of potentially disease relevant changes. (microbialcell.com)
Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. (oncotarget.com)

The experimental conditions have been further refined by the use of a biological buffer solution to stabilize the noncovalent complexes of rus~GDP and ras-GTP in solution prior to mass spectrometry analysis [25]. (docksci.com)

They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. (lookformedical.com)
Kinesin motor proteins use adenosine triphosphate hydrolysis to do work on microtubules (MTs). (silverchair.com)

A constitutively expressed subfamily of the HSP70 heat-shock proteins. (lookformedical.com)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)

Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) negative-selection screening and identified a requirement for the catalytic Jumonji (JmjC) domain and zinc finger domain for leukemia cell survival in vitro and in vivo. (bvsalud.org)
Hochmair J, Exner C, Betzel C, Mandelkow E , Wegmann S . Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro. (neurotree.org)

Isoforms H and N of Ras GTPase possess a unique ability to switch their lipid domain preference depending on the type of bound guanine nucleotide (GDP or GTP). (typeset.io)
In this paper, we report the observation of the nucleotide-dependent switch of lipid domain preferences of the semisynthetic lipidated N-Ras in raft lipid vesicles in the absence of other proteins. (typeset.io)
However the in-strand contacts and nucleotide binding sites are preserved in prokaryotes and in archaea. (wikipedia.org)
Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)

To detect segregation of Ras molecules in raft and disordered lipid domains, we measured Forster Resonance Energy Transfer (FRET) between the donor fluorophore, mant, attached to the protein-bound guanine nucleotides, and the acceptor, rhodamine-conjugated lipid, localized to the liquid-disordered domains. (typeset.io)

These pits are the entry route for macromolecules bound by cell surface receptors. (lookformedical.com)
Endosomes internalize macromolecules bound by receptors on the cell surface. (lookformedical.com)
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)

It is demonstrated that N-Ras preferentially populated raft domains when bound to Mant-GDP, while losing preference for rafts when it was associated with a GTP mimic, mant-GppNHp. (typeset.io)

A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. (lookformedical.com)
An extension of this research is the feasibility study of using ES/MS for probing the noncovalent interaction between protein molecules. (docksci.com)
Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)

The extracellular signaling protein Sonic hedgehog (Shh) requires dual lipidation for functional signaling, whereby N-terminal palmitoylation is performed by the enzyme Hedgehog acyltransferase (Hhat). (imperial.ac.uk)
Zl, 221 reported the first application of ES/MS for noncovalent binding between FKBP (an immunosuppressive binding pro tein) and immunosuppressive agents (FK506 and rapamycin) and the enzyme-substrate interaction in which the enzymatic reaction of hen egg-white lysozyme with various substrates were studied. (docksci.com)
protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)

Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)

A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. (lookformedical.com)
In the past decade, yeast have been frequently employed to study the molecular mechanisms of human neurodegenerative diseases, generally by means of heterologous expression of genes encoding the relevant hallmark proteins. (microbialcell.com)
Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING. (lookformedical.com)

PROBING interaction of human rus protein with its guest ligands guanosine diphosphate (GDP) and guanosine triphosphate (GTP), and the successful ES/MS detection of the ras-GDP noncovalent complex has recently been reported [24]. (docksci.com)
These findings implicate the potential role of PCAIs as anticancer agents through their direct interaction with monomeric G-proteins. (oncotarget.com)

Although a construct of only the motor domain of kinesin 13 binds to every heterodimer of a tubulin ring, a construct containing the neck and the motor domain occupies alternate binding sites. (silverchair.com)

Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. (wikipedia.org)
It is believed that the diverse range of structures formed by actin enabling it to fulfill such a large range of functions is regulated through the binding of tropomyosin along the filaments. (wikipedia.org)
The evolutionary origin of actin can be traced to prokaryotic cells, which have equivalent proteins. (wikipedia.org)
A large number of illnesses and diseases are caused by mutations in alleles of the genes that regulate the production of actin or of its associated proteins. (wikipedia.org)
Third, actin filaments can bind to many other proteins, which together help modify and organize microfilaments for their diverse functions. (wikipedia.org)
Actin is extremely abundant in most cells, comprising 1-5% of the total protein mass of most cells, and 10% of muscle cells. (wikipedia.org)
The actin protein is found in both the cytoplasm and the cell nucleus. (wikipedia.org)

This is exemplified by the neuronal tau proteins, which are critically involved in a class of neurodegenerative diseases collectively called tauopathies and which includes Alzheimer's disease (AD) as its most common representative. (microbialcell.com)
In this respect, although obviously lacking a brain with a multicellular neuronal network, simple unicellular yeast are of great value to investigate the effects of overexpression and single point-mutations in genes encoding key proteins on cell physiology and on the function of conserved signaling cascades. (microbialcell.com)

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

Rab40c is a SOCS box-containing protein which binds Cullin5 to form a ubiquitin E3 ligase complex (Rab40c/CRL5) to regulate protein ubiquitylation. (life-science-alliance.org)
Mechanistically, we found that Rab40c binds the protein phosphatase 6 (PP6) complex and ubiquitylates one of its subunits, ankyrin repeat domain 28 (ANKRD28), thus leading to its lysosomal degradation. (life-science-alliance.org)
They have been primarily found as components of ADAPTOR PROTEIN COMPLEX 2. (lookformedical.com)
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK. (lookformedical.com)
The outer surface of these vesicles are covered with a lattice-like network of coat proteins, such as CLATHRIN, coat protein complex proteins, or CAVEOLINS. (lookformedical.com)
A family of large adaptin protein complex subunits of approximately 90-130 kDa in size. (lookformedical.com)
An adaptor protein complex found primarily on perinuclear compartments. (lookformedical.com)
The effect of the declustering energy on complex dissociation was further extended to probe the noncovalent protein-ligand association of rus-GDP. (docksci.com)

protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)

Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
It is hypothesized that PCAIs work as anticancer agents by disrupting polyisoprenylation-dependent functional interactions of the G-Proteins. (oncotarget.com)

Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)

A family of large adaptin protein subunits of approximately 100 kDa in size. (lookformedical.com)
A family of medium adaptin protein subunits of approximately 45 KDa in size. (lookformedical.com)

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)

Ras proteins are represented by three Ras isoforms with a high degree of homology and nearly 90% sequence identity in the N-terminal GTPase domain33. (typeset.io)

Surface plasmon resonance analysis showed that JDI-4 and JDI-12 bind to JMJD1C and its family homolog KDM3B with modest affinity. (bvsalud.org)

protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)

Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a central role in the maintenance of DNA methylation. (cipsm.de)

Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
Although the members of these protein families are widely distributed among various types of somatic cells [10,11] , it is not known whether related proteins function in the acrosome reaction. (ommegaonline.org)
Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)

Starch binding domain-containing protein 1 (Stbd1) is a carbohydrate-binding protein that has been proposed to be a selective autophagy receptor for glycogen. (imperial.ac.uk)
Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
The chromo-domain binds histone H3 tails methylated on lysine 9. (cipsm.de)
These proteins share a core structure, the conserved G-box (GDP/GTP) binding domain, of approximately 170 residues [ 3 ]. (oncotarget.com)
Probable molybdopterin binding domain [Interproscan]. (ntu.edu.sg)
Molydopterin dinucleotide binding domain, Molybdopterin oxidoreductase Fe4S4 domain [Interproscan]. (ntu.edu.sg)
4Fe-4S binding domain, 4Fe-4S dicluster domain [Interproscan]. (ntu.edu.sg)

Application of electrospray mass spectrometry in probing protein-protein and protein-ligand noncovalent interactions. (docksci.com)
Ydimer] and protein-∧ [ vas-guanosine diphosphate (GDP)] noncovalent interactions. (docksci.com)

The obvious advantage is that a protein sample can be introduced directly from solution in its biologically active form for mass spectrometry analysis. (docksci.com)

They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)

We discuss how recent chemical proteomic approaches have delivered the first global overviews of protein lipidation in these organisms, contributing to our understanding of the role of this PTM in critical metabolic and cellular functions. (imperial.ac.uk)

These methods dramatically increase the likelihood of producing proteins that cannot fold or assemble appropriately. (cipsm.de)

A family of proteins that play a role as cofactors in the process of CLATHRIN recycling in cells. (lookformedical.com)

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)

A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. (lookformedical.com)

The outer surface of these vesicles is covered with a lattice-like network of the protein CLATHRIN. (lookformedical.com)

G-protein receptor kinases (GRKs) help terminate GPCR signaling through receptor desensitization and downregulation and also modulate signaling via phosphorylation-independent functions. (hellobio.com)

A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (lookformedical.com)
Reported as G q- G-protein inhibitor and broad-spectrum inhibitor for G q - and G s -proteins. (hellobio.com)

Together, these data suggest a model for kinesin 13 depolymerization in which increased efficiency is achieved by binding of one kinesin 13 molecule to adjacent protofilaments. (silverchair.com)

This study tested this hypothesis by determining the effect of the PCAIs on the levels of RAS and related monomeric G-proteins. (oncotarget.com)
Kaniyappan S , Balaji V, Wang Y, Mandelkow E . Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer's Disease. (neurotree.org)

Here, we show that mouse Stbd1 is a transmembrane endoplasmic reticulum (ER)-resident protein with the capacity to induce the formation of organized ER structures in HeLa cells. (imperial.ac.uk)

These results indicate that the second head of dimeric kinesin 13 does not have access to adjacent binding sites on the curved protofilament and suggest that the neck alone is sufficient to obstruct access. (silverchair.com)

Wegmann S , Biernat J, Mandelkow E . A current view on Tau protein phosphorylation in Alzheimer's disease. (neurotree.org)

Anatomy25

Organisms7

Diseases1

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology2

Phenomena and Processes54

Information Science4

Vesicular Transpor1

Peptides2

Subunit2

Membrane13

Posttranslational modifications2

Complexes1

Hydrolysis2

HSP702

Vitro2

Nucleotide4

Guanine1

Receptors4

Preferentially1

Molecules3

Enzyme3

Receptor Kinase2

Molecular3

Interaction2

Tubulin1

Actin7

Neuronal2

Translocation2

Complex8

Enzymes1

Functional2

Critically1

Subunits2

Regulation2

Isoforms1

Homolog1

Escherichia2

Found1

Function3

Domain8

Interactions2

Form1

Structure1

Organisms1

Methods1

Family1

Play2

Segment1

Outer1

Functions1

Broad2

Model1

Study2

Formation1

Sites1

View1