Atrophy temporal lobe. Medical search. Frequent questions

Hyperreligiosity is a symptom of Geschwind syndrome, which is associated with temporal lobe epilepsy. (wikipedia.org)
Hyperreligiosity may be associated with epilepsy - in particular temporal lobe epilepsy involving complex partial seizures - mania, frontotemporal lobar degeneration, Anti-NMDA receptor encephalitis, hallucinogen related psychosis and psychotic disorder. (wikipedia.org)
Stevens, 1966) have been reinterpreted (Blumer, 1975) to indicate that there is, in fact, a difference: those with temporal lobe epilepsy are more likely to have more serious forms of emotional disturbance. (wikipedia.org)
Seized: Temporal Lobe Epilepsy as a Medical, Historical, and Artistic Phenomenon. (wikipedia.org)
The "Natural" History of Medically Treated Temporal Lobe Epilepsy: What Can an Evidence-Based Approach Tell Us? (hindawi.com)
We systematically reviewed the literature to describe the "natural" history of medically treated temporal lobe epilepsy (TLE). (hindawi.com)
Temporal lobe epilepsy (TLE) is the most frequent medically refractory epilepsy syndrome seen in epilepsy outpatient clinics. (hindawi.com)
Mesial temporal lobe epilepsy (mTLE) associated with hippocampal sclerosis (mTLE-HS), a condition that can be detected by modern magnetic resonance imaging (MRI) techniques with a high sensitivity and specificity, is now the most common indication for epilepsy surgery. (hindawi.com)
Extrahippocampal integrity in temporal lobe epilepsy and cognition: thalamus and executive functioning. (utah.edu)
Thalamic atrophy and cognition in unilateral temporal lobe epilepsy. (utah.edu)
MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy. (utah.edu)
Quality of life and comorbid medical and psychiatric conditions in temporal lobe epilepsy. (utah.edu)
In humans the most frequent form is mesial temporal lobe epilepsy (mesial TLE) and is characterised by hippocampal sclerosis (HS). (infona.pl)
In 2005, based upon research involving several large French-Canadian families that presented with temporal lobe epilepsy, an expanded conceptualization of the molecular genetics of the autosomal recessive form NA was attained. (medscape.com)
Hippocampal sclerosis is associated with intractable TEMPORAL LOBE EPILEPSY. (bvsalud.org)

We conducted an interobserver study to assess agreement on visual rating of medial temporal lobe atrophy on coronal T1-weighted MRI. (nih.gov)
After dichotomizing medial temporal lobe atrophy into present or absent, a post hoc analysis revealed higher complete agreement (70%), with kappa values of 0.59 (95% CI = 0.51-0.67) and 0.62 (95% CI = 0.48-0.075), for the two techniques (all four raters). (nih.gov)
From this study we conclude that visual rating of medial temporal lobe atrophy on MRI in the coronal plane yields fair to good agreement among observers. (nih.gov)
We recommend this type of visual rating for use in clinical settings when a quick judgement on the presence of medial temporal lobe atrophy is needed. (nih.gov)
Mean rating scores for medial temporal lobe atrophy (MTA), periventricular hyperintensities (PVH), and white matter hyperintensities (WMH) for all subjects with dementia (n=71) according to APOE ϵ4 status. (jamanetwork.com)

We found that an increase in blood NfL may precede Alzheimer's disease-related changes in cortical atrophy and may be elevated in the preclinical stages of Alzheimer's disease," Damoiseaux said. (eurekalert.org)
Neuronal loss translates in specific spatiotemporal patterns of cortical atrophy, starting in the enthorinal cortex and spreading over other cortical regions according to specific propagation pathways. (frontiersin.org)
We developed a digital model of the cortical atrophy in the left hemisphere from prodromal to diseased phases, which is built on the temporal alignment and combination of several short-term observation data to reconstruct the long-term history of the disease. (frontiersin.org)
The model not only provides a description of the spatiotemporal patterns of cortical atrophy at the group level but also shows the variability of these patterns at the individual level in terms of difference in propagation pathways, speed of propagation, and age at propagation onset. (frontiersin.org)
Longitudinal MRI datasets of patients with mild cognitive impairments who converted to AD are used to reconstruct the cortical atrophy propagation across all disease stages. (frontiersin.org)
The model shows that, for instance, APOE carriers have a significantly higher pace of cortical atrophy but not earlier atrophy onset. (frontiersin.org)
This cortical atrophy presumably relates the traces of the progression of the lesions over the brain surface. (frontiersin.org)
CT of the brain was conducted 32 years after baseline examination (mean age=76 years) to evaluate cortical atrophy and white matter lesions. (bvsalud.org)

Pick disease is a term used to describe pathologic changes in FTD, including severe atrophy, neuronal loss, gliosis, and presence of abnormal neurons (Pick cells) containing inclusions (Pick bodies). (merckmanuals.com)
These modifications took the form of a structural change of the brain in particular an important neuronal loss and an atrophy of the brain cortex ( 7 , 8 ). (frontiersin.org)
Pick disease is defined pathologically by severe atrophy, neuronal loss, and gliosis. (medscape.com)

His case study "On the relationship between aphasia and senile atrophy of the brain" still serves as a frame of reference for apparently focal brain syndromes in diffuse or generalized degenerative diseases of the brain. (medscape.com)
[ 3 ] As Pick stated, "simple progressive brain atrophy can lead to symptoms of local disturbance through local accentuation of the diffuse process. (medscape.com)
Retinal assessments have been discussed as biomarkers for brain atrophy. (nature.com)
This observation by Dr. Brill is not unsurprising as the condition is most commonly seen in those people that have damaged the brain's orbitofrontal cortex (situated in the frontal lobes of the brain) and often caused by brain trauma , stroke, or a tumour. (psychologytoday.com)
The purpose was to determine the feasibility of functional MR imaging during a learning task in healthy elderly volunteers and in patients with Alzheimer's disease and to test our hypothesis that brain activation is decreased in the medial temporal lobe (MTL) memory system in patients with Alzheimer's disease compared with control volunteers. (ajnr.org)
Anticholinergic agents commonly used for colds and allergies have been linked with brain atrophy and dysfunction. (pharmacytimes.com)
They also had reduced glucose metabolism, as well as whole-brain and temporal lobe atrophy. (pharmacytimes.com)
The researchers thought this effect was additive, as more anticholinergic medications was associated with poorer executive function and increased brain atrophy. (pharmacytimes.com)
To the researchers' knowledge, this was the first study that looked at the relationship between anticholinergics and brain atrophy and metabolism. (pharmacytimes.com)
The brain structure imaging analysis of patients with AD and normal people (normal control, NC) has found that the gray matter volume of AD patients was significantly lower than that of normal people, and the gray matter in the hippocampus, temporal poles, and temporal islands also has significant shrinkage [ 1 ]. (hindawi.com)
In recent studies, measures of whole brain atrophy were strongly correlated with neuropsychological testing, explaining more variance than measures of lesion burden in patients with multiple sclerosis. (ajnr.org)
MR imaging generated measures of lesion burden (fluid-attenuated inversion recovery hyperintense volume), general atrophy (brain parenchymal fraction), central atrophy (lateral ventricle volume), and lobar atrophy (regional brain parenchymal fraction of frontal, temporal, parietal, and occipital lobes in each hemisphere). (ajnr.org)
Regional atrophy accounts for more variance than lesion burden, whole brain atrophy, or lateral ventricle volume in predicting multiple sclerosis-associated memory dysfunction. (ajnr.org)
Although modest correlations between MR imaging lesion ratings and cognitive dysfunction have been reported ( 11 - 16 ), recent research has found that cognitive dysfunction is more closely associated with brain atrophy than lesion burden ( 17 - 21 ). (ajnr.org)
When regression models were repeated with the third ventricle removed, a measure of whole brain atrophy (brain parenchymal fraction) accounted for most variance. (ajnr.org)
Despite the strong association between brain atrophy and cognitive dysfunction in multiple sclerosis, little is known about the clinical meaning of regional parenchymal atrophy. (ajnr.org)
Frontotemporal dementia (FTD) is a group of brain disorders caused by atrophy of the frontal and temporal lobes. (mentalhealth.com)
These changes result from shrinking frontal and temporal lobes, the areas of the brain that control behavior, movement, and language. (mentalhealth.com)
As the frontal and temporal lobes in the brain shrink due to FTD, the functions associated with those areas of the brain begin to deteriorate. (mentalhealth.com)
Jung and Damoiseaux concluded that research indicates that high blood levels of NfL reflect the severity of atrophy in several overlapping brain regions, especially the medial temporal lobe. (eurekalert.org)
Longitudinal studies also consistently found significant relationships between blood NfL and atrophy in brain regions vulnerable to Alzheimer's disease pathology. (eurekalert.org)
The review of the cross-sectional and longitudinal literature showed that blood NfL levels consistently predicted the severity of atrophy and glucose metabolism in brain areas commonly affected by Alzheimer's pathology. (eurekalert.org)
Cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease. (medindia.net)
Frontotemporal disorders, commonly called frontotemporal dementia, develop when the frontal (front) and temporal (side) lobes of the brain atrophy. (everydayhealth.com)
On the one hand, the spatial characterization of the lesions over the brain surface at each time, and, on the other hand, a temporal dynamic of these alterations that may differ from one region to another. (frontiersin.org)
Alzheimer's Disease is an accelerated form of age-related cognitive decline characterized by brain atrophy. (fatsoflife.com)
This study has uncovered a previously unknown association between higher omega-3 LCPUFA status and the potential for inhibition by supplemental B-vitamin intake of progressive brain atrophy in mild cognitive impairment in elderly people. (fatsoflife.com)
Brain structures that are affected in AD patients include the medial temporal lobe of the cortex, important for memory formation and storage, a general decrease in cortex volume, enlargement of the ventricles, and degeneration of the locus caeruleus. (fatsoflife.com)
OBJECTIVE: To examine the association between midlife tobacco smoking and late-life brain atrophy and white matter lesions. (bvsalud.org)
Macrocephaly was noted at birth, and rocephaly, frontotemporal brain atrophy his head circumference continued to grow and acute encephalopathic episodes char- parallel to the 98th centile. (who.int)

There were no associations between smoking and atrophy in the temporal or occipital lobe, or with white matter lesions. (bvsalud.org)

Structural analysis showed a striking correlation between semantic deficit and degree of atrophy in the anterolateral temporal lobe. (ucl.ac.uk)
Unlike Alzheimer disease, which typically presents with impairment of recent memory associated with entorhinal cortex and hippocampal dysfunction, Pick disease typically affects the frontal and/or anterolateral temporal lobes. (medscape.com)

while svPPA characteristically presents with vocabulary loss and impaired word comprehension associated with asymmetric anterior temporal lobe atrophy. (biomedcentral.com)
Functional analysis suggested that the anterior temporal lobes were being activated abnormally, possibly in an attempt to compensate for the damage, while the posterior inferior temporal lobe failed to activate despite being structurally intact. (ucl.ac.uk)
For example, the anterior temporal lobe may act as a 'convergence' region, integrating multimodal representations into a unique concept. (ucl.ac.uk)

In England and Europe, cases of frontal lobe dementia were described with progressive dysfunction of the frontal lobes. (medscape.com)
The condition described in the North American literature as primary progressive aphasia and that described in the European literature as frontal dementia have been combined under the term frontotemporal lobe dementia (FTD) or frontotemporal lobar degeneration (FTLD). (medscape.com)
An alternate term, frontotemporal lobar degeneration, relates to pathologies associated with the frontotemporal lobe dementia syndromes. (medscape.com)
Frontotemporal dementia (FTD) refers to sporadic and hereditary disorders that affect the frontal and temporal lobes, including Pick disease. (merckmanuals.com)
A form of presenile DEMENTIA characterized by cortical dementia, NEUROFIBRILLARY TANGLES without SENILE PLAQUES, Fahr's type CALCINOSIS, and ATROPHY in frontotemporal or TEMPORAL LOBE. (curehunter.com)
Progressive fluent dementia with temporal lobe atrophy. (bvsalud.org)
In families with an inherited frontal lobe dementia (some of which have been found to be pathologically or clinically indistinguishable from Pick disease), linkage to markers on chromosomes 17, 9, and 3 have been reported. (medscape.com)

The latter showed atrophy of the cerebellum and abnormal signal changes in both temporal lobes and the left occipital lobe. (medscape.com)

In the elderly control volunteers, activation during memory encoding was observed in medial and lateral temporal lobe structures (fusiform, parietal and occipital parts, and hippocampal formation) and in the frontal cortex, as reported previously in studies of young control volunteers. (ajnr.org)
In normals, the semantic network comprised the left anterior and inferolateral temporal lobe, inferior frontal lobe and temporo-parietal junction. (ucl.ac.uk)

The study of the temporal evolution of the cerebral cortex reveals an atrophy of the gray matter ( 9 ). (frontiersin.org)
CONCLUSION: Longstanding tobacco smoking was mainly associated with atrophy in the frontal lobe cortex. (bvsalud.org)

We hypothesize that a combination of plasma and structural MRI biomarkers, which are less costly and non-invasive, is predictive of longitudinal progression measured by atrophy and cognitive decline in early AD, providing a practical alternative to PET or cerebrospinal fluid biomarkers. (lu.se)

Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease: x-ray computed tomography, magnetic resonance imaging and Xe-133 SPECT studies. (jamanetwork.com)
Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease Alzheimers Dement. (usc.edu)

MR imaging is a valuable tool for characterizing multiple sclerosis lesions and atrophy ( 9 , 10 ). (ajnr.org)

Baseline plasma (p-tau 181 and neurofilament light chain) and MRI-based structural medial temporal lobe subregional measurements and their association with longitudinal measures of atrophy and cognitive decline were tested using stepwise linear mixed effect modeling in CN and MCI, as well as separately in the Aβ+/Aβ− subgroups. (lu.se)

This condition is thought to be related to the early occurring pathologic alterations in the medial temporal lobe (MTL) system (2) . (ajnr.org)
In the classic form of the disorder, central nervous system pathologic features include atrophy of the caudate and putamen and, to a lesser extent, the globus pallidus and substantia nigra. (medscape.com)

Volumetric measurements and visual assessment of MTL atrophy by use of MR imaging are sensitive markers of Alzheimer's disease, even for mild forms of the disease (3-8) . (ajnr.org)
The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort Alzheimers Dement. (usc.edu)
We recently examined potential relationship between tau protein uptake in medial temporal lobe (MTL) and volumetric measures of MTL subregions in a small dataset of Alzheimer's disease patients. (upenn.edu)

[ 7 ] can disproportionally affect the frontal and temporal cortical regions. (medscape.com)

C: Coronal view of T1-weighted MRI shows atrophy of the caudate nuclei. (medscape.com)

In addition, those who took anticholinergic medication had reduced total cortical volume and temporal lobe cortical thickness and greater lateral ventricle and inferior lateral ventricle volumes compared with those who weren't taking the medications. (pharmacytimes.com)

However, a certain amount of tissue has to be lost before these techniques show the characteristic abnormalities, and it may be hypothesized that dysfunction of the MTL system occurs before atrophy is present to the extent that it can be assessed. (ajnr.org)
However, the only study showing correlation between regional lobar atrophy (dorsal frontal) and concordant (executive function) neuropsychological dysfunction was based on semiquantified, visual inspection of MR imaging scans ( 24 ). (ajnr.org)

Based on previous findings, we expected that these tasks would result in activation of bilateral temporal and inferior frontal cortices. (ajnr.org)
of the head shows fronto-temporal atrophy carnitine levels in urine were elevated and and bilateral subdural haemorrhage glutaryl-CoA dehydrogenase activity in cul- tured fibroblasts was low. (who.int)

Primary progressive aphasia is a focal atrophy syndrome that may be associated with Pick disease, Alzheimer disease, or other pathology. (medscape.com)

Whether or not MTL atrophy is dependent on increasing amyloid load before the emergence of cognitive deficits is still disputed. (unige.ch)
The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. (ajnr.org)
Some of the focus is changing to non-pharmacological approaches aimed at restoring biochemical deficiencies that underlie the atrophy of neuronal tissue, and preventing the cognitive decline preceding AD. (fatsoflife.com)

Patients with multiple sclerosis showed significant atrophy and impairment on all neuropsychological tests. (ajnr.org)
Another study by the same group ( 23 ), asked whether, in a cross-sectional study, absolute or normalized measures of frontal atrophy would correlate best with neuropsychological tests. (ajnr.org)

Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. (jamanetwork.com)

Comparing the different stages of AD patients, it is found that hippocampus atrophy is significant in the initial stage. (hindawi.com)

Therefore, in this article, we aimed to explore the relationship between neuropsychological impairment and regional lobar atrophy after accounting for the influence of generalized lesion and atrophy measurements in patients with multiple sclerosis. (ajnr.org)

A fine-scale modeling of the atrophy propagation is likely to give a wider understanding of the disease evolution, as the structural markers seems reliable to assess the conversion to the AD stage, potentially carrying subtle indicators of the disease progression in early phases. (frontiersin.org)

If shrinkage is in the frontal lobes, personality and motor control changes will result. (mentalhealth.com)
If shrinkage is in the temporal lobes, a loss of language comprehension is more likely to occur. (mentalhealth.com)
Some people experience shrinkage in both lobes, resulting in several clusters of symptoms occurring simultaneously. (mentalhealth.com)

Then, the inferior lateral area of the temporal lobe changes obviously, and finally, the frontal lobe begins to shrink [ 2 ]. (hindawi.com)

Studies that claim to show no difference in emotional makeup between temporal lobe and other epileptic patients (Guerrant et al. (wikipedia.org)
Input data were grouped into three primary meta-analytic classes: gray matter atrophy, increased function, and decreased function in patients with major depression relative to healthy control subjects. (psychiatryonline.org)
Homocysteine is a known risk factor for vascular damage and associated with hypoperfusion of the neocortex and atrophy of the medial temporal lobe in AD patients. (fatsoflife.com)

Neuroimaging may support the diagnosis of Alzheimer disease, particularly if it reveals temporal lobe and hippocampal atrophy. (logicalimages.com)

Consequently, behavioral adaptation to advances in local time and to rotational shift work is slow and progressive, accompanied by temporal disorder of physiology. (jneurosci.org)
She also had progressive unsteady gait and slurred speech due to progressive cerebellar atrophy. (medscape.com)

We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis. (ajnr.org)
The clinical symptoms associated with FTD depend on the lobe that's affected. (mentalhealth.com)

results confirmed the importance of temporal regions for semantic processing and suggested that the inferior frontal lobe was not necessary for task performance. (ucl.ac.uk)

Clinically, the deficit appears restricted to the frontal and/or temporal lobes. (medscape.com)

The frontal lobe controls personality and movement, among other things, while the temporal lobe controls language, perception, and memory, to name a few. (mentalhealth.com)

Anatomy38

Organisms1

Diseases67

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology67

Phenomena and Processes20

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Humanities4

Information Science13

Named Groups1

Health Care16

Epilepsy15

Medial temporal lob5

Cortical atrophy8

Neuronal loss3

Brain30

White Matter Lesions1

Anterolateral temporal2

Anterior temporal3

Dementia7

Occipital lobe1

Parietal2

Cortex2

Biomarkers1

APOE2

Lesions1

Subregional1

Pathologic2

Alzheimer's3

Affect the frontal1

Coronal1

Lateral ventricle1

Dysfunction2

Bilateral2

Pathology1

Cognitive3

Neuropsychological Tests2

Amygdala1

Hippocampus1

Measurements1

Progression1

Shrinkage3

Inferior lateral1

Patients3

Alzheimer1

Progressive2

Clinical2

Semantic1

Deficit1

Personality1